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Bioproses dan Kontrol Kualitas Kultur Jaringan Tanaman
No full textBioproses Kultur Jaringan Tanaman/KJT (Plant Tissue Cultures) pada medium nutrisi dan kondisi aseptis yang terkontrol untuk pertumbuhan sel, jaringan dan organ tanaman, merupakan keunggulan KJT dibandingkan budidaya tanaman secara utuh untuk produksi senyawa aktif farmakologis dalam bahan baku Obat Bahan Alam Indonesia. Keunggulan KJT antara lain adalah produksi senyawa aktif lebih terkontrol, dan dapat diprediksi, tidak tergantung pada kondisi lingkungan, proses isolasi fitokimia relatif lebih cepat dan efisien, senyawa pengganggu yang timbul akibat faktor lingkungan dapat dihindari, bebas kontaminan dan pestisida, kultivasi tidak memerlukan lahan yang luas, produksi senyawa aktif dapat dilakukan dalam jumlah besar dan relatif cepat, peningkatan produksi dapat dilakukan dengan penambahan elisitor, prekursor maupun dengan teknik rekayasa metabolik. Selama bioproses dengan sistem KJT perlu adanya kontrol kualitas yang memonitor kestabilan genetik dan kuantitas senyawa aktif selama proses untuk menjamin perolehan senyawa aktif farmakologis yang tepat dan sesuai dengan rancangan pengembangan produk obat bahan alam.
Buku ini akan mengulas ruang lingkup kultur jaringan tanaman beserta teknologi bioproses, karakterisasi molekuler untuk memonitor adanya variasi genetik yang terjadi selama proses kultivasi serta analisis kandungan kimia terhadap kultur jaringan tanaman. Buku yang ditulis oleh tim penulis lintas disiplin di bidang farmasi dan bioteknologi ini mendeskripsikan pemahaman dan pembukaan wawasan melalui contoh praktis hasil riset dan aplikasi yang didukung dengan gambar dan tabel untuk membantu pembaca dalam memahami konsep dan memantik inspirasi dalam riset berkelanjutan dan lintas disiplin pada Bioproses dan Kontrol Kualitas Kultur Jaringan Tanaman
Literature Review: Analisis Manajemen Logistik Obat Di Instalasi Farmasi Dinas Kesehatan Kabupaten/Kota
Get PDFManajemen logistik obat adalah rangkaian kegiatan yang berkaitan dengan perencanaan, penyimpanan, pendistribusian, dan penghapusan obat yang dikelola secara optimal untuk memastikan jumlah dan jenis obat dan perbekalan kesehatan yang tepat. Studi ini menganalisis pengelolaan manajemen logistik obat di Instalasi Farmasi Dinas Kesehatan Kabupaten/Kota. Untuk melakukan peninjauan literatur, sepuluh artikel diambil melalui Google Scholar dengan kata kunci logistik obat, instalasi farmasi, dan dinas kesehatan. Hasil penelusuran menunjukkan bahwa penerapan manajemen logistik terkait langsung dengan beberapa masalah, termasuk sumber daya manusia, sarana dan prasarana, perencanaan, penyimpanan, pendistribusian, pencatatan, dan pelaporan obat. Semua layanan kesehatan, terutama kefarmasian, harus memenuhi persyaratan manajemen logistik obat. Dari hasil literatur review dapat diambil kesimpulan yaitu manajemen logistik obat di instalasi farmasi dinas kesehatan kabupaten/kota dapat meningkatkan efisiensi dan produktivitas pelayanan di fasilitas kesehatan jika diterapkan dengan baik
Exploring The Role Of Blockchain And Cryptocurrency In Reshaping Global Trade: A Bibliometric Analysis
Get PDFIn the rapidly evolving digital era, technological transformation has become a critical factor in
accelerating and streamlining global trade. Blockchain and cryptocurrency have emerged as innovations
with significant potential to revolutionize cross-border transactions by offering fast, intermediary-free
methods of transaction. Blockchain ensures transparency, security, and efficiency in managing global
supply chains and business transactions, while cryptocurrency enables faster and cheaper cross-border
payments, eliminating delays and high fees associated with traditional banking systems. The purpose of
this study is to explore the role of blockchain and cryptocurrency in reshaping global trade, analyze
patterns and trends in the global trade digital transformation literature, and identify the challenges and
opportunities faced by these technologies in the context of international trade. This study uses a
bibliometric approach to analyze relevant literature, resulting in four main clusters: Green (Global
Trade and Supply Chain), Blue (Ethereum Blockchain and Challenge), Red (Market and Currency), and
Yellow (Role and Example). The findings suggest that blockchain and cryptocurrency can enhance the
efficiency, security, and transparency of international trade; however, challenges such as cryptocurrency
price volatility, security issues, and limited technology adoption still need to be addressed to fully realize
the potential of these technologies
Enhancing CO2 sequestration efficiency: A comprehensive study of nanostructured MOF-composite membrane for sustainable climate solution
Get PDFThis study provides a detailed exploration of nanostructured Metal-Organic Frameworks (MOFs)-composite membranes as a novel and efficient solution for CO2 sequestration process. The integration of MOFs into membrane systems is shown to significantly enhance gas separation performance by improving both selectivity and permeability, thus addressing the inherent limitations of conventional CO2 capture technologies. A range of synthesis techniques, including solvothermal synthesis, layer-by-layer assembly, and in-situ growth, are discussed, highlighting their role in optimizing the interaction between MOFs and membrane materials. In addition, the CO2 capture and separation mechanism through the membrane are thoroughly discussed. The analysis further explores the impact of nanostructuring on the mechanical, chemical, and operational stability of the membranes, with particular attention to their potential for industrial scalability. Key challenges, such as MOF regeneration, economic feasibility, and environmental sustainability, are critically assessed. Additionally, the incorporation of advanced computational modelling and green synthesis methods is emphasized as essential in furthering the development of MOF-composite membranes. This study highlights the significant potential of these advanced materials to revolutionize CO2 capture technologies, contributing to more sustainable and scalable approaches to climate change mitigation
GIG Economy ShakeUp: How It's Reshaping Jobs, Paychecks and the World's Economy
Get PDFThe gig economy has arisen as a dynamic yet intricate factor in worldwide labor markets, providing workers with more flexibility but also posing substantial challenges concerning job security, wages, and legal protections. This research uses a bibliometric review of 980 academic articles and investigates significant elements influencing the gig economy, such as actual salaries, inflation rates, joblessness, data utilization, and gender interactions. Five primary groupings were detected, each illustrating the intricate connection among these variables. The results show that although the gig economy offers flexible work options, it also worsens problems like income inequality, exploitation, and gender disparities. Utilizing data-driven strategies and organizing labor movements are becoming more crucial in addressing these issues, providing gig workers with resources to enhance their work environments. This article discusses the economic and social impacts of the gig economy, and suggests policy suggestions to promote a fairer and more comprehensive job market for all employees
Saudara Sekandung,Seperjuangan: Kualitas Hubungan Saudara Dan Flourishing Pada Dewasa Awal
Get PDFPenelitian ini bertujuan untuk melihat hubungan antara kualitas hubungan saudara dengan flourishing di masa dewasa awal. Beberapa variabel seperti, tinggal terpisah atau bersama, intensitas kehangatan dan konflik yang dialami antar saudara dapat memberikan dampak bagi pertumbuhan flourishing seseorang. Partisipan yang terlibat dalam penelitian ini berjumlah 395 orang, berusia 18-25 tahun, berjenis kelamin laki-laki dan perempuan, memiliki setidaknya 1 saudara serta sudah tinggal terpisah selama minimal 1 tahun. Pengukuran dalam penelitian ini dilakukan menggunakan 2 skala yaitu Adult Sibling Relationship Questionnaire (ASRQ) dan PERMA Profiler. Hasil uji statistik menunjukkan bahwa ada hubungan signifikan antara flourishing dengan aspek-aspek kualitas hubungan saudara, warmth (r=0.229; p=0.000), conflict (r=0.128; p=0.001), namun tidak berkorelasi dengan aspek rivalry (r=-0.077; p=0.129). Hal ini menegaskan bahwa kualitas hubungan persaudaraan pada masa dewasa awal berkontribusi dalam pencapaian flourishing melalui konflik dan kehangatan yang dirasakan, serta permusuhan yang semakin berkurang. Konflik tidak dapat dipandang sebagai sesuatu yang negatif namun berkontribusi terhadap peningkatan kehangatan dan menunjang kualitas hubungan saudara
Effect of Giving Papaya Leaf Extract (Carica Papaya L.) on Changes in Fasting Blood Glucose in Male Wistar Rats (Rattus Norvegicus) Induced by Streptozotocin
Get PDFBackground: Diabetes mellitus is a disease characterized by an increase in blood glucose levels due to decreased insulin production or decreased insulin action. Diabetes cases are described as a serious problem globally in the 21st century and cases are increasing worldwide. One type of plant that can be used as a medicine is papaya leaf (Carica papaya L.) which is known to contain several active compounds such as flavonoids, saponins, tannins, and alkaloids. Objective: To determine the effect of papaya leaf extract (Carica papaya L.) on changes in fasting blood glucose levels of male Wistar rats with hyperglycemia conditions. Methodology: This research is an experimental research Randomized Controlled Trial (RCT) with Pretest-Postest Group Design study design. This study used 35 male white rats which were divided into 5 groups. Group I (without treatment), group II (STZ-NA), group III (STZ-NA and Glimepiride), group IV [papaya leaf extract at a dose of 150mg/Kg], group V (papaya leaf extract at a dose of 200mg/Kg). The data obtained after the study will be tested for normality which is then continued with non-parametric tests using the Kruskal-Wallis and Mann-Whitney U tests, and an effect size test is carried out to determine how much effect is produced from the papaya leaf extract given. Research Results: The administration of papaya leaf extract at a dose of 200mg/200grBody Weight in male Wistar rats in group 5 proved to reduce fasting blood glucose levels more significantly than the administration of glimepiride at a dose of 0.04 mg and papaya leaf extract at a dose of 150mg/Kg. Conclusion: Administration of papaya leaf extract (Carica papaya L.) can reduce fasting blood glucose levels in diabetic model rats effectively at a dose of 200mg/Kg
The Impact of Vitamin D Supplementation on Patients with Essential Hypertension and Vitamin D Deficiency
Get PDFBackground: The maintenance of calcium homeostasis and bone mineralization are two
important functions of vitamin D in bone health. Vitamin D deficiency is known to cause
cardiovascular, musculoskeletal, and other body systems diseases.
Objective: To examine how vitamin D affects hypertension in those who are deficient in it.
Methods: The PubMed and Google Scholar databases are used in this investigation to conduct a
literature review utilizing a narrative methodology that looks at and analyzes research findings
in regional or global literature.
Results: Blood pressure levels after taking vitamin D are dramatically reduced.
Conclusion: Patients who are vitamin D deficient can benefit from vitamin D to treat their
essential hypertension
Will the use of cashless subsidy potentially reduce illegal underground economy activity? A case study in Indonesia
Get PDFPurpose – This study was conducted to understand the potential of cashless subsidy to reduce illegal underground economy activity in Indonesia.
Research methodology – The research was done through a qualitative approach then analyzed based on the content analysis and sentiment analysis using Digital Public Services Index frim Digital Economy and Society Index (DESI) research methodology as base. The data used on this study are Indonesia e-news on kompas.com, detik.com, and tempo.co from March 2021- 2022 using two keywords “subsidi” (subsidy), “non-tunai” (cashless) and “nirsentuh” (contactless).
Findings – The result of this study shows illegal underground economy activity can be reduced by implementing cashless subsidy policy.
Research limitations – The data used on the research were big data obtained from e-news be- cause the lack primary reliable respondent. We could not estimate the cashless subsidy after COVID-19 was ended in Indonesia because the declaration of the end of COVID-19 pandemic in Indonesia was on 29 June 2023.
Practical implications – This study also provides two recommendations for those problems: (a) increase digital financial literacy awareness; (b) improve the formal economy activity.
Originality/Value – There still no specific research of cashless subsidy and their practice in shad- ow economy perspective, especially in developing countries such as Indonesia
Advancements and Challenges in Video-Based Deception Detection: A Systematic Literature Review of Datasets, Modalities, and Methods
Get PDFVideo-based deception detection has emerged as a promising field that leverages advances in
computer vision, machine learning, and multimodal analysis to capture a wealth of nonverbal cues for iden-
tifying deceptive behavior. However, the field faces significant challenges related to dataset development,
methodological approaches, and ethical considerations. This systematic literature review (SLR) aims to pro-
vide a comprehensive analysis of video-based deception detection research, with five distinct contributions:
1) an unprecedented analysis of 21 datasets, revealing critical gaps and opportunities in data resources; 2) a
novel evaluation framework for assessing dataset quality and ecological validity; 3) a systematic comparison
of multimodal integration approaches, identifying optimal strategies for combining visual, audio, and textual
cues; 4) a critical examination of temporal modeling techniques for capturing the dynamic nature of deceptive
behavior; and 5) a roadmap for addressing ethical challenges in deployment. Following the PRISMA
guidelines, we reviewed studies published between 2019 and 2024 in major databases, including IEEE
Xplore, ACM Digital Library, ScienceDirect, and Springer Link. The review process involved a rigorous
two-stage screening, which resulted in the inclusion of 42 primary research papers. Our analysis revealed
several key findings: 1) only 52.4% of identified datasets are publicly accessible, highlighting a critical
gap in research reproducibility; 2) multimodal approaches consistently outperform unimodal methods, with
accuracy improvements of 10-15%; 3) deep learning architectures, particularly LSTM variants and attention
mechanisms, demonstrate superior performance in capturing temporal aspects of deception; 4) the Real-Life
Trial Dataset emerged as the most frequently used dataset (65% of studies), indicating a preference for
high-stakes ecologically valid data; and 5) significant ethical challenges remain unaddressed, particularly
regarding privacy, bias, and cross-cultural validity. This review makes several novel contributions to advance
the field: 1) provides a comprehensive framework for dataset evaluation and development; 2) identifies
optimal strategies for multimodal integration and temporal modeling; 3) presents a structured approach
to addressing ethical considerations; and 4) offers a detailed roadmap for future research priorities. These
contributions will guide researchers in developing more robust, ethical, and generalizable deception detection
systems, while addressing critical gaps in current methodologies and datasets