Res Medica (E-Journal)
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Haemophilia, Past and Present
Get PDFINTRODUCTIONThe term haemophilia, meaning “lover of blood", was coined comparatively recently in the long history of bleeding disorders, having been first used in the early 19th century. Then it defined a bleeding disorder which was transmitted by certain unaffected females to some of their sons. Now, as a result of the enormous increase in scientific knowledge developed in the interim, haemophilia can be defined more precisely as a coagulation disorder transmitted in a sex-linked recessive manner and primarily expressed in males, in which the level of factor V I II clotting (or biological) activity in the blood is reduced below normal because some of the precursor molecules, (named immunological factor V III), are functionally abnormal and cannot be converted to clotting factor V III. The clinical grade of severity of the disorder breeds true and correlates well with the amount of circulating clotting factor V III, severely affected haemophiliacs having less than 1%, moderately affected between 1 and 5% and mildly affected between 5 and 50%. The normal range is 50 - 200%.
Society News
Get PDFThe following members of Council were elected at the Annual Extraordinary General Meeting held onWednesday, 7th May 1980: Senior President: Christopher Ingamells1st Junior President: Alex Hamilton 2nd Junior President: Brian Montgomery3rd Junior President: Hamish McRitchie Senior Secretary: Dorothy Russell Junior Secretary: Lyn McLartyConvenor of the Business Committee: Alastair McKinlayConvenor of the Publicity Committee: Roderick ElliottConvenor of the House Committee: lain LindsayConvenor of the Library Committee: Elizabeth BoyterConvenor of the Museum Committee: Sandra BrownConvenor of the Entertainments Committee: Lizbeth Jordan Non Council posts:Editor of Res Medica: Graeme DuncanConvenor of the Annual Dinner Committee: Lizbeth Jorda
From the Inside
Get PDFLetterWe are often told, "You don\u27t know what it feels like." This is often true, to imagine the plight felt by someone facing the consequences of a terminal illness will more than stretch empathy. Edinburgh medics face a newer, more intense form of this human misery, a cohort of young, vital people, cornered by drug addiction and threatened by AIDS. We present here a moving letter sent to RES MEDICA by a local drug user with HIV
Journalscan
Get PDFThis is a short collection of interesting items pertinent to medicine and science in general. It gives a taste of some of the current work in hand around the world. We would welcome any contributions of this nature, just a short chatty narrative of an interesting or amusing article that you have seen or read
RMS Dinner
Get PDFEach year the RMS holds its annual dinner, and this year was no exception. Traditionally the location of this get-together alternates between the Royal College of Physicians in Queen Street and the Royal College of Surgeons at Surgeon’s Hall. This year (our 254th session) it was our \u27turn\u27 to return to the ‘surgeons’.Although I’ve now been a member of the RMS for four years this was only my second time at the dinner, thus I’d never been inside Surgeons’ Hall. As for many people in Edinburgh, all that I’d seen of the famous college was its bus stop. Happily I’ve now seen the inside and what a fabulous host it was for our dinner.This year all went exceptionally well and I think it was enjoyed by all present. We were especially pleased to see so many students there, after all it is our Society’s dinner.
Lauder Brunton
Get PDFA mere glance at this, the chronological details of the career of Thomas Lauder Brunton would suffice to convince even the most uninformed that this symposium bears honour to one whose contribution to medicine and her allied sciences is of a degree which cannot adequately be assessed a full century later. When one considers that by the age of 30 he had gained the Gold Medal Doctorate in Medicine, a Doctorate in Science and had been elected to a fellowship of the Royal Society, it becomes obvious that his secret of success must have been present from the very beginning of his career. I make no apology therefore for not attempting a full biographical view of his distinguished career but merely illuminating some details of his early years in Edinburgh, when those firm foundations were being made
First Discussion
Get PDFDr. W.A. Alexander: I do not think it inappropriate at this time to recall that I met Sir Thomas Lauder Brunton in London in the Spring of 1914 at a dinner of the London University of Edinburgh Club, in my capacity as a Senior President of the Royal Medical Society at that time. During the evening I had the pleasure of sitting beside him and my recollection of him, is of a man of small stature with grey-white hair and a trim beard, he was venerable in my eyes but actually he was only 70 years of age. I remember his keen interest in what was happening in Edinburgh, especially in the Royal Medical Society. The occasion and the man remain vivid in my memory.Dr. Walter Sommerville (Middlesex Hospital
Chest Pain, Exercise Electrocardiography and Coronary Arteriography
Get PDFOver the last 6 or 7 years Dr. Richard Ross and I in the department of medicine at Johns Hopkins Medical School have had a continuing interest in objective methods which might be used in assessing the individual who comes to the physician complaining of chest pain. Angina pectoris is many things; it is a metabolic defect with lactate excess, it is a certain pathological picture, it is a group of individuals who are disposed to have certain things happen to them, but most of all angina pectoris is pain in the chest. It is pain in the chest as far as the patient is concerned, and this is the symptom on which the physician has to base important decisions concerning diagnosis, prognosis and treatment. The problem with chest pain is that it is a very subjective complaint, and a discussion with the patient is certainly the most satisfactory way to establish its cause
Prognosis of Angina Pectoris
Get PDFCoronary heart disease expresses itself usually as angina pectoris or myocardial infarction. At least in Norway, angina pectoris is the more common form, particularly in people under the age of 65. The vast majority of patients with myocardial infarction is admitted to hospitals while the majority of patients with angina pectoris as the sole expression of coronary heart disease seeks a general practitioner if he sees a doctor at all. Therefore the incidence of angina pectoris in the population is less well known, than the incidence of myocardial infarction and consequently the exact prognosis is hard to give
A review on the use of aspirin as a form of chemoprevention to reduce colorectal cancer
No full textBackground: Colorectal cancer (CRC) is the second most common cancer worldwide. Estimated lifetime risk of CRC is 5%, with an incidence of 1 million new cases and 600 000 deaths worldwideevery year. Lifestyle, dietary, and genetic factors play a crucial part in the development of colorectal cancer. Chemoprevention is a method of CRC prevention.Aim: This review aims to identify the effectiveness of aspirin in preventing CRC in high-, moderate- and low-risk patients.Method: Electronic databases were used to search for randomized controlled trials (RCTs) from 1989 to 2012 in MEDLINE, EMBASE, CINAHL, the Cochrane Database of Systemic Reviews, and Cochrane Central Register of Controlled Trials. The search terms employed were “hereditary colorectal cancer”, “Lynch syndrome”, “colorectal cancer”, “aspirin”, and “colorectal cancer”.Results: Aspirin reduces the incidence and recurrence of adenoma in patients with high to moderate risk of developing CRC.Conclusion: There is evidence which supports the use of aspirin in reducing the risk of colorectal cancer in genetically predisposed patients and moderate-risk groups. Higher doses of aspirin appear to reduce the incidence of CRC. It is unclear what the optimum dose to start is, and the duration of administration that will provide effective chemoprevention. Further research is needed to answer these questions