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Third-Year Student Nurses: Coping With The Challenges Of Management Postings In Private Universities
No full textBy embracing a growth mindset, building strong support networks, mastering time management, and developing leadership skills, student nurses are well-prepared to meet the challenges of their profession.
The final year of nursing education marks a significant milestone for student nurses. For third-year students in private universities, the culmination of their training often involves a rigorous management posting
AI Integration In Nursing Education: Empowering Student Nurses For The Future
No full textAI is not just transforming nursing education, it is also empowering a new generation of nurses to navigate an increasingly complex health care landscape with skill and compassion.
In the dynamic landscape of health care, where technology continues to reshape traditional practices, Artificial Intelligence (AI) stands out as a transformative force in nursing education
Antiviral Activity of Withanolide A Against Different Infectivity Phases of Dengue Virus Serotype 2 in Vero Cell Line
No full textDengue fever is caused by the Aedes mosquito-borne dengue virus, which is a global threat with 400 million cases reported annually and 5–20% mortality rate. Currently, there is no effective treatment available for dengue fever. Natural products like withanolides, which are steroidal lactones, have shown many good properties, including antiviral activity against other viruses. This study aimed to evaluate the anti-dengue virus serotype 2 activity of withanolide A and withanone in Vero cells. Withanolide A and withanone were well-tolerated in Vero cells with a half-maximal cytotoxic concentration of 0.4982 and 1.186 µM, respectively. Withanolide A and withanone exhibited good direct virus-inactivating effects against dengue virus serotype 2 with a half-maximal inhibitory concentration of 0.017 and 0.353 µM, respectively. Based on the selectivity index, withanolide A (selectivity index, 29.31) was determined to be safer and more effective in inhibiting dengue virus serotype 2 infection in Vero cells than withanone (selectivity index, 3.36). Further investigations conducted with withanolide A showed that it inhibited dengue virus serotype 2 during the pre- and post-infection stages in a dose-dependent manner. Withanolide A also effectively blocked dengue virus serotype 2 attachment and entry into Vero cells in a dose-dependent manner. These findings suggest that withanolide A showed potent anti-dengue activity and could serve as a promising antiviral agent for treatment of dengue infections
Megaproject governance's impact on mega construction project CPEC success: the mediating role of agile project management and the moderating effects of project complexity and project management office.
Get PDFIn the last few decades, mega project governance has become an essential subject for discussion in project management literature. Organizations used the project governance approach to meet the organizational objectives and goals. Yet, many projects fail, and the reasons are sometimes obscure because of the many problems involved in the governance and management of a project. Therefore, current study examined the influence of mega project governance on mega construction project success through mediating role agile project management, moderating effects of mega project complexity and the project management office as a moderated moderator. Data were collected from 327 project managers, middle management personnel, and CEOs involved in various mega construction projects in Pakistan under CPEC, utilizing purposive and convenience sampling techniques. The Partial Least Squares-Structural Equation Modeling (PLS-SEM) approach was employed to test the hypotheses using SmartPLS 4 software. The results indicate that mega project governance significantly and positively influences the success of mega construction projects. Furthermore, agile project management was found to mediate this relationship, demonstrating a positive and significant effect. Additionally, mega project complexity was observed to have a negative and significant moderating effect on both mega project governance and project success, while not significantly impacting the relationship between mega project governance and agile project management. Lastly, the project management office was found to be a significant moderated moderator, reducing the effects of both mega project complexity on mega project governance and the success of mega construction projects, as well as between mega project governance and agile project management. These findings demonstrate that mega project governance within a company, supported by effective agile project management, is the primary driver of sustained high performance and successful completion of mega construction projects. These results will make a valuable contribution to the field of project management
How negative factors influence youth hostel say aftermath COVID-19 pandemic
Get PDFThe bookings and revenues of youth hostels have significantly decreased because of the multiple effects of the COVID-19 pandemic. It is necessary to investigate young consumers' perceptions of visiting youth hostels aftermath this pandemic. The current study examines the relationship between multi-dimensions of perceived risk, three types of images, willingness to pay and visit intention. A convenience sampling was developed where 534 questionnaires were received, followed by subsequent empirical testing of the proposed hypotheses using SPSS and AMOS-SEM. Results showed that perceived risk negatively influenced cognitive and affective image, respectively. Cognitive and affective image positively influenced overall image and finally influenced willingness to pay and visit intention separately. In addition, cognitive image positively influenced affective image. The theoretical framework satisfactorily accounted for willingness to pay and intention, and our results help youth hostels practitioners invent efficient strategies to boost young consumers' willingness to pay and intention to visit youth hostels
A systematic review on the silica fibre thermoluminescence dosimeters for medical applications
No full textSilica fibre thermoluminescence (TL) dosimeters have demonstrated versatility in medical and industrial, offering high spatial resolution, sensitivity, water resistance, and insensitivity to electromagnetic fields. A systematic review focusing on the medical applications of silica fibre TLDs is conducted, highlighting the potential of these materials in medical radiation dosimetry. Despite some limitations, such as non-linearity at low energies and relatively high signal fading, silica fibre TL dosimeters have shown excellent TL performance. However, their application in clinical practice is yet to be established since the TL responses for a wide range of doses and energies are not accurately certified yet
Evaluating the impact of technological innovation and energy efficiency on load capacity factor: empirical analysis of India
No full textThe determinants of environmental degradation have been investigated many times by utilizing carbon dioxide emissions and/or ecological footprint. However, these traditional environmental degradation indicators do not consider the supply side of environmental problems. Therefore, this study focuses on the dynamic influence of financial development, energy efficiency, economic growth, and technological innovation on environmental degradation in India through the load capacity factor, including both the supply and demand sides of environmental problems. For that purpose, the recently developed dynamically simulated autoregressive distributed lag (ARDL) method is employed using the annual time-series data extending from 1980–2020. The dynamically simulated ARDL results demonstrate that financial development, economic growth, and technological innovation have a dynamic adverse impact on the load capacity factor, whereas energy efficiency has a positive dynamic influence on environmental quality. In addition, the results support the validity of the environmental Kuznets curve hypothesis as the negative effect of economic growth on environmental quality decreases over time. Based on the study findings, policy recommendations are provided for India. Finally, this study utilizing load capacity factor as an indicator for environmental quality will provide new topics in exploring the determinants of environmental degradation
Protective Mechanisms of Polyphenol-Enriched Blueberry Preparation in Preventing Inflammation in the Skin against UVB-Induced Damage in an Animal Model
Get PDFUVB significantly impacts the occurrence of cutaneous disorders, ranging from inflammatory to neoplastic diseases. Polyphenols derived from plants have been found to exhibit photoprotective effects against various factors that contribute to skin cancer. During the fermentation of the polyphenol-enriched blueberry preparation (PEBP), small oligomers of polyphenols were released, thus enhancing their photoprotective effects. This study aimed to investigate the protective effects of PEBP on UVB-induced skin inflammation. Topical preparations of polyphenols were applied to the skin of dorsally shaved mice. Mice were subsequently exposed to UVB and were sacrificed 90 min after UVB exposure. This study revealed that pretreatment with PEBP significantly inhibited UVB-induced recruitment of mast and neutrophil cells and prevented the loss of skin thickness. Furthermore, the findings show that PEBP treatment resulted in the downregulation of miR-210, 146a, and 155 and the upregulation of miR-200c and miR-205 compared to the UVB-irradiated mice. Additionally, PEBP was found to reduce the expression of IL-6, IL-1β, and TNFα, inhibiting COX-2 and increasing IL-10 after UVB exposure. Moreover, DNA methylation analysis indicated that PEBP might potentially reduce the activation of inflammation-related pathways such as MAPK, Wnt, Notch, and PI3K-AKT signaling. Our finding suggests that topical application of PEBP treatment may effectively prevent UVB-induced skin damage by inhibiting inflammation
Self-assembled micelles loaded with itraconazole as anti-Acanthamoeba nano-formulation
No full textAcanthamoeba castellanii are opportunistic pathogens known to cause infection of the central nervous system termed: granulomatous amoebic encephalitis, that mostly effects immunocompromised individuals, and a sight threatening keratitis, known as Acanthamoeba keratitis, which mostly affects contact lens wearers. The current treatment available is problematic, and is toxic. Herein, an amphiphilic star polymer with AB2 miktoarms [A = hydrophobic poly(ℇ-Caprolacton) and B = hydrophilic poly (ethylene glycol)] was synthesized by ring opening polymerization and CuI catalyzed azide-alkyne cycloaddition. Characterization by 1H and 13C NMR spectroscopy, size-exclusion chromatography and fluorescence spectroscopy was accomplished. The hydrophobic drug itraconazole (ITZ) was incorporated in self-assembled micellar structure of AB2 miktoarms through co-solvent evaporation. The properties of ITZ loaded (ITZ-PCL-PEG2) and blank micelles (PCL-PEG2) were investigated through zeta sizer, scanning electron microscopy and Fourier-transform infrared spectroscopy. Itraconazole alone (ITZ), polymer (DPB-PCL), empty polymeric micelles (PCL-PEG2) alone, and itraconazole loaded in polymeric micelles (ITZ-PCL-PEG2) were tested for anti-amoebic potential against Acanthamoeba, and the cytotoxicity on human cells were determined. The polymer was able to self-assemble in aqueous conditions and exhibited low value for critical micelle concentration (CMC) 0.05-0.06 µg/mL. The maximum entrapment efficiency of ITZ was 68%. Of note, ITZ, DPB, PCL-PEG2 and ITZ-PCL-PEG2 inhibited amoebae trophozoites by 37.34%, 36.30%, 35.77%, and 68.24%, respectively, as compared to controls. Moreover, ITZ-PCL-PEG2 revealed limited cytotoxicity against human keratinocyte cells. These results are indicative that ITZ-PCL-PEG2 micelle show significantly better anti-amoebic effects as compared to ITZ alone and thus should be investigated further in vivo to determine its clinical potential
Parental Impact of Cultural Values on the Uptake of Human Papillomavirus (HPV) Vaccination by Their Daughters: A Protocol of Qualitative Meta-synthesis
No full textThe aim of this systematic review is to explore how parents’ perspectives on the human papillomavirus (HPV) vaccination are influenced by their cultural values, specifically with regard to their daughters. Adolescent girls are generally the primary targets for HPV vaccination and, in the majority of countries, parents/legal guardians have overall authority on this issue. However, it appears that cultural values could prove a powerful indicator in the parental choices that affect the uptake of HPV vaccination, which therefore needs to be carefully considered. Thus, exploring parents’ views is critical in improving HPV vaccination coverage. Methods: A systematic literature search will be conducted using CINAHL, PsycINFO, EMBASE, PubMed and Science Direct to identify eligible studies published in the English language. Two reviewers will select the studies independently and the quality of the studies will be evaluated using the Critical Appraisal Skills Program (CASP) checklists. Thematic synthesis methods will be used to report themes specific to cultural values. Discussion: It is predicted that the results of the proposed review will be beneficial to identify and understand the culturally-related facilitators and barriers to the HPV vaccination of young women, as they are central to the HPV vaccination programme. Once concerns raised by parents are understood more fully, relevant interventions can be developed to address these concerns. This information is also crucial to the development of strategies to optimise HPV vaccine coverage among this population group by policy makers. Malaysian Journal of Medicine and Health Sciences (2024) 20(2): 379-384. doi:10.47836/mjmhs.20.2.4