42304 research outputs found
Sort by
Inovasi Kolaboratif: Jalan Baru Kampus dan Industri
No full textDi era ekonomi modern yang berbasis pengetahuan, kolaborasi antara dunia pendidikan tinggi dan industri menjadi semakin penting sebagai motor penggerak inovasi dan pertumbuhan. Kolaborasi ini pada dasarnya adalah jembatan strategis yang menghubungkan gudang ilmu pengetahuan di universitas dengan kebutuhan praktis di dunia usaha. Tujuannya adalah untuk menterjemahkan hasil-hasil riset akademis menjadi produk atau solusi yang dapat diaplikasikan oleh masyarakat dan memiliki nilai komersial. Kemitraan ini didorong oleh berbagai motivasi yang saling menguntungkan: pihak industri mencari akses terhadap teknologi mutakhir, keahlian para pakar, dan talenta baru, sementara pihak universitas membutuhkan pendanaan riset, relevansi kurikulum dengan dunia kerja, serta kesempatan untuk menyelesaikan masalah-masalah riil. Meskipun memiliki potensi besar, membangun kolaborasi yang efektif antara universitas dan industri bukanlah hal yang mudah dan sering kali menghadapi berbagai tantangan, terutama di negara berkembang. Perbedaan budaya kerja, tujuan yang tidak selaras, hingga isu-isu terkait kontrak dan hak kekayaan intelektual sering menjadi penghambat utama. Agar kerjasama ini berhasil, diperlukan pemahaman yang mendalam terhadap seluruh dinamikanya. Analisis yang komprehensif biasanya mencakup berbagai elemen, mulai dari bentuk kerjasama yang dijalin, motivasi dibaliknya, faktor-faktor pendukung dan penghambat, hingga hasil akhir dan dampak yang dirasakan kedua belah pihak, baik dari level individu yang terlibat langsung maupun dari level institusi secara keseluruhan
Ulcerative Colitis and Alcohol: Facts and Myths
Get PDFUlcerative colitis (UC) is a chronic inflammatory disease of the colon and rectum, characterized by symptoms such as diarrhea, hematochezia, abdominal pain, and distension. The etiology of UC remains unclear, but it is believed to result from a combinationof immune system, environmental, and genetic factors. Among environmental influences, dietary and lifestyle choices, including alcohol consumption, have been scrutinized for their potential impact on UC. Alcohol, a widely consumed beverage, has complex effects on the gastrointestinal system. While moderate alcohol intake is often associated with certain health benefits, its role in inflammatory bowel diseases like UC is contentious. Research indicates that alcohol can exacerbate UC symptoms by altering gutmicrobiota, increasing intestinal permeability, and enhancing inflammatory responses. This review explores the multifaceted relationship between alcohol consumption and UC, highlighting how alcohol can disrupt the gut barrier, modify microbiota composition, and interact with UC medications, potentially diminishing their efficacy. Despite some studies suggesting that certain types of alcohol, such as red wine, may have anti-inflammatory properties, the consensus is that individuals with UC should approach alcohol consumption with caution. The variability in individual responses to alcohol further complicates this issue. This review underscores the need for more research to fully understand the interplay between alcohol and UC and to provide clear guidelines for patients. Until then, it is advisable for UC patients to consult healthcare professionals to make informed decisions regarding alcohol use
The Influence of Behavioral Bias on Investment Decision with Risk Perception as a Mediating Variable: A Study on Generation Z at the Indonesia Stock Exchange
Get PDFThis study uses structural equation modeling to examine the direct and indirect relationships between behavioral biases and investment decisions with the mediating role of risk perception. This study was conducted among Generation Z individual investors who have been investing on the Indonesia Stock Exchange for several months to years. The behavioral biases examined include overconfidence bias, herding bias, and loss aversion bias, with data from 300 respondents collected through purposive sampling. The results show that risk perception mediates the relationship between overconfidence bias, herding bias, and loss aversion bias with investment decisions. Herding bias and loss aversion bias were found to have a direct relationship with risk perception. In addition, it was also found that herding bias, loss aversion bias, and risk perception have a direct relationship with investment decisions. This research is essential for investors to make more rational investment decisions and improve investment performance by recognizing the risks associated with behavioral biases. The increasing number of retail investors and Generation Z on the Indonesia Stock Exchange demands sound investment decisions. Behavioral biases often trigger irrational decisions and errors in portfolio management, while risk perception can strengthen or weaken the impact of behavioral biases on investment decisions. This study contributes theoretically to investment and behavioral finance, particularly regarding the mediating effect of risk perception
Strategic Analysis PT. Panorama Sentrawisata, TBK. (PANR)
Get PDFStudi ini membahas analisis strategis PT. Panorama Sentrawisata Tbk. (PANR), sebuah perusahaan pariwisata yang beroperasi di Indonesia dan terdaftar di Bursa Efek
Indonesia. Dalam konteks pemulihan industri pasca-pandemi COVID-19, PT. Panorama dihadapkan pada tantangan untuk merancang strategi yang berkelanjutan dan kompetitif. Berdasarkan berbagai analisis, termasuk matriks EFE, IFE, BCG, dan QSPM, penelitian ini merekomendasikan strategi product development untuk mengembangkan layanan pariwisata baru dan merambah ke bisnis promotor konser. Langkah ini diambil sebagai upaya untuk menarik minat wisatawan dan meningkatkan daya saing perusahaan. Penelitian ini menekankan pentingnya perencanaan yang mendetail dan pengembangan tenaga kerja muda untuk memahami tren pasar terkini
Faktor-Faktor yang Mempengaruhi Financial Wellbeing Generasi Z Berpenghasilan di Surabaya, Indonesia
Get PDFFinancial wellbeing generasi muda Indonesia yang berpenghasilan merupakan isu yang mendesak dimana sering kali dipengaruhi oleh financial literacy yang terbatas, pola pikir YOLO dan FOMO, serta gaya hidup hedonistik yang lebih mengutamakan kepuasan sesaat daripada stabilitas finansial jangka panjang. Maka, penelitian ini bertujuan untuk mengidentifikasi faktor-faktor penting yang memengaruhi financial wellbeing, dengan berfokus pada financial literacy, self-control, dan financial behavior, dan financial stress, serta membangun kerangka kerja untuk membimbing Generasi Z, khususnya yang berdomisili di Surabaya, menuju stabilitas keuangan yang berkelanjutan. Dengan pendekatan kuantitatif, data dikumpulkan dari total 203 responden melalui metode Snowball Sampling dengan kuesioner terstruktur. Studi ini menggunakan analisis SEM-PLS dengan software Smart PLS 4 untuk meneliti determinan financial wellbeing Generasi Z yang berpenghasilan di kota Surabaya. Hasil penelitian menunjukkan bahwa financial literacy, self-control, dan financial behavior secara signifikan memengaruhi financial wellbeing. Self-control secara positif memengaruhi financial behavior, yang menekankan peran pentingnya dalam mendorong pengambilan keputusan keuangan yang bijak, sementara financial behavior memediasi hubungan antara financial literacy, self-control, financial stress, dan financial wellbeing. Secara praktis, hal ini menunjukkan bahwa Generasi Z dan pemerintah harus mengambil langkah-langkah konkret; Generasi Z dapat memperoleh manfaat dari pendidikan keuangan tentang pengeluaran, manajemen utang, dan investasi. Sementara pemerintah dapat mendukung program financial literacy sebagai sumber daya yang mudah diakses bagi Generasi Z di Indonesia
Development and characterization of surface solid dispersion Moringa oleifera leaf extract-microcrystalline cellulose by co-grinding method
Get PDFContext: Moringa oleifera leaf extract is rich in flavonoid compounds and potential antioxidant sources. However, the development of M. oleifera leaf extract into an herbal product is limited by challenges such as inconsistent quality, hygroscopicity, and poor solubility. Surface solid dispersion (SSD) is a versatile method to enhance both the physical properties and solubility of such extracts.
Aims: To enhance the physical and solubility properties of M. oleifera leaf extract using SSD with microcrystalline cellulose as a carrier.
Methods: SSD was prepared using a co-grinding method with extract-to-carrier ratios of 1:2 and 1:4.
Results: This study revealed that the SSD effectively absorbed the extract onto the surface of microcrystalline cellulose. Hence, the SSD powder exhibited improved moisture content and flowability. Thermal and crystallinity analyses revealed a reduction in crystal lattice regularity compared to the pure extract, as evidenced by decreased enthalpy and diminished peak intensity. The total flavonoid content of SSD 1:2 was 14.70 ± 0.35 mg QE/g, whereas SSD 1:4 was 7.00 ± 0.07 mg QE/g. Flavonoid solubility compound from SSD 1:2 was 62.26 ± 0.62 μg/mL, while the solubility of SSD 1:4 was 63.58 ± 0.62 μg/mL. The solubility of the flavonoid compound from SSD preparation increased about 1.16-fold compared to the physical mixture.
Conclusions: SSD preparation of M. oleifera leaf extract improves its physical and chemical properties, making it more suitable for formulation
Ulasan: Terapi Herbal untuk Penyembuhan Luka Ulkus Kaki Diabetik (Review: Herbal Therapy for Diabetic Foot Ulcer Wound Healing)
Get PDFKomplikasi DM lebih lanjut dapat menyebabkan penderita DM mengalami diabetic ulcers. Pada luka kronis seperti diabetic ulcers, proses penyembuhan menjadi terhambat akibat adanya kondisi hiperglikemia, infeksi bakteri, dan vaskularisasi yang buruk. Penelitian mengenai agen penyembuhan luka dengan tanaman obat yang memiliki efektivitas terhadap penyembuhan luka diabetic ulcers telah banyak dilakukan. Tujuan dari review ini adalah penelusuran pustaka terkait tanaman obat atau herbal yang memeiliki aktivitas dalam penyembuhan diabetic ulcers. Metode yang digunakan adalah dengan mengumpulkan data dari berbagai artikel ilmiah yang membahas mengenai potensi tanaman obat yang terdaftar pada Farmakope Herbal Indonesia (FHI) yang terbukti baik secara in vivo atau in vitro atau uji klinis memiliki efektivitas penyembuhan luka pada diabetic ulcers. Kami mengulas 39 artikel dari 23 tanaman herbal yang memenuhi kriteria inklusi. Kesimpulannya adalah terdapat banyak penelitian berbasis hewan yang mengkonfirmasi aktivitas tanaman herbal dan konstituen aktifnya dalam penyembuhan luka diabetes. Aplikasi topikal produk herbal dan konstituen aktifnya dalam formulasi bisa menjadi alternatif yang baik untuk pengobatan luka diabetes
Genetic Polymorphisms as Treatment Biomarkers for Gynecological Malignancies Treated With Carboplatin and Paclitaxel: A Systematic Review
No full textPurpose
Gynecological tumors, which correspond to the group of neoplasms that affect the female reproductive system, have high incidence and mortality rates. This systematic review aimed to summarize the most recent advances in identifying pharmacogenetic variants associated with the clinical outcomes of carboplatin-paclitaxel chemotherapy in these patients.
Methods
A comprehensive literature search was conducted across eight databases to identify studies published up to July 17, 2024. Two reviewers independently selected the studies and extracted the data; disagreements were resolved by two additional reviewers.
Findings
Out of the 2375 records that were found, only 20 met the eligibility criteria. The main findings were: (1) The three most extensively investigated genes were ATP binding cassette subfamily C member 1 (ABCB1), cytochrome P450 2C8 (CYP2C8), and glutathione S-transferase P1 (GSTP1); (2) three variants, rs1128503 (ABCB1), rs10509681 and rs11572080 (CYPC28), appear to have a significant association with important adverse drug reactions (in particular, neutropenia, thrombocytopenia, and peripheral sensory neuropathy). Others, as is the case with rs1045642 (ABCB1) and rs1695 (GSTP1), have inconsistent results, and the extent to which these results can be extrapolated is still limited; and (c) most of the included studies concerned Asian or European patients.
Implications
Therefore, future research should include more extensive analyses with more inclusive cohorts. As a limitation of the study, a meta-analysis was not possible due to the significant heterogeneity among the studies
Optimization of Silver Nanoparticle Dermal Patch Films for Enhanced Wound Healing: Formulation and Characterization Study
No full textBackground: Silver nanoparticles (AgNPs) are known for their potent antibacterial properties, making it suitable for wound healing applications.
Aims: This study focuses on formulating AgNPs into dermal patch films DPFs), leveraging the adhesive properties of the film for the effective delivery of active ingredients.
Methods: AgNPs were synthesized through a green synthesis method using Plantago major L. Leaf extract as a bio-reductant. Five distinct formulations, ranging from AgNPs concentration of 0% (control); 0,005%; 0,01%; 0,05%; and 0,10%, were optimized and denoted as Formula 1 to 5 (F1-F5), respectively. The films were fabricated by solvent casting method employing a manual film applicator. A variety of evaluations were then performed on the films, including assessments of their physical and chemical characteristics. These characteristics included organoleptic properties, film thickness, folding endurance, surface pH, loss on drying (LOD), crystallinity, the interaction between active ingredients and excipients, the morphological characteristics of the films, and a wound healing study.
Results: All formulations resulted in smooth and transparent films. Favorable outcomes were observed in film thickness and surface pH measurements. Formulations F1-F4 demonstrated exceptional folding endurance (>200 times). This is also affirmed by a reduction in the -OH peak in the Fourier transform infrared (FTIR) spectrum. Powder X-Ray diffraction (PXRD) analysis showed that F1-F4 had adopted an amorphous structure, while F5 retained crystalline AgNPs. The drying process revealed that F5 exhibited the lowest moisture loss. Scanning electron microscope (SEM) imaging displayed distinct morphologies among the five formulations. F4 and F5 exhibited the highest percentage of wound healing.
Conclusion: The formulation of AgNPs synthesized through a green synthesis method, utilizing Plantago major L. leaf extract as a bio-reductant, has demonstrated significant improvements in the physical characteristics, particularly in formulations F1-F4. Notably, F4 exhibited the highest wound healing efficacy. Therefore, the findings of this study suggest that F4 (AgNPs 0.05%) represents the most promising dermal patch films formulation for enhanced wound healing applications
Ecological, Economic, and Sociological Impacts of Paper Consumption in Thesis Reporting Process: A Case Study of Indonesian University
No full textPurpose – This study investigates the impact of institutional policies and paper use in thesis
reporting process at YU. We analyze the impacts in ecological, economic, and sociological
perspectives.
Design/methodology/approach – This research employs a qualitative case study approach.
YU, a well-known private university in Indonesia, was chosen as the research object because it
is recognized as its performance on academic research in 2024. This research analyzes YU’s
policies regarding its student thesis process to understand how the policies and the paper used
were. We gained access to the YU database which is used as the basis for numerical
calculations of ecological impacts.
Findings – This study reveals there are no strict policies about paper use in thesis reporting at
university level to ministry level. It causes the use of paper to be neglected in the thesis
reporting process. The results show the ecological impacts of YU paper waste which leads to
carbon emissions and deforestation. From the perspective of economic impact, the paperintensive
thesis reporting process results in additional costs that must be covered by students.
Sociologically, managing printed paper impacts students’ studies sustainability.
Research limitations/implications – This study focuses primarily on YU as well-known private
universities, which may limit the broader generalization of the findings. However, the
ecological impacts should not be underestimated in sustainability evaluations. The economics
impact also important for Indonesia to attain its gold vision on 2045. The sociological impacts
by lessening student stress, encouraging scientific publication, and strengthening students’
resilience in completing their studies sustainably. The study offers important implications for
policymakers, university leaders, and academic communities. It encourages critical reflection
on institutional practices and highlights the role of higher education in driving sustainable
change. The findings underscore the need for proactive policy interventions and cultural shifts
to support the adoption of paperless academic practices, reinforcing universities as key agents
in sustainability efforts.
Originality/value – This study challenges long-standing academic traditions by questioning the
continued reliance on printed theses and highlighting the impact of paper use in thesis
reporting. This research offers a fruitful perspective by quantifying its ecological impact. This
research also highlights the economic and sociological impacts of paper use in the thesis
reporting process. These findings serve as a call to action for policymakers and academic
leaders to recognize the impact of paperless documentation and foster a culture of
sustainability within higher education