17362 research outputs found
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Biomarkers, isolation methods, and therapeutic implications of breast cancer stem cells
No full textBreast cancer metastasis and relapse remain uncontrollable despite significant advancements in early diagnosis and treatment, resulting in increased mortality. Breast cancer is the most frequently diagnosed cancer in women worldwide and has become the leading cause of cancer-related deaths. Cancer stem cells (CSCs) may play significant roles in tumor initiation, maintenance, invasion, relapse, metastasis, and therapy resistance. Although this small, highly heterogeneous, and restricted population of CSCs has been extensively studied, their cellular and molecular physiology remains unclear. Nonetheless, CSCs have increasingly become an attractive therapeutic target for combating advanced, treatment-resistant cancers. This necessitates the development of effective and reliable methods for their isolation and enrichment. This review provides an overview of the key characteristics of breast cancer stem cells (BCSCs) and illustrates their role in therapeutic resistance. Furthermore, it highlights various mechanisms underlying cancer cell adaptability and therapy-induced resistance across different breast cancer subtypes. The commonly used methods for BCSC isolation and identification are also discussed, as they could facilitate a deeper understanding of tumorigenesis, metastasis, resistance, and relapse, consequently contributing to the development of more effective therapeutic strategies for breast cancer
Terminalia catappa fruit and its industrial application: A review
No full textSome underexploited fruit species can be used for the extraction and isolation of functional/bioactive compounds, playing an important role in maintaining human health. T. catappa leaves and fruits have many medicinal uses, including antioxidant, anti-inflammatory, anticancer, antidiabetic, leprosy and headaches. The aim of this review is to describe the composition of T. catappa kernels which are examined from a critical interpretation concerning the suitable use. This review also compares the oil yields and their physicochemical properties for the purpose of evaluating the potential of T. catappa kernels as a source of natural edible oil with potential industrial uses. The demand for healthier vegetable oils is growing by the day as the primary sources of saturated oils are from animals and unsaturated oils from plants. Different parts of T. catappa, such as fruit flesh, seed, and bark are highly nutritious and rich in bioactive compounds. T. catappa kernel is usually consumed raw or roasted and has an almond-like taste because of its high unsaturated oil content (43.36–63.65 %). Highly unsaturated T. catappa kernel oil (TCKO) indicated that it can easily oxidize and be chemically unstable. Thus, it is not suitable to be used in its present state as an industrial fluid. T. catappa kernels could be a useful new source of edible oils that could also allow economic exploitation
Over a decade of maqashid sharia studies: a bibliometric analysis and direction for future research
No full textPurpose The purpose of this paper is to build a relationship between the quantitative and structural indicators of maqashid sharia studies produced from bibliometric analysis and the conceptual discussion developed through a thorough review of selected key literature.
Design/methodology/approach The study uses bibliometric analysis, collecting information drawn from 219 articles published in 68 journals during the period of 2006–2022. This study uses VOSviewer, RStudio, Microsoft Excel, and an examination of research time periods using the Scopus database to illustrate the citation analysis and keyword map. It is also strengthened by content analysis of selected studies. Findings The main research theme found in this study is the application of maqashid sharia in Islamic banks, with Islamic banks and Islamic finance among the most frequently used keywords. Meanwhile, the geographical spread of maqashid sharia research has reflected its universal acceptance, as it has spread across both Muslim-dominant and non-Muslim-dominant countries. Besides, maqashid sharia is found to be an extremely important subject for ensuring the ethical dimension of Islamic finance products and services, a more inclusive human development index, and contributing to the international agenda of Sustainable Development Goals. Lastly, future research is expected to broaden it into a multi-dimensional horizon, with several recommendations offered to enrich the understanding of maqashid sharia. Practical implications The findings of this study can be beneficial to multiple stakeholders in Islamic finance industry, including the management of Islamic banks, who can enhance the values of maqashid sharia in designing their products/services, and the regulators, who can formulate regulatory frameworks which are reflective of maqashid sharia principles. Social implications This study will assist future scholars in this field to formulate and design exciting research ideas and models to address the deficiencies found in the current implementation of maqashid sharia within Islamic finance industry. Originality/value The primary contribution of this study is to provide comprehensive review and discussion of selected significant literature on maqashid sharia and give direction for future research. In addition, this study also extends and incorporates the results of bibliometrics using the recent maqashid sharia studies published at the end of 2022
The mediating effect of perceived behavioral control in the relationship between participation intention and practice effect in educational practice
No full textMany researches have been carried out in the aspects of management and organization, preparation, implementation, summary and evaluation of educational practice, but there is no in-depth research on the students’ behavior in the process. However, students' own problems, such as attitude, frustration ability, adaptability to the new environment and family factors, all affect the educational practice effect, greatly hinder the improvement of students' teaching skills, which is the basic quality of qualified teachers, and are not conducive to students' career development and lifelong growth. This research is from the perspective of students who participate in educational practice, focuses on analyzing the relationship between students' perceived behavioral control, participation intention and practice effect used PLS-SEM. A pilot study was conducted with 60 students to test the reliability and validity of the instruments. Subsequently, 200 students who had completed the educational practice were selected for actual research through purposeful and random sampling. The results indicated that perceived behavioral control and participation intention positively predict the practice effect, as well as participation intention mediates the relationship between perceived behavioral control and practice effect. This current research offered theoretical support and practical suggestions for the educational practice, and education administrators can better adjust and improve education policies, so as to promote the improvement of teacher education quality, further promote educational curriculum reform
Comprehensive review of strategies for lactic acid bacteria production and metabolite enhancement in probiotic cultures: multifunctional applications in functional foods
No full textLactic acid bacteria (LAB) play a crucial role in probiotics, functional foods, and sustainable biotechnologies due to their ability to produce bioactive metabolites such as short-chain fatty acids, bacteriocins, vitamins, and exopolysaccharides. These metabolites aid in gut health, pathogen inhibition, and enhanced productivity in the food, pharmaceutical, and aquaculture industries. However, the high production cost remains a major challenge, necessitating cost-effective media formulations and bioprocess optimization. This review explores strategies for maximizing LAB yields and functionality through the precision control of key cultivation parameters, including temperature, pH, and agitation speed, ensuring probiotic viability in compliance with regulatory standards (≥106 CFU/g or mL). Furthermore, advances in metabolic engineering, synthetic biology, and the utilization of agro-industrial by-products are driving cost-efficient and eco-friendly LAB production. By integrating scalable fermentation technologies with sustainable resource management, LAB have the potential to bridge the gap between food security, environmental sustainability, and biotechnological innovation. This review provides a comprehensive overview of recent advances in LAB cultivation and bioprocess optimization, ensuring high-quality probiotic production for diverse industrial applications
Electrochemical DNA biosensor for the detection of infectious bronchitis virus using a multi-walled carbon nanotube-modified gold electrode
No full textInfectious bronchitis virus (IBV) is an enveloped, positive-sense, single-stranded RNA virus belonging to the genus Gammacoronavirus. It primarily infects avian species, causing respiratory and renal disease and irreversible damage to the oviduct, which can lead to high mortality rates in chickens. The lack of rapid and reliable diagnostic tools for on-farm IBV detection hampers timely disease management and control measures. The introduction of DNA biosensors offers a promising approach for the sensitive and specific detection of IBV, facilitating rapid identification and intervention. In this study, an electrochemical DNA biosensor with a multi-walled carbon nanotube (MWCNT)-modified gold electrode was developed for IBV detection. The biosensor targeted the target-specific 5 ′ untranslated region (5′ -UTR) of the IBV genome. Under optimal conditions, the immobilization and hybridization efficiencies were evaluated by cyclic voltammetry (CV) and differential pulse voltammetry (DPV), with methylene blue as a redox indicator. The developed DNA biosensor demonstrated a dynamic detection range from 2.0 × 10−12 to 2.0 × 10−5 mol L−1 , with a limit of detection (LOD) of 2.6 nM and a limit of quantification (LOQ) of 0.79 nM. Validation using a small subset of clinical samples, including crude complementary DNA, and polymerase chain reaction products, showed high recovery rates ranging from 95.41% to 99.55%. While these findings highlight the potential of the proposed DNA biosensor as an innovative diagnostic tool for IBV detection, this study remains a proof of concept. However, further validation using a large number of clinical samples is essential to assess its feasibility, robustness, and practical application in a real-world farm setting
Unveiling AI in education: a global bibliometric review of research trends, key theories, and innovations
No full textThe rapid advancement of Artificial Intelligence (AI) has profoundly transformed education, revolutionizing teaching methodologies, student engagement, and institutional decision-making. However, despite the increasing integration of AI-driven technologies such as intelligent tutoring systems, adaptive learning platforms, and generative AI tools like ChatGPT, there remains a pressing need for a systematic evaluation of research developments in this field. This study conducts a comprehensive bibliometric analysis to map global research trends, theoretical foundations, and key innovations in AI-powered education.Utilizing data from Scopus and Web of Science (WoS), this study analyzes 23,132 valid research papers using ScientoPy, a specialized bibliometric tool. The findings reveal a substantial surge in AI-related educational research, particularly post-2020, transitioning from theoretical discussions to practical applications in personalized learning, machine learning-driven assessments, and ethical AI governance. The United States, China, and the United Kingdom emerge as the leading contributors, while prolific publication sources include ACM International Conference Proceeding Series, Sustainability, and Education and Information Technologies. Citation analysis identifies influential studies that have shaped AI-driven educational policies, with prominent works addressing AI-assisted evaluations, the ethical challenges of AI in academic settings, and the role of generative AI in shaping modern pedagogy. This research also highlights dominant theoretical frameworks, including Self-Determination Theory and Activity Theory, offering insights into the cognitive and behavioral aspects of AI-enhanced learning environments. Moreover, emerging trends indicate growing research interest in AI applications in K-12 education, interdisciplinary collaborations, and the ethical implications of AIgenerated content in academia. By presenting a data-driven bibliometric perspective, this study serves as a critical resource for educators, policymakers, and researchers, fostering informed decision-making and promoting the responsible integration of AI in educational landscapes
Ovarian cyst and pregnancy. What is new? A literature review
No full textOvarian cysts with pregnancy constitute a dilemma and challenge in both diagnosis and treatment. This review aims to synthesize, analyze, and accumulate data from published research, particularly the more recent ones, describing the evolving practices in the past 10 years for managing ovarian masses complicating pregnancy. This is a result of the continuous discussion and conundrum surrounding the best course of action for treating adnexal masses in gestation. The frequency of these masses being detected has risen over the past 20 years due to more usage of sonography for pregnancy monitoring. This has also led to technological advancements in screening equipment and a delay in childbearing till later in life. Assembled data from published research, particularly the more recent ones, demonstrating the methods of treating ovarian cysts in pregnancy, have changed over the past 10 years. Most ovarian cysts that form during pregnancy are benign, most likely functional, and have the potential to disappear on their own. Thankfully, most of these tumors are discovered unintentionally during a normal ultrasound scan performed during the initial prenatal visit during the first trimester of pregnancy. Ultrasound is the first choice and recommended diagnostic modality for the preliminary finding and monitoring of ovarian cysts whether in or following pregnancy. When ultrasonography (US) imaging is inconclusive, magnetic resonance imaging (MRI) and computed tomography (CT) scans can be helpful supplements. Conservative, surgical, or ultrasound-guided aspiration of big cysts are all possible treatment options for ovarian cysts during pregnancy
Mualaf di Sabah: Kajian terhadap faktor peningkatan mualaf dan cabaran yang mereka hadapi
No full textSabah, known for its diversity in ethnicity, culture, and religion, has experienced a significant increase in the number of Muslim converts (mualaf) over the past few decades. This study aims to investigate the factors driving the rise in the number of mualaf in Sabah and the challenges they face after embracing Islam. The research employs a qualitative design with a mixed-method approach, incorporating both quantitative and qualitative data analysis. Quantitative data were obtained from the registration records of mualaf provided by authoritative documents such as the Sabah Islamic Religious Affairs Department (JHEAINS) for the period from 2010 to 2023. Qualitative data, on the other hand, were collected through semi-structured interviews with mualaf. Data analysis involved thematic analysis to identify key themes related to the factors influencing conversion to Islam and the challenges faced by mualaf. The study identifies several key factors influencing individuals' decisions to convert to Islam, including exposure through media, dakwah programs, and social interactions with the Muslim community. It also evaluates the main challenges faced by mualaf, such as social adaptation, cultural conflicts, and family-related issues. The findings reveal a significant increase in the number of mualaf in Sabah, but they also highlight various challenges, including insufficient social support, difficulties in adapting to a new culture, and issues related to integration within the Muslim community. This study hopes to provide valuable insights for improving support systems and integration strategies for mualaf in Sabah, enabling them to fully embrace and practice Islamic teachings while serving as agents of Islamic outreach in the futur
The influence of emotional intelligence on learning burnout in Chinese arts college students: The chain mediating effect of self-acceptance and perceived stress
No full textIntroduction: Art college students are under special pressure from a few sources, including study, employment, friends, emotions, family relations and other aspects. This can lead to a reasonable degree of learning burnout among art college students, which will have a negative impact on their physical and mental health, as well as their study and employment. However, there is a paucity of empirical studies on learning burnout among art students. Furthermore, the factors and mechanisms that contribute to learning burnout among art students remain unclear. The purpose of this study was to examine the relationship between emotional intelligence and learning burnout in Chinese art college students, and to identify the role of self-acceptance and perceived stress as sequential mediators. Methods: This study employed a completely random survey of three art universities in China to investigate the status of emotional intelligence, selfacceptance, perceived stress and learning burnout among art students and their relationships. The data was analyzed using an independent sample t-test and structural equation modelling. Results: A total of 678 valid samples were obtained from a study of Chinese art students. No significant differences were observed in the scores of emotional intelligences, self-acceptance, perceived stress, and learning burnout among participants of different genders. The results of the structural equation modelling indicated that emotional intelligence was negatively associated with learning burnout (β = −0.282, p < 0.001). The results indicated that self-acceptance (β = −0.140, p < 0.001) and perceived stress (β = −0.072, p < 0.001) had independent mediating effects. Furthermore, self-acceptance and perceived stress exhibited sequence mediating effects (β = −0.039, p < 0.001). Conclusion: The results of the study confirm that emotional intelligence is a significant factor in the learning burnout of art students. Furthermore, the findings demonstrate the mediating effect of self-acceptance and perceived pressure on this relationship. The findings provide a novel explanation for the mechanism underlying college students’ learning burnout