Archivio Istituzionale della Ricerca - Università degli Studi della Campania "Luigi Vanvitelli"
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Unravelling the impact of the chromobox proteins in human cancers
: Chromobox (CBX) proteins play a crucial role in regulating epigenetic processes. They are extensively involved in various biological processes, including embryonic development, stem cell maintenance, cell proliferation and apoptosis control. The disruption and malfunction of CBXs in cancer typically results in the interference or abnormal activation of developmental pathways, which facilitate the onset, growth, and advancement of cancer. This review initially introduces the physiological properties and functions of the CBXs. Subsequently, it examines the involvement of CBXs in different cancer types. Cancer hallmarks driven by CBXs are mediated through multiple mechanisms, including changes in gene expression patterns, epigenetic dysregulation of chromatin control, disruption of intracellular signaling and alterations in cell metabolism. The study also highlights novel potential anticancer therapeutics targeting CBXs in cancer. In this review we provide novel perspectives and a solid foundation for future investigations on CBXs as promising therapeutic targets for cancer treatment
Ordine pubblico e tutela del coniuge in buona fede
Il contributo analizza il rapporto tra ordine pubblico e tutela del coniuge in buona fede nel procedimento di delibazione delle sentenze ecclesiastiche di nullità matrimonial
Il fattore religioso nel diritto regionale
In contributo analizza la tutela del fattore religioso nel diritto regional
La protezione dei dati sensibili nello Stato della Città del Vaticano
Il contributo analizza la protezione dei dati sensibili nello Stato della Città del Vatican
The evolving landscape of renal surgery for complex renal masses (CRM): implications for oncologic and functional outcomes
Near-Field Synthesis of 1-D Shaped Patterns through Spectral Factorization and Minimally-Redundant Array-Like Representations
We introduce a novel approach for the mask-constrained power synthesis of 1-D fields enabling near-field shaping according to arbitrary masks. This method presents an innovative framework based on the spectral factorization technique and a warping strategy, allowing for an accurate representation of the near field as a minimally redundant bandlimited function. This provides valuable theoretical tools to effectively solve the problem. In fact, the synthesis is formulated as a linear programming problem followed by a polynomial factorization. Additionally, the approach allows for the a-priori identification of the minimum size of the source required to fulfill a given near-field intensity mask