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NeuroSkin®: AI-Driven Wearable Functional Electrical Stimulation for Post-Stroke Gait Recovery—A Multicenter Feasibility Study
No full text(1) Background: Functional Electrical Stimulation (FES) is a recognized method for post-stroke gait rehabilitation but remains underutilized due to workflow complexity and the need for manual configuration. NeuroSkin®, a wearable FES system integrating AI-driven stimulation and sensor-based gait monitoring, was developed to streamline clinical use by automating phase-specific, multi-muscle stimulation. (2) Methods: This retrospective multicenter feasibility study evaluated the integration of NeuroSkin® into routine inpatient rehabilitation. Fifteen subacute stroke patients across seven centers underwent 10 to 20 FES-assisted gait training sessions. Standardized assessments (10MWT, 6MWT, TUG, NFAC) were performed pre- and post-intervention. Therapists completed the System Usability Scale (SUS) questionnaire. (3) Results: All outcomes showed statistically significant improvement: walking speed and endurance increased by 70% and 171% respectively, TUG time decreased by 39%, and ambulation level improved by three NFAC categories. No adverse events were reported, and usability was rated as excellent (mean SUS score: 84.6). (4) Conclusions: NeuroSkin® was safely and effectively implemented in diverse clinical settings, demonstrating strong usability and promising functional benefits. These findings support the need for prospective controlled trials to confirm its clinical efficacy and broader applicability in stroke rehabilitation
Amorphous calcium phoshpate bioceramic nanoparticles and their cellular biocompatibility as a basis for application in medicine and dentistry
No full textNanoparticle materials are currently a promising platform for application in both preventive and regenerative medicine and dentistry. Artificially synthesized nano calcium phosphate systems, a promising class of bioceramic materials, have indicated potential application in tissue engineering due to its similarity to human bone and good biocompatibility. So far, the most commonly used biocompatibility tests have offered insights into the influence of materials on cell number and adhesion. This study investigates the cellular biocompatibility of amorphous calcium phosphate nanoparticles (NPsACP) and examines the impact of materials on intracellular phenomena, at the gene level. We assessed cytotoxicity through cell adhesion analysis, MTT and LDH assays, as well as flow cytometry analysis to evaluate cellular uptake, using immortalized human cell lines (HaCaT and HS-5). Additionally, gene expression analysis for anti-apoptotic and proliferation markers (Survivin, BCL2, HOX, and Ki67) was conducted to explore intracellular responses. The results revealed that NPsACP exhibit high biocompatibility, supporting cell viability within the 70–100% range. Overall, our findings highlight the strong potential of NPsACP bioceramics usage, not only in regenerative and reconstructive medicine but also as multifunctional platforms for therapeutic delivery, justifying their future investigation in clinical applications
Food grade nanostructures of pumpkin leaves protein/pullulan blend as a potential carrier for cobalamin
No full textNowadays, nanostructures made of biopolymers, such as proteins and polysaccharides, have gathered the growing attention of food scientists. In this study, pumpkin leaves from field crop side streams were processed to produce the protein isolate. The leaf protein isolate was investigated given the ability to encapsulate cobalamin (vitamin B12) in a blend with pullulan by electrospinning method. The starting blend solutions were characterized regarding the key factors that influence the formation of the fibers: viscosity, charge density carried by the jet, and surface tension. The results showed that the addition of the protein isolate (1% w/v) increased the conductivity of the pullulan solution (5% w/v), from 0.163 mS/cm to 1.420 mS/cm and the viscosity from 1.74±0.07 to 8.34±0.09 mPas. Cobalamin (at a concentration of 0.3 mg/mL) decreased the conductivity (0.978 mS/cm) and slightly increased the surface tension and viscosity of the final solution. SEM micrographs showed the formation of beads-on-fiber structures after the electro-hydrodynamic processing of the solutions. The protein caused the reduction of the beads compared to the beads obtained from neat pullulan (176.68 nm vs. 357.52 nm), while the mean fiber diameter was not affected (~22.5 nm). The combination of biopolymer pullulan and protein-rich pumpkin leaf extract has shown the properties of a potential carrier for the model vitamin
In situ synthesis of biocompatible NaY1−xGdxF4:Yb/Er nanoparticles for cell labeling and temperature sensing
No full textBiocompatible, up-converting NaY1-xGdxF4:Yb/Er nanoparticles have been successfully obtained in situ by chitosan assisted solvothermal synthesis, and were further characterized to check their potential for optical thermometry. The temperature dependent change in the green emission intensity, originating from the thermalization between 4S3/2 and 2H11/2 levels, implied maximum relative sensitivity of 1.3 %K−1 in the physiologically interesting temperature range. Presence of chitosan ligands at the nanoparticles surface promotes their biocompatibility. The nanoparticles concentration ranging from 10 to 50 µg/mL yielded viability higher than 80 % for HS-5 fibroblast and SCC-25 oral cancer cells. Efficient visualization of αNaY0.65Gd0.15F4:Yb0.18Er0.02 nanoparticles in cytoplasmic region of cells, under excitation at 976 nm, validates their potential to be used for cell labeling and temperature sensing in tissue.Peer-reviewed manuscript: [https://hdl.handle.net/21.15107/rcub_dais_17793
Метода за оптимизацију одрживих националних енергетских система на бази симулација
No full textТехничко решење је рађено за потребе научног пројекта Републике Србије (ИИИ42009) Интелигентне енергетске мреже на коме је један од аутора био руководилац (2010-2018) и шире за потребе међународне академске заједнице, образовних институција, институција енергетике и осталих институција Републике Србије које могу допринети њеном одрживом развоју. Суштина овог техничког решења јесте примена науке о енергетском планирању ради развоја техничко технолошких основа енергетског планирања сопственим снагама ради јачање конкуретности енерго-индустријског и енерго-привредног система Републике Србије у смислу избегавања свих непотребних трошкова а додатно кроз смањење емисија угљендиоксида и економски оправданог преласка на обновљиве изворе енергије. Ово техничко решење јесте иновација у облику новог начина оптимизације енергетских система (посебно Републике Србије) на бази симулација. Ово техничко решење је иновативно а настало је у оквиру научноистраживачког процеса описаног у докторској дисертацији одбрањеној на Електротехничком факултету 20. Априла 2016. године. Комерцијално исказана процењена вредност студије овог типа (EuropeAid/135625/IH/SER/RS у прилогу позив за достављање понуда) на међународном тржишту има горњу вредност 1.100.000 € (реда милион евра). Профит који се може исказати применом овог решења мери се милијардама евра (~1.000.000.000€) на годишњем нивоу (око 4 милијарде евра је разлика Подразумеваног и Одрживог сценарија 2030 год. стр. 43 монографије наслов) уколико би било примењено од стране Министарства енергетике. Тиме је и показана економска логика науке о енергетском планирању јер главни разлог драстичне разлике износа јесте оптимизација и прилагођавање структуре енергетског система Републике Србије условима измењене парадигме енергетске реалности.Техничко решење је описано у публикацији: Batas Bjelić, Ilija, and Nikola Rajaković. 2015. “Simulation-Based Optimization of Sustainable National Energy Systems.” Energy 91 (November): 1087–98 [https://doi.org/10.1016/j.energy.2015.09.006
Ultraviolet Radiation Knowledge and Exposure Practices Among Serbian High School Students: Results of a Nationwide Survey
No full textThe incidence of skin carcinoma has significantly increased among the Serbian population, with mortality rates among the highest in the world. Basic interventions can reduce the effects of ultraviolet radiation (UVR) exposure, especially in youth, and decrease incidence and morbidity. This study is the first cross-sectional nationwide research on knowledge, attitudes, and sun exposure practices among Serbian high school students. The results revealed that fewer than 5% of students can correctly interpret the sunburn effect of a given UV index, while sun protection strategies are infrequently adopted. Most students (55.97%) expressed favorable attitudes regarding tanning, while more than half (64.48%) reported moderately high and high exposure. Females are more likely than males to expose themselves to UVR, especially intentionally. Females use protection more than males, while even 62.65% of males use protection insufficiently. The most commonly used sun protective measures were sunscreen and shade. The results indicate the necessity for innovative and
age-suitable education methods and age- and gender-directed awareness campaigns for skin cancer prevention and the promotion of sun safety. Specifically, campaigns aimed at females should focus on motivating reduced intentional exposure, while those targeting males should emphasize the consistent use of sun protection measures
Transgenerational and/or Transcultural Transformation of the Reality of the Village Community: the Zduhać, the Zmijar or the (Rural) Esoteric
No full textЗа време дугогодишњих истраживања демонолошких предања, сусретао
сам се са поменима посебних појединаца за које се веровало, или који
су за себе тврдили да поседују одређене моћи. Најчешће сам се сретао са
змијарима. Занимљиво је да су неки од њих били „потомци здухаћа” од
којих су, како тврде, „наследили моћ”. Други су задржали „моћи” предака,
али су правац деловања усмерили ван свог културног или географског окружења као својеврсни „сеоски езотерици”. Трећи саговорници су „моћи”
развили кроз нетрадицијске изворе сазнања, а метод, циљ и простор деловања проширили у односу на село. У овом тексту анализирамо три (идентитетска) модела дефинисана различитим извором сазнања или овладавања моћи, као и методом, односно, циљем специфичног деловања. Како
у тексту настојим да укажем, ови специфични идентитети представљају
одраз хибридизације друштвене и културне стварности дефинисане кроскултурним дијалогом који обликује хабитус, односно идентитете мојих саговорника данас. Ове феномене посматрам као последицу прилагођавања постмодерном или пак, (пост)постмодерном свету у односу на који
заједнице фигурирају као платои промишљања стварности, сопства и стратегија опстанка својих припадника.Throughout my years of researching demonological traditions, I have
encountered mentions of certain individuals who were believed to possess,
or who themselves claimed to have, specific powers. Most commonly, I
came across zmijari (snake charmers). Interestingly, some of them were
“descendants of zduhaći,” from whom they claimed to have “inherited their
power.” Others retained the “powers” of their ancestors but directed their
activities beyond their cultural or geographical environment, functioning
as a kind of “rural esoterics.” A third group of interlocutors developed their
“powers” through non–traditional sources of knowledge, expanding the
method, purpose, and scope of their activities beyond the village. In this
text, I analyse three (identity) models, each defined by a different source of
knowledge or mastery of power, as well as by the method and specific goal
of their practice. As I aim to demonstrate, these distinct identities reflect
the hybridization of social and cultural reality, shaped by cross–cultural
dialogue that in turn forms the habitus—or, in other words, the identities
of my interlocutors today. I view these phenomena as a consequence of
adaptation to the postmodern or even post–postmodern world, in which
communities function as platforms for rethinking reality, the self, and the
survival strategies of their members
Youth Activism in Roma Communities in Serbia: Citizens’ Association Ternipe from Pirot
No full textDespite the fact that in the last few decades numerous
initiatives have been launched aimed at improving the position of
marginalized and minority communities the position of the Roma
population in Serbia is still fragile, unfavorable and potentially
endangered. The aforementioned community is making great
efforts to reduce existing forms of discrimination in the areas of
education, health and employment. In addition to numerous
forms of engagement in improving the social position of Roma
men and women, the Roma community in Serbia is increasingly
paying attention to young people who are recognized by the
aforementioned community as potential initiators and carriers of
various and necessary changes in society. There are very good
examples of networking of young Roma men and women who
work together to improve the quality of life of young people,
helping them to acquire competencies, and resolve relevant
issues, thereby making a significant contribution to the
development of local Roma communities, but also to society as a
whole. In this context, we present the Citizens’ Association
Ternipe (CAT) from Pirot, which deals with the integration of
Roma men and women, with a special emphasis on youth and women. The name of their organization means “youth” in
Romani language. CAT has a clear vision, which is “a society
without prejudice and discrimination, with equal opportunities
for all.” CAT perceives youth as one of the key subjects in
emancipatory processes. Young people within this association act
through learning, volunteerism, respect for diversity, support for
education and employment, freedom of speech and participation
in social life. In the presentation, we pay special attention to peer
education, which has a certain tradition of practice in the
exemplary association. Our goal is to point out the importance of
youth activism in the context of marginalized and minority
communities through mentioned example, and to discuss its
potency, but also its limitations in the context of the Roma
community in Serbia
National Minority Protection as Transfer of Political Culture in the Kingdom of Yugoslavia
No full textThe notion of national minority protection in interwar Europe is often perceived merely as an obligation imposed on the countries of the “New Europe” established in practice by the “Little Treaty of Versailles.” This article approaches national minority protection from the perspective of creating a new framework as a “transnational cultural space” by reshaping and transferring the concepts of minority, ethnic, cultural, and religious diversities. In doing so, a novel framework of European political culture emerged in exploring and defining the rights of individuals and groups symbolized in education in the mother tongue, the legalization of cultural associations, and personal, non-territorial, and territorial autonomy. The research encompasses an analysis of works by experts in the Kingdom of Yugoslavia, the practical application of policies meant to ensure the rights of national minorities, and the scope of the system itself and the reception of the new concept among members of the “Yugoslav nation” and their fellow citizens who were members of “non-Yugoslav” communities. I analyze the context of the cultural transfer imposed by the Great Powers and the process of mutual exchange and construction of new practices. They were transformed by emulating other countries, reshaping the discourse on national minorities, and through assimilation policies or population transfer
Enhanced Control of Single Crystalline Ag Dendritic Growth on Al Foil via Galvanic Displacement and Simultaneous Oxidation of D‐Glucose
No full textA facile synthesis platform for the formation of stable single crystalline Ag dendrites is demonstrated. Using a porous electrospun polyacrylonitrile nanofiber network on Al foil as a template facilitates more uniform dendritic growth in the presence of D-glucose. In contrast, a denser polymer network restricts the nucleation site availability on the Al foil, highlighting the critical role of the substrate. The growth formation of silver dendrites is reduced in the solution when two simultaneous processes occur: The electroreduction of Ag+ in the D-glucose solution and galvanic displacement driven by the interaction of Ag+ with the aluminum substrate. High-resolution transmission electron microscopy analysis shows the single crystalline nature of Ag dendrites grown from the Al substrate, revealing atomic structures with closely packed layers forming highly faulted face-centered cubic and hexagonal close-packed structures. The remarkable long-term stability of Ag dendrites is primarily attributed to their single crystalline structure, with additional contributions from capping by D-gluconic acid, as confirmed by Raman analysis. This novel approach to the generation of highly stable Ag dendrites has significant potential for applications such as surface-enhanced Raman scattering, which has to date been considered to be very sensitive to environmental effects.Supplementary material: [https://onlinelibrary.wiley.com/action/downloadSupplement?doi=10.1002%2Fsmsc.202400478&file=smsc202400478-sup-0001-SuppData-S1.pdf