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Recensioni: La pandemia dei dati. Ecco il vaccino
Get PDFI dati siamo noi, nessuno si senta escluso. Siamo noi che con i nostri comportamenti quotidiani, con una certa negligente superficialità, ali- mentiamo gli algoritmi del web creando la ricchezza smisurata delle FANGAM1 e la loro centralità nell'economia mondiale
Recensioni: Sbagliando non si impara. Perché facciamo sempre le scelte sbagliate in amore, sul lavoro e nella vita quotidiana
Get PDFLe scienze cognitive e l'economia comportamentale nel giro di un decennio si sono trasformate da discipline esoteriche per soli addetti ad argomento comune, quotidianamente dibattuto su quotidiani e social. Il volume di Sara Garofalo ne è un esempio perché offre al lettore una serie di esempi, esercizi e test in cui semplici situazioni di vita quotidiana rivelano l'ormai nota fallibilità della
architettura delle scelte della nostra specie, ovvero la nostra 'razionalità limitata' preconizzata dalle ricerche,
ogni volta riconosciute con il Nobel, dello psicologo Herbert Simon tra gli anni Cinquanta e Settanta del secolo
scorso, poi sviluppata in economia dallo psicologo Daniel Kahneman e dall'economista comportamentale Richard Thaler in anni recenti
Mesalazine-induced Hypersensitivity Pneumonitis
Get PDFA 57-year-old woman with Crohn's disease (ulcerative proctitis) treated with mesalazine (5-ASA) developed worsening respiratory distress and cough. The lack of response to antibiotics and the results of bronchoalveolar lavage led to the diagnosis of mesalazine-related hypersensitivity pneumonitis, an infrequent entity. Symptoms improved after discontinuation of mesalazine and the administration of corticosteroid therapy. The authors discuss the diagnosis and management of this rare condition
Clear Cell Carcinoma of the Thymus: An Improbable Enemy
Get PDFIntroduction: Thymic clear cell carcinoma is the most uncommon subtype of thymic carcinoma, with 20 cases reported worldwide.Case description: We present the case of a 61-year-old female with dyspnoea and chest pain for 2 days. Computed tomography (CT) angiography showed pulmonary thromboembolism and the existence of mediastinal and bilateral hilar lymphadenopathy, the largest infracarinal with an inferior axis of 25 mm, and also, micronodules on the left pulmonary parenchyma. The patient was admitted for aetiological assessment and underwent anticoagulant therapy. After a month, she had an ischaemic stroke, the sequelae of which proved to be fatal. The autopsy showed a mass in the superior-anterior mediastinum, with dimensions of 11×8×6 cm, corresponding to a thymus signet ring cell primary carcinoma. The immunohistochemistry study revealed that this mass was positive for AE1/AE3, CK5/6 and CK7.Conclusion: The clinical, morphological and immunophenotypic diversity of this tumour makes its diagnosis a difficult multidisciplinary challenge, which requires a high level of clinical knowledge and accurate imaging and histological investigation
Hypercalcaemia: An Extremely Rare Presentation of Hepatosplenic T-Cell Lymphoma
Get PDFHypercalcaemia is a frequent finding in malignancies including lymphomas. However, there are no reports of hypercalcaemia in hepatosplenic T-cell lymphoma (HSTCL). HSTCL is a rare and aggressive neoplasm which is usually difficult to diagnose. We present a case of HSTCL in which hypercalcaemia was the initial presentation
Chronic Copper Sulfate Poisoning
Get PDFCopper, as a salt, is toxic and has the potential to harm multiple organs. Copper intoxication causes intravascular haemolysis followed by liver and kidney failure that can be fatal. We present a case of chronic copper sulfate poisoning in a 66-year-old man with dysphagia to solids and liquids, anaemia, acute kidney injury, liver cytolysis and hypocalcaemia. The patient improved with supportive care, but chronic kidney disease was established. Anamnesis was crucial for the diagnosis, given the non-specific signs and symptoms. The history of chronic exposure to pest treatment with a blue dust cloud made us suspect copper sulfate poisoning
Successful Use of a GLP-1 Receptor Agonist as Add-on Therapy to Sulfonylurea in the Treatment of KCNJ11 Neonatal Diabetes
Get PDFSulfonylurea monotherapy is the standard treatment for patients with the most common form of permanent neonatal diabetes, KCNJ11neonatal diabetes, but it is not always sufficient. For the first time, we present a case of successful use of a GLP-1 receptor agonist as add-on therapy in the treatment of a patient with KCNJ11 neonatal diabetes and insufficient effect of sulfonylurea monotherapy. Good glycaemic control was maintained with a HbA1c level of 48 mmol/mol (6.5%) at the end of 26 months’ follow-up
Drug-induced Liver Injury Due to a Horse Chestnut Dietary Supplement
Get PDFDrug-induced liver injury (DILI) is the most common cause of acute liver failure in the Western world. In recent years, natural herbal and dietary supplements have become widely available to the general public and have increased in popularity. Reports of idiosyncratic liver injury caused by such supplements have also increased over the last decade. Horse chestnut is a herb used in dietary supplements primarily for complications of venous insufficiency. Clinically significant acute liver injury has been very rarely associated with its use. We present the case of a 70-year-old man with idiosyncratic horse chestnut-induced liver injur
Myasthenia Gravis Revealing Hodgkin’s Lymphoma
Get PDFIntroduction:
Myasthenia gravis is a rare autoimmune disease caused by autoantibodies directed against the synapses of the neuromuscular junction.
Patient and methods:
We report the case of a young patient with myasthenia gravis associated with Hodgkin's lymphoma.
Results:
A 22-year-old patient presented with a 2-month history of severe weakness associated with muscle fatigability and intermittent ptosis without dysphonia or respiratory signs. Clinical examination revealed generalized myasthenia. The EMG did not show post-synaptic block, and anti-acetylcholine receptor antibodies were elevated at 3 nmol/l (normal ≤0.3 nmol/l). CT of the thorax showed an anterior medial mass. Immunohistochemistry of the mass revealed mixed cellularity Hodgkin’s lymphoma.
Conclusion:
The association of lymphomas with myasthenia gravis has been rarely reported
Necrotizing Fasciitis of the Breast Underlying an Autoimmune Disease
Get PDFNecrotizing fasciitis is a serious soft tissue infection that causes necrosis of the subcutaneous tissues and the muscle fascia. It is associated with a high mortality rate of around 25%. Necrotizing fasciitis of the breast is a rare entity. It is a rapidly progressive life-threatening condition which can lead to sepsis with multiple organ failure. We describe a case of necrotizing fasciitis of the right breast in a 48-year-old patient diagnosed with systemic sclerosis–rheumatoid arthritis overlap syndrom