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Experimental drugs in randomized controlled trials for long-COVID: what’s in the pipeline? A systematic and critical review
No full textIntroduction: Over three years have passed since the emergence of coronavirus disease 2019 (COVID-19), and yet the treatment for long-COVID, a post-COVID-19 syndrome, remains long overdue. Currently, there is no standardized treatment available for long-COVID, primarily due to the lack of funding for post-acute infection syndromes (PAIS). Nevertheless, the past few years have seen a renewed interest in long-COVID research, with billions of dollars allocated for this purpose. As a result, multiple randomized controlled trials (RCTs) have been funded in the quest to find an effective treatment for long-COVID.
Areas covered: This systematic review identified and evaluated the potential of current drug treatments for long-COVID, examining both completed and ongoing RCTs.
Expert opinion: We identified four completed and 22 ongoing RCTs, investigating 22 unique drugs. However, most drugs were deemed to not have high potential for treating long-COVID, according to three pre-specified domains, a testament to the ordeal of treating long-COVID. Given that long-COVID is highly multifaceted with several proposed subtypes, treatments likely need to be tailored accordingly. Currently, rintatolimod appears to have modest to high potential for treating the myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) subtype, LTY-100 and Treamid for pulmonary fibrosis subtype, and metformin for general long-COVID prevention
Diabetes Mellitus and Its Therapy in Brunei Darussalam – A Critical Revisit
Get PDFIntroduction: Diabetes is becoming an increasingly common condition across the world including Brunei Darussalam. Bruneian population, although is relatively small, represents a miniature urban community of neighbouring Southeast Asian countries as they share similar dietary and ethnicity patterns. Thus, it would be valuable to examine the findings of studies conducted among Bruneians. This study aimed to identify and review research related to the practice of patients with DM in Brunei Darussalam in order to identify associated factors influencing diabetic medication knowledge and adherence.
Methods: This narrative review analyzed literature related to DM and its therapy in Brunei Darussalam. Other issues consisting of knowledge and adherence related to DM were also explored. Databases (Scopus, PubMed, and Google Scholar) were used to search literature published up to May 2022. Search terms “diabetes mellitus”, “Brunei” combined using Boolean operator were used.
Results and Discussion: Conducting appropriate studies in Brunei Darussalam can benefit the government and policymakers to implement effective measures and programmes to combat the diabetes epidemic. Despite the government’s efforts, additional relevant stakeholders must be included in order to work together and engage in these initiatives in order to increase diabetes awareness, give people the power to make healthy decisions, and ultimately reduce the prevalence of diabetes in Brunei Darussalam. Patients’ medication knowledge proficiency plays a main component of ensuring appropriate and safe use of medication prescribed to them.
Conclusion: Relatively poor medication knowledge and inappropriate diabetes-related practices were observed in studies conducted in Brunei Darussalam. However, no study has been done which directly measures both medication awareness and compliance among Brunei Darussalam T2DM patients. Future studies can focus on the relation between these two factors in different geographical locations of the world that are characterized by different diabetes-related practices and culture
A worldwide perspective on large carnivore attacks on humans
No full textLarge carnivores have long fascinated human societies and have profound influences on ecosystems. However, their conservation represents one of the greatest challenges of our time, particularly where attacks on humans occur. Where human recreational and/or livelihood activities overlap with large carnivore ranges, conflicts can become particularly serious. Two different scenarios are responsible for such overlap: In some regions of the world, increasing human populations lead to extended encroachment into large carnivore ranges, which are subject to increasing contraction, fragmentation, and degradation. In other regions, human and large carnivore populations are expanding, thus exacerbating conflicts, especially in those areas where these species were extirpated and are now returning. We thus face the problem of learning how to live with species that can pose serious threats to humans. We collected a total of 5,440 large carnivore (Felidae, Canidae, and Ursidae; 12 species) attacks worldwide between 1950 and 2019. The number of reported attacks increased over time, especially in lower-income countries. Most attacks (68%) resulted in human injuries, whereas 32% were fatal. Although attack scenarios varied greatly within and among species, as well as in different areas of the world, factors triggering large carnivore attacks on humans largely depend on the socioeconomic context, with people being at risk mainly during recreational activities in high-income countries and during livelihood activities in low-income countries. The specific combination of local socioeconomic and ecological factors is thus a risky mix triggering large carnivore attacks on humans, whose circumstances and frequencies cannot only be ascribed to the animal species. This also implies that effective measures to reduce large carnivore attacks must also consider the diverse local ecological and social contexts
Parenting Practices and Adolescents' Mental Health: The Mediating Role of Perceived Maternal and Paternal Acceptance-Rejection and Adolescents' Self-Efficacy
Get PDFParenting practices are essential in promoting children’s mental health, especially in effective and ineffective parenting. The use of ineffective parenting practices is no longer encouraged in the west; however, it remains a common practice among Asian households. Ineffective parenting consists of inconsistent discipline, corporal punishment, and poor monitoring which may result in mental health consequences. Thus, this study assessed the mediating effects of adolescents’ self-efficacy and parental acceptance-rejection on the relationship between ineffective parenting practices and adolescents’ mental health. The current study involved a total of 761 school-going Malaysian adolescents aged 13–18 (38.5% males; Mage = 15.65; SDage = 1.43). This study utilized a cross-sectional design where it measured adolescents’ mental health, ineffective parenting practices, parental acceptance-rejection, and adolescents’ self-efficacy. Both paternal and maternal parenting practices and acceptance-rejection were measured independently. Adolescents’ self-efficacy and perceived paternal and maternal acceptance-rejection were found to be significant mediators for ineffective parenting practices and adolescents’ mental health. Our findings suggest that ineffective parenting practices will result in perceived parental rejection and lower self-efficacy which in turn resulted in poorer mental health among adolescents. It means parents should be mindful of their parenting approaches as they have a direct and indirect impact on the mental health of their offspring
Hepatitis B virus DNA methylation and its potential role in chronic hepatitis B
No full textHepatitis B virus (HBV) infection led to 66% liver deaths world-wide in year 2015. Thirty-seven per cent of these deaths were the result of chronic hepatitis B (CHB)-associated hepatocellular carcinoma (HCC). Although early diagnosis of HCC improves survival, early detection is rare. Methylation of HBV DNA including covalently closed circular DNA (cccDNA) is more often encountered in HCC cases than those in CHB and cirrhosis. Three typical CpG islands within the HBV genome are the common sites for methylation. The HBV cccDNA methylation affects the viral replication and protein expression in the course of infection and may associate with the disease pathogenesis and HCC development. We review the current findings in HBV DNA methylation that provide insights into its role in HCC diagnosis
Current practices and future trends in cockroach allergen immunotherapy
Get PDFPurpose of review: This review evaluates the current modes of allergen-specific immunotherapy for cockroach allergens, in terms of clinical outcomes and explores future trends in the research and development needed for a more targeted cockroach immunotherapy approach with the best efficacy and minimum adverse effects.
Summary: Cockroach allergy is an important risk factor for allergic rhinitis in the tropics, that disproportionately affects children and young adults and those living in poor socio-economic environments. Immunotherapy would provide long-lasting improvement in quality of life, with reduced medication intake. However, the present treatment regime is long and has a risk of adverse effects. In addition, cockroach does not seem to have an immuno-dominant allergen, that has been traditionally used to treat allergies from other sources. Future trends of cockroach immunotherapy involve precision diagnosis, to correctly identify the offending allergen. Next, precision immunotherapy with standardized allergens, which have been processed in a way that maintains an immunological response without allergic reactions. This approach can be coupled with modern adjuvants and delivery systems that promote a Th1/Treg environment, thereby modulating the immune response away from the allergenic response
Validation of Multi-epitope Peptides Encapsulated in PLGA Nanoparticles Against Influenza A Virus
No full textBackground: Influenza is a highly contagious respiratory disease which poses a serious threat to public health globally, causing severe diseases in 3-5 million humans and resulting in 650,000 deaths annually. The current licensed seasonal influenza vaccines lacked cross-reactivity against novel emerging influenza strains as they conferred limited neutralising capabilities. To address the issue, we designed a multi-epitope peptide-based vaccine delivered by the self-adjuvanting PLGA nanoparticles against influenza infections.
Methods: A total of six conserved peptides representing B- and T-cell epitopes of Influenza A were identified and they were formulated in either incomplete Freund's adjuvant containing CpG ODN 1826 or being encapsulated in PLGA nanoparticles for the evaluation of immunogenicity in BALB/c mice.
Results: The self-adjuvanting PLGA nanoparticles encapsulating the six conserved peptides were capable of eliciting the highest levels of IgG and IFN- γ producing cells. In addition, the immunogenicity of the six peptides encapsulated in PLGA nanoparticles showed greater humoral and cellular mediated immune responses elicited by the mixture of six naked peptides formulated in incomplete Freund's adjuvant containing CpG ODN 1826 in the immunized mice. Peptide 3 from the mixture of six peptides was found to exert necrotic effect on CD3+ T-cells and this finding indicated that peptide 3 should be removed from the nanovaccine formulation.
Conclusion: The study demonstrated the self-adjuvanting properties of the PLGA nanoparticles as a delivery system without the need for incorporation of toxic and costly conventional adjuvants in multi-epitope peptide-based vaccines
Self-compassion promotes mental help-seeking in older, not in younger, counselors
No full textWhile self-compassion and mental help-seeking are two important aspects emphasized in mental health literature and counseling practice, very little research has focused on how these two are associated particularly among counseling professionals–individuals providing mental health support to others but whose mental health are often overlooked. This cross-sectional study investigated a moderated mediation model examining the role of age and attitudes in the positive influence of self-compassion on mental help-seeking intention. Using a paper-and-pencil survey, data were collected from a total of 158 Filipino counseling professionals. Results revealed that mental help-seeking attitudes significantly and partially mediated the positive association between self-compassion and mental help-seeking intention. Additionally, age significantly moderated the positive relationship between self-compassion and mental help-seeking attitudes. The significant positive influence of self-compassion on mental help-seeking attitudes was strong among older participants, weak among middle-age, and diminished among younger participants. The findings provided insights on the importance of a self-compassion-based approach to counselor training. The implications of preserving counselors’ mental health in counseling practice were discusse
Psychometric Validation and Environmental Psychological Correlates of the Light Triad Traits: Evidence from a Non-Western Country
No full textAbstract: The Light Triad Scale (LTS) measures the concept of the Light Triad, which was conceptualized as personality traits that reflect a person’s loving and beneficent orientation toward others, consisting of Faith in Humanity, Humanism, and Kantianism. As a novel construct, the Light Triad has yet to establish its structural validity in non-Western countries and needs to demonstrate its association with environmental psychology constructs. This study aims to: (1) examine the structural and criterion validity of the LTS in the Philippines and (2) determine the influence of the Light Triad on environmental concerns and green purchase intentions. Data were collected through an online survey completed by 447 Filipino adolescents. Comparing three models (i.e., one-factor, two-factor, and intercorrelated three-factor models), the present findings corroborated the original model which proposed an intercorrelated three-factor model of the LTS. The LTS demonstrated criterion validity by establishing correlations with relevant measures of environmental psychological constructs. Additionally, path analysis showed that Humanism and Kantianism predicted green purchase intentions via an increase in environmental concern. Measurement and conceptual strengths, future directions, and limitations are discussed
Changes in Perception of Illness during Cardiac Rehabilitation Programme among Patients with Acute Coronary Syndrome: A Longitudinal Study
Get PDFLittle is known about the changes in perception of illness among patients with the acute coronary syndrome (ACS) during cardiac rehabilitation programme (CRP). The purpose of this study is to determine changes in perception of illness with ACS patients during CRP to evaluate the association of patients’ characteristics with the perception of illness at the end of Phase II of CRP. A descriptive longitudinal study was conducted among 450 patients who attended 8-weeks of Phase II CRP at 2 public hospitals in Malaysia and perception of illness was assessed using Brief Illness Perception Questionnaire (BIPQ). The assessment was conducted before Phase II (T0), during the 4th session (T1), and at the end of right after the 8th session (T2). One-way repeated measures of ANOVA analysed the changes of perception at T1 and T2 while logistic regression analysis evaluated the association of patients’ characteristics with the perception of illness at T2. Perception of illness changed during and after CRP from T0 to T1, and T1 to T2 (p < 0.001). The patient viewed ACS as an illness that changed from being more acute to a chronic condition as the sessions progressed. Previous history of acute myocardial infarction (OR = 2.380, 95% CI 1.46, 5.49) and angioplasty intervention were both found to be associated with the perception of illness (OR = 3.857, 95% CI 1.55, 9.61). Perception of illness changed during CRP and these changes are associated with patients’ previous history of cardiac events. Phase II can be viewed as the second window of opportunity for healthcare professionals to intervene early in modifying the perception of illness