58178 research outputs found
Sort by
PPKBSM, Pusat Pengajian Kejuruteraan Bahan dan Sumber Mineral (2025) EBB346 OCTOBER 2025.
No full text
7th International Conference on Libraries (ICOL) 2025 “Towards Sustainable Future Libraries”
No full textThe International Conference on Libraries (ICOL), organized by
Universiti Sains Malaysia (USM) Library since 2005, will celebrate the
20th years anniversary in 2025 with its seventh edition.
Scheduled on 23 - 24 September 2025, at Penang, Malaysia, the
conference will focus on the theme "Towards Sustainable Future
Libraries."
Sustainable future libraries embracing practices, technologies, and
strategies aimed at ensuring long-term environmental, social, and
economic sustainability. Libraries are adopting eco-friendly designs
and technologies, such as energy-efficient buildings, green
certifications, and the use of renewable energy sources.
Future libraries are leveraging emerging technologies, including
artificial intelligence (AI), digitization, and cloud computing, to create
more efficient and accessible services.
It also prioritizes open access to information and resources, providing
free or low-cost access to digital collections, research papers, and
educational materials.
ICOL 2025 will serve as a platform for information professionals from
Malaysia and beyond to share knowledge, discuss trends, and explore
developments in librarianship and information technology.
It has grown to become one of the major events for information
professionals in Malaysia. The program’s presentations are also
applicable to public, academic, school, and special libraries’ interests
Insights into the interaction between statins and monocarboxylate transporter 1: a molecular docking approachl
No full textStatins are commonly prescribed in the management of cardiovascular diseases;
however, they can lead to statin-associated muscle symptoms (SAMS), which are often
related to mitochondrial dysfunction. Monocarboxylate transporter (MCT1) is a
proton-linked monocarboxylate transporter that facilitates the cellular uptake of
statins, influencing their pharmacokinetics and potential effects on cellular metabolism
and mitochondrial function. Although direct interactions between statins and MCT1
are not well-documented, emerging evidence suggests that mitochondrial dysfunction
associated with statins may involve MCT1-mediated mechanisms, potentially through
alterations in lactate transport and metabolic regulation.. This study explores the
molecular interactions between statins and MCT1, focusing on their binding affinities
and the subsequent effects on mitochondrial function and gene regulation. The 3D
structure of MCT1 from Rattus norvegicus was modeled using the Swiss-Model
database, based on similar sequences from Mus musculus. Molecular docking
analyses, employing both blind and specific docking methods, indicated that
atorvastatin lactone had the highest binding affinity to MCT1 (-8.7 kcal/mol and -9.2
kcal/mol, respectively), followed by rosuvastatin lactone (-7.5 kcal/mol and -7.9
kcal/mol), simvastatin lactone (-7.7 kcal/mol for both), pravastatin lactone (-7.4
kcal/mol for both), and simvastatin acid (-5.7 kcal/mol and -6.0 kcal/mol). Of all
statins analyzed, simvastatin acid does not have any hydrogen bonds with amino acid
residues of MCT1 thus could explained its lowest binding affinity. It unlike other statins. Important binding residues, including LEU132, TYR70, and THR388, were
identified as essential for ligand interactions. By identifying the key molecular
interactions that contribute to SAMS, this study establishes a solid framework for early
prediction of MCT1 involvement during the pathology proces
Evaluation of etlingera elatior flower aqueous extract (EEAE) as treatment of colon cancer in rat model (pilot study)
No full textColon cancer is a type of cancer that occurs in the colon or rectum. Therefore, sometimes it is also known as colorectal cancer (CRC). It is a leading cause of cancer-related deaths worldwide, even though there are available treatments for colon cancer, undesirable side effects often accompany it. Etlingera elatior, known as bunga kantan in Malaysia, is a traditional medicinal plant with high potential therapeutic effects with excellent antimicrobial, antioxidant, anticancer, antidiabetic, anti-inflammation, and anti-ageing properties. However, limited scientific research has been conducted on its antitumour effects against colon cancer. Therefore, this study investigates the in vivo antitumour effects of E. elatior flower aqueous extract (EEAE). EEAE is extracted using the sonication method. Toxicological assessment was performed using the brine shrimp lethality assay (BSLA) with a series of concentrations including concentrations of 10 mg/ml, 1 mg/ml, 3 mg/ml, 300 μg/ml, 100 μg/ml, 30 μg/ml, and 10 μg/ml. The LC50 of EEAE determined after the 24-hour incubation period was 2286 ppm (μg/ml), classifying EEAE as non-toxic based on Meyer and Clarkson toxicity standards. The antitumour efficacy of EEAE was further evaluated in an Azoxymethane-induced colon cancer model using male Sprague-Dawley rats. Histological analysis with Hematoxylin and Eosin (H&E) and Masson-Trichrome (MT) staining demonstrated substantial improvements in colon morphology upon treatment with EEAE. These findings suggest that EEAE is a promising natural product with antitumour properties against colon cancer, with no observed toxicity in vivo. Further research is warranted to explore its therapeutic potential and underlying mechanism
Exploring the neural presentation of rhythmic quranic recitations using functional brain connectivity
Get PDFNeuronal oscillations provide temporal and spatial signals that interact with the neural network to coordinate distinct neural processes into a higher cognitive function. The low-frequency neuronal oscillations, i.e., theta (4 – 7 Hz) and alpha (8 – 13 Hz), were the focus of most studies studying the effect of listening to Quranic recitations. This was based on the notion that these oscillations indicate the calmness and relaxation effect induced when listening to the Quranic recitation. This present study expanded the role of neuronal oscillations to include the high-frequency gamma waves (30 – 80 Hz) and the theta and alpha waves for previously unexplored neural correlate of rhythmic Quranic recitations. Thirty (30) healthy participants (n = 15 Muslim, 15 = non-Muslim) were randomly recruited and subjected to simultaneous recording magnetoencephalography (MEG) and electroencephalography (EEG) (M/EEG) to record the brainwaves response during passive listening to three different Quranic recitation styles, i.e., Murattal Asim, Murattal Susi and Tarannum Asli of the Ayatul Kursi verse. Ayatul Kursi is the greatest verse in the Al-Quran, which has healing linguistic and rhythmic aesthetics. The recorded M/EEG data were pre-processed and analysed using Brainstorm software in MATLAB environment. The average volume source estimation of the neuronal oscillations was estimated from the 170 brain regions of the AAL3 atlas. Higher theta activities were found at the anterior cingulate cortex (ACC) and midcingulate cortex (MCC) in the Muslim group and hippocampus in the non-Muslim group. High alpha activities could be seen at the precuneus in both groups, indicating increased mind-wandering. Both groups also showed alpha activation in the brain regions correlated to the visual network, proposing visual mental imagery of the auditory stimuli. The central regions of the brain seemed to be activated in all auditory stimuli in both groups, indicating there were language and speech perceptions involved. The results emphasize that, despite the likely extent of familiarity differences to rhythmic Quranic recitation between the Muslim and non-Muslim groups, widespread brain activations were shown involving regions that have roles in emotion, cognition, empathy, memory processing, visual imagery and language perception. The majority of the brain regions where source estimations were made had shown significant correlations (p<0.05). Whole brain source-level functional connectivity of the M/EEG data was quantified using Phase Locking Value (PLV). There was significant theta phase synchrony between the right middle frontal gyrus (MFG) and the left angular gyrus (AG), points to the role of MFG in reorienting the attention, presumably from the shifting of attention from mind-wandering to focusing on the Quranic recitation. Meanwhile, synchronising the cerebellum and the regions at the inferior parietal lobule in theta and increased alpha synchrony at the central regions might point to language perception and processing of the phonological information. Functional connectivity at the visual and default mode networks (DMN) could also be seen in alpha and gamma oscillations. Furthermore, increased Rolandic operculum and ACC engagement in gamma oscillation correlate to a positive feeling when listening to the rhythmic Quranic recitation. To summarise, the current study is the first of its kind of theta, alpha, and gamma neuronal oscillations to show that listening to Quranic recitations with different rhythmic styles of Ayatul Kursi may represent the neural correlate that underlie the anecdotal claims reported to influence positive emotion, social cognition, empathy, attention, language perception, and memory processing with the evidence of the brain connectivity mapping
BDT223 -Invertebrate and Vertebrate Zoology (Zoologi Invertebrata dan Vertebrata)
Get PDFSecond Semester Examination
2023/2024 Academic Session
February 2024
BDT223 -Invertebrate and Vertebrate Zoology
(Zoologi Invertebrata dan Vertebrata)
Duration : 2 hours
(Masa: 2jam
Lahore pregnancy cohort study; association of maternal nutritional status, environmental factors and psychological status with neonatal anthropometric data and pregnancy outcomes among Pakistani pregnant women
Get PDFIn Pakistan, prevalence of maternal mortality rates is on higher side than in other developing countries. The Lahore Pregnancy Cohort Study is a comprehensive investigation designed to explore the intricate relationship between maternal nutritional status, environmental factors, psychological factors, and their impact on neonatal anthropometric data and pregnancy outcomes among pregnant women and neonate’s health in Pakistan. The LPCS was a two-year prospective cohort study started in 2019 that recruits Pakistani pregnant women from Fatima Memorial Hospital Lahore, Pakistan through convenient sampling technique. Participants of the study (approximately 227) between the age of 19-40 years were interviewed in three intervals. (2nd, 3rd trimester and postpartum). The mother’s information was collected from the hospital records and via a self-structured questionnaire. With a focus on the Pakistani population, this comprehensive study data on maternal nutritional status, encompassing dietary habits, and body mass index (BMI). Environmental factors, such as socioeconomic status, food insecurity, are also assessed to determine their potential influence on pregnancy outcomes. The psychological status of pregnant women is evaluated, including stress, anxiety and depression. Pregnancy outcomes such as gestational weight gain (GWG), gestational diabetes mellitus (GDM) and anemia. Furthermore, it investigated factors
linked to infant’s birth outcomes, such as birth length, weight, head circumference, abdominal circumference and APGAR score. Significant findings highlighted that mostly respondent is food secured (100 %) and mild depression is observed among the mothers. Socio-demographic, socio-economic and dietary variables are associated with the prevalence of anemia. There exists a significant difference between the prevalence of anemia at different points in pregnancy and post-partum with mean Hb levels of 11.61 ± 1.05 (2nd trimester), 11.11 ± 1.62 (3rd trimester) and 10.41 ± 1.56 (post-partum). Mean score comparison showed that fasting and random blood glucose were also significantly different at different time points among study respondents (p < 0.05). Insufficient consumption of dietary intake is observed, with a higher reliance on supplements (p < 0.01) to meet their nutritional needs. In addition, dietary adequacy was found to be related with anthropometric measurements with different food item effecting differently. Moreover, 44.9% newborns were female while 55.1% were male with 18.5% of neonates having lower birth weight. The study underscored the positive effects of environmental factors and psychological health. In conclusion, this study highlighted key issues related to maternal and infant health in Lahore. The findings from this study hold the potential to inform public health initiatives, healthcare policies, and interventions aimed at improving maternal and neonatal health in Pakistan. Ultimately, the goal is to contribute to the enhancement of prenatal care and the overall well-being of expectant mothers and their offspring in this region
BST405- Conservation Ecology and Natural Resources (Ekologi Pemuliharaan dan Sumber Alam)
Get PDFFirst Semester Examination
2023/2024 Academic Session
February 2024
BST405- Conservation Ecology and Natural Resources
(Ekologi Pemuliharaan dan Sumber A/am)
Duration: 2 hours
(Masa: 2 jam
BTT211 I BTT306- Techniques in Biotechnology (Teknik Biotekno/ogi)
Get PDFFirst Semester Examination
2023/2024 Academic Session
February 2024
BTT211 I BTT306- Techniques in Biotechnology
(Teknik Biotekno/ogi)
Duration: 2 hours
(Masa: 2 jam