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Reduction of Amyloid-β deposition and attenuation of memory deficits by Tolfenamic acid.
No full textWe have previously reported that tolfenamic acid treatment decreases the amyloidogenic proteins in C57BL/6 and in old hemizygous R1.40 transgenic mice via the degradation of the transcription factor specificity 1 protein (Sp1). The lowering of amyloid- protein precursor (A PP) and amyloid- (A ) in hemizygous R1.40 transgenic mice was accompanied by reversal of the identified spatial reference and working memory deficits observed in the mouse model. In this study, we examined the ability of tolfenamic acid to reduce the amyloid plaque burden, as well as to ameliorate spatial learning and memory deficits in homozygous R1.40 mice. Results from immunohistochemical analysis indicated that tolfenamic acid treatment resulted in a profound decrease in cerebral A plaque burden that was accompanied by improvements in spatial working memory assessed by spontaneous alternation ratio in the Y-maze. These results provide further evidence that tolfenamic acid could be utilized as a repurposed drug to modify Alzheimer’s disease pathogenesi
The impact of external financing on dependency : non-governmental organizations in the 1967 occupied Palestinian territories before and after the Oslo accords case study
No full textSpatial quality of municipal wastewater flowing in Wadi Al Zomar and infiltrated through wadi bed
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The impact of utilizing relevant video clips on Eighth Graders' conceptual change and achievement in the topic of living organisms differentiation and classification
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