Archivio Istituzionale della Ricerca - Università degli Studi della Campania "Luigi Vanvitelli"
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Numerical Investigation on the Static and Dynamic Behaviour of an Additive Manufactured UAV’s Horizontal Tail
No full textIn recent years, the advancement of new manufacturing technologies has greatly influenced engineering applications. Among these, the additive manufacturing technology has been progressively applied to aircraft structures design and production, as it allows the effective optimization of the strength and the outstanding reduction of the weight in structural components. The research activity presented in this paper is focused on the static and dynamic numerical verification of the horizontal tail of an UAV, entirely Designed for Additive Manufacturing (DfAM) with Technopolymers. A proper selection of a variable internal infill has been introduced to reduce the overall weight of the structural component, while static and dynamic numerical analyses, simulating low-speed impacts, have been adopted to evaluate the structural strength and the ability of the proposed configuration to withstand damage onset and evolution due to in-service loads and impact events. The obtained numerical results indicate that the structural components Designed for Additive Manufacturing can be considered effective in terms of weight reduction and they are characterised by stresses significantly below the failure limits of the proposed techno Polymer. They also demonstrate good resistance of the proposed structural components to low-speed impacts without compromising the overall structural performance of components selves. This study provides solid bases for increasing the use of Additive Manufacturing technologies in the aviation industry
Biosimilars Versus Originators in Children With Juvenile Idiopathic Arthritis: A Real-World Experience
No full textIntroduction: We aimed to evaluate the efficacy, safety, and immunogenicity profile of Etanercept (ETA) and Adalimumab (ADA) biosimilars (BIOs) compared to their originators in children with juvenile idiopathic arthritis (JIA). Method: Eighty-one JIA children treated with ETA or ADA originators or BIOs were examined at baseline (T0) and after 3- (T1), 6- (T2), 12- (T3), and 24-(T4) months after starting treatment. Results: Lower Juvenile Arthritis Disease Activity Score 10 (JADAS-10) scores were reported at T1, T2, T3, and T4 in JIA children treated with BIOs than originators (all p < 0.05). At T1 and T3, anti-drugs antibodies levels were lower in children receiving BIOs than originators (p = 0.04 and p = 0.0007, respectively), even after adjustments (both p < 0.05). Relapses were lower for BIOs compared to originators (p < 0.001). Safety profile was comparable between the groups (p > 0.05). Discussion: A better overall profile of BIOs than originators was demonstrated in JIA children, but larger confirmatory studies are needed
Hortensin 4, main type 1 ribosome inactivating protein from red mountain spinach seeds: Structural characterization and biological action
No full textHere, we report the primary structure of hortensin 4, main type 1 ribosome inactivating protein (RIP) isolated from Atriplex hortensis seeds. The complete sequencing was achieved by a combination of mass spectrometry coupled with Edman degradation. The amino acid sequence of hortensin 4 matches with that of Atriplex patens type 1 RIP, deduced from the cDNA sequence (AC: ABJ90432.1). The protein consists of 254 amino acid residues, without cysteinyl residues and a N-Acetylhexosamine chain at position Asn231. Structural studies (CD spectrum and 3D model) show a protein core typical of RIPs, and the amino acid residues of active site are conserved. In addition, to get insight into the protective effects of hortensin 4 against pathogens and its putative biotechnological applications, we evaluated the: i) N-glycosylase activity against the tobacco mosaic virus (TMV) RNA; (ii) antifungal activity towards Trichoderma harzianum and Botrytis cinerea, by damaging fungal ribosomes; and (iii) inhibition of human primary glioblastoma NULU cells proliferation, with cytotoxicity enhanced in the presence of temozolomide, used as a chemotherapeutic agent. Altogether, the multiple biological activities of hortensin 4 could be exploited both to improve the resistance to various pathogens by engineering transgenic plants and to develop useful tools for cancer therapy
Modeling a double-shell dome interconnected with a wooden structure: San Gennaro Chapel in Naples
No full textThe remarkable antique wooden umbrella structure embedded within the double dome of the Cathedral of Naples astonishes with its complexity and grandeur. Over the past decade, eminent scholars have investigated this structure; however, the authors believe that it warrants an additional perspective—an interdisciplinary approach that integrates the complexity of graphic representation with structural assessment—to better understand the purpose behind the construction of such an extraordinary and uncommon element within Neapolitan Baroque masonry domes. This study aims to analyze the dome as a unified system by employing a combination of methodologies, including limit analysis and the study of reticular wooden structures. The theoretical framework considers the principles governing masonry structures (modeled as no-tension materials) and timber elements analyzed through elastic theory. The focus is on defining the interaction between these two structural systems, building upon Heyman’s theories on curved masonry structures.
The combination of these distinct materials results in a structurally complex and inhomogeneous system, revealing the rationale behind the creation of a 'forest' of solid chestnut wood. To fully comprehend the function of the entire structure, it is crucial to recognize that the timber framework supports the upper dome without imposing additional loads on the lower one. This design was conceived to ensure the stability of the elliptical upper dome. The research investigates the structural and functional imperatives that led engineers to conceive such a sophisticated system in a highly challenging environment. Furthermore, it examines the changes in the structural behavior of the current system compared to the original design, which did not account for the presence of the wooden structure
G. Tessuto, Constructing Scholarly Ethos in Non-mainstream Medical Research Writing Discursive and Linguistic Strategies
No full textAt a time when mainstream, biomedical research and practice continue to frame
the discourse about health, non-mainstream, or alternative/complementary medical
research is now gaining ground in some academic publishing venues. While
non-mainstream researchers are likely to work twice as hard to survive on a very
uneven playing field, they must also develop rational appeals to believability in
order to be persuasive in their own writing. In this chapter, I set out to explore
the discursive and linguistic strategies employed by alternative/complementary
medicine scholars to see how and to what extent they convey a scholarly ethos
that entails building their own authority, credibility, and expertise and recognizing
the values of their academic community. Taking a corpus-driven approach to
academic articles in this field, I look at how authors project themselves and their
work and persuade their audience about their arguments and perspectives in this
form of writing. To do so, I rely on the cover term of evaluation in academic discourse
analytical research to examine stance-making resources for their linguistic
realization in both quantitative and qualitative terms and to identify the attendant
meanings for interaction and persuasion that establish the writers’ ethos on the
topics they discuss. Conclusions are drawn about the relevance of such findings
for discourse activities enacted by the non-mainstream academic community
Antimicrobial Lock Therapy in Clinical Practice: A Scoping Review
No full textAntimicrobial lock therapy (ALT) prevents microbial colonization in central vein catheters and treats existing catheter-related bloodstream infections (CRBSIs); the ALT assessment involves several key considerations. First, identifying which patients are suitable candidates is crucial. Additionally, understanding the clinical contexts in which is utilised provides insight into its applications. Examining when ALT has been employed and analyzing trends in its use over time can highlight its evolving role in patient care. Equally important is understanding how ALT is administered, including the specific agents used. Lastly, determining whether there is sufficient existing literature is essential to evaluate the feasibility of conducting future systematic reviews. This study is a scoping review adhered to the PRISMA-ScR guidelines and followed a five-stage methodological framework. Of the 1024 studies identified, 336 were included in the analysis. Findings highlight the widespread use of ethanol and taurolidine for CRBSIs prevention and the concurrent use of ALT with systemic antimicrobials to treat CRBSIs without catheter removal. ALT improves clinical outcomes, including post-infection survival and catheter retention. From our analysis, we have concluded that both an umbrella review of systematic reviews and a network meta-analysis comparing lock solutions can provide clearer guidance for clinical practice
Long-term clinical outcomes of asymptomatic patients with spontaneous type 1 Brugada electrocardiographic pattern undergoing electrophysiologic study for risk stratification
No full textInvestigating the causal pathways among psychopathological variables, cognitive impairment, and real-life functioning in people with schizophrenia
No full textThe present study aimed to investigate the causal relationships among cognitive impairment, psychopathology, and real-life functioning in a large sample of people with schizophrenia, using a data-driven causal discovery procedure based on partial ancestral graphs (PAGs). This method may provide additional insights for the identification of potential therapeutic targets to promote recovery in people with chronic schizophrenia. State-of-the-art instruments were used to assess the study variables. Two PAGs were generated at baseline and after 4 years of follow-up to model the nature of the causal relationships linking psychopathology, cognition, and functioning. The study sample was composed of more than 600 clinically stable patients with schizophrenia at two time points. The PAGs model indicated that working memory impairment is the first ancestor of the causal links, influencing all the other neurocognitive domains, social cognition, and functional capacity, which in turn affects everyday life functioning. From this domain of functioning a causal link is directed to disorganization and positive symptoms, and another to work skills and interpersonal relationships domains; the latter had a direct link to asociality and the other domains of negative symptoms. The structure of the PAGs did not differ significantly between baseline and follow-up, indicating the stability of the causal relationship model investigated cross-sectionally at both time points. The role of working memory impairment in the pathways to functional outcomes in schizophrenia highlights the importance of implementing integrated pharmacological and cognitive remediation interventions targeting neurocognition. The impact of everyday life and interpersonal functioning on the clinical presentation of schizophrenia suggests that integrated and personalized treatments, promoting relevant skills to improve these functional outcomes, may have a beneficial impact on clinical outcomes
Benzyl Benzoate 25% Versus Permethrin 5% for Scabies. Are Topical Drugs Still Required in the Oral Ivermectin Era?
No full textCivitas Dei. Sistemi abitativi complessi.
No full textIl testo illustra il lavoro svolto da docenti, dottorandi e studenti del Workshop | Laboratorio di progettazione
intensiva per l’a.a. 2024/2025 sull’Unité d’Habitation Transitoire di Le Corbusier. Attraverso un processo di
sperimentazione e adattamento, gli studenti hanno sviluppato proposte architettoniche che rielaborano i
singoli lotti concepiti da Le Corbusier, declinandoli in soluzioni innovative capaci di rispondere alle esigenze
contemporanee dell’abitare collettivo. L’approccio progettuale mira a bilanciare densità, qualità degli spazi
e sostenibilità, ponendo particolare attenzione alla relazione tra le unità residenziali e gli spazi condivisi. Il
risultato è un insieme di progetti che esplorano nuovi modi di abitare, capaci di coniugare sperimentazione
tipologica e vivibilità, nell’ottica di una città pensata come organismo dinamico, inclusivo e aperto