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Novel biodegradable nanocarriers for enhanced drug delivery
No full textWith the refinement of functional properties, the interest around biodegradable materials, in biorelated applications and, in particular, in their use as controlled drug-delivery systems, increased in the last decades. Biodegradable materials are an ideal platform to obtain nanoparticles for spatiotemporal controlled drug delivery for the in vivo administration, thanks to their biocompatibility, functionalizability, the control exerted on delivery rates and the complete degradation. Their application in systems for cancer treatment, brain and cardiovascular diseases is already a consolidated practice in research, while the bench-to-bedside translation is still late. This review aims at summarizing reported applications of biodegradable materials to obtain drug-delivery nanoparticles in the last few years, giving a complete overview of pros and cons related to degradable nanomedicaments
(Review article) Sponsorship bias in the comparative efficacy of psychotherapy and pharmacotherapy for adult depression: meta-analysis
No full textBackground:Sponsorship bias has never been investigated for non-pharmacological treatments like psychotherapy.AimsWe examined industry funding and author financial conflict of interest (COI) in randomised controlled trials directly comparing psychotherapy and pharmacotherapy in depression.Method: We conducted a meta-analysis with subgroup comparisons for industry v. non-industry-funded trials, and respectively for trial reports with author financial COI v. those without.Results: In total, 45 studies were included. In most analyses, pharmacotherapy consistently showed significant effectiveness over psychotherapy, g = -0.11 (95% CI -0.21 to -0.02) in industry-funded trials. Differences between industry and non-industry-funded trials were significant, a result only partly confirmed in sensitivity analyses. We identified five instances where authors of the original article had not reported financial COI.ConclusionsIndustry-funded trials for depression appear to subtly favour pharmacotherapy over psychotherapy. Disclosure of all financial ties with the pharmaceutical industry should be encouraged
An unusual case of acquired pedophilic behavior following compression of orbitofrontal cortex and hypothalamus by a Clivus Chordoma
No full textThe Accounting Network: How Financial Institutions React to Systemic Crisis
No full textThe role of Network Theory in the study of the financial crisis has been widely spotted in the latest years. It has been shown how the network topology and the dynamics running on top of it can trigger the outbreak of large systemic crisis. Following this methodological perspective we introduce here the Accounting Network, i.e. the network we can extract through vector similarities techniques from companies’ financial statements. We build the Accounting Network on a large database of worldwide banks in the period 2001–2013, covering the onset of the global financial crisis of mid-2007. After a careful data cleaning, we apply a quality check in the construction of the network, introducing a parameter (the Quality Ratio) capable of trading off the size of the sample (coverage) and the representativeness of the financial statements (accuracy). We compute several basic network statistics and check, with the Louvain community detection algorithm, for emerging communities of banks. Remarkably enough sensible regional aggregations show up with the Japanese and the US clusters dominating the community structure, although the presence of a geographically mixed community points to a gradual convergence of banks into similar supranational practices. Finally, a Principal Component Analysis procedure reveals the main economic components that influence communities’ heterogeneity. Even using the most basic vector similarity hypotheses on the composition of the financial statements, the signature of the financial crisis clearly arises across the years around 2008. We finally discuss how the Accounting Networks can be improved to reflect the best practices in the financial statement analysis
A generation-attraction model for renewable energy flows in Italy: A complex network approach
No full textIn recent years, in Italy, the trend of the electricity demand and the need to connect a large number of renewable energy power generators to the power-grid, developed a novel type of energy transmission/distribution infrastructure. The Italian Transmission System Operator (TSO) and the Distribution System Operator (DSO), worked on a new infrastructural model, based on electronic meters and information technology. In pursuing this objective it is crucial importance to understand how even more larger shares of renewable energy can be fully integrated, providing a constant and reliable energy background over space and time. This is particularly true for intermittent sources as photovoltaic installations due to the fine-grained distribution of them across the Country. In this work we use an over-simplified model to characterize the Italian power grid as a graph whose nodes are Italian municipalities and the edges cross the administrative boundaries between a selected municipality and its first neighbours, following a Delaunay triangulation. Our aim is to describe the power flow as a diffusion process over a network, and using open data on the solar irradiation at the ground level, we estimate the production of photovoltaic energy in each node. An attraction index was also defined using demographic data, in accordance with average per capita energy consumption data. The available energy on each node was calculated by finding the stationary state of a generation-attraction model
Perspectives on optimal control of varicella and herpes zoster by mass routine varicella vaccination
No full textHerpes zoster arises from reactivation of the varicella–zoster virus (VZV), causing varicella in children. As reactivation occurs when cell-mediated immunity (CMI) declines, and there is evidence that re-exposure to VZV boosts CMI, mass varicella immunization might increase the zoster burden, at least for some decades. Fear of this natural zoster boom is the main reason for the paralysis of varicella immunization in Europe. We apply optimal control to a realistically parametrized age-structured model for VZV transmission and reactivation to investigate whether feasible varicella immunization paths that are optimal in controlling both varicella and zoster exist. We analyse the optimality system numerically focusing on the role of the cost functional, of the relative zoster–varicella cost and of the planning horizon length. We show that optimal programmes will mostly be unfeasible for public health owing to their complex temporal profiles. This complexity is the consequence of the intrinsically antagonistic nature of varicella immunization programmes when aiming to control both varicella and zoster. However, we show that gradually increasing—hence feasible—vaccination schedules can perform better than routine programmes with constant vaccine uptake. Finally, we show the optimal profiles of feasible programmes targeting mitigation of the post-immunization natural zoster boom with priority
Simplified modelling of chiral lattice materials with local resonators
No full textA simplified model of periodic chiral beam-lattices containing local resonators has been formulated to obtain a better understanding of the influence of the chirality and of the dynamic characteristics of the local resonators on the acoustic behaviour. The beam-lattice models are made up of a periodic array of rigid heavy rings, each one connected to the others through elastic slender massless ligaments and containing an internal resonator made of a rigid disk in a soft elastic annulus. The band structure and the occurrence of low frequency band-gaps are analysed through a discrete Lagrangian model. For both the hexa- and the tetrachiral lattice, two acoustic modes and four optical modes are identified and the influence of the dynamic characteristics of the resonator on those branches is analysed together with some properties of the band structure. By approximating the ring displacements of the discrete Lagrangian model as a continuum field and through an application of the generalized macro-homogeneity condition, a generalized micropolar equivalent continuum has been derived, together with the overall equation of motion and the constitutive equation given in closed form. The validity limits of the dispersion functions provided by the micropolar model are assessed by a comparison with those obtained by the discrete model
Asymptotics for randomly reinforced urns with random barriers
No full textAn urn contains black and red balls. Let Zn be the proportion of black balls at time n and 0≤LL, then bn is replaced together with a random number Rn of red balls. Otherwise, no additional balls are added, and bn alone is replaced. In this paper we assume that Rn=Bn. Then, under mild conditions, it is shown that Zn→a.s.Z for some random variable Z, and Dn≔√n(Zn-Z)
Optimal design of auxetic hexachiral metamaterials with local resonators
No full textA parametric beam lattice model is formulated to analyse the propagation properties of elastic in-plane waves in an auxetic material based on a hexachiral topology of the periodic cell, equipped with inertial local resonators. The Floquet-Bloch boundary conditions are imposed on a reduced order linear model in the only dynamically active degrees-offreedom. Since the resonators can be designed to open and shift band gaps, an optimal design, focused on the largest possible gap in the low-frequency range, is achieved by solving a maximization problem in the bounded space of the significant geometrical and mechanical parameters. A local optimized solution, for a the lowest pair of consecutive dispersion curves, is found by employing the globally convergent version of the Method of Moving asymptotes, combined with Monte Carlo and quasi-Monte Carlo multi-start techniques
