5324 research outputs found
Sort by
RAPD Assessment of In Vivo Induced Genotoxicity of Raw and Treated Wastewater to Albino Rat
No full textKinetics and mechanism of oxidation of alcohols
No full textThis paper describes the kinetics and mechanism of oxidation of several monohydric alcohols to the
corresponding aldehydes and ketones by bis(quinuclidine)bromine(I) bromide in the presence of pyridinium
trifluoroacetate. All evidence from the thermodynamic
parameters, deuterium kinetic isotope effect, and Hammett
reaction constants supports a two-step mechanism and
suggests that the transfer of hydride ion from the substrate
to the oxidant is the rate-determining step
Challenges and opportunities of health care supply chain management in the United States
No full textElmuti,Dean:
Omran,Omar:This article explores current supply chain management challenges and initiatives
and identifies problems that affect supply chain management success in the U.S.
health-care industry. In addition, it investigates the impact of health care supply
chain management (SCM) initiatives on the overall organizational effectiveness. The
attitudinal results, as well as the performance results presented in this study
support the claim of health care proponents that the SCM allows organizations to
reduce cost, improve quality, and reduce cycle time, and leads to high performanc
Light cluster formation in low density nuclear matter and the stability of hot nuclei [Article]
No full textTalahmeh,Saeda
Biofilm-derived Legionella pneumophila evades the innate immune response in macrophages
No full textAuthors include Natalia S. Fernández Dávila, Kyle Caution, Anwari Akhter,
Basant A. Abdulrahman, Mia Tazi, Hoda Hassan, Laura A. Novotny, Lauren O. Bakaletz and
Amal O. AmerLegionella pneumophila, the causative agent of Legionnaire’s disease, replicates in human alveolar macrophages to establish infection. There is no human-to-human transmission and the main source of infection is L. pneumophila biofilms established in
air conditioners, water fountains, and hospital equipments. The biofilm structure provides protection to the organism from disinfectants and antibacterial agents. L. pneumophila infection in humans is characterized by a subtle initial immune response, giving time for the organism to establish infection before the patient succumbs to pneumonia.
Planktonic L. pneumophila elicits a strong immune response in murine, but not in human macrophages enabling control of the infection. Interactions between planktonic L. pneumophila and murine or human macrophages have been studied for years, yet the interface between biofilm-derived L. pneumophila and macrophages has not
been explored. Here, we demonstrate that biofilm-derived L. pneumophila replicates significantly more in murine macrophages than planktonic bacteria. In contrast to planktonic L. pneumophila, biofilm-derived L. pneumophila lacks flagellin expression, do
not activate caspase-1 or -7 and trigger less cell death. In addition, while planktonic L. pneumophila is promptly delivered to lysosomes for degradation, most biofilm-derived bacteria were enclosed in a vacuole that did not fuse with lysosomes in murine macrophages. This study advances our understanding of the innate immune response to biofilm-derived L. pneumophila and closely reproduces the natural mode of infection in huma
Padico Holding : developing responsiveness through corporate social responsibility
No full textThe field of business ethics is an area of growth, both in the business and education sectors in the Arab world, including Palestine. But most research on this subject has been carried out
in the USA and Europe, which gives most of the issues related to this field a distinctively American or European character. As an alternative, this case attempts to shed the light on a wide range of socio economic, educational and business issues that are typically encountered in Palestine and to explain innovative approaches to resolving key dilemmas related to resolving the skill shortage that affects the competitiveness of Palestinian enterprises. It will do so by looking at Padico Holding, a pioneer in developing a creative program adapted to the enterprise sector’s needs. The case draws its analysis from international theories and concepts by explaining Padico’s sense of responsibility towards community inspired by Kant’s ethics of duty, which is demonstrated in its business societal orientation built around the “stakeholder model”
Scalable product line configuration: A straw to break the camel's back
No full textSoftware product lines are hard to configure. Techniques that work for medium sized product lines
fail for much larger product lines such as the Linux kernel with 6000+ features. This paper presents simple heuristics that help the Indicator-Based Evolutionary Algorithm (IBEA) in finding sound and optimum configurations of very large variability models in the presence of competing objectives. We employ a combination of static and evolutionary learning of model structure, in addition to utilizing a pre-computed solution used as a “seed” in the midst of a randomly-generated initial population. The seed solution works like a single straw that is enough to break the camel’s back –given that it is a feature-rich seed. We show promising results where we can find 30 sound solutions for configuring upward of 6000 features within 30 minute
