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Daratumumab for PRCA after HCT: study and practical considerations from the EBMT Transplant Complications Working Party
No full textAbstract Pure red cell aplasia (PRCA) is a relevant complication after ABO-mismatched allogeneic hematopoietic cell transplantation (HCT). No standard treatment exists, and practice is heterogenous. In this study, we took advantage of an international collaboration to describe characteristics and outcomes of patients receiving daratumumab for PRCA following first allogeneic HCT. We identified 45 patients meeting these criteria (median patient age, 56 years). The median time from HCT to PRCA was 55 days (IQR, 36–116) and all patients were transfusion-dependent at time of daratumumab start. Daratumumab was first-line treatment in 16 patients (36%), most patients (67%) received daratumumab intravenously, and median time from PRCA diagnosis and daratumumab start was 88 days (IQR, 59–219). Incidence of transfusion independence was 69% (95% confidence interval [CI], 52–80%) at 6 months and 80% (95% CI, 62–90%) at 12 months. Incidences of hemoglobin and reticulocyte recoveries were respectively 56 and 78% at 6 months and 65 and 83% at 12 months. Survival at 12 months was 81%, and of 8 deaths, 7 were GVHD- or infection-related. One death was associated with hemolytic anemia. This is the first international and largest study on the use of daratumumab for PRCA after allogeneic HCT, showing high response rates superior to that reported for other treatments. Seven incidents of severe adverse events (mostly infections) underscore the need for close monitoring, proactive management, and comparative studies to determine the role for daratumumab for PRCA. Last, based on these data and a comprehensive literature review, we provide practical consideration for modern PRCA treatment
TFDE drive on LNG tanker
No full textTFDE pogon predstavlja naprednu tehnologiju koja omogućuje korištenje tri vrste goriva – ukapljenog prirodnog plina („boil-off gasa“), dizelskog goriva i teškog brodskog goriva. Ovakva fleksibilnost omogućuje optimalno upravljanje potrošnjom goriva i smanjenje emisije štetnih plinova, što je u skladu s globalnim ekološkim zahtjevima i regulativama. Završni rad se bavi analizom TFDE (Tri-Fuel Diesel Electric) pogonskog sustava na tankerima za prijevoz ukapljenog prirodnog plina (LNG). Prijevoz LNG-a se odvija kroz kompleksan sustav koji uključuje specijalizirane LNG brodove te posebne morske i lučke terminale s naprednom tehnološkom infrastrukturom. Cilj je omogućiti učinkovit i ekonomski isplativ prijevoz. Ovakvi sustavi pogona temelje se na elektromotorima koji dobivaju energiju iz generatora napajanih gorivima. Za razliku od klasičnih mehaničkih pogona, ovdje se mehanička snaga proizvodi putem električne energije. Dodatna prednost je korištenje isparene količine tereta (tzv. „boil-off gas“) kao goriva – dioTFDE propulsion represents an advanced technology that enables the use of three types of fuel – liquefied natural gas (boil-off gas), diesel fuel and heavy marine fuel. This flexibility enables optimal management of fuel consumption and reduction of harmful gas emissions, which is in accordance with global ecological requirements and regulations. The final thesis deals with the analysis of the TFDE (Tri-Fuel Diesel Electric) propulsion system on tankers for the transport of liquefied natural gas (LNG). The transport of LNG (liquefied natural gas) takes place through a complex system that includes specialized LNG ships and special sea and port terminals with advanced technological infrastructure. The goal is to enable efficient and economically viable transportation. Such propulsion systems are based on electric motors that receive energy from fuel-powered generators. Unlike classic mechanical drives, here mechanical power is produced through electrical energy. An additional advantage is the use of the evapor
Burners on marine boilers
No full textBrodski generatori pare proizvode paru koja se koristi za pogon parnih turbina, pomoćnih uređaja (poput crpki i separatora) te za grijanje različitih sustava na brodu. Oni omogućuju stabilnu i učinkovitu pretvorbu energije iz goriva u toplinsku i mehaničku energiju unutar brodskog energetskog sustava. Gorači brodskih generatora pare ključna su komponenta sustava za proizvodnju pare jer osiguravaju učinkovito izgaranje goriva i stabilan rad generatora pare. Njihov razvoj usko je povezan s napretkom pomorske tehnologije i prilagodbom različitim vrstama goriva, loživog ulja, boil-off plina (BOG) na LNG brodovima te kombiniranog izgaranja ulja i plina.Marine steam generators produce steam that is used to power steam turbines, auxiliary equipment (such as pumps and separators), and for heating various systems on board. They enable stable and efficient conversion of energy from fuel into thermal and mechanical energy within the ship’s power system. Burners in marine steam generators are a key component of the steam production system, ensuring efficient fuel combustion and stable operation of the steam generator. Their development is closely linked to advances in marine technology and adaptation to different types of fuel, including fuel oil, boil-off gas (BOG) on LNG carriers, and combined oil-gas combustion
Puppeteer : Odyssey retelling
No full textThe final work named Puppeteer is an Odyssey retelling comic. The work was made on the course Digital Illustration IV. With the use of vibrant illustrations and text elements, the author tells a story about the adventures of the man who’s trying to go home. Different layouts and perspectives help to show power and emotions of the characters.
The final work was made in the form of a digital illustration using InDesign and Procreate
Authenticity assessment of honeydew honey based on phytochemical profile
No full textConsidering the health-beneficial properties of honeydew honey and difficulties in its authenticity assessment, a high-performance thin-layer chromatography (HPTLC) fingerprint method in combination with multivariate analysis was developed, in order to relate phenolic profiles of selected honey samples to their verified botanical origin and biological activity. The HPTLC chromatograms were obtained using two derivatization reagents, vanillin-sulfuric acid and 2,2-diphenyl-1-picrylhydrazyl (DPPH) solution. Phenolic profiles of samples indicated the uniformity within each honey variety, but also variability among different botanical origin. Chemometric evaluation, including principal component analysis and partial least squares discriminant analysis, hyphenated with chromatographic method provided a discriminative and predictive methodology for classification of Hungarian oak, Evergreen oak, Montpellier maple and Silver fir honey samples. The analysis highlighted the significance of specific phenolic compounds (e.g., RF = 0.31, 0.41, 0.51) for distinguishing the samples, underscoring the potential for accurate botanical authentication of samples, particularly Hungarian oak honey, based on its chemical profile. The HPTLC-DPPH method demonstrated a high potential for differentiating samples based on antioxidant activity, offering an efficient alternative to other techniques for antioxidant activity determination. PLS-DA models successfully predicted the botanical origin of Quercus spp., Evergreen oak and Hungarian oak. This approach can be useful for ensuring the quality control of honeydew honey products, providing an efficient and resource-saving alternative to more advanced analytical techniques. Additionally, caffeic acid emerged as the most potent antioxidant across the selected honeydew honey varieties. This highlights the potential of caffeic acid as a key bioactive compound contributing to the health-promoting properties of honeydew honey
Congenital pseudoarthrosis of the clavicle
No full textUrođena pseudoatroza ključne kosti iznimno je rijetka anomalija obilježena nesrastanjem medijalne i lateralne osifikacijske jezgre. Prvi put je opisana 1910. godine i od tada je zabilježeno tek tristotinjak slučajeva. Pojavnost ove anomalije je oko 1:150.000, a dijagnoza se većinom postavi u adolescentskoj dobi. U ranijoj dobi često se previdi jer se zadebljanje ključne kosti protumači kao posttraumatski kalus. Ključna kost je prva kost koja osificira intrauterino s razvijenim osifikacijskim centrima (medijalni i latealni) već sredinom četvrtog tjedna gestacije, koji se međusobno spoje krajem sedmog tjedna. Veći dio ključne kosti razvija se iz medijalnog dijela (oko 80%). Prvi radiološki znakovi okoštavanja medijalnog kraja vide se između 13. i 14. godine života. Etiologija još uvijek nije razjašnjena. Jedna teorija povezuje pojavu povišenog pritiska potključne arterije, druge ju povezuju s intrauternim položajem fetusa ili kao mogući nasljedni poremećaj. Liječenje prirođene pseudoartroze ključne kosti kontraverzno je. Opisani slučajevi većinom su liječeni konzervativno, osobito ako su bili asimptomatski. Kirurški su pak liječeni oni s funkcionalnim ograničenjima, iz estetskih razloga, te djeca koja su osjećala progresivnu bol. Kirurško liječenje se preporučuje i kod djece kojima su ulomci razmaknuti više od 1 cm. Predložene tehnike za stabilizaciju su različite: intramedularna Kirschnerova žica, pločica i vijci, Steinmannov čavao te vanjska fiksacija. U većini slučajeva potreban je koštani transplantat, osobito u starije djece, a najčešće mjesto donora je krista ilijaka. Optimalna dob za operativno liječenje jest između treće i šeste godine života, kada je mogućnost komplikacija najmanja. Prijelomi ključne kosti i urođena pseudartroza teško se razlikuju kod male djece, osobito pri prvom pregledu. Iako je urođena pseudartroza rijetka, treba na nju misliti jer neliječena u predškolskoj dobi može imati lošije ishode u kasnijoj dobi. Autori u ovom radu daju pregled dosadašnjih spoznaja o urođenoj pseudoartrozi ključne kosti te razmatraju terapijske postupke.Congenital pseudarthrosis of the clavicle is an extremely rare anomaly characterized by the failure of fusion between the medial and lateral ossification centers. First described in 1910, only about 300 cases have been documented since. The incidence of this anomaly is approximately 1 in 150,000, with diagnosis mostly occurring in adolescence. In early childhood, it is often overlooked as clavicular thickening may be misinterpreted as a post-traumatic callus. The clavicle is the first bone to ossify in utero, with developed ossification centers (medial and lateral) by the middle of the fourth week of gestation, which fuse by the end of the seventh week. Most of the clavicle develops from the medial part (around 80%). The initial radiographic signs of ossification at the medial end become visible between the ages of 13 and 14. The precise etiology of this malformation remains unclear. One theory links it to increased pressure from the subclavian artery, while others associate it with fetal intrauterine positioning or a possible hereditary disorder. The treatment of congenital pseudarthrosis of the clavicle is controversial. Most documented cases have been treated conservatively, especially if asymptomatic. Surgical intervention is reserved for those with functional limitations, esthetic concerns, or progressive pain. Surgery is also recommended in children with a gap between fragments exceeding 1 cm. Various stabilization techniques have been proposed, including intramedullary Kirschner wire, plates and screws, Steinmann pins, and external fixation. Bone grafting is often required, especially in older children, with the iliac crest being the most common donor site. The optimal age for surgical treatment is between three and six years, as complication rates are lower. Clavicle fractures and congenital pseudarthrosis are challenging to distinguish in young children, especially during initial examination. Although congenital pseudarthrosis is rare, it should be considered as untreated cases in preschool years may result in poorer outcomes later. The authors of this paper provide a review of current knowledge on congenital pseudarthrosis of the clavicle and discuss therapeutic approaches
Safety margin in ECDIS
No full textU ovom završnom radu se obrađuje sigurnosna margina Informacijskog sustava i prikaza elektroničkih karata (engl. Electronic Chart Display and Information System – ECDIS). Glavni cilj rada je razjasniti značajke sigurnosne margine ECDIS sustava koje su od izuzetne važnosti za pravovremeno otkrivanje opasnosti i minimaliziranje ljudskih pogrešaka u navigaciji. Sigurnosna margina može se podijeliti na horizontalnu i vertikalnu komponentu. U radu će naglasak biti na primjeni i postavljanju sigurnosnih margina. U horizontalnom smislu razjasnit će se postavke kako bi brod plovio na sigurnoj udaljenosti od navigacijskih opasnosti, dok će se u vertikalnom smislu, razjasniti postavljanje parametra vezanih za sigurnosnu dubinu. Analizirat će se i određene nezgode koje su nastale upravo zbog nepravilnog korištenja i postavljanja sigurnosnih parametara vezanih za dubinu zbog kojih je došlo do nasukavanja brodova.This thesis addresses the safety margin of the Electronic Chart Display and Information System (ECDIS). The main goal of the thesis is to clarify the safety margins of the ECDIS system, which are crucial for the timely detection of hazards and minimizing
human errors in navigation. Safety margin can be divided into horizontal and vertical component. The emphasis of the thesis will be on the application and setting of safety margin. In the horizontal sense, it will explain the settings required for the vessel to navigate at a safe distance from navigational hazards, while in the vertical sense, it will clarify the parameters related to safety depth settings. The thesis will also analyze accidents that occurred due to improper configuration of safety margins, which led to the grounding of vessels
Časoslov vojvode od Berrya braće Limbourg
No full textTema završnog rada je Časoslov vojvode od Berrya braće Limbourg. U radu se raspravlja o naručitelju, vojvodi od Berryja, te o iluminatorima, braći Limbourg, U središnjem dijelu rada analizira se struktura rukopisa. Posebna je pažnja posvećena minijaturama koje prikazuju dvanaest kalendarskih mjeseci
Traditional medieval wooden sacred architecture in Scandinavia
No full textVikinška plemena počela su graditi tradicijske drvene sakralne crkve u Skandinaviji nakon što je vikinški vođa Olaf I. Tryggvason preuzeo vlast u Norveškoj i počeo širiti kršćanstvo na njezinim obalnim regijama. Pretpostavlja se da su kršćani nastavili poštovati tradiciju Germana podižući crkve na mjestima njihovih nekadašnjih hramova. Germanska plemena imala su izrazit utjecaj na arhitekturu tradicijskih drvenih crkava, što se prepoznaje u njihovom naglašavanju središnjeg stupa i simbolike „Stabla svijeta“. U arhitekturi drvenih crkava uočavaju se i srodnosti s kamenim bazilikama Zapadne Europe, a neki specifičnu konstrukciju njihovih krovova vezuju s orijentalnim pagodama Kine i Japana. Smatra se da je nekoć postojalo više od 1300 tradicijskih drvenih crkava u Norveškoj, no danas je sačuvano tek 28. Iako su nastajale na području čitave Skandinavije, tek ih je nekolicina očuvano izvan Norveške. Većina sačuvanih datira iz 11. i 12. stoljeća. Postoji četiri glavnih tipova skandinavskih drvenih sakralnih crkvi na temelju njihovog rasporeda prostorija i konstrukcije: jednostavne drvene crkve, crkve s produženim glavnim brodom, crkve s istaknutim središnjim stupom te crkve s podignutom lađom. Srednjovjekovne drvene crkve nastavile su tradiciju štovanja poganskih bogova. U drvo su često urezivani značajni motivi i likovi iz poganskih religija, poput nordijskih bogova, viteza Sigurda, zmajeva i biljnih vitica. Velik dio unutrašnjih oslika drvenih crkava danas nije očuvan. Slikarstvo je bilo ograničeno na područje oltara i baldahina, a posebno je značajan antependij s prikazom Kristova Raspeća iz crkve u Røldalu. Nekoliko je uzroka nestajanja drvenih crkava, a to su klimatski utjecaji, požari te ljudsko djelovanje; osobito 1990-ih godina zbog nastanka sotonističkog pokreta u Norveškoj. Specifičnost drveta kao materijala uvjetuje posebne metode zaštite drvenih crkava. Umjetnik i povjesničar umjetnosti Johan Christian Clausen Dahl osnovao je Društvo za očuvanje drevnih norveških spomenika te potaknuo procese rekonstrukcija i restauracija brojnih drvenih crkava širom Skandinavije