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Relationship Between Complex PTSD Symptoms and Emotion Dysregulation : graduation thesis
No full textBackground: Complex posttraumatic stress disorder is characterized by core PTSD symptoms along with disturbances in self-organization, including affective dysregulation, negative self- concept, and interpersonal difficulties. Emotion dysregulation is considered a central component of cPTSD, yet the specific relationship between emotion dysregulation and distinct cPTSD symptom clusters warrant further exploration. Methods: A cross-sectional study was conducted among military veterans (N = 62) using the DERS-16 to assess emotion dysregulation and the International Trauma Questionnaire to measure cPTSD symptoms. Descriptive statistics, the Kolmogorov-Smirnov test, and box plots were used to evaluate variable distributions. Due to non-normality, Spearman correlation coefficients were calculated to assess associations between emotion dysregulation and cPTSD symptom severity. ANOVA tests were conducted to examine further correlations. Analyses were performed using JASP version 0.19.3, with significance set at p f 0.05. Results: Strong positive correlations were found between overall cPTSD severity and emotion dysregulation. DSO symptom clusters were significantly more correlated with emotion dysregulation than core PTSD clusters. Among PTSD symptoms, avoidance showed moderate correlation with emotion dysregulation, re- experiencing showed a weak correlation, and threat-related symptoms were not significantly associated. Furthermore, longer combat duration was significantly related to higher emotion dysregulation and more severe DSO symptoms, particularly impulsivity, emotional clarity, and lack of regulation strategies. Conclusions: The findings reinforce the conceptualization of cPTSD as a disorder fundamentally rooted in emotion dysregulation. DSO features, especially affective dysregulation and negative self-concept, appear intrinsically linked to difficulties in managing emotional responses. Additionally, prolonged trauma exposure (e.g., extended combat) contributes significantly to these difficulties
Translation and Adaptation of the Survey of Organizational Research Climate to the Croatian Context
No full textAn organizational climate based on research integrity is one of the key goals of contemporary universities and scientific organizations. Survey of Organizational Research Climate is widely tested and used instrument for measuring organizational climate based on research integrity developed in the USA; however, its successful use in different cultures and environments requires translation and adaptation. This study aims to translate and adapt Survey of Organizational Research Climate to the social, legal, and cultural context of Croatia in a three-phase process. First, we translated the survey into Croatian using a double-blind forward and backward translation method. Next, we conducted a content validity assessment in which experts examined whether all relevant aspects of the research integrity climate were successfully translated and adapted to the Croatian context. Finally, a face validity assessment was performed to evaluate the comprehensibility of the survey among typical representatives of the academic population in Croatia. Croatian version of the Survey of Organizational Research Climate survey will enable successful monitoring and evaluation of organizational climate in Croatian educational institution with internationally comparable results
Treatment of chondral knee lesions
No full textPhysical activity is an important component of health and well-being for people of all ages.
Unfortunately, physical activity also carries a risk of injury. The knee joint, due to its location and complex functioning, is very susceptible to damage. The annual incidence of any clinically diagnosed soft-tissue knee injury for the whole population is estimated to be 720 per 100,000 persons [1]. The knee is the most commonly injured joint by adolescent athletes, with an estimated 2.5 million sports-related injuries presenting to emergency departments annually. [2].
The term chondral knee lesions refer to a damage or an alteration of the physiological structure of the articular cartilage of the knee joint. The cartilage is a white smooth tissue covering the epiphyses of the bones where they come together to form joints. Its function is to reduce friction during movement and provide cushioning to absorb impact. When the cartilage is damaged, it can lead to pain, swelling and reduced function of the knee
Impact of Light Pollution on the Development of Obesity by Influencing the Quality of Sleep : Graduation Thesis
No full textThe increasing prevalence of light pollution has been recognized as a significant environmental factor influencing sleep quality and metabolic health. This thesis investigates the hypothesis that light pollution contributes to obesity development by dysrupting sleep patterns. Exposure of artificial light at night interferes with the circadian rhythm, leading to melatonin suppression, fragmented sleep, delayed sleep onset and hormonal imbalances. Leptin, ghrelin and cortisol are mostly affected by ALAN and contribute to increased hunger and appetite, weight gain, fat accumulation and insulin resistance. This paper shows recent evidence, by presenting several studies and review papers linking higher obesity rates to light pollution. This thesis underlines the importance of recognizing light pollution as a modifiable risk factor in the obesity epidemic and advocates for integrated approaches to combine environmental, lifestyle and interventions to improve human health
The impact of IglF mutant of Francisella tularensis LVS strain on the intracelullar replication
No full textFrancisella tularensis je gram - negativna, fakultativno unutarstanična bakterija koja uzrokuje bolest tularemiju u životinja i ljudi. Zbog visoke infektivnosti, širenja aerosolom i sposobnosti izazivanja teške kliničke slike F. tularensis je kategorizirana kao potencijalni bioteroristički agens. F. tularensis subsp. holarctica soj LVS (engl. live vaccine strain) je živo atenuirano cjepivo. LVS je virulentan za miševe, ali ne i za ljude pa se često koristi u eksperimentalnim istraživanjima virulencije roda Francisella. Francisella tularensis je bakterija koja ima široki raspon domaćina, a primarni rezervoar bolesti su glodavci i zečevi. Glavni mehanizam patogeneze je sposobnost Francisella da izbjegne prepoznavanja i eliminaciju od strane imunološkog sustava unutar stanica domaćina. Jedan od glavnih čimbenika virulencije F. tularensis je atipični sustav sekrecije tipa VI (T6SS) koji je pod kontrolom Francisella patogenog otoka (FPO). Sastavljanje T6SS ovisi o iglF, iglI, iglJ i iglG. Iako je otkrivena uloga brojnih gena, uloga iglF gena u patogenezi tularemiji još uvijek nije istražena. Cilj ovog završnog rada bio je odrediti ulogu iglF gena na unutarstanično razmnožavanje F. tularensis, određivanjem broja bakterija u imortaliziranim mišjim makrofagima nakon infekcije s F. tularensis subsp. holarctica sojem LVS, mutantom ΔiglF i njenom komplemetantom iglF/iglF. Stanice su inficirane u omjeru 1:100. Broj unutarstaničnih bakterija određen je 2, 24, 48, 72 i 168 sati nakon infekcije. Analizom razlika unutarstaničnog preživljavanja F. tularensis subsp. holarctica soja LVS, mutante ΔiglF i komplementante iglF/iglF jasno se vidi da je prisutnost funkcionalnog iglF gena nužna za učinkovito preživljavanje i razmnožavanje unutar domaćinske stanice. Najznačajniji
pokazatelj istraživanja je statistički značajno smanjenje broja unutarstaničnih bakterija mutante ΔiglF u svim promatranim vremenskim razdobljima.Francisella tularensis is a gram-negative, facultative intracellular bacterium that causes the disease tularemia in animals and humans. Due to its high infectivity, aerosol spread, and ability to cause severe clinical symptoms, F. tularensis has been categorized as a potential bioterrorist agent. F. tularensis subsp. holarctica strain LVS (live vaccine strain) is a live attenuated vaccine. LVS is virulent in mice but not in humans, and is often used in experimental studies of Francisella virulence. Francisella tularensis is a bacterium with a wide host range, and the primary reservoir of the disease is rodents and rabbits. The main mechanism of pathogenesis is the ability of Francisella to evade recognition and elimination
by the immune system within host cells. One of the primary virulence factors of F. tularensis is the atypical type VI secretion system (T6SS), which is regulated by the Francisella pathogenicity island (FPI). The assembly of the T6SS depends on iglF, iglI, iglJ, and iglG. Although the role of numerous genes has been discovered, the role of the iglF gene in the pathogenesis of tularemia has not yet been investigated. This final work aimed to determine the role of the iglF gene in the intracellular reproduction of F. tularensis by measuring the number of bacteria in immortalized mouse macrophages after infection with F. tularensis subsp. holarctica strain LVS, mutant ΔiglF, and its complement iglF/iglF. Cells were infected at a ratio of 1:100. The number of intracellular bacteria was determined 2, 24, 48, 72, and 168 hours after infection. By analyzing differences in intracellular survival of F. tularensis subsp. holarctica strain LVS, ΔiglF mutants, and iglF/iglF complements show that the presence of a functional iglF gene is necessary for efficient survival and reproduction within the host cell. The most significant indicator of the research is a statistically significant decrease in the number of intracellular bacteria of the ΔiglF mutant in all observed periods
Quality of life of patients with chronic lymphocitic leukemia
No full textKronična limfocitna leukemija (KLL) je najčešća leukemija odraslih u zapadnim zemljama, a karakterizira je nakupljanje zrelih, ali funkcionalno nekompetentnih B-limfocita u krvi, koštanoj srži i limfnim čvorovima. Većina bolesnika je u trenutku dijagnoze asimptomatska, a liječenje se započinje tek kod pojave simptoma ili progresije bolesti. Dijagnoza se temelji na laboratorijskim nalazima i fenotipskoj analizi stanica. U terapiji se najčešće koriste ciljani lijekovi, poput inhibitora BTK i BCL2, koji su zamijenili kemoterapiju u prvoj liniji liječenja. Prognoza varira, ali relativno petogodišnje preživljenje iznosi oko 89%. Kvaliteta života (HRQoL) pacijenata značajno je narušena zbog umora, infekcija, nuspojava liječenja, emocionalnog stresa i socijalnih problema. Za procjenu HRQoL-a koriste se standardizirani upitnici (EORTC QLQ-C30, QLQ-CLL17), koji bilježe simptome i opterećenja pacijenata. Kvaliteta života varira ovisno o stadiju bolesti i vrsti terapije – pacijenti koji se prate bez terapije često imaju bolju fizičku, ali lošiju emocionalnu i socijalnu dobrobit u usporedbi s onima koji su na terapiji. Umor i briga o budućnosti najčešći su i najteži problemi koji utječu na sve dimenzije HRQoL-a.
HRQoL u pacijenata s KLL-om izuzetno je važan aspekt liječenja, osobito s obzirom na produljeni životni vijek zahvaljujući novim terapijama. Brojni simptomi i izazovi često narušavaju HRQoL, a personalizirani, holistički pristup liječenju može značajno pridonijeti njegovom poboljšanju. Nužno je daljnje prilagođavanje i standardizacija alata za mjerenje HRQoL-a te uključivanje šire populacije bolesnika u istraživanja.Chronic lymphocytic leukemia (CLL) is the most common leukemia in adults, and is characterized by the accumulation of mature but functionally incompetent B-lymphocytes in the blood, bone marrow, and lymph nodes. Most patients are asymptomatic at the time of diagnosis, and treatment begins only when symptoms appear or the disease progresses. Diagnosis is based on laboratory findings and phenotypic analysis of the cells. Targeted drugs, such as BTK and BCL2 inhibitors, are most often used in therapy, which have replaced chemotherapy in the first-line treatment. The prognosis varies, but the relative five-year survival is about 89%. The quality of life (HRQoL) of patients is significantly impaired due to fatigue, infections, side effects of treatment, emotional stress, and social problems. Standardized questionnaires (EORTC QLQ-C30, QLQ-CLL17) are used to assess HRQoL, which record patients' symptoms and burden. Quality of life depends on the stage of the disease and the type of therapy – patients who are on active surveillance have better physical, but worse emotional and social well-being compared to those who are on therapy. Fatigue and concern about the future are the most common and most difficult problems related to all dimensions of HRQoL.
HRQoL in patients with CLL is an extremely important aspect of treatment, especially considering the prolonged life expectancy due to new therapies. Numerous challenges often impair HRQoL, and a personalized, holistic approach to treatment can significantly contribute to its improvement. Further adaptation and standardization of tools for measuring HRQoL and the inclusion of a wider patient population in research are necessary
Improvement of Oxidative Stability and Antioxidative Capacity of Virgin Olive Oil by Flash Thermal Pretreatment—Optimization Process
No full textFlash thermal pretreatment (FTT) is a promising technique for enhancing virgin olive oil (VOO) quality. This study investigated the effects of FTT, both cooling (15–25 °C) and heating (30–40 °C), on phenolics, tocopherols, fatty acid composition, oxidative stability (OSI), antioxidant capacity (AC), and volatile composition in VOOs from three Croatian varieties: Istarska Bjelica, Levantinka, and Oblica. A full factorial experimental design was used with two independent variables: treatment temperature and olive variety. Olive pastes were treated after crushing and before malaxation. Data were evaluated using ANOVA, partial least squares (PLS) regression, and response surface methodology (RSM). Istarska Bjelica showed the highest OSI improvement (+16%) mostly linked to elevated phenolic compounds. Levantinka exhibited moderate responses, with slight OSI and AC declines. Oblica was most sensitive to heating, showing OSI and AC reductions (up to 28%), despite increased oleocanthal and olacein. RSM identified optimal FTT temperatures for each variety: 18.9 °C (Istarska Bjelica), 15.4 °C (Levantinka), and 15.5 °C (Oblica). These findings support variety-specific FTT as an effective strategy to improve VOO functional and sensory quality
The impact of LLMs on negotiation preparation in supermarket chains' sales and procurement departments in Primorsko-goranska County
No full textThis thesis explores the impact of LLMs on the negotiation preparation in supermarket chains' sales and procurement departments in Primorsko-goranska County. The main objective was to examine the degree to which LLMs are used there, especially with the purpose of preparing for business negotiations, and whether the users are content with the models’ role in improving their negotiation outcomes. The research was conducted using a survey that 75 respondents filled in. The main finding is that only 29% of the respondents ever used LLMs for professional purposes in general, and almost none use them to prepare for their business negotiations. However, the research also confirms the ongoing trend of more and more employees using LLMs at work, implying that the models may play a significant role in helping negotiators prepare for negotiations in the future.Ovaj rad istražuje utjecaj LLM-ova (velikih jezičnih modela) na pripremu za pregovore u odjelima prodaje i nabave lanaca supermarketa na području Primorsko-goranske županije. Glavni cilj bio je ispitati u kojoj se mjeri LLM-ovi koriste u tim odjelima, posebno za pripremu poslovnih pregovora, te jesu li korisnici zadovoljni ulogom modela u poboljšavanju ishoda njihovih pregovora. Istraživanje je provedeno putem ankete koju je ispunilo 75 ispitanika. Najvažniji rezultat istraživanja je da je samo 29% ispitanika ikada koristilo LLM-ove u profesionalne svrhe općenito, a gotovo nitko od njih ne koristi ih za pripremu poslovnih pregovora. Ipak, istraživanje potvrđuje i sve izraženiji trend sve češćeg korištenja LLM-ova na radnom mjestu, što implicira da bi modeli u budućnosti mogli imati značajnu ulogu u pripremi pregovarača za pregovore
The impact of negotiation tactics on business negotiations of independent musicians in the concert industry sector in Croatia
No full textTema rada je utjecaj pregovaračkih taktika na poslovno pregovaranje nezavisnih glazbenika u hrvatskoj koncertnoj industriji. Istraživanje se fokusira na to kako različite taktike, priprema za pregovore i korištenje digitalnih alata utječu na uspjeh glazbenika u dogovaranju nastupa.
Cilj je bio identificirati najučinkovitije pregovaračke taktike, analizirati utjecaj pripreme i edukacije te ulogu digitalnih alata u unaprjeđenju pregovaračke komunikacije i organizacije nastupa. Kao istraživačka metoda korištena je online anketa provedena među 70 nezavisnih glazbenika. Rezultati pokazuju da sustavna priprema i korištenje suradničkih taktika doprinose uspješnijem poslovnom pregovaranju, dok digitalni alati dodatno olakšavaju komunikaciju i kontrolu procesa.The topic of this thesis is the impact of negotiation tactics on business negotiations conducted by independent musicians in the Croatian live music industry. The research focuses on how different tactics, negotiation preparation, and the use of digital tools influence musicians’ success in arranging performances.
The aim was to identify the most effective negotiation tactics, analyze the impact of preparation and education, and examine the role of digital tools in improving negotiation communication and event organization. The research method used was an online survey conducted among 70 independent musicians. The results show that systematic preparation and the use of collaborative tactics contribute to more successful business negotiations, while digital tools further facilitate communication and process control
Quaternions and 3D geometric transformations
No full textTeorija kvaterniona poznata je još od 1843. godine, kada ju je otkrio irski matematičar William Rown Hamilton. Zbog njene nekomutativne prirode, u početku se ovoj teoriji pristupalo s oprezom, no kvaternioni su s vremenom pronašli značajne primjene u različitim područjima. Danas igraju važnu ulogu u računalnoj grafici, sustavima upravljanja zrakoplovima, kvantnoj fizici,... Unatoč širokom spektru primjena, kvaternioni se rijetko spominju tijekom obrazovanja, stoga je cilj ovog rada približiti pojam kvaterniona, objasniti njihovu algebarsku strukturu te pokazati kako ih možemo koristiti za jednostavno i precizno opisivanje rotacija u trodimenzionalnom prostoru