Gutenberg Open Science (Univ. Mainz)
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Electrochemical hydrodehalogenation based on 3D-printed electrodes
No full textAdditive manufacturing has emerged as a versatile platform for electrode fabrication, offering cost efficiency, design flexibility, and compatibility with a wide range of materials. Electrochemical dehalogenation represents a critical strategy for the removal of toxic halogenated organic pollutants, such as chloroacetic acids, which pose significant environmental and health risks. The use of earth-abundant metals, including iron, copper, and nickel, as well as carbon-based materials, further enhances the sustainability and scalability of this approach. This concept article describes the electrochemical reduction of trichloroacetic acid at conventional electrodes and reviews the current state of research on electrochemical dehalogenation at additively manufactured electrodes. From this perspective, the further integration of advanced fabrication techniques, along with the application of machine learning and artificial intelligence, presents significant opportunities for innovation in materials and processes. In addition to electrode fabrication, the incorporation of in situ spectroscopy is proposed to gain deeper insight into the underlying reaction mechanisms. To bridge the gap between fundamental research and the implementation of new processes in industrial applications, a series of process optimization strategies is also outlined
Interaction of tumor cells and cancer-associated fibroblasts in radiation-induced senescence
No full text25 Seiten ; Illustratione
Sicherheit und Effektivität der peroralen endoskopischen Myotomie an Ösophagus und Magen
No full text70 Seiten ; Illustrationen, Diagramm
The translation and validation of the procrastination and precrastination traits scale in the modern Arabic Language
No full textProcrastination and precrastination are distinct self-regulatory behaviors that influence individual functioning and well-being. Despite growing interest in these constructs, culturally adapted and psychometrically validated tools in Arabic-speaking contexts remain limited. This study addresses this gap by translating, validating, and evaluating the psychometric properties of the Arabic version of the Procrastination and Precrastination Traits Scale (PPTS). The present study aimed to examine the factorial structure, reliability, and convergent and divergent validity of the Arabic PPTS among Arabic-speaking adults and explore its associations with life satisfaction and standardized measures of procrastination. A sample of 1,000 participants (mean age = 27.93 years, standard deviation (SD) = 5.73; age range = 18–38) completed an online survey comprising the 18-item PPTS, the 12-item Pure Procrastination Scale (PPS), and the 5-item Satisfaction with Life Scale (SWLS). Descriptive analyses, confirmatory factor analysis (CFA), reliability testing, and bivariate correlations were conducted to assess psychometric performance. CFA supported a two-factor model with good fit indices (CFI = 0.939; TLI = 0.930; RMSEA = 0.05; SRMR = 0.04). All the items loaded significantly onto their respective factors: procrastination (items 1–10) and precrastination (items 11–18). Internal consistency was good for both subscales (procrastination: α = 0.861, ω = 0.861; precrastination: α = 0.788, ω = 0.803). Procrastination was positively correlated with PPS (r = 0.781, p < 0.001) and negatively correlated with SWLS (r = -0.475, p < 0.001). Conversely, precrastination was negatively associated with PPS (r = -0.405, p < 0.001) and positively associated with SWLS (r = 0.249, p < 0.001), supporting both convergent and divergent validity. The Arabic PPTS has adequate factorial validity, good reliability, and meaningful construct validity. It provides a culturally appropriate instrument for assessing behavioral tendencies of delay and hastiness, with implications for psychological assessment, educational interventions, and cross-cultural research on self-regulation and well-being
Die Rolle der Weiterbildung in der Ära von New Work : Perspektiven auf die Bedeutung von Lernen in der Personalentwicklung
No full textTransformationsprozesse wie Digitalisierung und demografischer Wandel verändern die Arbeitsrealität und fordern individuelle Selbstorganisation. New Work/New Learning markieren dabei ein neues Verhältnis von Arbeit und Mensch – mit Fokus auf Flexibilität und Selbststeuerung. In diesem Kontext gewinnt die betriebliche Weiterbildung an Bedeutung, um Transformationsprozesse zu begleiten, wobei die Personalentwicklung eine zentrale Rolle im Schnittfeld von Arbeit und Lernen spielt. Die Diskussion um New Work und New Learning wird oft aus einer (betriebs-)wirtschaftlichen Perspektive geführt, während die Erwachsenenbildung, obwohl betroffen, weniger thematisiert wird. Dieser Beitrag untersucht das Verständnis von Lernen im Rahmen von New Work-Konzepten und die Bedeutung von Weiterbildung als Instrument zur Gestaltung struktureller Veränderungen. Dies wird durch problemzentrierte Interviews mit Personalentwickler:innen und eine qualitative Inhaltsanalyse erreicht
Direct interaction between TDP-43 and Tau promotes their co-condensation, while suppressing Tau fibril formation and seeding
No full textNeuronal aggregates of Tau are a hallmark of Alzheimer’s disease (AD), but more than half of the patients exhibit additional TDP-43 inclusions, while some have co-aggregates of the two proteins. The presence of such co-aggregates is associated with increased disease severity, although whether there is a causal relationship remains unclear. Here, we demonstrate that Tau and TDP-43 mutually promote each other’s condensation through direct interaction in vitro, forming irregularly-shaped or multiphasic co-condensates with lower TDP-43 mobility, but higher Tau mobility. While Tau promotes TDP-43 aggregation in vitro, TDP-43 suppresses formation of Tau fibrils and instead causes formation of oligomeric Tau and Tau/TDP-43 species. These co-assemblies hinder Tau seeding in a biosensor assay specific for proteopathic Tau seeds. Consistent with these data, insoluble material extracted from AD patient brains with Tau/TDP-43 co-aggregates exhibits reduced Tau seeding compared to AD patient brains with Tau aggregates only. In contrast, patient-derived extracts from AD patient brains with Tau/TDP-43 co-aggregates are highly potent in seeding new TDP-43 aggregates in a TDP-43 reporter cell line. Our results suggest that direct interaction between TDP-43 and Tau may suppress Tau pathology, while promoting TDP-43 pathology in Alzheimer’s disease patients
Reconfigurable transient polymer networks based on heteroleptic metal–ligand complexes
No full textWe present a polymer network platform based on metal–ligand complexes that enables reconfiguration through the sequential introduction of polymeric ligands and metal ions. Using tetraPEG functionalized with sterically demanding and slim ligands, we demonstrate four network states. However, the interference from competitive parallel complexations is reflected in rheology as additional relaxation modes. A simple kinetic model rationalizes the extent of reconfiguration as a function of thermodynamic preference, revealing the critical role of competitive complexation. DFT calculations confirm that ligand denticity stabilizes heteroleptic complexes and drives the reconfiguration pathway. Together, experiment, modeling, and computation establish a comprehensive framework for designing reconfigurable transient polymer networks
Unlocking the potential of student teachers : a practical approach to promote competence development through competence standards
Full text linkEducational science competences are considered one of the most important topics in teacher training. They also play an important role in various areas of effective teaching. Even though professional competences of student teachers have already been widely discussed based on several theoretical models, no study to date examines the promotion of student teachers’ competence development in practice. As part of this framework, we established a competence grid for student teachers to assess and support individualizing students’ learning paths. The grid is meant to stimulate self-reflection, which should help individuals raise awareness for their learning progress and make performance levels visible. Initial empirical results from a survey with first and second semester students (n = 309) demonstrated practical applicability and reliability (α = .82) of the assessment grid, which allows to design further steps towards professionalisation
Einfluss der Biologisierung mit autologen Thrombozytenkonzentraten und Hyaluronsäure auf die Vaskularisation und Angiogenese in ovo
Full text link80 Seiten ; Illustrationen, Diagramm
Humandifferenzierung im Vergleich
Full text linkMenschen sind laufend in Prozesse einseitiger oder wechselseitiger Kategorisierung involviert. Sie unterscheiden sich sowohl voneinander – etwa im Hinblick auf Alter, Geschlecht, Herkunft, Leistung, Konfession etc. – als auch von nicht-menschlichen Entitäten wie Tieren, Göttern oder Artefakten. Verstehen kann man einzelne Formen solcher Humandifferenzierungen jedoch nur, wenn man sie systematisch mit anderen Formen vergleicht. Wie solche Vergleiche konzeptuell anzulegen sind und empirisch durchgeführt werden können, ist Thema des vorliegenden transdisziplinär ausgerichteten Bandes.420 Seite