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Ropivacaine: An Unusual Cause of Neuroleptic Malignant-Like Syndrome
Get PDFRopivacaine is commonly used for post-operative pain management. We describe a case of neuroleptic malignant-like syndrome in a woman administered ropivacaine delivered using a drug infusion balloon. The presenting symptoms were confusion, agitation and fever. Blood analysis showed elevated C-reactive protein, leucocytosis and increased creatine phosphokinase. As intoxication was suspected, ropivacaine was suspended and the patient gradually improved. Possible leakage of ropivacaine into the intrathecal space may have resulted in central nervous system toxicity
Chronic Lymphocytic Leukaemia: Rare Involvement of the Central Nervous System
Get PDFInvolvement of the central nervous system, although uncommon, is one of the most frequent extramedullary manifestations of chronic lymphocytic leukaemia (CLL). Various conditions can lead to neurological symptoms in CLL patients and distinguishing between clinically significant CLL involvement of the CNS and other aetiologies can be challenging.The authors report the case of a 90-year-old woman with a previous diagnosis of low-risk CLL who presented to the emergency room with altered mental status. After the most frequent causes were ruled out and considering the underlying disease, CNS infiltration by clonal B-cells was hypothesised and later confirmed. Treatment was initiated, but the patient died soon afterwards
Urinary Dysfunction Improvement after Treatment with Sativex® in a Multiple Sclerosis Patien
Get PDFNabiximols has been approved to treat multiple sclerosis-related spasticity symptoms; it also improves symptoms such as pain, urinary dysfunction and sleep disturbance. We report the case of a 43-year-old patient with multiple sclerosis who started add-on treatment with nabiximols for moderate spasticity (self-reported discomfort by the Numeric Rating Scale 6/10); she experienced a remarkable improvement in pre-existing urinary dysfunction. Nabiximols enables treatment of more spasticity-related symptoms, reducing the need for symptomatic medications and avoiding the unnecessary adverse effects produced by polytherapy
Il Centro CISAS "Centro Internazionale di Studi Avanzati su Ambiente, Ecosistema e Salute Umana"
Get PDFMPL-Positive Essential Thrombocytosis Presenting as Budd-Chiari Syndrome in a Middle-Aged Woman with an Initially Normal Platelet Count
Get PDFBudd-Chiari syndrome (BCS) results from an occlusion of the hepatic venous flow which in turn leads to portal hypertension causing ascites and other signs of liver dysfunction. Here, we present the case of a 43-year-old woman with recurrent ascites who was found to have BCS secondary to an inferior vena cava thrombosis extending into the hepatic veins. Although she had a normal platelet count on admission, additional laboratory investigations revealed an MPL mutation. She was discharged on anticoagulation with apixaban and later found to have thrombocytosis on repeat blood work, confirming the diagnosis of essential thrombocytosis, following which she was started on myelosuppressive therapy with hydroxyurea
Hodgkin’s Lymphoma Presenting as Multiple Cavitary Lung Lesions
Get PDFHodgkin Lymphoma (HL) typically presents similarly to an infectious etiology, thus awareness of its atypical presentations is essential. We present a case of an adult woman who was found to have HL after presenting with a dry, non-productive cough and showing cavitary lesions on chest computed tomography (CT). We also describe the clinical, laboratory, and radiological workup done leading to the diagnosis and management of HL in a critical care setting
Rare decays from NA62
No full textRecent results from the NA62 experiment at CERN are presented.
The analysis of the K+ → π+νν¯ decay has been performed with the full dataset available. Upper limits have been set on the BR(π0 → invisible) and BR(K+ → π+X) where X is a new scalar or pseudoscalar particle. The preliminary result on the formfactor measurement in the decay K+ → π+μ+μ− is reported
Characterizing the Spectral Energy Distribution of blazars as candidates for neutrino emission
No full textBlazars are potential neutrino emitters as suggested by the detection of a high-energy neutrino in the direction of the flaring Blazar TXS 0506+056, in 2017. However, the origin of neutrinos from this source is still unclear. This work aims at finding and characterizing other Blazars with similar features as TXS 0506+056. We selected sources from the most recent Fermi Catalogue, the 4LAC, finding 4 candidates. They were characterized through a multiwavelength analysis, which revealed some peculiarities in the SED of the candidate
Niobium and titanium surface modification via anodic oxidation in Ca/P containing solutions for osteogenesis
No full textTransition metals are the materials of choice for the development of orthopaedic implants due to their biocompatibility. We focused on the surface modification of niobium and titanium through anodic oxidation to promote their osteogenic properties. Anodizing in solutions containing Ca and P allowed us to tailor the oxide morphology and chemical composition. By tuning the anodizing potential, mesoporous oxide layers with a surface chemical composition mimicking hydroxyapatite are obtained. By combining AFM, SEM and XPS we evaluated the
increase in porous size and layer thickness as a function of the applied potential and correlated it to the oxide chemical composition
Functional magnetic resonance imaging on spinal cord
No full textFunctional magnetic resonance imaging (fMRI) is a powerful technique for the functional investigation of the brain and spinal cord. Although some progress has been recently made, many issues still need to be solved for fMRI to be used for clinical and preclinical investigations of the spinal cord. Currently, we are developing new strategies to apply fMRI on the spinal cord of healthy subjects and in patients. These strategies include acquisition and data analysis protocols for the reduction of physiological noise (due to cardiac pulse and respiration), which is the main reason for the low signal-to-noise ratio observed in functional series of the spinal cord