Scientia, Dipòsit d’Informació Digital del Departament de Salut
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Prenatal, Perinatal, and Postnatal Factors in a Cohort of Very Preterm and Very Low Birth Weight Toddlers with Suspected Autism Spectrum Disorder
Full text linkAssociated factors; Autism spectrum disorder; Prospective longitudinal studyFactores asociados; Trastorno del espectro autista; Estudio longitudinal prospectivoFactors associats; Trastorn de l'espectre autista; Estudi longitudinal prospectiuThere is growing interest in the identification of prenatal, perinatal, and postnatal factors that correlate with autism spectrum disorders (ASD) and these have been extensively studied in the general population. This study aimed to investigate the relationship between these factors and the elevated likelihood of being diagnosed with ASD in the very preterm and very low birth weight population. Conducted as a prospective longitudinal study, this research monitored 133 neonates born very preterm (less than 32 weeks of gestation) or weighing less than 1,500 g at birth from birth until 2 years of age. Having a mother born abroad, low gestational age, bronchopulmonary dysplasia, hearing loss, longer NICU stay and low Apgar score of 10 min were associated with an increase in suspected ASD. Conversely, cesarean delivery, and full-dose corticosteroid maturation were associated with a lower incidence of ASD. Some factors associated with ASD in the very preterm population may differ from those found in the general population. Large-scale studies with longitudinal datasets are warranted.Open Access Funding provided by Universitat Autonoma de Barcelona
Extracellular RNA drives TNF-α/TNF-receptor-1 mediated cardiac ischemia/reperfusion injury: Mechanistic insights and therapeutic potential of RNase1
Full text linkAcute ST-segment elevation myocardial infarction; Acute myocardial infarction; CardioprotectionInfarto agudo de miocardio con elevación del segmento ST; Infarto agudo de miocardio; CardioprotecciónInfart agut de miocardi amb elevació del segment ST; Infart agut de miocardi; CardioproteccióMyocardial ischemia/reperfusion (I/R) injury causes cardiomyocyte death and exacerbates inflammation. Emerging evidence implicates extracellular RNA (eRNA) and tumor necrosis factor-α (TNF-α) as key mediators. We hypothesize that eRNA released from ischemic cardiomyocytes amplifies I/R injury via TNF/TNF-receptor- 1 (TNF-R1) signaling, and that hydrolysis of eRNA by RNase1 can attenuate I/R injury by disrupting this pathway. Here, we investigated the mechanistic role of eRNA and its interplay with TNFα α α signaling in cardiac I/ R injury, and evaluated the therapeutic potential of RNase1 and cyclosporine-A (CsA). In ST-segment elevation myocardial infarction patients, plasma eRNA levels were significantly elevated 2 h post-percutaneous coronary intervention (PCI), correlating positively with Creatine Kinase (CK). In murine I/R and hypoxia/reoxygenation models, eRNA released from stressed cardiomyocytes acted as a damage-associated molecular pattern, triggering TNFshedding via TACE/ADAM17 and activating TNF-R1-mediated inflammation, mPTP opening, and cell death. Genetic deletion of TNFα or TNF-R1 abrogated eRNA-induced cytotoxicity, while TNF-receptor- 2 (TNF- R2) deficiency exacerbated injury. Pharmacological inhibition of TACE with TAPI suppressed TNFα release and preserved cell viability. RNase1 effectively degraded eRNA, blocking upstream pro-inflammatory signaling, whereas CsA preserved mitochondrial integrity by preventing mPTP opening. Notably, RNase1 and CsA showed synergistic protection in vivo when administered at reperfusion, significantly reducing myocardial infarct size. These findings identify eRNA as both a biomarker and pathogenic mediator of myocardial I/R injury, and support a dual-targeted strategy using RNase1 and CsA to interrupt the TNFα /TNF-R1-driven inflammatory and mitochondrial death pathways. Targeting both upstream inflammatory and downstream mitochondrial mechanisms represents a promising cardioprotective intervention for acute myocardial infarction
Aconsegueix la targeta sanitària individual (TSI) del teu nadó en pocs passos [cartell]
Full text linkInfant; Targeta sanitària; Identificació del pacientNiño; Tarjeta sanitaria; Identificación del pacienteChild; Health card; Patient identificationInfografia adreçada als pares de nadons per tal de demanar la targeta sanitària.Infographic aimed at parents of babies to request a health card.Infografía dirigida a los padres de bebés para solicitar la tarjeta sanitaria
Preoperative immunotherapy with atezolizumab and tiragolumab in patients with colorectal liver metastases—the PURPLE trial
Full text linkColorectal liver metastases; Preoperative immunotherapy; AtezolizumabMetàstasis hepàtiques colorectals; Immunoteràpia preoperatòria; AtezolizumabMetástasis hepáticas colorrectales; Inmunoterapia preoperatoria; Atezolizuma
Research advances and future directions in female ADHD: the lifelong interplay of hormonal fluctuations with mood, cognition, and disease
Full text linkAttention-deficit/hyperactivity disorder; Menstrual cycle; Sex hormonesTrastorn per dèficit d'atenció i hiperactivitat; Cicle menstrual; Hormones sexualsTrastorno por déficit de atención i hiperactividad; Ciclo menstrual; Hormonas sexualesIntroduction: Attention-Deficit/Hyperactivity Disorder (ADHD) in girls and women is under-recognised and under-researched, despite increasing awareness of clinical challenges and unmet needs. This review by the Eunethydis Special Interest Group on Female ADHD, addresses current knowledge and identifies research gaps for future work. Issues in women with ADHD across the lifespan such as late diagnosis, pubertal development, sexual health, hormonal birth control, executive function difficulties, and gynaecological disorders associated with ADHD are highlighted.
Methods: The review synthesises existing literature and self-reported experiences of women with ADHD to explore the impact of hormonal fluctuations [puberty, menstrual cycle, pregnancy, (peri)menopause] on ADHD symptoms and mood disturbances. It examines the interplay of oestrogen and progesterone with dopaminergic pathways, when periods of lower oestrogen may affect cognition, as well as the manifestation of executive function deficits, and the intersection of ADHD with reproductive health.
Results: Hormonal transitions exacerbate ADHD symptoms and mood disturbances, yet pharmacological research and tailored treatments are lacking. Executive function deficits manifest differently in girls and women with ADHD and are influenced by neuropsychological and neurobiological profiles. Diagnostic practices and sociocultural factors contribute to delayed diagnoses, increasing the risk of comorbidities, impaired functioning, and diminished quality of life. Undiagnosed women have increased vulnerability to premenstrual dysphoric disorder, postpartum depression, and cardiovascular disease during perimenopause.
Discussion: Longitudinal, sex-specific studies incorporating hormonal status and lived experience are needed. Individualised interventions should be developed to address the unique needs of girls and women with ADHD. Addressing these gaps will advance more equitable diagnosis, management, and support for girls and women with ADHD, improving outcomes across the female lifespan
Identificación de necesidades en innovación asistencial en el SISCAT: innovar con propósito, con visión participada y alineada con las prioridades estratégicas del sistema de salud
Full text linkInnovació assistencial; Identificació necessitats; Sistema de salut de CatalunyaInnovación asistencial; Identificación necesidades; Sistema de salud de CataluñaHealthcare innovation; Needs identification; Catalan healthcare systemL’objectiu principal d’aquest projecte ha consistit a identificar, des del punt de vista estratègic, professional i del ciutadà, els àmbits assistencials on es percep que la innovació pot tenir un alt potencial d’impacte (demanda en innovació assistencial). És a dir, aquelles àrees on es considera que la innovació pot demostrar capacitat per millorar els resultats en salut i la qualitat de vida de la població, augmentar l’eficiència en l’ús dels recursos públics, enfortir l’accessibilitat i l’equitat i donar suport als professionals de la salut, amb eines més segures, precises i adaptades a les seves necessitats.El objetivo principal de este proyecto ha consistido en identificar, desde el punto de vista estratégico, profesional y del ciudadano, los ámbitos asistenciales en los que se percibe que la innovación puede tener un alto potencial de impacto (demanda en innovación asistencial). Es decir, aquellas áreas en las que se considera que la innovación puede demostrar capacidad para mejorar los resultados en salud y la calidad de vida de la población, aumentar la eficiencia en el uso de los recursos públicos, reforzar la accesibilidad y la equidad y dar apoyo a los profesionales de la salud, con herramientas más seguras, precisas y adaptadas a sus necesidades.The main objective of this project has been to identify, from a strategic, professional, and citizen perspective, the areas of healthcare delivery in which innovation is perceived to have a high potential for impact (demand for healthcare innovation). In other words, those areas in which innovation is considered capable of demonstrating improvements in health outcomes and the population’s quality of life, increasing efficiency in the use of public resources, strengthening accessibility and equity, and supporting healthcare professionals with safer, more precise tools tailored to their needs
CarDiac magnEtic Resonance for prophylactic Implantable cardioVerter defibrillAtor ThErapy in Non-Dilated Left Ventricular Cardiomyopathy: a sub-study from the DERIVATE registry
Full text linkCardiac magnetic resonance; Dilated cardiomyopathy; Non-dilated left ventricular cardiomyopathyRessonància magnètica cardíaca; Cardiomiopatia dilatada; Cardiomiopatia ventricular esquerra no dilatadaResonancia magnética cardiaca; Cardiomiopatía dilatada; Cardiomiopatía ventricular izquierda no dilatadAims
Accurate risk stratification for patients with non-dilated left ventricular cardiomyopathy (NDLVC) remains challenging due to lack of dedicated clinical trials. This post hoc analysis aims to delineate the arrhythmic risk and assess the incremental value of cardiac magnetic resonance (CMR) imaging in the CarDiac magnEtic Resonance for prophylactic Implantable-cardioVerter defibrillAtor ThErapy (DERIVATE) study cohort meeting the NDLVC diagnostic criteria.
Methods and results
Patients with NDLVC from the DERIVATE registry were identified in the absence of left ventricular (LV) dilatation and in the presence of non-ischaemic LV scarring (‘fibrotic NDLVC’) or isolated LV systolic dysfunction (LV ejection fraction < 50%) without fibrosis (‘hypokinetic NDLVC’). The primary endpoint was all-cause mortality. Major adverse arrhythmic cardiac events (MAACE) were the secondary endpoint and included sudden cardiac death (SCD) and aborted SCD. One hundred and ninety-seven NDLVC patients were identified from the cohort of the DERIVATE study (mean age: 59 ± 14 years; male: 135). Over a median follow-up of 2.7 years, 15 (8%) patients died and 8 (4%) experienced MAACE. Patients with ‘hypokinetic’ NDLVC had significantly lower rates of MAACE than non-ischaemic dilated cardiomyopathy (NIDCM) (P = 0.001), while patients with ‘fibrotic’ NDLVC had same rate of both primary (P = 0.48) and secondary endpoints (P = 0.616) compared with NIDCM patients. Multivariable analysis identified late gadolinium enhancement (LGE) with midwall distribution as an independent predictor of MAACE in NDLVC patients (hazard ratio 6.7, 95% confidence interval: 1.33–33.67; P = 0.021).
Conclusion
NDLVC patients exhibit a heterogeneous risk profile for arrhythmic events. The presence of midwall LGE, similarly to NIDCM, is a significant predictor of MAACE, highlighting the importance of CMR imaging for risk stratification.Research supported by the Italian Ministry of Health, Ricerca Corrente to Centro Cardiologico Monzino IRCCS
Stay Active, Stay Healthy: A Cross-Sectional View of the Impact of Physical Activity Levels on Health Parameters of Older Adults Institutionalized in Nursing Homes of Barcelona
Full text linkPhysical activity;
Older adults;
Institutionalized careActivitat física;
Persones grans;
Atenció institucionalitzadaActividad física;
Personas mayores;
Atención institucionalizadaBackground: Institutionalized older adults represent a vulnerable population. It is important to understand that higher levels of physical activity in older adults are associated with less risk of cardiovascular diseases, better cognition, and lower inflammaging and sarcopenia levels. The main objective was to evaluate the differences in health parameters in institutionalized older adults who perform different levels of weekly physical activity. The secondary objective was to analyze if weekly physical activity levels are a predictor of health parameters. (2) Methods: A cross-sectional observational study was conducted in nursing homes with adults over 75 years of age. A total of 76 participants was divided into three groups based on their weekly physical exercise frequency (1 day/week, 2 days/week, and 3 days/week). We measured demographic and anthropometric variables, along with cognitive level through the Mini Exam of Lobo. Handgrip strength, leg muscle strength, and power were also evaluated, and C-reactive protein levels were assessed through blood tests. Physical performance was measured using the Short Physical Performance Battery and walking speed. (3) Results: Significant differences were found in body mass index (p < 0.01; ES = 0.96), muscular strength (p < 0.01; ES = 0.70), and power (p < 0.01; ES = 1.09), Short Physical Performance Battery (p < 0.01; ES = 1.46) and walking speed (p < 0.01; ES = 0.87), cognitive function (p < 0.01; ES = 1.21), and C-reactive protein levels (p < 0.01; ES = 1.73), favoring the group who performed 3 days/week of physical activity. (4) Conclusions: Institutionalized older adults with three days per week of physical activity have greater physical and muscle function and less cognitive decline. Three days of weekly physical activity is associated with systemic inflammation and better cognitive status in institutionalized older adults.This work was supported by the project entitled: SAFE socks. El mitjó amb contracció muscular integrada per augmentar la seguretat de persones grans i d’esportistes (2021 LLAV 00066). Departament de Recerca. Generalitat de Catalunya
Detecció de noves substàncies psicoactives: informe sobre consum problemàtic i conseqüències - 2024
No full textSistema Espanyol d’Alerta Ràpida; Substàncies psicoactives; NotificacionsSpanish Rapid Alert System; Psychoactive substances; NotificationsSistema Español de Alerta Rápida; Sustancias psicoactivas; NotificacionesAquest informe presenta el gràfic de l’evolució de les notificacions de noves substàncies psicoactives al SEAT i de la tipologia de les mostres analitzades per l’Associació Benestar i Desenvolupament (ABD) en el marc del seu projecte Energy Control, de reducció de riscos en l’àmbit del consum recreatiu de drogues
Migraine stigma and general knowledge of migraine: A cross-sectional European survey
Full text linkStigma scale for chronic illnesses 8-item; General population knowledge; Severe migraineEscala de estigma para enfermedades crónicas de 8 ítems; Conocimiento de la población general; Migraña severaEscala d'estigma per a malalties cròniques de 8 ítems; Coneixement de la població general; Migranya severaBackground
The stigma associated with migraine impacts patients’ quality of life, mental health and their willingness to seek treatment. The present study aimed to gain insights into the stigma from the patient's perspective and to assess migraine knowledge among people without the condition.
Methods
This cross-sectional descriptive, quantitative study used two surveys (survey 1, open April 2023 to July 2023; survey 2, September 2023 to November 2023). The surveys were distributed to local patient organisations across 26 European countries and nine countries in South and North America, Asia and Oceania.
Results
Survey 1 received 3712 answers. Most respondents were women (3444; 92.8%), 45–54 years (1090; 29.4%) and experienced severe migraine (2047; 55.1%). Most participants viewed their migraine as disabling (2655; 71.5%) and felt that medical professionals only partially understood (2135; 57.5%). Survey 2 gathered 774 responses, with most of the participants being partners (202; 26.1%), friends (196; 25.3%) or other relatives (110; 14.2%) of individuals with migraine. The significant majority of respondents demonstrated a high understanding of migraine (573; 74.0%) and predominantly recognised migraine as disabling and impacting personal and professional life. Responders felt a high degree of stigma, more from work colleagues and medical professionals than from their social network.
Conclusions
The disabling nature of migraine, combined with the associated stigma, aggravates the challenges faced by patients. There is an urgent need for improved medical education, public awareness campaigns and possible revisions in medical terminology to better support people with migraine and mitigate the stigma they encounter. Importantly, medical professionals need to re-double efforts to check their behaviour to avoid adding to the burden of our patients