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Assessment of protective properties of viscoelastic coating on steel by the novel paste electrolyte cell
No full textU okviru ovog rada bilo je potrebno ispitati zaštitna svojstva komercijalne viskoelastične prevlake na osnovi poliizobutilena nanesene na površinu čelika. Metoda korištena za ispitivanje je elektrokemijska impedancijska spektroskopija, primjenom ReCorr® QCQ uređaja. Uz jednostavnost nanošenja i ekološku prihvatljivosti prevlake, impedancijska ispitivanja provedena na neoštećenom uzorku ukazuju na izvrsna zaštitna svojstva prevlake. U svrhu ispitivanja zaštitnih svojstava prevlake u neidealnim uvjetima, uzorak je mehanički oštećen, a impedancijski ispitivanja su pokazala da prevlaka na neoštećenim dijelovima i dalje pruža izvrsnu zaštitu od korozije. Nadalje, impedancijska mjerenja su provedena na mehanički oštećenom uzorku koji je prethodno izložen uvjetima 100 %-tne vlažnosti te na uzorku koji je izložen 3,5 %-tnoj otopini NaCl. Rezultati ispitivanja ukazali su na to da prevlaka ima loša zaštitna svojstva u prisustvu mehaničkih oštećenja koja prodiru do površine čelika, ali pokazuje izvrsna zaštitna svojstva pri mehaničkim oštećenjima koja ne prodiru do površine čelika. Osim toga, bilo je potrebno odrediti vodoupojnost prevlake upotrebom rezultata impedancijskih mjerenja nakon izlaganja uzorka vlažnim i slanim uvjetima te dobivene rezultate usporediti s rezultatima iz literature. Iz rezultata je vidljivo da prevlaka pokazuje veću vodoupojnost pri izlaganju vlažnim uvjetima nego pri izlaganju slanim uvjetima. Primjena EIS metode korištenjem ReCorr® QCQ uređaja pokazala se kao jednostavna i praktična metoda za ispitivanje zaštitnih svojstava viskoelastične prevlake. Također omogućava potvrdu značaja okolišnih uvjeta i vrste oštećenja za zaštitna svojstva prevlake.The task of this paper was to test the protective properties ofcommercial polyisobutylene-based viscoelastic coating applied to the steel surface. The method used for testing is electrochemical impedance spectroscopy, using the ReCorr® QCQ device. In addition to easy application and environmental acceptability of the coating, impedance tests performed on undamaged sample indicate excellent protective properties of the coating. In order to examine the protective properties of the coating under non-ideal conditions, the sample was mechanically damaged, and impedance results showed that the coating on undamaged parts still provides excellent protection against corrosion. Furthermore, impedance measurements were performed on a mechanically damaged sample that was previously exposed to conditions of 100 % humidity and on a sample that was exposed to a 3,5 % NaCl solution. Test results indicated that the coating has poor protective properties in the presence of mechanical damage that penetrates to the steel surface, but shows excellent protective properties in the presence of mechanical damage that does not penetrate to the steel surface. Also it was necessary to determine the water uptake of the coating using the results of impedance measurements after exposing the sample to humid and salt conditions, and to compare the obtained results with the results from the literature. It is evident from the results that the coating shows higher water uptake when exposed to humid conditions than when exposed to salt conditions. The application of the EIS method using the ReCorr® QCQ device proved to be a simple and practical method for testing the protective properties of the viscoelastic coating. It also enables confirmation of the importance of environmental conditions and the type of damage for the protective properties of the coating
Application of the Full Factorial Plan and Response Surface Methodology in the study of biodegradation of polystyrene by bacterial culture Delftia acidovorans
No full textŠirom svijeta na godišnjoj razini odbace se velike količine plastičnog otpada u okoliš. Jedan od velikih problema je jednokratna plastika i nerazvijeni sustavi za gospodarenje otpadom koji su doveli do gomilanja plastike. Jednom odbačena, plastika može dugi niz godina biti prisutna u okolišu. Pod utjecajem raznih vremenskih i vanjskih uvjeta razgrađuje se na manje čestice poznate kao mikroplastika. Osim toga, mikroplastika se proizvodi s namjerom dodavanja u razne kozmetičke proizvode i proizvode za osobnu njegu. Polistiren je jedna od najčešće korištenih vrsta plastike, pa shodno tome i često pronađen u okolišu. Utjecaj MP-a na organizme i ljudsko zdravlje nije još dovoljno istražen, ali činjenica da je sveprisutna i pronađena i u najudaljenijim mjestima na zemlji izazvala je veliku pozornost i zabrinutost.
K tome doprinosi velika specifična površina sposobna vezivati razne onečišćujuće tvari iz okoliša kao i razne patogene. Zbog toga se sve više provode razni testovi ekotoksičnosti na širokom broju organizama. Osim upoznavanja sa svim mogućim posljedicama izloženosti
MP-u, važno je razviti učinkovite načine njezinog uklanjanja iz okoliša. Posao je izazovan jer zbog svoje male veličine MP uspješno prolazi kroz razne sustave za filtraciju. Procesi biorazgradnje MP-a su obećavajuće zelene metode koje je potrebno razviti i prilagoditi određenim vrstama plastike i mikrobne zajednice. Kod ispitivanja MP-a za dobivanje cjelokupnih informacija važno je koristiti i prikladne metode karakterizacije. U radu je ispitana biorazgradnja MP čestica PS-a bakterijskom kulturom Delftia acidovorans prema punom faktorskom planu. Ispitani su optimalni uvjeti za proces biorazgradnje; pH–vrijednost, broj okretaja rotacijske tresilice i optička gustoća stanice bakterije. Pokus je trajao 30 dana a tijekom tog perioda određivane su vrijednosti ukupnog, organskog i anorganskog ugljika, te broj živih bakterijskih stanica. Potencijalno otpušteni aditivi analizirani su LC/MS metodom, a promjene u strukturi na FTIR_ATR. Ispitana je i ekotoksičnost filtrata primjenom morske bakterije Vibrio fischeri. Rezultati su pokazali da je došlo do određene biorazgradnje MP-a. Dobiveni optimalni uvjeti su pH–vrijednost (8), OG (0,5) i broj okretaja rotacijske tresilice od 172,12 rpm.All over the world, large amounts of plastic waste are thrown into the environment every year. One of the problems is single-use plastic and underdeveloped waste management systems that have led to the accumulation of plastic. Once discarded, plastic can be present in the environment for many years. Under the influence of various weather and external conditions, it breaks down into smaller particles known as microplastics. In addition, microplastics are produced with the intention of being added to various cosmetic and personal care products. Polystyrene is one of the most commonly used types of plastic, and therefore often found in the environment. The influence of MP on the organism and human health has not yet been sufficiently investigated, but the fact that it is ubiquitous and found even in the most remote places on earth has caused great attention and concern. A large specific surface capable of binding various pollutants from the environment as well as various pathogens contributes to this. For this reason, various ecotoxicity tests are increasingly carried out on a wide number of organisms. In addition to becoming familiar with all the possible consequences of exposure to MP, it is important to develop effective ways of removing it from the environment. The work is challenging because due to its small size, MP successfully passes through various filtration systems. MP biodegradation processes are promising green methods that need to be developed and adapted to specific types of plastics and microbial communities. When testing MP, it is important to use appropriate characterization methods to obtain complete information. In this paper, the biodegradation of MP particles of PS by the bacterial culture Delftia acidovorans was examined according to the full factorial plan. The optimal conditions for the biodegradation process were tested; pH-value, the number of revolutions of the rotary shaker and the optical density of a bacterial cell. The experiment lasted 30 days, and during this period the values of total, organic and inorganic carbon, and the number of living bacterial cells were determined. Potentially released additives were analyzed by LC/MS method, and changes in structure by FTIR_ATR. The ecotoxicity of the filtrate was also tested using the marine bacterium Vibrio fischeri. The results showed that there was a certain biodegradation of MP. The obtained optimal conditions are pH-value (8), OG (0.5) and the number of revolutions of the rotary shaker of 172.12 rpm
Photocatalytic decomposition of torasemide with imobilised TiO2
No full textPosljednjih nekoliko desetljeća farmaceutski aktivni spojevi smatrani su zagađivalima u nastajanju zbog njihovog kontinuiranog otpuštanja i postojanosti u vodenom okolišu čak i pri niskim koncentracijama. No sve veći broj istraživačkih članaka potvrđuje njihovu prisutnost analiziranjem različitih dotoka iz postrojenja za pročišćavanje otpadnih voda, bolničkih otpadnih voda i površinskih voda diljem svijeta. Rastuća zabrinutost u vezi s farmaceuticima, koji pokazuju veliki otpor prema konvencionalnim metodama uklanjanja, potaknula je opsežna istraživanja na području njihove učinkovite sanacije. Ovaj istraživački rad pruža procjenu heterogenog fotokatalitičkog procesa za uklanjanje farmaceutika torasemida kao potencijalne metode za primjenu prilikom pročišćavanja zagađenih vodenih sustava, uz primjenu fotokatalizatora na bazi TiO2. Kako bi potvrdili prikladnost analitičke metode za određivanje torasemida u vodi provedena je njena validacija koja se sveukupno pokazala zadovoljavajućom. Provedeni su i preliminarni eksperimenti hidrolize, adsorpcije i fotolize koji nemaju značajan utjecaj na razgradnju te se oslanjamo isključivo na fotokatalizu. Nakon toga ispitani su utjecaji pH vrijednosti i početne koncentracije farmaceutika pri čemu su određeni i optimalni uvjeti za razgradnju, a to su pH 4 i 5 mg/L. Provedeno je ispitivanje utjecaja „hvatača“ reaktivnih čestica pri čemu se pokazalo kako •OH radikali imaju najveću ulogu u razgradnji. Prilikom promatranja razgradnje smjese farmaceutika, imatiniba i torasemida, zaključilo se kako se povećanjem koncentracije smjese smanjuje brzina razgradnje što je posljedica zasićenosti površine fotokatalizatora. Razni ioni prisutni u matici vode također pokazuju velik utjecaj na fotokatalizu farmaceutika od kojih kompleksne huminske kiseline najviše usporavaju razgradnju. U konačnici primjenom realne otpadne vode fotokatalitički proces se najviše usporio zbog prisutnosti raznih onečišćenja. Analizom otopine torasemida nakon fotokatalitičke razgradnje pri optimalnim uvjetima utvrđeno je 7 različitih transformacijskih produkata koji su potencijalno štetniji od primarnog farmaceutika i tijekom eksperimenta moguće usporili razgradnju torasemida natjecanjem za vezno mjesto na fotokatalizatoru.In recent decades, pharmaceutical agents have been considered as emerging pollutants due to their continuous release and persistence in the aquatic environment, even at low concentrations. However, a growing number of research articles confirm their presence through the analysis of various influents from wastewater treatment plants, hospital effluents, and surface waters worldwide. Increasing concern about pharmaceuticals that exhibit significant resistance to conventional removal methods has led to extensive research in the area of their effective remediation. This research provides an evaluation of the heterogeneous photocatalytic process for the removal of the pharmaceutical torasemide as a potential method for application in the cleanup of polluted water systems using a TiO2-based photocatalyst. To verify the suitability of the method, its validation was carried out, which proved to be satisfactory overall. Preliminary experiments on hydrolysis, adsorption and photolysis were performed, which showed no significant effect on degradation, thus relying solely on photocatalysis. Subsequently, the influences of pH and initial pharmaceutical concentration were investigated, and optimal degradation conditions were determined to be pH 4 and 5 mg/L. An investigation of the effects of scavengers of reactive particles revealed that •OH radicals played the most important role in degradation. Observing the degradation of a pharmaceutical mixture, imatinib and torasemide, it was found that increasing the mixture concentration decreased the degradation rate due to saturation of the catalyst surface. Various ions present in the water matrix also exert a significant influence on pharmaceutical photocatalysis, with complex humic acids inhibiting degradation the most. Finally, when real wastewater was used, the photocatalytic process was significantly slowed down by the presence of various impurities. Analysis of the torasemide solution after photocatalytic degradation under optimal conditions revealed seven different transformation products that are potentially more harmful than the primary pharmaceutical compound and further hinder torasemide degradation as they compete for binding sites on the photocatalyst
Synthesis, characterization and thermal transformation of new styryl-heterocycles and quantum-chemical study of the reaction mechanism
No full textCilj ovog rada bio je prirediti nove heterocikličke stilbenske sustave koji će se podvrgnuti termičkim ispitivanjima u pokušaju sinteze indanskih i indenskih derivata. Početni prekursori pripravljeni su Wittigovom reakcijom, pri čemu su dobiveni stilbenski i monosupstituirani sustavi. Termička ispitivanja u kiselom mediju provedena su na pripravljenim stilbenskim sustavima, a prisutnost indanskih i indenskih produkata uočena je samo kod tiofenskih derivata. Kvantno-kemijskim metodama ispitana su sva eksperimentalna zapažanja dobivena u radu.The aim of this work was to prepare heterocyclic stilbene systems that will be subjected to thermal reaction in an attempt to synthesize indane and indene derivatives. The initial precursors were prepared by the Wittig reaction, whereby stilbene and monosubstituted systems were obtained. Thermal reactions in acidic medium were performed on the prepared stilbene systems, and the presence of indane and indene products was observed only in thiophene derivatives. All the experimental observations obtained in the work were examined by quantum-chemical methods
The effect of multi-functional excipients on the drug release profile
No full textGlavni cilj ovog eksperimentalnog istraživanja je ispitati utjecaj višenamjenskih pomoćnih tvari na profil oslobađanja lurasidon-hidroklorida. Formulacijom lijeka s pažljivo odabranim funkcionaliziranim pomoćnim tvarima moguće je priparaviti dozorni oblik ciljanih primjenskih svojstava. U ovom istraživanju pripremane su tablete lurasidon-hidroklorida koje se razlikuju po granulometrijskim te morfološkim svojstvima funkcionalizirane pomoćne tvari - manitola. Kompresibilna svojstva D(-) manitola znatno su poboljšana granuliranjem. Provedena je detaljna granulometrijska i morfološka analiza različitih manitola. Granulometrijske karakteristike punila dovedene su u vezu s profilom oslobađanja djelatne tvari. Najbolji profil oslobađanja lurasidon-hidroklorida pokazuju tablete s višenamjenskim pomoćnim tvarima M200 + PLX188.The main objective of this experimental study is to investigate the effect of multi-functional excipients on the release profile of lurasidone hydrochloride. By formulating drugs with carefully selected functionalized excipients, it is possible to prepare dosage form of aimed end-use properties. In this research, lurasidone hydrochloride tablets were prepared with different granulometric and morphological properties of the functionalized excipient mannitol. Compressive properties of D(-)-mannitol are significantly improved by granulation. Detailed granulometric and morphological analyses were carried out. The granulometric properties of the filler are linked to the release profile of the drug. The best release profile of lurasidone hydrochloride was found for tablets with multi-functional excipients M200 + PLX188
Continuous random variables and applications
No full textOvaj završni rad istražuje ključne aspekte kontinuiranih slučajnih varijabli i njihove primjene u statistici i inženjerstvu. Fokus je stavljen na analizu normalne distribucije, funkcije gustoće i distribucije vjerojatnosti te njihovu primjenu u različitim kontekstima. Osim toga, rad se bavi eksponencijalnom i beta distribucijom, objašnjavajući njihove karakteristike i praktične primjere uporabe. Posebna pažnja posvećena je primjeni ovih distribucija kroz konkretne primjere, čime se ilustrira njihova upotreba u stvarnim situacijama. Kroz detaljnu analizu i grafičke prikaze, rad doprinosi dubljem razumijevanju i korištenju ovih statističkih metoda.This thesis explores the key aspects of continuous random variables and their applications in statistics and engineering. The focus is on the analysis of normal distribution, probability density, and distribution functions, along with their applications in various contexts. Additionally, the thesis covers the exponential and beta distributions, explaining their characteristics and practical examples of usage. Special attention is given to the practical applications of these distributions through specific examples, illustrating their use in real-world situations. Through detailed analysis and graphical representations, the thesis contributes to a deeper understanding and utilization of these statistical methods
The effect of compatibilizers based on maleic anhydride on the thermal properties and stability of blends of polyethylene and waste polyamide powder
No full textU ovome radu ispitan je utjecaj kompatibilizatora poli(etilen-g-maleinskog anhidrida)
(PE-g-MA) na toplinska svojstva i stabilnost mješavina polietilena (PE) i otpadnog poliamidnog praha (PA). Uzorci su pripremljeni umješavanjem na Brabender gnjetilici i prešanjem na hidrauličkoj preši. Toplinska svojstva polimera u ovom radu određivana su pomoću tehnike diferencijalne pretražne kalorimetrije (DSC) i dinamičko mehaničke analize (DMA), a toplinska stabilnost pomoću termogravimetrijske analize (TGA). Rezultati DSC analize pokazali su kako miješanje polimera PE i PA u različitim omjerima kao ni dodatak kompatibilizatora ne utječu znatno na talište i kristalište PE i PA faze u mješavinama. Također, prisutnost PE otežava stvaranje kristalne faze PA u mješavinama bez i s kompatiblizatorom. TGA analizom utvrđeno je da je početak gubitka mase u kompatibliziranim mješavinama pomkanut na niže temperature u odnosu na odgovarajuće mješavine bez kompatibilizatora što upućuje na to da ne dolazi do povećane interakcije između komponenata mješavina koju promiče kompatibilizator. Uspoređujući rezultate DMA analize mješavina bez i s kompatibilizatorom nije vidljiva veća razlika, odnosno kompatibilizator PE-g-MA ne pospješuje mješljivost PE i PA.In this thesis, the influence of compatibilizer PE-g-MA on thermal proporties and stability of polyethylene (PE) and waste polyamide powder (PA) blends were investigated. Samples were prepared by mixing in a Brabender kneader and pressing with a hydraulic press. The thermal properties of polymers were investigated using differential scanning calorimetry (DSC) and dynamic mechanical analysis (DMA) and thermal stability was determined using thermogravimetric analysis (TGA). The results of the DSC analysis showed that the mixing of PE and PA polymers in different proportions as well as the addition of compatibilizer do not significantly affect the melting point and crystallinity of the PE and PA phases. Also, the presence of PE limits the crystallization of PA in blends without and with compatiblizer. TGA analysis determined that the onset of mass loss in compatibilized blends was shifted to lower temperatures compared to the corresponding blends without compatibilizer, indicating that there is no increased interaction between the blend components promoted by the compatibilizer. Comparing the results of the DMA analysis of blends without and with a compatibilizer, no significant difference is observed, meaning that the PE-g-MA compatibilizer does not enhance the miscibility of PE and PA
Extraction of bioactive components from immortelle by deep eutectic solvents
No full textCilj ovog rada je bilo primijeniti niskotemperaturna eutektička otapala, tzv. „zelena otapala“ za ekstrakciju bioaktivnih komponenti iz smilja kao zamjenu za konvencionalna organska otapala, koja mogu biti štetna i za okoliš i za ljude. Ispitivani su DES-ovi na bazi kolin-klorida (ChCl) i etilen-glikola (EG) te betaina (B) i etilen-glikola (EG). Za obje vrste DES-ova istraženi su molarni omjeri HBA:HBD 1:3, 1:4 i 1:5. Ekstrahirani su polifenolni spojevi: fenolne kiseline, flavonoidi i treslovine iz smilja. Smilje, (lat. Helichrysum italicum) je vrijedna ljekovita biljka koja je među širom populacijom najpoznatija po svojoj sposobnosti za regeneraciju kože i prisutna je u mnogim kozmetičkim proizvodima luksuznih brendova kao i u industriji parfema zbog svojeg karakterističnog mirisa. Određivanje sadržaja polifenolnih spojeva provedeno je prema postupcima iz Europske farmakopeje, UV/VIS spektrofotometrijom. Za fenolne kiseline i flavonoide određen je ekstrakcijski kapacitet procesom višestupanjske ekstrakcije. Nadalje, određena je koncentracija cikorijske kiseline, derivata kafeinske kiseline, u različitim ekstraktima cvijeta smilja metodom tekućinske kromatografije visoke djelotvornosti (HPLC, engl. high-performance liquid chromatography). Na temelju eksperimentalnih podataka o ekstrakciji fenolnih kiselina najboljim se pokazao DES B:EG 1:5 s najvećom dodanom masom suhe tvari smilja. Najlošijim se pokazao B:EG 1:3 s najmanjom dodanom masom suhe tvari smilja. Za određivanje flavonoida najboljim se pokazao B:EG 1:3 s najvećom masom, a najlošijim ChCl:EG 1:5 s najvećom masom smilja. Za određivanje sadržaja treslovina najboljim se prikazao ChCl:EG 1:4 s najmanjom masom smilja, a najlošijim ChCl:EG 1:3 s najvećom masom. Zbog prevelikih oscilacija sadržaja treslovina, ekstrakcijski kapacitet određivao se samo za fenolne kiseline i flavonoide. Zaključeno je da je ravnotežni ekstrakcijski kapacitet postignut u 1. stupnju i za fenolne kiseline i flavonoide. Osim toga, tekućinskom kromatografijom visoke djelotvornosti određena je koncentracija cikorijske kiseline. Najveću koncentraciju imao je uzorak ChCl:EG 1:5 s najvećom masom, a najmanju ChCl:EG 1:4 s najmanjom masom suhe tvari smilja.The aim of this work was to apply deep eutectic solvents, "green solvents", for the extraction of bioactive components from immortelle as a substitute for conventional organic solvents, which may be harmful to both the environment and humans. DESs based on choline chloride (ChCl) and ethylene glycol (EG) and betaine (B) and ethylene glycol (EG) were tested. HBA:HBD molar ratios of 1:3, 1:4 and 1:5 were used for both types of DESs. Polyphenolic compounds were extracted: phenolic acids, flavonoids and tannins from immortelle. Immortelle (lat. Helichrysum italicum) is a valuable medicinal plant that is best known among the wider population for its ability to regenerate the skin and is present in many cosmetic products of high-end brands as well as in the perfume industry due to its characteristic smell. The determination of the content of polyphenolic compounds was carried out according to the procedures of the European Pharmacopoeia, by UV/VIS spectrophotometry. For phenolic acids and flavonoids, the extraction capacity was determined by a multi-stage extraction process. Furthermore, the concentration of chicory acid, a derivative of caffeic acid, in different immortelle flower extracts was determined using the high performance liquid chromatography (HPLC) method. Based on the experimental data on the extraction of phenolic acids, DES B:EG 1:5 with the highest added mass of immortelle dry matter proved to be the best. B:EG 1:3 proved to be the worst, with the smallest added mass of immortelle dry matter. For the determination of flavonoids, B:EG 1:3 with the largest mass was the best, and ChCl:EG 1:5 with the largest mass of immortelle was the worst. ChCl:EG 1:4 with the smallest mass of immortelle was the best, and ChCl:EG 1:3 with the largest mass was the worst. Due to excessive fluctuations in the content of tannins, the extraction capacity was determined only for phenolic acids and flavonoids. It was concluded that the equilibrium extraction capacity was reached in the 1st stage for both phenolic acids and flavonoids.
In addition, the concentration of chicory acid was determined by high-performance liquid chromatography. The sample ChCl:EG 1:5 with the highest mass had the highest concentration, and ChCl:EG 1:4 with the lowest mass of immortelle dry matter had the lowest concentration
Control system design of a dividing wall column in the 2-3-3 configuration
No full textDestilacijske kolone s razdjelnim stijenkama inovativan su koncept toplinske separacijske tehnologije za dobivanje destilacijskih proizvoda visoke čistoće uz smanjenje potrošnje energije i troškova ulaganja. KRS kolona u 2-3-3 konfiguraciji za dobivanje četiri proizvoda sastoje se od jedne kolone s rebojlerom, dva kondenzatora i tri razdjelne stijenke.
Zbog razdjelnih stijenki u unutrašnjosti kolone postoje dvije raspodjele kapljevine i tri raspodjele pare. U ovome radu korišteni su procesni simulatori Chemcad i Aspen HYSYS za izradu pojednostavljenih statičkih i proširenog dinamičkog modela, sinteze sustava za vođenje, provedbu analize osjetljivosti i ispitivanja u zatvorenom regulacijskom krugu, dok je obrada podataka provedena u MS Excelu. Sintetizirana regulacijska shema dinamičke simulacije kolone pokazuje mogućnost stabilnog vođenja kolone pri unošenju poremećaja.
Vrijeme potrebno da bi se postiglo stacionarno stanje nakon unesenog poremećaja varira od proizvoda do proizvoda za svaki ispitani slučaj, a uočeno je kako se teža ključna komponenta brže stabilizira od lakše.Distillation columns with dividing walls (DWC) are an innovative concept of thermal separation technology for obtaining high-purity distillation products, while reducing energy consumption and investment costs. DWC in a 2-3-3 configuration for obtaining four products consists of one column with a reboiler, two condensers and three dividing walls.
Due to dividing walls, there two liquid and three vapor splits need to be ensured inside the column. In this work, process simulators Chemcad and Aspen HYSYS were used to create a simplified steady-state and extended dynamic models, perform synthesis of a control system, implement sensitivity analysis and perform closed-loop tests, while data processing was carried out in MS Excel. The sythesized control system showed stable control of the column when disturbances were introduced. The time required to reach a steady state after an introduced disturbance varies from product to product for each case tested, and it has been observed that the heavier key component stabilizes faster than the lighter one