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PROFILING OF AGGREGATION-PRONE MOTIFS IN ALPHA-SYNUCLEIN AND IMPLICATION FOR TARGETED THERAPEUTIC DEVELOPMENT
No full textProbing dark matter halo profiles with multiband observations of gravitational waves
No full textIn this paper, we evaluate the potential of multiband gravitational wave observations from a dHz space-based detector and third-generation ground-based gravitational wave detectors to constrain the properties of dark matter spikes around intermediate-mass ratio inspirals. The presence of dark matter influences the orbital evolution of the secondary compact object through dynamic friction, which leads to a phase shift in the gravitational waveform compared to the vacuum case. Our analysis shows that the proposed Indian space-based detector GWSat, operating in the dHz frequency band, provides the most stringent constraints on the dark matter spike parameters, as IMRIs spend a significant portion of their inspiral phase within its sensitivity range. While third-generation ground-based detectors such as the Einstein Telescope and Cosmic Explorer offer additional constraints, their contribution is somewhat limited, particularly for higher mass systems where the signal duration in their frequency bands is shorter. However, for systems with detector-frame total masses Mz<400M⊙, Cosmic Explorer and Einstein Telescope could improve the estimation of the chirp mass, symmetric mass ratio, luminosity distance, and dark matter spike power-law index by more than 15%. Nonetheless, their impact on the constraint of spike density is minimal. These results highlight the crucial role of dHz space-based detectors in probing dark matter interactions with gravitational wave sources
Multi-class classification of control room operators� cognitive workload using the fusion of eye-tracking and electroencephalography
No full textChemical process industries are hazard intensive. Most industrial accidents occur today due to human error. For safe and efficient operation, it is therefore critical to ensure optimal operator performance. With the advent of Industry 4.0 and concomitant digitalization, the role of operators has become cognitively challenging. Therefore, it is imperative to assess the cognitive performance of operators. One of the major constructs to understand cognitive performance is the cognitive workload. An increase in cognitive workload often leads to degradation in performance. Traditional assessment techniques fail to capture cognitive aspects of performance. Recently, researchers in various domains such as aviation, driving, marine, and nuclear power have started to utilize physiological measures to gauge the cognitive workload of their operators. In our previous works, we have used electroencephalography (EEG) and eye-tracking separately to assess the cognitive workload of operators in the process industries. In contrast, in this paper, we explore the benefits of their fusion in classifying process industry control room operators� workload into low, medium, and high classes while they tackle abnormal situations. The methodology employs the fusion of metrics derived from pupil, gaze, and EEG data to train a decision tree-based model for workload classification. Our results reveal that fusion leads to an increase in classification accuracy of upto 22 %. The work has the potential to identify the expertise level of operators and hence, can be critical in ensuring their optimal performance. � 2023 Elsevier B.V., All rights reserved
Cooling Crystallization of Sulfamethazine-Acetylsalicylic Acid Cocrystal: Estimating Nucleation Kinetics and Real-Time Phase Identification
No full textCooling cocrystallization of 1:1 sulfamethazine-acetylsalicylic acid (SMZ-ASA) cocrystal from acetonitrile is investigated based on the ternary phase diagrams (TPDs) established at 5, 15, 25, and 35 °C. Nucleation kinetics of the cocrystal and pure coformers analyzed using classical nucleation theory (CNT) revealed that the nucleation rate of the cocrystal is significantly lower, approximately 1/111 times that of pure ASA and 1/21 times that of SMZ at similar supersaturations. Cooling cocrystallization was scaled up from 20 mL to 2 L, transitioning from a magnetically stirred to an overhead-stirred system. This scale-up facilitated the study of nucleation and the successful production of cocrystals in larger volumes. Cooling in the stable cocrystal region in the TPD produced pure cocrystals. Cooling crystallization in the SMZ + cocrystal region near the SMZ invariant point in TPD led to the formation of pure cocrystal instead of SMZ-cocrystal mixture due to the influence of nucleation kinetics. Conversely, in the ASA + cocrystal region near the ASA invariant point, a mixed solid phase was obtained. In-situ Raman spectroscopy revealed that pure ASA nucleated first, followed by cocrystal formation approximately 30 min later
Corrigendum to “Image of ideals under linear K-derivations and the LNED conjecture” [Journal of Pure and Applied Algebra 229 (2025) 108041] (Journal of Pure and Applied Algebra (2025) 229(9), (S002240492500180X), (10.1016/j.jpaa.2025.108041))
No full textThe author regrets having missed acknowledging the funding received for the original published article having DOI doi.org/10.1016/j.jpaa.2025.108041. The funding detail is as follows: SERB-sponsored project (Grant No. CRG/2022/007047) as a Research Associate at IIT Gandhinagar from April 3 to November 6, 2024. The author would like to apologise for any inconvenience caused
JWST-ALMA study of a hub-filament system in the nascent phase
No full textContext. Star clusters, including high-mass stars, form within hub-filament systems (HFSs). Observations of HFSs that remain unaffected by feedback from embedded stars are rare yet crucial for understanding the mass inflow process in high-mass star formation. Using the JWST NIRCAM images, a recent study reported that the high-mass protostar G11P1 is embedded in a candidate HFS (G11P1-HFS; 2H+(1–0) data, we confirm the presence of G11P1-HFS and study the dense gas kinematics. Methods. We analyzed the position–position–velocity (PPV) map and estimated on-sky velocity gradient (Vg) and gravity (Fg) vectors. We examined the spatial distribution of the gas velocity and the H2 column density. Results. A steep Vg of 5 km s−1 pc−1 and −7 km s−1 pc−1 toward either side of G11P1-hub and a decreasing Vg toward the hub identify G11P1-HFS as a small-scale HFS in its nascent phase. Additionally, the Vg and Fg align along the filaments, indicating gravity-driven flows. Conclusions. This work highlights the wiggled funnel-shaped morphology of an HFS in PPV space and suggests the importance of sub-filaments or transverse gas flows in mass transportation to the hub
Dengue virus suppression by 25-hydroxycholesterol is mediated by a combination of membrane fusion inhibition, innate immune activation and cholesterol biosynthesis dysregulation
No full textExperimental investigation of laterally loaded model piles in sand improved by limited gravel zone in the surrounding
No full textpH-responsive release of small molecule pharmaceuticals from a reworked adsorbent hydrogel for environmental applications
No full textHydrogels that are engineered for environmental and biomedical applications possess an overlapping set of material and surface properties. In this work, we have repurposed a poly(acrylic acid-co-vinyl sulfonic acid) (PAcVSA) hydrogel that has been previously used for organic dye removal, for the pH-sensitive release of small molecule pharmaceuticals. The engineered PAcVSA hydrogel displayed highly pH-sensitive swelling behaviour with a percentage swelling of 6000% or more in the pH range of 5-8. The known pharmaceutical sulfadiazine (SDA) and an indigenously developed small molecule pharmaceutical (TBS), displayed pH-responsive cumulative release of 82.1% and 80.6% of SDA and TBS, respectively, at pH 5 over 24 h. The difference in cumulative release percentage of the small molecules from PAcVSA at pH 5 and pH 8 is superior compared to other reported pH-responsive synthetic hydrogels. The kinetic modelling of release from the loaded PAcVSA hydrogels suggests different mechanisms underlying release, with Fickian diffusion for SDA and polymer relaxation for TBS. This work represents the successful cross-use of an adsorbent hydrogel relevant for environmental remediation, towards the distinctive carry and release of small molecule pharmaceuticals