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    Neutrino astronomy: The story so far

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    The IceCube project transformed a cubic kilometer of transparent natural Antarctic ice into a Cherenkov detector. It discovered PeV-energy neutrinos originating beyond our Galaxy with an energy flux that is comparable to that of GeV-energy gamma rays and EeV-energy cosmic rays. We review the results from IceCube’s first decade of operations: the measurement of the diffuse flux, which has been characterized with multiple techniques, and the search for its sources. We subsequently review the multimessenger data that identified the supermassive black hole TXS 0506+056 as a source of cosmic neutrinos and draw attention to the accumulating indications that cosmic neutrinos are associated with gamma-ray– obscured active galaxie

    Measurements in charmless B decays at Belle II

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    We report on preliminary measurements of branching fractions, charge-parity-violating asymmetries, and longitudinal polarization fractions in charmless bottom-meson decays from the Belle II experiment. We use samples of electron-positron collisions collected in 2019 and 2020 at the Υ(4S) resonance, corresponding to integrated luminosities of up to 62.8 fb−1. The results are compatible with known values, indicating good understanding of early detector performance

    Appello di Science for Peace and Health 2022 contro le diseguaglianze e discriminazioni di sesso e di genere

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    La congiuntura che stiamo vivendo rende necessaria una riflessione circa la disponibilità e l'accesso ai vaccini anti-Covid19 che hanno reso possibile, dall'inizio del 2021, l'abbattimento dei contagi, il rallentamento dell'ondata pandemica e un graduale allentamento delle misure di salute pubblica come il distanziamento sociale e interventi estremi come le quarantene (lockdown). Tuttavia, la distribuzione e la somministrazione dei vaccini è stata accompagnata – e ancora alimenta – discussioni, pole- miche e dibattiti

    Severe Obstructive Sleep Apnoea Leading to Raised Intracranial Pressure Hydrocephalus in a Patient with Aqueduct Stenosis

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    We present the case of a patient with severe obstructive sleep apnoea (OSA) and hypoventilation syndrome who had hydrocephalus and acquired aqueduct stenosis. A link between these conditions in our patient is postulated. We discuss the mechanisms through which this might have occurred and the potential problems which might arise in applying non-invasive ventilation to a patient with hydrocephalus

    A Seasonal Cause of Encephalitis: Influenza Virus A (H3N1) Infection

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    Influenza virus infection can have a range of presentations, from asymptomatic to life-threatening disease. We present the case of a 57-year-old woman with a known history of schizophrenia (controlled with medication) who presented to our emergency department in a coma after experiencing a seizure. She had reported flu-like symptoms in the previous week, which evolved to dyspnoea and altered mental status culminating in seizures and coma. Influenza virus A (H3N1) was identified in the cerebrospinal fluid. Although a rare cause of encephalitis, the influenza virus should be considered in the differential diagnosis, especially during epidemics

    Midthoracic Pain, Sentinel Arterial Haemorrhage and Exsanguination after a Symptom-Free Interval (Chiari's Triad) is Diagnostic of Arterio-Oesophageal Fistula: A Life-Threatening Cause of Gastrointestinal Bleeding

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    Introduction: Arterio-oesophageal fistulae are a very uncommon cause of severe gastrointestinal bleeding, and mostly result from an aberrant right subclavian artery and mediastinal surgery or prolonged endotracheal/nasogastric intubation.Material and Methods: We present the case of a patient with an oesophageal adenocarcinoma and haematemesis due to a subclavian arterio-oesophageal fistula after mediastinal radiotherapy. Conclusion: We discuss the rare, life-threatening condition of acute erosion of the left subclavian artery caused by an oesophageal tumour and presenting with Chiari's triad

    Severe L-asparaginase-induced Hypertriglyceridaemia Treated with Plasmapheresis

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    L-asparaginase is used for the treatment of acute lymphoblastic leukaemia. Hypertriglyceridaemia is a side effect and associated with potentially fatal complications, including acute pancreatitis. Plasmapheresis may have a role in treatment when triglycerides are >2000 mg/dl.We report the case of a 39-year-old woman treated with L-asparaginase for acute lymphoblastic leukaemia, who developed severe hypertriglyceridaemia (6560 mg/dl) and acute pancreatitis. Intravenous insulin infusion was started, along with fenofibrate and atorvastatin administration, and platelet transfusion. Plasmapheresis was carried out leading to a frank decline in serum triglyceride levels (366 mg/dl), a decrease in pancreatic enzymes and clinical improvement.The diagnosis of pancreatitis secondary to L-asparaginase should lead to immediate drug withdrawal, and plasmapheresis should be considered when serum triglyceride values exceed 2000 mg/dl. In our case, there was a 95% triglyceride removal rate. This response illustrates the strong effectiveness of early treatment with plasmapheresis in severe and symptomatic hypertriglyceridaemia associated with L-asparaginase

    Diagnosis of Primary Cardiac T-cell Lymphoma: Feasibility and Safety of Endomyocardial Biopsy Guided by Pre-acquired Cardiovascular Magnetic Resonance

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    Background: Multimodality imaging of a cardiac mass lesion may raise suspicion of a primitive cardiac lymphoma (PCL). However, a definitive diagnosis requires histopathological confirmation.Methods: This report describes the methodology we used to perform biopsy sampling of a cardiac mass lesion affecting a 45-year-old man. In order to increase endomyocardial biopsy diagnostic accuracy, we used pre-acquired cardiac magnetic resonance (CMR) images to guide the bioptome on a cardiac site overtly infiltrated by the suspected tumour. The right ventricular outflow tract was identified as the target site for biopsy sampling. To reduce the risk of the procedure, the biopsy was performed at a safe distance from the tip of a diagnostic quadripolar catheter positioned at the level of the pulmonary valve, previously identified by pacing manoeuvres. The reported approach demonstrated safety and diagnostic accuracy, allowing the identification of an extremely rare PCL subtype of T-cell origin.Conclusion: Biopsy sampling of a suspected tumour may be safely and accurately performed using pre-acquired CMR images to guide the bioptome on the target site

    Pancreatic Lipoma: A Pancreatic Incidentaloma Diagnosis with Computed Tomography

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    Lipoma of the pancreas is a rare benign tumour which is usually discovered incidentally on imaging. We present a case of an incidentally discovered pancreatic lipoma in a 79-year-old man with non-metastatic prostate adenocarcinoma who was referred to radiology for follow-up imaging. Fat-containing tumours originating from the pancreas are very rare. Most lipomas show characteristic features on imaging that allow their differentiation. We present the imaging features of a pancreatic lipoma on ultrasound, CT and MRI, discuss the differential diagnosis, and provide a brief review of the literature

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