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The impact of the Covid-19 pandemic on the treatment of patients with low back pain in the Department of Emergency Medicine of the Split-Dalmatia County
No full textCilj istraživanja: Analizirati strukturu i broj pacijenata liječenih od lumbalnog bolnog sindroma na Zavodu za hitnu medicinu Splitsko -dalmatinske županije u periodu od ožujka 2019. - ožujka 2022. godine. Utvrditi postoji li značajan utjecaj pandemije bolesti COVID-19 na broj pacijenata liječenih od lumbalnog bolnog sindroma kroz analizu podataka o broju liječenih pacijenata u perioda prije pandemije (ožujak 2019. - ožujak 2020.), periodu prilagodbe na pandemiju (ožujak 2020. - ožujak 2021.) te periodu nakon prilagodbe na pandemiju (ožujak 2021. - ožujak 2022.).
Metode: Istraživanje je provedeno na sekundarnim podacima dobivenim od Zavoda za hitnu medicinu Splitsko – dalmatinske županije. Uzorak su činili svi pacijenti pedijatrijske (0 - 19), radno aktivne (20 - 64) i umirovljeničke (65 - 100) dobi, muškog i ženskog spola, liječeni od lumbalnog bolnog sindroma ambulantno ili putem intervencije tima za hitnu pomoć u periodu od ožujka 2019. - ožujka 2022.
Rezultati: Ovo istraživanje je pokazalo promjene u broju pacijenata liječenih od lumbalnog bolnog sindroma na Zavodu za hitnu medicinu Splitsko - dalmatinske županije u periodu od ožujka 2019. - ožujka 2022., a na koje je utjecala pandemija bolesti COVID-19.
Zaključci: Istraživanje je pokazalo da postoji značajna razlika u broju ambulantno liječenih pacijenata na Zavodu za hitnu medicinu Splitsko-dalmatinske županije tokom perioda prije pandemije bolesti COVID-19 (ožujak 2019. - ožujak 2020.), perioda prilagodbe na uvjete pandemije (ožujak 2020. - ožujak 2021.) te perioda nakon prilagodbe na uvjete pandemije (ožujak 2021. - ožujak 2022.). S druge strane, nije utvrđena razlika u broju intervencija timova hitne pomoći kod pacijenata sa lumbalnim bolnim sindromom u promatranom vremenskom periodu. Osim toga, utvrđen je statistički značajno niži broj ambulantno liječenih pacijenata u periodu prilagodbe na uvjete pandemije u odnosu na period prije pandemije, dok nije utvrđena statistički značajna razlika u broju ambulantno liječenih pacijenata u periodu nakon prilagodbe na uvjete pandemije u odnosu na period prije pandemije. Također, nije utvrđena statistički značajna razlika u broju intervencija timova hitne pomoći za pacijente sa lumbalnim bolnim sindromom uspoređujući period prije pandemije u odnosu na period prilagodbe na pandemiju te uspoređujući period prije pandemije u odnosu na period nakon prilagodbe na pandemiju.Research objectives: The aim of this master thesis was to analyse the structure and number of patients treated for lumbar pain syndrome in the Department of Emergency Medicine of the Split-Dalmatia County in the period from March 2019. to March 2022. Another research objective was to determine whether there is a significant impact of the pandemic of the disease COVID-19 on the number of patients treated for lumbar pain syndrome through the analysis of data on the number of patients treated in the period before the pandemic (March 2019. - March 2020.), the period of adaptation to the pandemic (March 2020. - March 2021.) and the period after adaptation to the pandemic (March 2021. - March 2022.).
Methods: The research was conducted on secondary data obtained from the Department of Emergency Medicine of the Split-Dalmatia County. The sample consisted of all paediatric (0 - 19), working (20 - 64) and retired (65 - 100) age patients, male and female, treated for lumbar pain syndrome on an outpatient basis or through the intervention of an emergency team in the period from March 2019. - March 2022.
Results: This research showed changes in the number of patients treated for lumbar pain syndrome at the Department of Emergency Medicine of the Split-Dalmatia County in the period from March 2019 to March 2022, which were affected by the COVID-19 pandemic.
Conclusions: The research showed that there is a significant difference in the number of outpatients treated at the Department of Emergency Medicine of the Split-Dalmatia County during the period before the COVID-19 pandemic (March 2019. - March 2020.), the period of adaptation to the conditions of the pandemic (March 2020. - March 2021.) and the period after adaptation to the conditions of the pandemic (March 2021. - March 2022.). On the other hand, no significant difference was found in the number of interventions by emergency teams in patients with lumbar pain syndrome in the observed time period. In addition, a statistically lower number of outpatients treated in the period of adaptation to pandemic conditions was found compared to the period before the pandemic, while no statistically significant difference was found in the number of outpatients treated in the period after adaptation to pandemic conditions compared to the period before the pandemic. Also, no statistically significant difference was found in the number of interventions by emergency teams for patients with lumbar pain syndrome comparing the period before the pandemic compared to the period of adaptation to the pandemic and comparing the period before the pandemic compared to the period after adaptation to the pandemic
Comparison between Breast MRI and Contrast-Enhanced Mammography
No full textSažetak:
Uvod: Zračenje i MRI igraju ključnu ulogu u probiru i dijagnozi raka dojke. CEM koristi X-zrake za otkrivanje abnormalnosti dojke, dok MRI daje detaljne informacije o mekom tkivu. Ove tehnike snimanja pomažu u ranom otkrivanju i boljim ishodima liječenja raka dojke.
Cilj rada: Cilj rada je pojedinačno prikazati tehniku kontrastne mamografije i magnetske rezonancije dojke te izdvojiti prednosti i nedostatke svake od tih metoda kako bi se omogućila njihova usporedba.
Rasprava: CEM nudi prednosti u prikazivanju dojki, uključujući točno određivanje stadija tumora, otkrivanje dodatnih lezija i praćenje odgovora na liječenje. Koristan je kod nejasnih mamografskih nalaza i kod rizičnih žena s gustim grudima. CEM kombinira prednosti mamografije s mogućnostima poboljšanja kontrasta. Međutim, ima veću dozu zračenja i artefakte. MRI dojke pruža detaljne slike, bolju identifikaciju lezija i procjenu odgovora na liječenje. Preporučuje se visokorizičnim pacijentima i može otkriti tumore koji su propušteni drugim metodama. Nove tehnike kao što su DWI i skraćeni protokoli nude dodatne mogućnosti. MRI dojke ima ograničenja, uključujući artefakte i cijenu. CESM je održiva alternativa MRI-u visoke osjetljivosti i specifičnosti. CEM i MRI imaju svoje prednosti i ograničenja te su potrebna daljnja istraživanja.
Zaključak: Prikaz raka dojke napredovao je s tehnikama kao što su mamografija, CEM i MRI. Kombinirana uporaba CEM i MRI poboljšava dijagnostičku točnost. Standardizirani sustavi izvješćivanja pomažu u komunikaciji i poboljšavaju brigu o pacijentima. Tekući napredak i standardizacija dodatno poboljšavaju ove tehnike snimanja. Oni mijenjaju liječenje raka dojke i poboljšavaju ishode pacijenata.Summary:
Introduction: X-rays and MRI play crucial roles in breast cancer screening and diagnosis. CEM uses X-rays to detect breast abnormalities, while MRI provides detailed soft tissue information. These imaging techniques aid in early detection and better treatment outcomes for breast cancer.
Aim of the paper: The aim of the paper is to present the technique of contrast mammography and magnetic resonance of the breast individually and to distinguish the advantages and disadvantages of each of these methods in order to enable their comparison.
Discussion: CEM offers advantages in breast imaging, including accurate tumor staging, detection of additional lesions, and monitoring treatment response. It is useful in cases of unclear mammography findings and for high-risk women with dense breasts. CEM combines the benefits of mammography with contrast enhancement capabilities. However, it has higher radiation dose and artifacts. Breast MRI provides detailed images, better lesion identification, and assessment of treatment response. It is recommended for high-risk patients and can detect tumors missed by other methods. New techniques like DWI and abbreviated protocols offer additional options. Breast MRI has limitations, including artifacts and cost. CESM is a viable alternative to MRI with high sensitivity and specificity. CEM and MRI have their own advantages and limitations, and further research is needed.
Conclusion: Imaging of breast cancer has advanced with techniques such as mammography, CEM and MRI. The combined use of CEM and MRI improves diagnostic accuracy. Standardized reporting systems aid communication and improve patient care. Ongoing advances and standardization further improve these imaging techniques. They are changing breast cancer treatment and improving patient outcomes
Molecular diagnostics and targeted treatment of colon cancer
No full textCilj: Cilj ovog rada je prikazati molekularno testiranje kojim se utvrđuje status gena KRAS, NRAS i BRAF kao prediktivnih biomarkera kod pacijenata s karcinomom debelog crijeva radi primjene ciljane terapije u njihovu liječenju.
Materijal i metode: Materijal koji se koristi za analizu je tumorsko tkivo pacijenta. Opisan je postupak izolacije DNA, mjerenja koncentracije DNA te umnožavanje DNA uz pomoć komercijalno dostupnih kitova.
Rezultati: Rezultati koji se dobiju metodom lančane reakcije polimerazom u stvarnom vremenu (RT-PCR) obrađuju se softwerski, a potom se analiziraju postojeće mutacije u uzorku pacijenta.
Zaključak: U ovom radu prikazana je važnost molekularnog testiranja gena KRAS, NRAS i BRAF kod pacijenata s kolorektalnim karcinomom u svrhu primjene ciljane terapije. Kako bi se provela analiza i utvrdila prisutnost mutacija, potrebno je iz uzorka tumorskog tkiva izolirati DNA, odrediti njenu koncentraciju, a zatim ju umnožiti.Objectives: The aim of this paper is to present molecular testing that determines the status of KRAS, NRAS and BRAF genes as predictive biomarkers in patients with colon cancer for the purpose of applying targeted therapy in their treatment.
Material and methods: The material used for analysis is the patient's tumor tissue. The procedure for DNA isolation, measurement of DNA concentration and DNA amplification with the help of commercially available kits is described.
Results: The results obtained by the real-time polymerase chain reaction (RT-PCR) method are processed by software, and then the existing mutations in the patient's sample are analysed.
Conclusion: This paper shows the importance of molecular testing of KRAS, NRAS and BRAF genes in patients with colorectal cancer for the purpose of applying targeted therapy. In order to carry out the analysis and determine the presence of mutations, it is necessary to isolate DNA from the tumor tissue sample, determine its concentration, and then multiply it
Laboratory diagnosis of echinococcosis
No full textHidatidoza je svjetska zoonoza uzrokovana larvalnim stadijem trakavice Echinococcus, koja je
endemična u mnogim dijelovima svijeta. Ehinokokoza je relevantan zdravstveni problem u nerazvijenim
područjima gdje ne postoji veterinarska kontrola. Patogenost ehinokokne ciste ovisi o mehaničkom
učinku same ciste. Najčešća lokacija hidatidnih cističnih lezija je u jetri s nižom prijavljenom
incidencijom u bilo kojem drugom organu ili tkivu. Dijagnoza ehinokokoze ovisi o kliničkim,
radiološkim i serološkim nalazima. Uključuje kombinaciju medicinske anamneze, fizikalnog pregleda,
laboratorijskih testova i slikovnih pretraga poput ultrazvuka, CT – a ili MRI – a. Osnova je liječenja
kirurški zahvat koji se kombinira s antihelmintikom albendazolom. Preventivni programi usmjereni su na
dehelmintizaciju pasa, koji su konačni domaćini.Hydatid disease is a global zoonosis caused by the larval stage of the Echinococcus
tapeworm, which is endemic in many parts of the world. Echinococcosis is a relevant health problem in
underdeveloped areas where there is no veterinary control. The pathogenicity of the hydatid cyst depends
on the mechanical effect of the cyst itself. The most common location of hydatid cystic lesions is the
liver, with lower reported incidences in any other organ or tissue. The diagnosis of echinococcosis relies
on clinical, radiological, and serological findings. It combines a medical history check, physical
examination, lab testing, and imaging tests such an MRI, CT scan, or ultrasound. The cornerstone of
treatment is surgical intervention combined with the anthelmintic drug albendazole. Preventive programs
are focused on deworming dogs, which are the definitive host
Amniocentesis in the University Hospital Center Split
No full textDijagnostika kromosomopatija je važan dio prenatalne zaštite trudnica. Najčešće izvođena metoda
antenatalne dijagnostike kromosomopatija ploda je amniocenteza, točnije rana amniocenteza s ciljem
kariotipizacije ploda. Analizom cijelog ispitivanog razdoblja većina ranih amniocenteza je napravljena
između 16. i 20. tjedna trudnoće. Uvođenje kombiniranog testa i kasnije neinvazivnog prenatalnog testiranja
pomaklo je prosječnu dob trudnoće za izvođenje rane amniocenteze tjedan dana: od dominantno navršenih 17
tjedana na 16. Najčešća indikacija za izvođenje rane amniocenteze u ispitivanoj populaciji je životna dob
trudnice. Uočeno smanjenje udjela ranih amniocenteza zbog obiteljske i osobne anamneze sa značajnim
padom zadnjih godina znak je dobre kliničke prakse i vremenom razvijenih internih postupnika indiciranja
metoda invazivne prenatalne dijagnostike. Pojavom neinvazivnog prenatalnog testiranja broj ranih
amniocenteza u Klinici za ženske bolesti i porode KBC Split značajno se smanjio, a udio patoloških nalaza
kariograma povećao.Diagnostic of chromosomopathies is an important part of prenatal care for pregnant women. The
most commonly performed method of antenatal diagnosis of fetal chromosomal abnormalities is
amniocentesis, more precisely early amniocentesis with the aim of fetal karyotyping. By analyzing the entire
examined period, most early amniocentesis were performed between the 16th and 20th weeks of pregnancy.
The introduction of the combined test and later non-invasive prenatal testing moved the average gestation age
for performing early amniocentesis for one week: from the dominantly completed 17 weeks to 16. The most
common indication for performing early amniocentesis in the studied population is the age of the pregnant
woman. The observed reduction in the proportion of early amniocentesis due to family and personal history
with a significant decrease in recent years is a sign of good clinical practice and developed internal procedures
for indicating methods of invasive prenatal diagnostics. With the advent of non-invasive prenatal testing, the
number of early amniocentesis in the Clinic has significantly decreased and the share of pathological
karyogram findings has increased
The role of the midwife in intrapartum monitoring and the risk of giving birth to a child with the umbilical cord wrapped around the neck
No full textCilj ovog rada bio je istražiti utječe li omotana pupkovina oko vrata u porodu na učestalost rađanja hipoksične djece, ocijenjeno Apgar score – om te povećava li učestalost rađanja carskim rezom. Provedeno je retrospektivno istraživanje u Klinici za ženske bolesti i porode KBC – a Split u razdoblju od 1. srpnja 2022. do 1. listopada 2022. godine. Tijekom navedenog razdoblja ukupno je bilo 1075 poroda. Studijsku grupu činili su porodi s omotanom pupkovinom oko vrata kojih je bilo 168, dok je ostatak od 907 poroda predstavljao kontrolnu skupinu. Rezultati rada obuhvaćali su: broj poroda, rodnost, termin poroda, način poroda, težinu novorođenčadi, Apgar score, pH pupkovine, duljinu pupkovine te broj omotaja pupkovine oko vrata fetusa. Istraživanjem je dokazano kako omotana pupkovina oko vrata ne utječe na nepovoljne ishode trudnoće, kao ni na nižu vrijednost Apgar score – a. Također je potvrđena hipoteza iz dostupne literature koja govori o tome kako omotana pupkovina oko vrata nije indikacija za porod carskim rezom.The aim of this study was to investigate whether a nuchal cord during childbirth affects the incidence of hypoxic infants, as assessed by Apgar score, and whether it increases the rate of cesarean section deliveries. A retrospective study was conducted at the Department of Obstetrics and Gynecology, Clinical Hospital Center Split, from July 1, 2022, to October 1, 2022. During this period, a total of 1,075 deliveries were included. The study group consisted of deliveries with a nuchal cord, totaling 168 cases, while the remaining 907 deliveries formed the control group. The study's results included the number of deliveries, birth rate, gestational age, mode of delivery, newborn weight, Apgar scores, umbilical cord pH, cord length, and the number of cord wraps around the fetus's neck. The study demonstrated that a nuchal cord does not have an impact on adverse pregnancy outcomes or lower Apgar scores. Additionally, the hypothesis from available literature was confirmed, indicating that a nuchal cord is not an indication for cesarean section
Nursing care for patients with hip fracture
No full textPrijelom kuka nije tako čest slučaj kada se promatra udio u svim oblicima prijeloma
kod ljudi. Međutim kada je riječ o osobama starije životne dobi jasno je kako se pojavljuje u
značajnom broju slučajeva te uzrokuje mnogobrojne i opasne komplikacije. Uloga medicinske
sestre i tehničara je da u svim fazama procesa liječenja osiguraju pacijentu pružanje odgovarajuće
zdravstvene njege te na takav način pospješi njegov oporavak te povratak svakodnevnom životu,
aktivnostima i bližnjimaHip fracture is not such a common case when looking at the proportion of all types
of fractures in humans. However, when it comes to elderly people, it is clear that it appears in a
significant number of cases and causes numerous and dangerous complications. The role of the
nurse and technician is to ensure that the patient is provided with adequate health care at all stages
of the treatment process and in this way accelerates his recovery and return to everyday life,
activities and loved ones
Assessment of sarcopenia in hospital conditions
No full textSarkopenija se definira kao gubitak mišićne mase u kombinaciji s promjenama u tjelesnoj funkciji i kvaliteti mišića uzrokovano starenjem ili kroničnim bolestima. Česti uzroci sarkopenije su i disbalans spolnih hormona te manjak tjelesne aktivnosti zbog čega se sarkopenija, osim u starijoj životnoj dobi, može pojaviti i kod mlađe populacije. Za dijagnostiku sarkopenije postoje brzi i jednostavni testovi, ali još uvijek nisu dovoljno prepoznati i redovno korišteni u sklopu fizioterapijske procjene. Cilj ovog rada je povećati svijest o jednostavnosti, lakoći i potrebi provođenja testova za dijagnostiku sarkopenije. Proveli smo testiranje na 9 nasumično odabranih ispitanika različitih dobnih skupina i različitog indeksa tjelesne mase (ITM). Ispitivanje se sastojalo od Upitnika za procjenu snage, hodanja uz asistenciju, ustajanja sa stolice, penjanja stepenicama i padova (SARC-F), Kratkog seta testova fizičkih sposobnosti (SPPB), Idi i ustani testa (TUG) i Manualno mišićnog testa (MMT). Testiranje je trajalo svega 10 do 15 minuta po sudioniku. Rezultati svih ispitanika su ukazivali na izrazito nizak rizik od sarkopenije ili da rizika uopće nema. Iako su rezultati ispitivanja sudionika slični, zamjetne razlike među ispitanicima vidljive su u rezultatima SPPB testa u kojem su 4 ispitanika različite životne dobi pokazala znakove manjeg fizičkog ograničenja, ali nedovoljno da bi se ustanovio rizik od sarkopenije. Rizik od sarkopenije nastaje već u mladosti te ukoliko se na vrijeme ne prepozna i ne liječi, njezine posljedice izravno utječu na kvalitetu života počevši od invalidnosti pa sve do morbiditeta. Ovim istraživanjem dokazana je jednostavnost i brzina testova za dijagnostiku sarkopenije koje bi trebalo uvrstiti u svakodnevnu fizioterapijsku procjenu kako bi se mogla na vrijeme otkriti, ali i liječiti ova bolest.Sarcopenia is defined as a loss of muscle mass in combination with changes in physical function and muscle quality caused by aging or chronic diseases. Common causes of sarcopenia are an imbalance of sex hormones and a lack of physical activity, which is why sarcopenia, apart from the elderly, can also occur in the younger population. There are quick and simple tests for the diagnosis of sarcopenia, but they are still not sufficiently recognized and regularly used as part of physiotherapy assessment. The aim of this work is to increase awareness of the simplicity, ease and necessity of conducting tests for the diagnosis of sarcopenia. We conducted testing on 9 randomly selected subjects of different age groups and different body mass index (BMI). The examination consisted of Questionnaire for Assessment of Strength, Assisted Walking, Rising from a Chair, Climbing Stairs and Falls (SARC-F), Short Physical PerformanceBattery Test (SPPB), Timed Up and Go (TUG) and Manual Muscle Test (MMT). . The testing lasted only 10 to 15 minutes per participant. The results of all subjects indicated an extremely low risk of sarcopenia or no risk at all. Although the results of the participant's tests are similar, noticeable differences between the subjects are visible in the results of the SPPB test in which 4 subjects of different ages showed signs of minor physical limitation, but not enough to establish the risk of sarcopenia. The risk of sarcopenia arises already at a young age, and if it is not recognized and treated in time, its consequences directly affect the quality of life, starting with disability and ending with morbidity. This research proved the simplicity and speed of tests for the diagnosis of sarcopenia, which should be included in the daily physiotherapy assessment in order to be able to detect and treat this disease in time
Perioperative nursing care for patient with spinal injuries
No full textOzljede kralježnice spadaju u najteže ozljede u traumatologiji, pogotovo ako su udružene s ozljedom
kralježnične moždine. Posljedice same ozljede za pacijenta i njegovu obitelj mogu biti iznimno teške sa
više aspekata pacijentova života kao što su medicinski, socijalni, ekonomski i psihološki aspekt. Pacijenti
s ozljedom kralježnice mogu zahtijevati postupak liječenja od konzervativnog pa sve do operacijskog
postupka. Medicinske sestre imaju ključnu ulogu u pružanju kvalitetne zdravstvene njege tijekom
perioperacijskog razdoblja. Svojim specijaliziranim znanjem i stručnošću one mogu pomoći da pacijenti s
ozljedom kralježnice dobiju najvišu kvalitetu skrbi. Perioperacijska skrb ima tri elementa koja uključuju
psihičku i fizičku pripremu bolesnika za operacijski zahvat, zbrinjavanje bolesnika u operacijskoj dvorani,
zdravstvenu njegu u sobi za buđenje i na bolesničkom odjelu. Perioperacijska faza završava otpuštanjem
bolesnika iz bolnice ili premještanjem u rehabilitacijsku ustanovu. Procjenom zdravstvenog stanja
bolesnika, te drugih čimbenika formira se sestrinska dijagnoza koja je temelj plana zdravstvene njege i
provedenih intervencija. Medicinske sestre moraju predvidjeti potencijalne komplikacije kao što su
infekcije, krvarenja te posljedice dugotrajnog ležanja.
Važna je suradnja multidisciplinarnog tima kojeg čine kirurški tim, fizioterapeut, radni terapeut,
psiholog te socijalni radnik koji sastavljaju odgovarajući plan skrbi o bolesniku s ozljedom kralježnice.Spine injuries are among the most serious injuries in traumatology, especially if they are associated
with a spinal cord injury. The consequences of the injury itself for the patient and his family can be
extremely difficult with many aspects of the patient's life such as medical, social, economic and
psychological aspects. Patients with a spinal cord injury may require a course of treatment ranging from
conservative to surgical. Nurses play a key role in providing quality healthcare during the perioperative
period. With their specialized knowledge and expertise, they can help patients with spinal cord injuries
receive the highest quality of care. Perioperative care has three elements, which include psychological and
physical preparation of the patient for surgery, care of the patient in the operating room, medical care in the
recovery room and in the patient ward. The perioperative phase ends with the patient's discharge from the
hospital or transfer to a rehabilitation facility. By assessing the patient's health condition and other factors,
a nursing diagnosis is formed, which is the basis of the health care plan and implemented interventions.
Nurses must anticipate potential complications such as infections, bleeding, and the consequences of
prolonged bed rest.
It is important to cooperate with a multidisciplinary team consisting of a surgical team, a physiotherapist,
an occupational therapist, a psychologist and a social worker who draw up an appropriate care plan for a
patient with a spinal cord injury
Somatostatine receptor scintigraphy in diagnosis of neuroendocrine tumors
No full textU ovom radu detaljno se obrađuje tema neuroendokrinih tumora i primjena scintigrafije somatostatinskih receptora kao ključne slikovne dijagnostičke metode za njihovu dijagnostiku i praćenje. Neuroendokrini tumori rijetki su tipovi tumora, međutim njihova incidencija u svijetu je u stalnom i značajnom porastu. To su tumori koji mogu nastati u različitim dijelovima tijela, a koji sadrže velike koncentracije somatostatinskih receptora. Zahvaljujući scintigrafiji somatostatinskih receptora, danas je moguće otkriti neuroendokrine tumore koji nisu bili vidiljivi nekim drugim dijagnostičkim metodama, a s obzirom na vrlo visoku osjetljivost postala je jedna od najčešćih nuklearno-medicinskih metoda u otkrivanju i detekciji neuroendokrinih tumora.
Cilj ovoga rada bio je istražiti ulogu scintigrafije somatostatinskih receptora u obradi neuroendokrinih tumora u Kliničkom bolničkom centru Split. Provedeno je istraživanje u kojem je sudjelovalo ukupno 73 bolesnika, a svi podatci prikupljeni su na Kliničkom zavodu za nuklearnu medicinu Kliničkog bolničkog centra Split. U obzir su se uzimali parametri o spolu i dobi bolesnika, izmjerenoj vrijednosti kromogranina A i prisutnosti patološkog nakupljanja radiofarmaka. U svrhu analize, prikupljeni podatci o bolesnicima statistički su obrađeni i prikazani kroz tablice i slike. U istraživanju je sudjelovalo znatno više žena (60%) nego muškaraca (40), a prosječna starost iznosila je 63.58 godina.
Rezultati istraživanja otkrivaju značajne statističke razlike u vrijednostima patološkog nakupljanja radiofarmaka, ovisno o spolu i dobi bolesnika, ali i u vrijednostima kromogranina A u odnosu na dobnu skupinu bolesnika. Ovo istraživanje donosi spoznaje o važnosti korištenih parametara pri dijagnostici neuroendokrinih tumora, te potvrđuje ključnu ulogu scintigrafije somatostatinskih receptora u pravodobnoj identifikaciji i praćenju ovih tumora.This paper extensively discusses the topic of neuroendocrine tumors and the application of somatostatin receptor scintigraphy as a key imaging diagnostic method for their diagnosis and monitoring. Neuroendocrine tumors are rare types of tumors, but their incidence is steadily increasing worldwide. These tumors can develop in various parts of the body and contain significant concentrations of somatostatin receptors. Thanks to somatostatin receptor scintigraphy, it is now possible to detect neuroendocrine tumors that may not have been visible using other diagnostic methods, and due to its high sensitivity, it has become one of the most common nuclear medicine methods for detecting and diagnosing neuroendocrine tumors.
The aim of this study was to investigate the role of somatostatin receptor scintigraphy in the evaluation of neuroendocrine tumors at the Clinical Hospital Center Split. The study included a total of 73 patients, and all data were collected at the Department of Nuclear Medicine of the Clinical Hospital Center Split. Parameters such as gender, age of patients, measured chromogranin A levels, and the presence of pathological accumulation of radiotracer were considered. For the purpose of analysis, the collected patient data were statistically processed and presented through tables and figures. The study involved a significantly higher number of females (60%) than males (40%), with an average age of 63.58 years.
The research results reveal significant statistical differences in the values of pathological radiopharmaceutical accumulation based on gender and age of the patients, as well as in the values of chromogranin A concerning the patients' age group. This study provides valuable insights into the importance of the used parameters in diagnosing neuroendocrine tumors and confirms the crucial role of somatostatin receptor scintigraphy in timely identification and monitoring of these tumors