735962 research outputs found
Sort by
Am I dependent on a lifetime use of antipsychotics? A qualitative analysis of Q&A data about stopping and tapering antipsychotics from the perspective of users and their relatives
No full textBackground: Many antipsychotic users at some point want to stop their antipsychotic. They mention side effects, functioning, experiencing no benefits and health concerns as motivations. The aim was to explore questions antipsychotic users and their relatives have about stopping or tapering antipsychotics. Methods: Data were used from a publicly available anonymous expert Q&A in which experts answered questions about mental health. Questions about stopping or tapering antipsychotics asked by antipsychotics users and their relatives were analysed using an inductive content analysis. Results: A total of 3000 questions were screened, where 426 were about antipsychotics and 194 were about stopping or tapering antipsychotics. The most common question was whether it was sensible to stop. Questions focused on how fast to taper, what their minimum dose should be, where to find support and when withdrawal symptoms or side effects would subside. Motivations were side effects, difficulties in functioning and experiencing no benefits. Barriers were lack of support and return of symptoms. Facilitators were support and experiencing a relief from side effects and/or symptoms. Discussion: Antipsychotic users and their relatives are left with many questions about tapering antipsychotics. These questions reveal attitudes, preferences and concerns that are important to address when discussing antipsychotic treatment.</p
Range-only distributed safety-critical formation control based on contracting bearing estimators and control barrier functions
No full textThis article proposes a distributed multiagent formation control framework, ensuring rigorous safety and solely relying on range-only measurements. To address the challenge of rigid formation control without bearing information, we introduce a bearing estimator with respect to a single landmark. This estimator enables integration with conventional distance-based formation controllers while preserving distributed deployments. To ensure collision-free trajectories in cluttered environments, we develop a safety-critical control law that includes the estimated bearings with control barrier functions (CBFs), formally guaranteeing obstacle avoidance. We rigorously prove the convergence of the bearing estimator, the asymptotic stability of the desired formation shape and the continuity of safety control inputs. The effectiveness of the proposed approach is demonstrated through simulations with multiple agents and obstacles, as well as experimental validation using quadcopters in a cluttered lab environment. A video showcasing the studyand experimental results is available at https://www.youtube.com/watch?v=iV0pNrtZbxM
Blended PC Peer Review Model:Process and Reflection
No full textThe academic peer review system is under increasing pressure due to a growing volume of submissions and a limited pool of available reviewers, resulting in delayed decisions and an uneven distribution of reviewing responsibilities. To address this challenge, the International Conference on Mining Software Repositories (MSR) 2025 introduced a Blended Program Committee (PC) peer review model for its Technical Track. Building upon the community’s earlier experience with the Shadow PC (2021 and 2022) and Junior PC (2023 and 2024), the new model pairs up one Junior PC member with two regular PC members as part of the core review team of a given paper, instead of adding them as an extra reviewer. This paper presents the rationale, implementation, and reflections on the model, including insights from a post-review author survey evaluating the quality and usefulness of reviews. Our findings highlight the potential of Junior PCs to alleviate reviewer shortages, foster inclusivity, and sustain a high-quality peer review process. We offer lessons learned and recommendations to guide future adoption and refinement of the model
Autosomally-encoded segregation distortion of sex chromosomes
No full textSome selfish genetic elements drive at meiosis to achieve transmission distortion, breaking the rules of Mendelian segregation to enhance their own evolutionary success. It has been shown that enhancers of drive must act in cis in order to gain the selfish benefit of drive and that suppressors of drive will be selected at unlinked loci. Here, we model the evolution of an autosomal trans-acting gene (Distorter) that causes the Y chromosome (or even 0 chromosome) to drive without driving itself, a phenomenon we call 'remote-control meiotic drive'. We show that such a gene may spread in the population when linked to a second locus, Assister, whose alleles are transmitted at different frequencies through sperm as compared to eggs, for which we consider various scenarios, such as sexually antagonistic selection or sex-limited drive. Depending on the mechanistic details of sex-chromosome drive, Distorter's spread can additionally facilitate transitions between XY and X0 sex determination. Our results provide a proof of principle that stretches the current understanding of segregation modifier and sex allocation theory. Moreover, we identify alternative evolutionary trajectories that could also lead to remote control drive and discuss its potential applications in developing synthetic sex-ratio-distorting elements for use in pest management, for example.</p
Preparing to Hit the Ground Running:Adding RISC-V Support to EESSI
No full textRISC-V-based high-performance processors and accelerators gain more interest for running scientific workloads. While RISC-V is already supported in Linux distributions such as Debian Sid and Ubuntu, a comprehensive stack of performance-optimized software installations is missing. For x86_64 and aarch64, EESSI already streams such software installations to any machine worldwide. Hence, we were also interested in whether one could provide such software stacks for RISC-V-based systems. The benefit would not only be that a stack with software installations optimized for RISC-V becomes easily accessible, but it would also integrate a development environment with toolchains and dependencies. This would help port more software to RISC-V, thereby increasing the platform’s viability for running scientific workloads. In this paper, we describe our work on supporting the RISC-V ISA in EESSI - what issues we encountered and how we solved them. We explain our progress on implementing the core components of EESSI - CernVM-FS and Gentoo Prefix - and discuss lessons learned that could provide valuable insights for software developers porting codes to RISC-V. In summary, our experience is that researchers will soon use RISC-V...</p
Synchronously modulating the universal diffusion of cations and anions by separator integration:A versatile approach toward safe and high-performance lithium-metal batteries
No full textDespite the great potential of lithium metal batteries (LMBs) for next-generation energy storage systems, the practical application still suffers from safety issues and capacity fading due to irregular ion diffusion from both anode and cathode. Herein, a sandwich separator consisting of PP substrate and two-side coated NH2-MIL-101 (NM) layers (NM-PP-NM) is designed to integrally modulate the interfacial diffusion of both anions and cations. Ordered micropores of NM endow separator with physical confinement toward cations (Li+, Fe2+, and Mn2+) and anions (polysulfide anions and electrolyte anions), contributing to regulated multi-ion diffusion. Moreover, chemisorptions between NM and ions (polysulfide, Fe2+, and Mn2+) validated by density functional theory simulations effectively alleviate the undesirable cathode crossover. Meanwhile, amino groups can participate in the formation of solid electrolyte interface and improve interfacial stability. Due to the modulated Li+ flux and uniform Li plating/stripping, a desirable lifespan of ∼2600 h with ultralow overpotential for a Li-Li symmetrical cell is achieved by equipping the NM-PP-NM separator. Benefit from the regulated diffusion of both anions and cations, NM-PP-NM exhibits excellent versatility in various LMBs, including lithium-sulfur, Li-LiFePO4, and Li-LiNi0.8Mn0.1Co0.1O2 (NMC811) battery systems. Both the safety and electrochemical performances of the above LMBs are greatly enhanced, emphasizing the versatility and potential of the developed multifunctional integration strategy for separator modification.</p
A novel colorimetric sensor composed from alkaline phosphatase-graphene oxide nanoconjugates and enzyme induced gold nanoparticle aggregation for the detection of deoxynivalenol-3-glucoside
No full textGrains and goji berry are highly susceptible to fungal and mycotoxin during the processing and storage. Current detection methods require the use of complex sample preparation, expensive analytical platforms and professional operators, making rapid on-site detection difficult. This study explored a sensor based on β-Co(OH)2 nanosheets mediated composite material from graphene oxide (MGO), polyethyleneimine (PEI), and alkaline phosphatase (ALP) referred as MGO@PEI-ALP conjugate for the detection of masked mycotoxin (Deoxynivalenol-3-glucoside, D3G) in goji berries. The new sensor was able to detect D3G in the range of 0.50–3.50 mg/L with a 0.30 mg/L limit of detection, well below the maximum standard limit (1.0 mg) specified by the European Union. Meanwhile, this method could effectively remove D3G from complex dietary agricultural products. This study suggested a rapid visualization approach for the recognition of masked mycotoxin, offering valuable insights for food safety and quality.</p