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Toxicity assessment of ethanolic Moringa oleifera leaf extract (Mole) using zebrafish (Danio rerio) model
Full text linkMoringa oleifera, locally known as ‘Kelor’ in Malay, is a medicinal plant valued in Malaysia and other countries. It is renowned for its therapeutic bioactive compounds and offers significant health benefits, including anticancer and anti-inflammatory properties. However, the toxicity profile of ethanolic M. oleifera leaf extract (MOLE) has not been well explored. This study aims to assess the toxicity profile of MOLE using a zebrafish (Danio rerio) model. Zebrafish embryos were subjected to MOLE (n ≥ 15; 24h post-fertilisation (hpf)) at a concentration of 5-1000 μg/mL, and the survival rate, hatching rate, heart rate, and morphological development of zebrafish embryos were monitored daily for up to 72 h. Embryo media was used as a control. MOLE treatment was shown to be safe at concentrations ≤ 400 μg/mL with LC50 values of 1186 ±7 μg/mL, 560.1 ±7 μg/mL, and 445.1 ± 7 μg/mL at 24, 48, and 72 h post-treatment, respectively. A significant mortality rate and low heartbeat were recorded in embryos exposed to > 800 μg/mL across the three time points. MOLE did not affect the hatching rate. Although there was a significant difference observed in embryos treated with > 800 μg/mL at 72 h post-treatment, these were not attributable to MOLE effects, as the embryos had died before hatching. Scoliosis was predominantly observed in embryos subjected to MOLE concentrations ranging from 25 to 200 μg/mL. The present data demonstrated that MOLE exhibited concentration- and time-dependent toxicities. Further studies are needed to identify the effective concentrations of MOLE for therapeutic application in in vitro and in vivo models
Majlis Promosi UPM Bersama Media 2025, platform perkukuh hubungan strategik bersama media
No full textSERDANG, 8 Mei – Universiti Putra Malaysia (UPM) menganjurkan Majlis Promosi UPM Bersama Media 2025 sebagai usaha memperkukuhkan hubungan strategik antara universiti dan pihak media
Agro@UPM dedahkan staf baharu kepada teknologi pertanian moden
No full textSERDANG, 15 Mei- Program Kembara Ilmu Agro@UPM membuka peluang kepada 69 staf pelaksana baharu Universiti Putra Malaysia (UPM) untuk mendalami teknologi dan amalan pertanian moden berteraskan inovasi dan kelestarian
Buluh berpotensi menjadi alternatif tanaman negara, masih berdepan cabaran pelaksanaan
No full textSERDANG, 15 Mei – Industri buluh di Malaysia dikenal pasti mempunyai potensi besar sebagai salah satu sumber ekonomi baharu negara, namun usaha pelaksanaannya masih berada pada peringkat awal dan berhadapan dengan pelbagai cabaran teknikal serta struktur
