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Phytochemical Characterization And Wound Healing Property Of Euphorbia Hirta L.
Get PDFEuphorbia hirta l, an annual plant that belongs to the euphorbiaceae family,
is a common traditional remedy for several diseases. Currently, there are few
investigations on this plant as a treatment for wound healing, particularly the bioactive
compounds and mechanism of action. Therefore, this study focused on isolating the
main active compounds associated with the wound-healing activity of e. Hirta. The
aerial parts of the plant were collected from the northern part of malaysia and iraq and
then were extracted with solvents of different polarities: hexane, chloroform,
methanol, and water. All extracts were screened for total phenolic and flavonoid
contents and antioxidant and anti-inflammatory activities. Additionally, all extracts
were assessed for potential wound healing activity by measuring the migration and cell
viability of human fibroblast cells, hs27. Then the methanol extracts were further
fractionated to identify the active compounds. The structure elucidation of isolated
compounds was confirmed using liquid chromatography-mass spectrometry (lcms/
ms), nuclear magnetic resonance (nmr), and high-performance liquid
chromatography (hplc). Subsequently, molecular docking was performed on the
isolated compounds to analyse their binding interactions with the glycogen synthase
kinase-3β (gsk3b) and casein kinase 1 (ck1) proteins. The level of mrna
expression of four cytokines (il1b, il6, tnf, and col1a1) after treating human
fibroblasts with different compounds were assayed. The e. Hirta extract yielded a
different type of compounds: kaempferol
Prehypertension and its associated factors among type ii diabetes mellitus patients in Kelantan
No full textBackground: Prehypertension is defined by systolic blood pressure ranging from 120 to139 mmHg and/or diastolic blood pressure of 80 to 89 mmHg. Type II Diabetes Mellitus (T2DM) patients with prehypertension face higher risks of cardiovascular morbidity and mortality compared to normotensive T2DM patients. However, many T2DM patients remains unaware of their prehypertensive status and the associated increased CVD risks.
Objective: This study aims to determine the proportion of prehypertension and its associated factors among Type II Diabetes Mellitus patients in Kelantan for year 2022.
Methodology: This cross-sectional study was conducted from December 2023 to June 2024 using secondary data from Kelantan National Diabetes Registry (NDR) clinical audit datasets for the year 2022. Data of T2DM patients who were more than 18 years old and documented not hypertensive in the registry was collected using a proforma and analysed using IBM SPSS version 28 software.
Results: There were 8657 T2DM patients clinical audit datasets in Kelantan NDR for the year 2022, of which, 825 patient datasets fulfilled the study criteria and were included in the study. Descriptive and multiple logistic regression analysis were performed. The proportion of prehypertensive T2DM patients was 73.5% (606 patients) with a mean (SD) age of 55.8 (11.30) years old, majority being the female patients at 402 patients (66.3%) and of Malay ethnicity at 585 (96.5%) patients. Only 41 (6.8%) patients were smoker while 330 (54.5%) patients had dyslipidaemia.
Majority of patients were overweight [254 (41.9%) patients] and obese [215 (35.5%)
patients] with 370 (61.1%) patients having abnormal waist circumference. The mean (SD) of HbA1c level was 8.31% (2.21) while 87 (14.4%) patients experienced microalbuminuria. Significant association with prehypertension was found for age (aOR 1.02; 95% CI: 1.003, 1.03; p = 0.012), sex (aOR 1.54; 95% CI: 1.10, 2.15; p = 0.013) and smoking (aOR 2.19; 95% CI: 1.02, 4.73; p = 0.045)
Conclusion: There was a high proportion of prehypertension among T2DM patients in Kelantan in the year 2022. Besides non-modifiable factors age and sex, smoking was significantly associated with prehypertension among T2DM patients thus highlighting the importance of smoking cessation promotion for T2DM patients to prevent the development of prehypertension
Developing Hopfield Neural Networks Using Gaussian Distributed Small World Topology For Visual Object Tracking
Get PDFVisual object tracking (vot) is considered a challenging research topic in
artificial intelligence. Today, many industries rely on object tracking technologies to
identify errors, monitor environments, and make timely decisions based on tracking
results. Visual object tracking has enabled many innovations, such as autonomous
vehicles, traffic monitoring systems, remote medical diagnostic systems, and more
cutting-edge applications are on the horizon. However, among these notable
achievements, it is worth noting that, unlike these object-tracking techniques, a human
brain is more efficient for object tracking tasks and requires fewer resources. Recent
neuroscience studies have shown that artificial neural networks organized as real
cortical connectivity may perform more efficiently in complex recognition tasks.
Therefore, a novel visual object tracking method based on hopfield neural networks
is proposed in this study. A small-world network is employed as the topology of the
neural network model. However, a biological feature is integrated into the small-world
network model: the exponential decay rule, which may mimic some characteristics of
the structure of the cerebral cortex. In the neural network, each pixel of video frames
is assigned to a neuron at the corresponding position. Pixel strength is characterized as
the state of a neuron. The video frame is memorized after all neurons in the neural
network have been trained to a stable state. A bionic mechanism utilizing the
associative memory property of a bionic hopfield neural network is proposed to track
objects in video frames
Compatibility And Biodegradability Of Biopolyester-Based Blends With Poly(3-Hydroxybutyrate-Co-3-Hydroxyhexanoate) (Phbh) As A Blend Matrix
Get PDFPoly(3-hydroxybutyrate-co-3-hydroxyhexanoate) (phbh) has been evaluated to have excellent degradability in marine environment. However, its performance for application is still limited. A series of properties enhancement is deemed necessary to improve the potential of phbh being both a high-performance material and readily biodegradable. In this study, phbh containing 5 and 17 mol% 3-hydroxyhexanoate (3hh) were blended with atactic poly(3-hydroxybutyrate) (phb), polycaprolactone (pcl), and polybutylene succinate (pbs) at different ratios by the solvent-casting method. Phbh-5%/atactic phb and phbh-17%/atactic phb showed a single glass-transition temperature (tg), indicating miscibility in the amorphous state. Immiscibility was observed in the phbh-5%/pcl and phbh-17%/pcl blends based on the non-transitioning tg of the phbh component, presence of two distinct tg values for some of the blend films, and individual crystallization manner. The thermal properties and spherulitic morphologies of the phbh-5%/pbs blend films suggested partial miscibility. The enzymatic degradability of the three types of blends by ralstonia pickettii t1 phb depolymerase and burkholderia cepacia lipase was investigated. Depending on the enzyme–substrate specificity, miscibility, and phase structure of the blend, the enzymatic erosion rate was different among the three types of blends
Travel Intention Of International Tourists To Jordan In Post-Pandemic
Get PDFCovid-19 has disrupted international travel due to which the tourism sector in jordan has seen a drop in the number of international tourists, who represent the main source of tourism income which is a significant contributor to the gross domestic product (gdp). There are limited studies that have investigated the significant impact of pandemic-related factors on tourist travel intention post-pandemic from tourists' perspective. Considering the significance of this issue, the study examined the influence of travel motivation, risk perception, and destination image of international tourists who visited jordan post-pandemic to predict their future travel intention. A questionnaire was used to collect data from the tourists. In this regard, 460 questionnaires were distributed among the tourists between 4th and 31 december 2022 through e-mails, social media channels, official tourism websites, and accommodation sites. In this study, 290 questionnaires were used for data analysis. Pls-sem has been used for the hypotheses testing. The results found that travel motivation and destination image have a significant influence on travel intention to visit jordan post-pandemic. Whereas, risk perception did not significantly influenced travel intention. The findings can help tourism policymakers and industry practitioners to develop effective strategies to attract more visitors to the country and promote sustainable destination after crisis
The Effects Of Financial And Technological Literacies On Sustainability Performance Of Ikm In Indonesia: Mediating Role Of Competitive Advantage
Get PDFBusinesses today face evolving challenges and opportunities, particularly in the fields of finance and technology. It is crucial to stay informed about these changes to maintain competitiveness. In the small and medium enterprises (sme) sector, a particular obstacle is evident: many owners/managers believe that strategic planning is only for large companies, leading to a lack of strategic direction. Financial literacy (fl) and technology literacy (tl) are essential for smes, as these skills directly impact their ability to gain competitive advantage (ca) and achieve sustainable performance (sp), in alignment with the sustainable development goals (sdgs). This study aims to investigate the relationship between fl and tl, and how they contribute to ca and sp. Utilizing the resource-based view (rbv) theory and the triple bottom line (tbl) theory, with ca as a mediator, this study proposes a comprehensive framework. Data was collected through a quantitative survey using a stratified random sampling technique involving 407 sme respondents and was analyzed using partial least squares structural equation modeling (pls-sem) and artificial neural networks (ann). Findings highlight fl, particularly internal and external aspects of companies, along with specific dimensions of tl (ict policies and human resources in ict), as critical factors influencing ca. Additionally, it was found that ca positively impacts sp, serving as a mediator between fl and sp. However, ca only mediates the relationship between ict policies and sp within tl, not for other tl dimensions. The study's conclusions were validated using ann
Exploration, Creation And Evaluation Of Plant Image In Ceramic Artworks In Jingdezhen City, China
Get PDFContemporary PICA combines ceramic media with a long history, plant motifs, and modern innovative thinking. Significant changes have taken place compared with the past. However, regarding theory, the research on plant motif, cultural meaning, creation technique, and application form is insufficient in China. Regarding practice, the plant motif is outdated, and ceramic artists must try to implement innovation and update the traditional creation mode. Therefore, this research aims to explore the application, creation, and innovation of plant images in contemporary ceramic artworks. First, discovers the aesthetic characteristics, cultural meanings, application forms and expressive features of plant image in ceramic artworks through literature research and observation. Second, uses questionnaire survey and expert interview method to research and collect data. The SPSS software was used to quantitatively analysis the data of 103 respondents, aiming to understand people's perception and preference for PICA and variant correlation and influence relationships. NVivo’s software conducted a qualitative analysis of the interview content of 6 ceramic experts and explored the main concerns and thinking angles of creation. Third, apply experimental creation method to implement the practice, collecting various plant images for modelling and texture, collage and hollowing, colour experiment, and comprehensive material creation. The results show that: (1) 46.6% respondents prefer flower motifs, culture meaning showing personal expectations, natural materials, abstract and creative shapes, rich glaze or texture, handmade, and used in home decoration
The Determinants Of Innovative Behavior Among Early Childhood Educators In Guangdong: The Mediating Role Of Self Efficacy
Get PDFThis study focused on investigating the factors influencing innovative
behavior among educators through the mediating role of self-efficacy in early
childhood education in Guangdong, China, through the dual lens of social cognitive
theory and social exchange theory. Using a quantitative research approach, data were
collected from 476 educators through a questionnaire survey-based method. The
primary independent variables investigated include focused instruction, professional
community, instructional leadership, shared leadership, and trust in the principal.
Innovative behavior functioned as the dependent variable, while educators’ selfefficacy
was positioned as the mediating variable. The findings demonstrate
significant positive associations between the independent variables and the educators’
self-efficacy, as well as between the educators’ self-efficacy and their innovative
behavior. Crucially, self-efficacy emerged as a potent mediator in the relationship
between the designated independent variables and innovative behavior. These results
highlight the instrumental role that self-efficacy plays in fortifying educators’
innovative capacities in early childhood education. Drawing on these empirical
discoveries, this research introduces the innovation and efficacy training model as a
recommendation for educators, including those factors explored by this study
Preclinical Evaluation Of Mechanisms Underlying Chemotherapy-Induced Ovarian Dysfunction And The Restorative Potential Of Mesenchymal Stem Cells In Premature Ovarian Insufficiency
Get PDFConventional chemotherapy, while effective in eliminating cancer cells, unfortunately, inflicts collateral damage on normal cells with heightened proliferative capacity, particularly causing ovarian toxicity. This study delves into elucidating the underlying mechanisms of chemotherapeutic drug-induced ovarian damage, aiming to pave the way for the development of fertility-preserving adjuncts for female patients undergoing conventional cancer treatment. In this context, mesenchymal stem cells-extracellular vesicles (MSC-EVs), as promising cell-free therapeutic agents, demonstrate notable advantages in addressing ovarian dysfunction. However, the precise mechanisms through which MSC-EVs ameliorate chemotherapy-induced ovotoxicity remain unclear. The primary objectives of this study are to elucidate the toxicity of chemotherapeutic drugs on the ovary, unravel the potential mechanisms leading to follicle loss, and investigate the therapeutic potential of Menstrual blood-derived endometrial stem cell (MenSC)-EVs transplantation in alleviating chemotherapy-induced ovarian dysfunction
