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Occupational Therapy for Establishing a Morning Routine to Prevent Delirium After Hip Fracture Surgery: A Randomised Controlled Feasibility Study
No full textBackground: Older patients are at a greater risk of developing postoperative delirium following hip fractures. Thus, multicomponent, non-pharmacological interventions are recommended for preventing delirium. However, there is no consensus on the specific components that should be included in these interventions. Therefore, we developed an occupational therapy to establish a morning routine (OT-EMR), incorporating the three components recommended in a Cochrane review. This study aimed to assess the feasibility of this program in patients aged ≥ 80 years following acute hip fracture surgery. Methods: This randomised controlled feasibility trial compared the outcomes of usual occupational therapy with those of OT-EMR, which included daily interventions to support independence in activities of daily living each morning and group therapy sessions. Both groups received standard care, including early mobilisation, nutritional regulation, and other standard measures. The primary outcomes were delirium occurrence within 14 postoperative days and quality of life (QOL) on postoperative days 7 and 14. Results: Forty-nine patients were enrolled (recruitment rate: 51.0%), and 45 patients (mean age: 89.2 years, standard deviation: 5.1) completed the study. The retention rate of the OT-EMR was 88.0%. The respective incidence of delirium and the median duration of delirium were 45.5% and 1.5 days in the OT-EMR group, compared with 56.5% and 3.0 days in the control group. The respective mean QOL values on days 7 and 14 were 0.570 and 0.612 in the OT-EMR group, compared with 0.475 and 0.560 in the control group. Effect sizes were small across all outcomes. Conclusions: Implementation of OT-EMR was feasible, but its effects on delirium incidence and QOL were small. Further improvements in the program implementation and research methods are essential for study continuation. Trail Registration: University Hospital Medical Information Network Clinical Trials Registry number: UMIN000055541.journal articl
Hydralazine Lowers Serum Triglyceride Levels by Enhancing Farnesoid X Receptor Signaling and Adipose Triglyceride Lipase Expression : In Vivo Evidence from Male Spontaneously Hypertensive Rats
Full text linkBackground : Hydralazine (HYD) is a vasodilator widely used for the management of hypertension and related conditions, including heart failure and eclampsia. While previous studies have shown that HYD mitigates hepatic steatofibrosis induced by a high-fat, high-cholesterol diet in spontaneously hypertensive rats (SHRs), its precise effects on lipid metabolism remain unclear. This study investigated the impact of HYD on serum and hepatic lipid profiles and explored potential underlying mechanisms. Methods : Male SHRs received HYD via drinking water (60 mg/L) for either four or ten weeks, followed by analyses of clinical parameters and hepatic gene expression. Results : HYD significantly reduced serum triglyceride (TG) levels at both time points. In the liver, HYD markedly upregulated small heterodimer partner, a target gene of the farnesoid X receptor (FXR), as well as adipose triglyceride lipase (ATGL). After ten weeks of HYD treatment, the expression of peroxisome proliferatoractivated receptor α was also significantly elevated, coinciding with reduced serum TG levels. Conclusion : These findings suggest that HYD lowers lipid levels primarily by activating the FXR signaling pathway and enhancing ATGL expression, highlighting a novel pharmacological role of HYD in lipid metabolism.journal articl
History of the Management of a Coffee Plantation in Ulu Baram, Sarawak
Full text linkdepartmental bulletin pape
発言抑制傾向とアサーション行動の関係における職場環境認識の調整効果
Full text link本研究は，発言抑制傾向とアサーション行動の関係において，職場環境認識の役割を明らかにし，発言しやすい職場環境について検討するため，発言抑制傾向とアサーション行動との関係における職場環境認識の調整効果を分析した。社会人190 名と学生146 名を対象に調査を行った結果，職場環境の中でも，特に「職場への適応」と「居場所安心感」を得られていると，発言抑制傾向があってもアサーション行動が促進されることが確認された。一方で，職場環境が整っていない場合，スキルが高くても「個人的限界の表明」が抑制された。これにより，個人のスキル向上だけでなく，職場環境改善の必要性が示された。departmental bulletin pape
援助要請行動のプロセスとセルフスティグマの関連
Full text link本研究の目的は援助要請行動のプロセスモデルの各段階における意思決定にセルフスティグマと「自立」の捉え方がどのように関連があるのかを検討することであった。質問紙調査を実施し，大学生・大学院生101 名(男性25 名，女性75 名，無回答１名)を分析対象とした。分析の結果，身近な他者へのセルフスティグマは友人への援助要請の検討だけでなく，学生相談機関への援助要請の検討にも影響を与えている可能性が示唆された。心理的自立観における自己完結の信念が強いほど学生相談機関への援助要請の検討が促進されていることから，自身の持つ援助資源を適切に活用していると捉えられることで援助要請行動につながる可能性が示唆された。departmental bulletin pape
Tezepelumab Targeting Thymic Stromal Lymphopoietin Enhances Steroid Sensitivity in Patients With Severe Asthma
No full textjournal articl
Supporting Data: Sunlight-Driven Oxidation of Cellulose in Solution Using Stabilized WO3 Photoanodes
No full textPrimary data produced by the authors for the paper entitled “Sunlight-Driven Oxidation of Cellulose in Solution Using Stabilized WO3 Photoanodes.”datase
Does early administration of denosumab delay bone healing after intertrochanteric femoral fractures?（大腿骨転子部骨折術後の早期デノスマブ投与は骨癒合を遅らせるのか？）
Full text link信州大学Shinshu University博士（医学）次の雑誌に発表。 /Journal of Orthopaedic Science 30(1) :136-141(2025); doi:10.1016/j.jos.2024.03.005 © 2024 The Japanese Orthopaedic Association. Published by Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.doctoral thesi