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Economic Security and Trade Secret Law ～On the Case of Industrial Espionage by a Sovereign Nation
Get PDFArticle信州大学経法論集 16 : 131-190, (2024)departmental bulletin pape
Sedimentary environments change of the Miocene to Pleistocene in the Thakkhola region, central Nepal
Get PDFThe Thakkhola area in Nepal, one of the grabens north-south direction on the boundary between the Himalayas and the Tibetan Plateau, is filled by Miocene to Pleistocene deposits. The Thakkhola Formation in the study area is divided into twelve lithofacies based on grain size, sedimentary structure, and fossil assemblages, and into eight facies association based on the combination of lithofacies. The sedimentation of the Thakkhola Formation can be interpreted as follows, gravel-bed braided river deposits, gravel-sand meandering river deposits, gravel -bed braided river deposits with siltstones, gravel-sand braided river deposits, and sand braided river deposits. Paleosols are found mainly on floodplains, lakes, bars, and levees. Some paleosol horizons with well-developed soil horizons and illuvial clay indicate a warm climate, while paleosols with rhizolith of CaCO3 deposited around the roots suggest an environment of repeated intermittent rain and arid periods.Article環境科学年報 46 : 22-26, (2024)journal articl
Integrative Analysis of an Animal Model of CASK Abnormality : From Protein to Social Behavior
Get PDFArticle信州医学雑誌 72(3) : 131-140, (2024)journal articl
Direct Evidence that 4ʼ-O-methylpyridoxine Induces Hyperactivity and Convulsions due to Pyridoxal Phosphate Deficiency in the Brain
Get PDFGinkgo biloba seed (GBS) poisoning is caused by the toxic substance 4’-O-methylpyridoxine (MPN). Gammaaminobutyric acid (GABA) in the brain is suggested to be involved in the convulsion-inducing effect of MPN. To clarify the direct effects of MPN in the brain on behavior and changes in vitamin B6 and GABA concentration, we intrathecally administered MPN (5-80 nmol) to mice. Some of them developed hyperactivity and seizures. Incidence of behavioral abnormalities were correlated with the MPN dose/body weight. In the analysis of the brain, mice with hyperactivity shown decreased Pyridoxal-5’-phosphate (PLP) and decreased GABA/Glutamae (Glu) ratio. Administered MPN dose/body weight was negatively correlated with PLP (p＜0.001) and GABA/ Glu ratio (p＝0.004) in the brain. MPN concentration in the brain negatively correlated with PLP (p＜0.001) and GABA/Glu ratio (p＜0.001), and a positive correlation between concentration of MPN and phosphorylated MPN (4’-O-methylpyridoxine-5’-phosphate, MPNP) was found (p＝0.01). We report for the first time that MPNP is produced from MPN in vivo and MPN decreases PLP concentrations in the brain, resulting in the decrease of GABA/Glu ratio and this change leads to behavioral changes.Article信州医学雑誌 72(3) : 159-167, (2024)journal articl
放線菌に対する抗生物質の濃度依存的作用の解析
Get PDF信州大学(Shinshu university)博士（医工学）この博士論文は、次の学術雑誌論文を一部に使用しています。 / Applied and Environmental Microbiology 89(10) :e01133-23(2023); doi:10.1128/aem.01133-23 / Current Microbiology 77 :2933-2939(2020); doi:10.1007/s00284-020-02126-9Thesis向井 慶一郎. 放線菌に対する抗生物質の濃度依存的作用の解析. 信州大学, 2024, 博士論文. 博士（医工学）, 甲第10号, 令和06年03月20日授与.doctoral thesi
Practical Use of ICT for Teaching Kanji Shape Understanding in the First Year of Junior High School
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