18105 research outputs found
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A study exploring women’s experiences, knowledge, attitudes, and perceptions of fibroids in Diepsloot, South Africa
Get PDFThis study is an exploration of women’s experiences, knowledge, attitudes, and perceptions of fibroids. It is underpinned by social constructionism and the common-sense model of self- regulation theoretical frameworks. Eight in-depth semi-structured interviews were conducted with women in Diepsloot, South Africa. The study aimed to include diverse perspectives, thus participants included women who consulted biomedical and cultural practitioners or both. The findings of the research reveal that women’s experiences with fibroids are complex because of the many decisions they have to make about the diagnosis and treatment options and the multiple, and sometimes intersecting temporary disruptions, caused by fibroids. Furthermore, the low levels of awareness about fibroids and the prevailing culture of silence surrounding women’s reproductive health have negative consequences for women living with fibroids as this can result in delayed diagnosis and treatment. The findings highlight the importance of raising awareness about fibroids in communities such as Diepsloot where awareness initiatives are insufficient, given the high prevalence of fibroids among reproductive age black women.Thesis (MA) -- Faculty of Humanities, Sociology, 202
Decolonizing the curriculum: a case study of the Humanities Faculty at Rhodes University
Get PDFThis thesis explores students’ experiences in the Faculty of Humanities at Rhodes University, specifically focusing on their perspectives on decolonization. The thesis has two central aims: first, to investigate the students’ general understanding of decolonizing the curriculum and second, to examine their experiences within the Humanities Faculty and their perception of how decolonized the faculty is. Through in-depth interviews with students in the faculty, the study aimed to answer questions regarding students’ thoughts on the decolonization of university curricula and their experiences within the Faculty of Humanities at Rhodes University. The findings reveal diverse student views on decolonization, with definitions of decolonization provided by students touching on topics such as the Africanization or Indigenization of the curriculum, systemic transformation, the importance of unlearning colonial ideologies and the relationship between language and decolonization. The students’ perceptions of the level of decolonization they witness in the faculty are categorized along three lines: the views of those who believe the departments they interact with are decolonized, the views of those who think efforts are being made but more progress is needed, and those who see no evidence of decolonization. The thesis highlights that while some students believe that positive steps towards decolonization are being taken, others express scepticism and call for a more diverse representation of scholars and scholarship and a departure from traditional Eurocentric approaches.Thesis (MA) -- Faculty of Humanities, Political and International Studies, 202
No way to escape: a crime fiction
Get PDFThis study presents a model for science engagement that incorporates journalistic approaches. This model emerges from a project that aimed to create engagement and communication around a genetically modified sugar cane variety, developed by the South African Sugarcane Research Institute (SASRI). In this project, we engaged with small scale growers in the North and South Coast region of KwaZulu-Natal. This study’s methodology is based in action research and an iterative approach to science communication and engagement. It draws and reflects on an action research cycle captured through video documentary as a way to effectively and thoroughly collect, analyse and interpret data and produce through the case study. Based on this action research process a model for science engagement is proposed and reflected on and interrogated by scientists and science communicators through a focus group engagement (see model here as part of this thesis): https://drive.google.com/file/d/14UD1qd4fPcqIZrkESq5v2wgJ1Y2Q7hON/view?usp=sharing. I reflect, using video, on this model and how it incorporates principles and techniques for public engagement drawn from different approaches to journalism and communication studies, I argue that science engagement can benefit from drawing from journalistic approaches to public engagement such as those emerging from development communication, public journalism and development journalism. The submission of this thesis includes various other videos as part of the overall thesis.Thesis (MA) -- Faculty of Humanities, Languages and Literatures, 202
Post migration factors associated with elevated symptoms of posttraumatic stress disorder, depression, and anxiety, among refugees in Cape Town
Get PDFThere has been a heavy influx of refugees in South Africa due to wars, conflicts, political persecution, and economic recessions around the world. As a result, South Africa hosts the highest number of African refugees, who are susceptible to mental health problems because of their exposure to war, violence, and post migration stressors. The current study assessed post migration predictors of post-traumatic stress disorder (PTSD), depression and anxiety symptoms among refugees in Cape Town South Africa. A cross-sectional survey of refugees from war- and conflict-torn countries settled in Cape Town was conducted between February and May 2023. Study participants (N = 147) were selected using respondent driven sampling technique. Data were collected using a questionnaire made up of the Post-traumatic Stress Disorder Checklist (PCL-5), Patient Health Questionnaire (PHQ-9), Generalised Anxiety Disorder-7 (GAD-7), and the Post- Migration Difficulties Checklist (PMLDs), to assess PTSD, depression, anxiety and PMLDs, respectively. Descriptive and inferential statistics were used to analyse the questionnaire data. The prevalence of PTSD, anxiety and depression symptoms was 26.5%, 33.3% and 33.3%, respectively. Regression analyses identified discrimination, poor access to health services, and poor access to food as the major predictors of common mental disorders among refugees. The document-seeking process, unemployment stress, language difficulties, not getting help with welfare, fears of being sent home and isolation, were also associated with symptoms of mental health conditions. These results suggest that psychological distress symptoms are highly elevated among refugees and are associated with post-migration stressors. Mental health interventions for refugees should not only address psychological difficulties but also consider the socio-economic needs of refugees.Thesis (MA) -- Faculty of Humanities, Psychology, 202
Mediating learning of electrostatics through stories on cultural beliefs and practices about lightning to Grade 7 township school learners
Get PDFThe Curriculum and Assessment Policy Statement (CAPS) document mandates that teaching and learning should start with the knowledge and experiences of learners from home or communities when teaching Natural Sciences. The aim is to bridge the gap between the science content learned in the school classroom and the science accessible to learners in their homes and community environments. CAPS claims that it ‘embraces local indigenous knowledge’ but it does not specify how this should be done in schools. As a result, little or no integration of Indigenous Knowledge (IK) is enacted in many of our schools in South Africa and learners seem to find science inaccessible and irrelevant to their everyday lives. It is against this backdrop that this interventionist study sought to mediate learning of electrostatics through harnessing stories on cultural beliefs and practices about lightning to Grade 7 township school learners. This study is located within the interpretivist and Indigenous research paradigms, central to which is to develop a greater understanding of how people make sense of the contexts in which they live and work. Within the Indigenous research paradigm, I focused on the Ubuntu perspective. Furthermore, this study was conducted in an under-resourced school located in the Sarah Baartman District, Eastern Cape Province of South Africa. The participants were Grade 7 Natural Sciences learners and two Indigenous Knowledge Custodians (IKCs). In addition, one Natural Sciences teacher was my critical friend. Focus group interviews (sharing circles), group activities, observations (participatory and lesson observation), and learners’ journals were used to gather data. Vygotsky’s sociocultural theory and Ogunniyi’s Contiguity Argumentation Theory were used as theoretical frameworks in this study. The findings of the study revealed that both the group activity and the presentations by the Indigenous Knowledge Custodians on stories on cultural beliefs and practices about lightning enabled learners’ argumentation and sense-making of electrostatics. The study thus recommends that science teachers should make efforts to tap into the cultural heritage of IKCs to make science accessible and relevant to learners' everyday life experiences.Thesis (MEd) -- Faculty of Education, Secondary and Post-School Education, 202
A descriptive study of lead arm muscle activation patterns during cricket batting
Get PDFIntroduction: Kinematic studies identify elbow extension and wrist flexion as key movements for bat swinging speed during cricket batting. Knowledge of lead arm muscle activation during cricket batting may provide a greater understanding of the mechanics leading to the generation of faster bat speed. Aim: The current investigation aimed to determine selected muscle activation of cricketer's lead arm, maximum bat swinging speed and angular separation of the pelvis and thorax in the transverse plane (known as the X-angle) during a distance-hitting batting protocol. Materials and Methods: 12 cricket players playing for a South African school 1st XI school team aged 16-19 years completed a distance-hitting batting protocol. Due to issues in data recording two participants' data was excluded leading to 10 participants being kept in the final analyses.Participants attempted to hit straight lofted drives while facing full-length deliveries at 80-100 km.h-1 from a bowling machine. Each participant faced 12-24 balls split into overs while lead arm muscle activation, bat speed, and angle of lead-elbow flexion were recorded. Each participant's elbow and wrist flexors and extensors were monitored by electromyography (EMG) units while they batted. The EMG units were placed on the wrist flexor and extensor origins and on Triceps and Biceps Brachii. Muscle activation for each muscle was recorded in millivolts (mv) and divided by the maximum measurement of voluntary muscle activation to determine the percentage of maximum voluntary contraction (%MVC) during each shot. Percentage MVC for batting phases of backlift, downswing, contact and follow-through were averaged to compare average %MVC per muscle across all batters and obtain inter-participant variability. Lead arm elbow angle and the %MVC of the elbow and wrist muscles will be compared between successful and unsuccessful shots for analysis. Each participant's lead arm elbow angle was monitored in degrees of flexion by a goniometer placed across the anterior aspect of the elbow joint. Due to the data not having a normal distribution, non-parametric tests were used to establish the variance between dependent variables. To determine the effect of multiple groups on the independent variables a Kruskal-Wallis test for ANOVA was used. Where significant differences were identified, multiple pairwise comparisons were completed to determine where the differences occurred. Results: Successful Lofted straight drives (32 shots) were compared to unsuccessful shots (101 shots) across all participants. Participants and batting phase were found to be significantly different for lead arm elbow angle and muscle activation however shot type was not found to be significantly different. Meaning that lead arm elbow angle and muscle activation differ based on the participant observed or based on the batting phase observed. The backswing phase recorded a higher amount of elbow flexion (155.25°) for Lofted straight drive compared to unsuccessful shots (157.86°) and lower activation across all muscles for Lofted straight drive. The lofted straight drive had a higher amount of elbow flexion (129.52°) compared to unsuccessful shots (149.24°) for the downswing phase and muscle activation was similar with greater variation for unsuccessful shots. At contact Lofted straight drive had a higher amount of elbow flexion (153.44° v 160.13°), and higher activation in the Biceps brachii (34.61% v 28.41%) and Triceps brachii (51.07% v 43.02%). For the follow-through phase Lofted straight drives had a higher amount of elbow flexion (144.87° v 149.59°) and greater Forearm extensor activation (37.13% v 31.28%). There was a large variation across all phases (coefitient of variation between 8.79%-70.28%) with backswing having the least variation and contact having the greatest. Meaning that the backswing phase is fairly predictable for batters and the contact phase is highly variable. Conclusion: Muscle activation increased in the last few milliseconds before contact. The Forearm extensor had the greatest activation during the backswing and follow-through phases. During the downswing phase, Forearm flexors had the greatest activation and at contact, the Triceps brachii had the greatest activation. This study emphasizes the importance of forearm and elbow muscle for batting. Appropriate strengthening of the muscles could also help a batter execute a powerful lofted drive. Future studies with objective measures linked to batting success in prior studies can build on the importance of these findings for batter success. This study provides insight into individual batter techniques and identifies important topics for future research.Thesis (MSc) -- Faculty of Science, Human Kinetics and Ergonomics, 202
Carbonylation of cyclohexene with carbon dioxide (CO2) using transition metals as heterogeneous and homogeneous catalysts
Get PDFFrom a green chemistry perspective, carbon dioxide (CO2) emerges as an appealing C1 synthon, given its abundance in the atmosphere and cost-effectiveness. Many essential chemicals for daily life are derived from fossilized carbon sources like coal, petroleum, and natural gas. However, the by-product of these processes, CO2, poses environmental risks when excessively emitted as a greenhouse gas. Achieving a balance between carbon emissions and removal is crucial to address environmental concerns surrounding CO2. Utilizing CO2 as a C1 source in organic synthesis holds promise for mitigating this balance in the long term. Combining CO2 with other underutilized fine chemicals, such as alkanes, alkenes, and alkynes, to produce more valuable platform chemicals presents an economically viable strategy due to carbon dioxide’s abundance, low cost, and recyclability. Despite its simplicity, CO2's high thermodynamic stability and low kinetic reactivity, owing to its highly oxidized state, pose challenges to its use as a feedstock. Overcoming these hurdles requires catalysts to enhance CO2 reactivity. Our work focuses on developing and employing catalytic systems capable of activating CO2 as a C1 synthon in reactions with cyclohexene and a reducing agent to yield carboxylic acids or esters. In one approach, we have developed heterogeneous catalyst systems comprising transition metals (Au, Fe, Ni, Ru) supported on metal oxide (TiO2). Characterization techniques such as TEM, EDX, UV-Vis, BET, and XRD were used to study the properties of these materials. The catalysts were evaluated in a reaction involving cyclohexene, CO2, and H2O. In another approach, we explored the use of cyclo-tris(tetracarbonylruthenium) [Ru3(CO)12] as a homogeneous catalyst in a reaction involving cyclohexene, methanol, and CO2 in the presence of an ionic liquid, 1-Butyl-3-methylimidazolium chloride ([BMIM]+Cl-). 1H NMR and ATR-FT-IR were utilized to characterize [BMIM]+Cl-. The reaction product was characterised utilizing GC-MS. Upon seeing that Ru3(CO)12 changes color from orange to black when exposed to heat, an investigation was undertaken on the kind of transformations that the catalyst undergoes. This investigation was carried out with the hopes of finding the structures that could be resulting from Ru3(CO)12 during the reaction and their significance to it. The orange and black Ru complexes were characterized utilizing DSC, TGA, ATR-FT-IR and PXRD.Thesis (MSc) -- Faculty of Science, Chemistry, 202
Design and fabrication of millifluidic devices for maintenance of tissue cultures under perfusion
No full textRestricted access. Expected release in 2026.Thesis (MSc) -- Faculty of Science, Biotechnology Innovation Centre, 202
The investigation of novel Benzimidazoles as anti-cancer agents in triple negative breast cancer cell lines
No full textAccess restricted. Exxpected release in 2026.Thesis (MSc) -- Faculty of Science, Biochemistry, Microbiology & Bioinformatics, 202
Search for acrylonitrile-based inhibitors of SAR-Cov-19 main and papain-like proteases through covalent docking and high-throughput virtual screening
Get PDFThe sudden outbreak of SARS-CoV-2 formerly known as the 2019 novel coronavirus (2019-nCoV) quickly turned into a pandemic of coronavirus disease 2019 (COVID-19), the scale of which has never been seen before. High infection rates and mortality from COVID-19 placed pressure on global health services, and this has been to the detriment of the global economy. However, treatment options for COVID-19 are still very limited; hence, it is now as important as ever that researchers explore searching for new compounds with pharmacokinetic properties that inhibit the two COVID proteases - the main protease (Mpro) and the papain-like protease (PLpro). The main protease is a cysteine protease; as such, it is susceptible to permanent inhibition by reactive species (warheads) that may covalently bind to cysteine residues. One such class of compounds is acrylonitriles, in which the reactive acrylonitrile is reactive towards cysteine through a Michael addition reaction. The resulting covalent interaction is permanent and inactivates the cysteine residue and hence the protease within the context of the COVID-19 life-cycle. In this context, this study seeks to utilize computational-based approaches to identify acrylonitrile-based inhibitors of coronavirus drug targets. To do this, the ZINC database has been screened for compounds containing acrylonitrile functionality, due to its known nature as a warhead that binds to cysteine residues. Pharmacokinetic properties are computed to evaluate the viability of identified inhibitors, and covalent and non-covalent molecular docking approaches to the Mpro enzyme crystal structure have also been used to assess the identified systems. To gather more information and evaluate the most promising systems, a subset of the most promising compounds have been subjected to molecular dynamics simulation (for both covalently bound and non-covalently bound systems).Thesis (MSc) -- Faculty of Science, Biochemistry, Microbiology & Bioinformatics, 202