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The World Input-Output Database:Content, Concepts and Applications
No full textThis article describes the contents and construction of the World Input-Output Database (WIOD). This database contains annual time-series of world inputoutput tables, covering the period from 1995 onwards. Underlying concepts, construction methods and data sources are considered. In addition, the WIOD provides data on labour and capital inputs for forty countries, making it useful for a wide range of applications. We illustrate this by analysing recent trends in international production fragmentation, competitiveness and patterns of specialisation. We give guidance to prudent use and discuss possible improvements and extensions.
The Role of Resource Misallocation in Cross-country Differences in Manufacturing Productivity
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Preperoxisomal vesicles can form in the absence of Pex3
No full textWe demonstrate that the peroxin Pex3 is not required for the formation of peroxisomal membrane structures in yeast pex3 mutant cells. Notably, pex3 mutant cells already contain reticular and vesicular structures that harbor key proteins of the peroxisomal receptor docking complex—Pex13 and Pex14—as well as the matrix proteins Pex8 and alcohol oxidase. Other peroxisomal membrane proteins in these cells are unstable and transiently localized to the cytosol (Pex10, Pmp47) or endoplasmic reticulum (Pex11). These reticular and vesicular structures are more abundant in cells of a pex3 atg1 double deletion strain, as the absence of Pex3 may render them susceptible to autophagic degradation, which is blocked in this double mutant. Contrary to earlier suggestions, peroxisomes are not formed de novo from the endoplasmic reticulum when the PEX3 gene is reintroduced in pex3 cells. Instead, we find that reintroduced Pex3 sorts to the preperoxisomal structures in pex3 cells, after which these structures mature into normal peroxisomes.