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Unintentional Dual Benefit: Improvement in Secondary Polycythemiain a Patient Receiving Chemotherapy for Metastatic Clear Cell RenalCell Carcinoma
Get PDFComplete blood counts are frequently collected from cancer patients, but laboratory findings may be misleading. Secondary polycythemia can occur in renal cell carcinoma (RCC) due to erythropoietin (EPO) stimulation. Therefore, complete blood counts should be closely monitored to prevent complications such as thrombosis. We discuss the case of a 47-year-old man with metastatic RCC who presented with secondary polycythemia that improved with chemotherapy. His secondary erythrocytosis was anticipated, but his haemoglobin levels were lower than expected after therapy. This article discusses the treatment and diagnosis of secondary polycythemia in patients with RCC
Autoimmune Haemolytic Anaemia (AIHA) Secondary to Yersinia enterocolitica Septicemia: The Second Case Reported in the Literature
Get PDFYersinia enterocolitica infection is an uncommon but potentially fatal zoonosis, especially when it culminates with septicaemia. Post-infectious complications like reactive arthritis and erythema nodosum are well described in the literature. On the other hand, the association between yersinosis and autoimmune haemolytic anaemia (AIHA) has only been established in one clinical case. We present a case of an 87-year-old man admitted for AIHA, whose was successfully treated only after the identification and treatment of yersinosis
Multiorgan Ultrasonography for the Diagnosis of Pulmonary Embolism
Get PDFThe main ultrasound criterion for diagnosing pulmonary infarction is the presence of triangular/wedge-shaped or rounded, hypoechogenic, homogeneous, pleura-based lesions. When used in point-of-care, ultrasonography of several organs can facilitate the diagnosis of pulmonary embolism in a patient presenting with chest pain. We describe a case of chest pain which we thought was due to angina, but point-of-care ultrasonography directed us to a diagnosis of pulmonary embolism
Invasive Pulmonary Aspergillosis after COVID-19 Pneumonia
Get PDFCOVID-19 emerged in China in late 2019 and quickly spread worldwide. The severe immunomodulation and depletion of lymphocytes caused by the virus and its therapy led to an increase in the incidence of superinfections. COVID-19-associated pulmonary aspergillosis (CAPA) is a new entity with increasing incidence and high associated mortality. We present the case of a 68-year-old patient admitted to our ward after recovering from severe COVID-19 pneumonia. Due to worsening of her clinical condition, chest computed tomography was performed and a lung abscess was documented with the identification of Aspergillus niger. Despite therapy with voriconazole, the patient’s condition deteriorated, culminating in her death
Nonlocal vertices, UV "opaqueness" and causality
No full textNonlocal field theories have seen a revival of interest in recent years. Such theories possess nonlocal vertices characterized by some nonlocality length scale l. This amounts to loss of resolution for scales finer than l. There are many physical arguments for expecting such resolution loss for l of the order of Planck length. The wavelet decomposition of fields, which analyses field configurations in terms of successive resolution scales, is a natural framework for addressing this as outlined here. Some recent results on unitarity and causality in the presence of
nonlocal vertices are also briefly mentioned
Cosmological perturbations in Palatini formalism
No full textIn this article, we discuss cosmological perturbations of scalartensor theories in Palatini formalism. First we introduced an action where the Ricci scalar is conformally coupled to a function of a scalar field and its kinetic
term and there is also a k-essence term consisting of the scalar and its kinetic term. This action has three frames that are equivalent to one another: the original Jordan frame, the Einstein frame where the metric is redefined, and the Riemann frame where the connection is redefined. We calculated the quadratic action and the sound speed of scalar and tensor perturbations in three different frames and show explicitly that they coincide. Furthermore, we showed that for such action the sound speed of gravitational waves is unity. Thus, this model serves as dark energy
as well as an inflaton despite the presence of the dependence of the kinetic term of a scalar field in the non-minimal coupling, different from the case in metric formalism. We then proceeded to construct the L3 action called Galileon terms in Palatini formalism and compute its perturbations. We found that there are essentially 10
different (inequivalent) definitions in Palatini formalism for a given Galileon term in metric formalism. We also saw that, in general, the L3 terms have a ghost due to Ostrogradsky instability and the sound speed of gravitational waves could potentially deviate from unity, in sharp contrast with the case of metric formalism.
Interestingly, once we eliminate such a ghost, the sound speed of gravitational waves also becomes unity. Thus, the ghost-free L3 terms in Palatini formalism can still
serve as dark energy as well as an inflaton, like the case in metric formalism
Hair Spray Induced Cardiomyopathy
Get PDFInhalants are common drugs of abuse. Hydrocarbons, the active ingredient in most inhalants, exert depressant effects on the central nervous system, causing a ‘high’. In the heart, hydrocarbon toxicity can predispose patients to arrhythmias and heart failure through increased sympathetic susceptibility. We present the case of a 28-year-old female who developed dilated cardiomyopathy in the setting of chronic inhalant abuse
Directional analysis of sub-MeV 7Be solar neutrinos in Borexino
No full textBorexino is a liquid scintillator detector located at the Laboratori Nazionali del Gran Sasso (LNGS), Italy with the main goal to measure solar neutrinos. Liquid scintillator detectors are excellent neutrino detectors due to their
high light yield and thus a low energy threshold and high energy resolution. But, they suffer from the loss of directional information that is typically present in water
Cherenkov neutrino detectors. However, in a liquid scintillator, there is still a subdominant amount of Cherenkov light emitted much faster with respect to the slower, yet dominant scintillation light. Borexino has successfully exploited this Cherenkov light signal from the first few PMT hits of an event to provide the first ever directional measurement of sub-MeV solar neutrinos, through the novel technique called Correlated and Integrated Directionality (CID). This is also the first signature of
directionality in neutrinos elastically scattering off electrons in a liquid scintillator detector. Through this measurement, the 7Be interaction rate in the detector has
also been extracted. Future liquid scintillator detectors can benefit from this method for background suppression and disentanglement of signals from different directions
Neutrinoless double beta decay search with XENON1T and XENONnT
No full textThe primary goal of the XENON experiment consists in finding
the first direct evidence for the existence of Dark Matter in the Universe via its scattering with xenon target nuclei in a dual-phase time projection chamber detector. The unprecedented low level of background reached demonstrated this detector technology to be suitable also for other exciting rare-events searches among which the neutrinoless double beta decay of 136Xe. The discovery of such a process will shed light on another fundamental challenge in physics nowadays about the nature of neutrinos. In this proceeding I will discuss the current status of neutrinoless double beta decay of 136Xe search in XENON1T. In the context of the advancement of the XENON program, XENONnT is currently collecting its first scientific data in the underground INFN Laboratori Nazionali del Gran Sasso in Italy. With its target mass of 5.9 tonnes of liquid xenon and designed with a high level of background reduction, the XENONnT experiment aims to increase the predecessor sensitivity in rare-events searches. In this proceeding I will also report on the ongoing sensitivity projection studies for neutrinoless double beta decay search in XENONnT
Come sottomettere una proposta progettuale in Horizon Europe. Aspetti amministrativi e finanziari
Get PDFIn questo documento verranno indicati i passaggi, la documentazione e le informazioni necessari a sottomettere proposte progettuali in risposta alle Call del Programma Horizon Europe nell’ambito della Programmazione 2021-2027 della Commissione Europea. Queste linee guida sono state sviluppate per venire incontro alle richieste d’informazione dei ricercatori, come ausilio per la presentazione di proposte progettuali. Esse sono state elaborate a partire dall’AGA–Annotated Model Grant Agreement (versione del 31/11/2021), dalla Standard Application Form (versione del 21/01/2022), dalla normativa di riferimento nazionale, dalle direttive del Consiglio Nazionale delle Ricerche, dalla partecipazione a giornate informative europee e dal confronto con il National Contact Point di APRE (Agenzia per la Promozione della Ricerca Europea)