Res Medica (E-Journal)
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    The Contributors

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    John F. Munro, M.B., Ch.B., M.R.C.P.(E), William A. Branford, B.Sc., Christopher Smith, M.B., Ch.B., M.R.C.P.(E), Geoffrey D. Hargreaves, James Williamson, M.B., Ch.B.. F.R.C.P.(E), John Parker, B.Sc. and Peter Calverly

    Books

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    Principles and Practice of Medical Computing: £3. Churchill Livingstone. L. G. Whitby and W. Lutz.Textbook of Medical Treatment, 12th Edition, £4.25. Longman Group Ltd., 1971. Edited Alstead, MacGregor and Girdwood.An Introduction to Clinical Research. £1.50 Churchill Livingstone. W. P. Small and Urban Krause.The Significance of Physical Signs in Medicine (1st Edition). £2.25. H. K. Lewis and Co., Ltd., Peter Mills.Jamieson\u27s Illustrations of Regional Anatomy, Section V II, Lower Limb: Livingsone: £1. Revised by Robert Warmsley and T. R. Murphy, 9th Edition.Statistics in Small Doses. £2. A Livingstone Medical Text. Churchill Livingstone. W. M. Castle

    Current Topics in Epilepsy

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    Human epilepsies, by definition, are recurrent, self-sustained, paroxysmal disorders of brain function characterised by excessive firing of cerebral neurones. The underlying biochemical and morphological disturbances in the brain which are responsible for epilepsy are not clearly understood except that they appear to be diverse and hence the immediate difficulty in advancing a common mechanism for these disorders. Most probably they are different diseases but the clinical manifestations of these are similar. This view would certainly be compatible with the complex nature of neuronal control mechanisms both at the cellular and organisational level. In this article there will be a stress on possible biochemical disorders both in humans and in experimental epilepsies, the drug treatment of these, and an evaluation of the clinical relevance of experimental animal models

    The Treatment of Chronic Atherosclerotic Occlusion of the Lower Limbs – A Review of 30 Cases

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    Atherosclerosis affects large elastic and muscular arteries, the most commonly and severely affected being the aorta. The cerebral, coronary, and renal arteries, and the arteries of the lower limbs are also frequently involved. The principal pathological changes are intimal thickening and fibrous tissue proliferation, whichcause narrowing and occlusion. Ischaemia of -tissues distal to points of obstruction occurs unless adequate collateral channels have had time to develop. Although atherosclerosis is a generalised disease, three main sites of occlusion in the lower limbs are recognised (Macpherson e t al., 1971), the aortic bifurcation (aorto-iliac disease), the superficial femoral artery (femoro-popliteal), and more distant arteries (peripheral).The purpose of this paper is to review the results of direct arterial surgery to the aorto-iliac vessels in a consecutive series of 30 patients and to correlate them with the indications for surgery and the nature of the lesions as determined by preoperative arteriography

    The G.P. Obstetrician - Gone For Ever?

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    I never accept proffered cups of tea during the course of duty — well, hardly ever. The one invariable exception used to be the inevitable cup offered by the proud new father: his one constructive act at the time of the delivery at a home confinement. What could be more happy, more natural, more satisfying that the birth of a new baby in the environment of its parents\u27 home, in the midst of the family to which it was the newestaddition? When all went well — and that was undoubtedly the norm — the pleasure, indeed the unequivocal joy, of all concerned, parents, midwives, grannies, doctors — was one of the great abiding satisfactions of general practice.There was, though, an obverse side to the coin. The prolonged labour with exhaustion starting to supervene, the occasional limp, apnoeic babe, the mother bleeding steadily with placenta stuck, these could cause concern and anxiety and sometimes downright alarm never fully compensated for even by the existence of the most efficient flying squad

    Rab and his Friends

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    It is not unreasonable to see why medical textbooks come and go. The eternal truths found in anatomy can well be translated from edition to edition, hence the popularity and survival of Cunningham\u27s and Jamieson\u27s textbooks. It is not unexpected that the great textbooks of past such as Thomson and Myles Operative Surgery or Bennett’s Textbook of Physiology should have fallen by the way.A few writings from the past, however, are rarely read and this is to be regretted. One such is John Brown\u27s Horae Subsecivae. Much of the work provides somewhat ponderous reading for modern readers who have turned away from Scott to Hemingway to Le Carré. Such readers are hardly likely to relish verbose Victorian writers. However, within his writings John Brown had a masterpiece,namely \u27Rab and his Friends\u27, which came in the second series. In a gentle way it describes John Brown\u27s hero, James Syme.Edinburgh has been famous in a variety of ways, not least of which for its surgeons. It is difficult to say who is the greatest of Edinburgh\u27s surgeons but in any discussion it would be impossible to dismiss Syme from the final analysis. It is curious that the greatest accolade that could be given to him was \u27the Napoleon of surgery It is improbable that any modern surgeon would like his accolade to be \u27the Hitler of surgery\u27.

    The Future of Trimethoprim

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    From a dissertation read before the Society on 11th February, 1981.Co-trimoxazole became available for medical use towards the end of 1968 and represented a successful marriage of the old and the new, being a combination of a sulphonamide and a new drug called trimethoprim. Today it is one of the most widely prescribed drugs in the United Kingdom, and is used extensively in urinary and respiratory tract infections. More recently, however, trimethoprim has been released for use on its own, and this has raised considerable controversy as to which is the drug of choice.Three original claims for co-trimoxazoleSimple laboratory tests suggest that a combination of trimethoprim and a sulphonamide will inhibit bacterial growth at concentrations lower than either drug on its own. More formal assays which compare the drugs over a range of concentrations confirm that the antibacterial effect of the combination greatly exceeds a purely additive response. The drugs\u27 interaction is said to be synergistic, although no single definition of the term synergy has ever been universally accepted

    The Drife Diaries

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    HumourAs readers will be aware, Teviot Row is alive with rumours that an ex-Edinburgh medical student is threatening to publish the diaries he kept during his undergraduate days in the “Swinging Sixties" . His former colleagues, now distinguished medical men, are said to have offered large sums as “hush money ” to “Doctor X”, and several Edinburgh publishing houses have experienced burglaries and arson attacks, as well as telephone calls hinting at complications should the publisher ever need medical treatment. Undaunted, in what must be journalism’s coup of the decade, Res Medica has secured exclusive rights to these manuscripts, and after consultation with our lawyers (who advise us that their authorship must remain a closely guarded secret) we now present the first extracts from The Drife Diaries

    Medical Faculty Ball

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    The R.M.S. was in charge of this year’s “ball of the season”, on Valentine’s Day, in the Assembly Rooms. As usual it was a best seller with most of the 770 people buying their tickets in the first week of sales

    Editorial

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    Rapid advances in molecular biology over the last decade has rekindled interest in hereditary diseases such as cystic fibrosis. This particular disease is the most common genetic disorder in Caucasian populations and much effort has gone into determining its biochemical and genetic basis. It was just over a year ago that the cystic fibrosis gene was finally localised and cloned. But has the discovery of the gene provided more questions than answers?The main article on cystic fibrosis describes the general features of the disease while the accompanying article on the cystic fibrosis gene discusses the significance and implications of its discovery.Both these articles are written by medical students. We would welcome any contributions from students such as results from honours projects or on any other topics relevant to medical students in general. Res Medica is essentially a student medical journal and aims to provide an opportunity for medical students to express themselves

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