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Routledge International Handbook of Deindustrialization Studies
No full textThe Routledge International Handbook of Deindustrialization Studies is a timely volume that provides an overview of this interdisciplinary field that emerged in response to the widespread decline of manufacturing and heavy industry from the 1980s onward. Edited by prominent figures in the field, the volume brings together many of the leading scholars from a range of countries across the globe to offer a multifaceted overview of deindustrialization and its impact.
Deindustrialization has been cited as one of the factors behind the rise of the far right, and to a lesser extent the far left, across Europe, the rise and success of Trumpism in the US, and the Brexit vote as well as the more recent and sudden erosion of UK Labour’s ‘Red Wall’ of the North of England. This collection brings together scholars of deindustrialization around the globe and from a wide variety of academic disciplines including history, sociology, politics, geography, economics, anthropology, literature, arts practice, photography, heritage, and cultural studies. In doing so, the volume explores the roots of deindustrialization across the world, highlights the key themes and issues in the field, illustrates the intersectional and interdisciplinary character of the field, and shows how deindustrialization lies at the heart of many of the key political, cultural, social, and economic issues of our time.
Written in a clear and accessible style, the Handbook is a comprehensive interdisciplinary volume for this young but maturing field. The volume is a valuable resource for students, teachers, and researchers interested in industrial decline, closure, and the multifaceted impacts they cause. It speaks to readers across the arts, humanities, and social and political sciences concerned with deindustrialization broadly defined
Federated learning for intelligent transportation systems: use cases, open challenges, and opportunities
No full textIntelligent transportation systems (ITSs) leverage a network of interconnected infrastructures utilizing advanced technologies to improve traffic management and safety. Federated learning (FL) has emerged as a pivotal method within ITSs, enabling decentralized collaborative model training without direct data sharing, thus preserving privacy and enhancing system efficiency. This article explores the integration of FL in ITSs, focusing on FL’s application in traffic flow prediction, trajectory prediction, parking space estimation, and traffic target recognition. Despite its potential, FL deployment faces challenges, including data heterogeneity, communication and bandwidth constraints, and resource limitations on edge devices. Addressing these challenges is crucial for realizing the full potential of FL in ITSs. This article provides a comprehensive survey of existing FL implementations in ITSs, discusses inherent challenges, and outlines future research directions aimed at overcoming these obstacles
Psychological challenges in children with tracheostomies and their families – a qualitative study
Get PDFPrevious research has shown that paediatric tracheostomy can be a very difficult experience for the whole family. Despite this, as far as we are aware, no paediatric airway service in the United Kingdom includes a dedicated psychologist.
This study aims to provide information on parents' thoughts regarding the psychological support currently offered in a tertiary paediatric setting.
This is a qualitative study using in depth interviews to explore themes. The participant group was parents of children under 18 with a current tracheostomy.
This study demonstrated a high demand for a psychological support service among those under the care of airway services. Parents valued continuity of care and ongoing support throughout the child's journey of care. We did not detect any perceived stigma associated with referral to psychological services.
Although our study is small, our sample is representative of the targeted cohort and qualitative analysis allowed in depth insight into parents' priorities
Parity-specific differences in spatial genetics and dispersal in the common lizard
Get PDFDispersal is a key demographic parameter that plays an important role in determining spatial population dynamic and genetic structure. Linking differences in dispersal patterns to key life-history traits is often confounded by inconsistent environmental pressures experienced by different populations. To explore the link between dispersal and life history, we focus on a site where oviparous and viviparous lineages of the common lizard (Zootoca vivipara) are found adjacent to each other. We take advantage of this shared environment to investigate parity-specific dispersal patterns using high resolution, individual-level spatial genetic autocorrelation and population genomic approaches (11,726 SNPs; 293 oviparous and 310 viviparous individuals). We found isolation-by-distance patterns to be present in both the oviparous and viviparous populations. Density was 2.5 times higher in the viviparous population than the oviparous one, though heterozygosity and genetic diversity measures were similar in the two populations. We found marked differences in the extent of genetic neighbourhoods between the lineages, with the viviparous population showing both dispersal (σ) and spatial genetic autocorrelation (Moran’s I) at two-fold greater geographic distances than the oviparous population. We found clear evidence of male-biased dispersal from genetic estimates in the viviparous population. In the oviparous population, evidence of male-biased dispersal is weak or absent. These differences are likely to be closely linked to specific requirements of the alternative reproductive strategies and may be the demographic consequences of mother-offspring interactions. Fine-scale geographic and individual-level measures are key to understanding parity mode differences at microevolutionary scales and to better identifying their ecological and evolutionary impacts
Light and high temperatures control epigenomic and epitranscriptomic events in Arabidopsis
Get PDFLight and temperature are two key environmental factors that control plant growth and adaptation by influencing biomolecular events. This review highlights the latest milestones on the role of light and high temperatures in modulating the epigenetic and epitranscriptomic landscape of Arabidopsis to trigger developmental and adaptive responses to a changing environment. Recent discoveries on how light and high temperature signals are integrated in the nucleus to modulate gene expression are discussed, as well as highlighting research gaps and future perspectives in further understanding how to promote plant resilience in times of climate change
Biased constitutive signaling of the G protein-coupled receptor GPR35 suppresses gut barrier permeability
Get PDFAgonist-independent, or constitutive, activity is an integral feature of G protein-coupled receptors, but its relevance in pathophysiological settings is generally poorly explored. GPR35 is a therapeutic target in inflammatory diseases of the lower gut. In colonic organoids from a human GPR35a-expressing transgenic mouse line, the GPR35 inverse agonist CID-2745687 increased barrier permeability substantially, indicating that constitutive receptor activity contributes to maintaining epithelial barrier integrity. High constitutive activity of GPR35 was also observed in both HT-29 and HEPG2 cells that express GPR35 endogenously. Mechanistic investigations in recombinant in vitro systems revealed that the constitutive activity of GPR35a was biased and not equivalent across signaling pathways. Hence, no constitutive interactions of the receptor with arrestin-adaptor proteins or activation of Gαo-containing G protein heterotrimers were detected while, even at low GPR35a expression levels, substantial constitutive activation of heterotrimers containing either Gα12 or Gα13 was observed. Similar biased constitutive activity was observed for the human GPR35b isoform. The extent of constitutive and agonist-mediated activity was dependent on receptor expression level. At high receptor levels, constitutive activation of Gα12 or Gα13 masked any agonist-induced effects while low expression levels with low constitutive activity allowed measurement of agonist-induced responses. These results highlight roles, selectivity, and the extent of constitutive activity of GPR35 in cells and tissues that express this receptor endogenously and highlight the contribution of its constitutive activity to maintaining the colonic epithelial barrier, potentially limiting the development of inflammatory bowel diseases
ARTeFACT: Benchmarking Segmentation Models on Diverse Analogue Media Damage
Get PDFAccurately detecting and classifying damage in analogue media such as paintings, photographs, textiles, mosaics, and frescoes is essential for cultural heritage preservation. While machine learning models excel in correcting degradation if the damage operator is known a priori, we show that they fail to robustly predict where the damage is even after supervised training; thus, reliable damage detection remains a challenge. Motivated by this, we introduce ARTeFACT, a dataset for damage detection in diverse types analogue media, with over 11,000 annotations covering 15 kinds of damage across various subjects, media, and historical provenance. Furthermore, we contribute human-verified text prompts describing the semantic contents of the images, and derive additional textual descriptions of the annotated damage. We evaluate CNN, transformer, diffusion-based segmentation models, and foundation vision models in zero-shot, supervised, unsupervised and text-guided settings, revealing their limitations in generalising across media types. Our dataset is available at https://daniela997.github.ioIARTeFACTI as the first-of-its-kind benchmark for analogue media damage detection and restoration
Pernicious ignorance and the marginalisation of third space professionals: reflections on lived experience
Get PDFThis article is part reflection and part case study based upon my work as a third space worker (Whitchurch, 2023a) since at least 2010. I will surface a recurring challenge encompassing the recognition and visibility of third space professionals in higher education as educators who experience silencing stemming from pernicious ignorance. Accordingly, I use Dotson’s notion of pernicious ignorance (2011, p.238) to analyse a reflective vignette to illustrate a challenge that undermines third space practitioners. The aim is to equip readers with theory that they can use to counter negative workplace behaviours, whether observed, experienced, or both, while strengthening their positions as third space professionals
R-loops acted on by RNase H1 influence DNA replication timing and genome stability in Leishmania
Get PDFGenomes in eukaryotes normally undergo DNA replication in a choreographed temporal order, resulting in early and late replicating chromosome compartments. Leishmania, a human protozoan parasite, displays an unconventional DNA replication program in which the timing of DNA replication completion is chromosome size-dependent: larger chromosomes complete replication later then smaller ones. Here we show that both R-loops and RNase H1, a ribonuclease that resolves RNA-DNA hybrids, accumulate in Leishmania major chromosomes in a pattern that reflects their replication timing. Furthermore, we demonstrate that such differential organisation of R-loops, RNase H1 and DNA replication timing across the parasite’s chromosomes correlates with size-dependent differences in chromatin accessibility, G quadruplex distribution and sequence content. Using conditional gene excision, we show that loss of RNase H1 leads to transient growth perturbation and permanently abrogates the differences in DNA replication timing across chromosomes, as well as altering levels of aneuploidy and increasing chromosome instability in a size-dependent manner. This work provides a link between R-loop homeostasis and DNA replication timing in a eukaryotic parasite and demonstrates that orchestration of DNA replication dictates levels of genome plasticity in Leishmania
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