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Terapie con estrogeni/ progestinici e corea di Sydenham. Riflessioni da una mapping review sulla prescrizione e sull’informazione ai pazienti
No full textLe terapie con estrogeni/progestinici (EPTs) sono state associate all’insorgenza di corea. Le domande su questo argomento rivolte a un’associazione di pazienti (la Sydenham’s Chorea Association, www.sydenhamschorea. com) hanno stimolato la nostra revisione della letteratura (database multipli, dall’inizio ad agosto 2024), da cui è emerso che la corea di Sydenham (Sc) può rappresentare un indicatore di rischio d’insorgenza di corea con le EPTs. Ciò ha stimolato una riflessione sull’uso e sulla necessità d’informazioni adeguate sulle EPTs nelle persone con una storia di Sc. Sarebbero importanti a questo riguardo una rilevazione più accurata del fenomeno di riattivazione della corea durante l’uso delle EPTs in persone con precedente Sc, così come l’identificazione della strategia terapeutica più adatta (es. di contraccezione ormonale) e del momento più opportuno per discuterla con questi pazienti.
Estrogen/progestin therapies (EPTs) have been associated with the development of chorea. Questions on this topic addressed to a patients’ association (the Sydenham’s Chorea Association, www.sydenhamschorea.com) prompted our mapping review of the literature (multiple databases, from the beginning to August 2024), from which emerged that Sydenham’s chorea (Sc) may represent an indicator of the risk of developing chorea with EPTs. This has stimulated a reflection on the use and need for balanced information on EPTs in people with a history of Sc. A more accurate detection of the phenomenon of chorea reactivation during the use of EPTs in persons with previous Sc and the identification of the most suitable therapeutic strategy (e.g. hormonal contraception) and the most appropriate time to discuss it with these patients would be of relevance in this regard. The full English version is available from: https://gbox.garr.it/garrbox/s/v4poBtZdKA1Azk
“Uma simples flor nos teus cabelos claros” = “Just a flower in your long, blonde hair”
No full textEnglish translation of 'Uma simples flor nos teus cabelos claros' by José Cardoso Pires
The Green Blueprint: designing future cities with urban green infrastructure and ecosystem services in the UK
Get PDFUrbanisation in the context of climate change and rapid population growth presents an urgent need for innovative and sustainable urban planning. This study introduces the Green Blueprint, an original, spatially grounded, and evidence-informed conceptual framework designed to systematically embed ecosystem services into the planning, governance, and design of resilient and equitable cities in the United Kingdom. Unlike existing research that typically treats Urban Green Infrastructure (UGI) as a discrete intervention or evaluates its benefits in isolation, the Green Blueprint integrates cross-sectoral governance, multifunctional land use, and participatory planning into a coherent, scalable model for urban resilience. Developed through a qualitative, interpretivist methodology and critical documentary analysis of secondary data including policy documents, academic literature, and case studies from London, Manchester, and Sheffield, this framework highlights how embedding ecosystem services such as carbon sequestration, stormwater management, biodiversity enhancement, and public health into the urban fabric can support long-term climate adaptation and social equity. Rather than serving as a review, this paper advances a novel theoretical contribution through empirical synthesis and thematic cross-case comparison. It further identifies enabling governance structures and implementation pathways to support policy innovation and practical application. This study contributes a transferable planning template for cities aiming to achieve systemic UGI integration, offering clear value for scholars, practitioners, and policymakers engaged in sustainable urban development in the Anthropocene
Private equity buyout pricing, returns, and portfolio firm performance across UK regions
Get PDFPrior empirical investigations of private equity activity indicates that it is concentrated in central financial hubs. Using comprehensive UK data on deal valuations, companies’ financial performance, and estimates of returns on buyout transactions, we study regional variations in deal pricing, portfolio firm performance, and deal returns. Our findings show that PE sponsors pay higher valuations for buyout targets in London and the South East relative to other UK regions. However, portfolio companies located in London and the South East do not exhibit greater gains in productivity and operating performance than their peers in peripheral regions. Our results also suggest that buyout returns are similar across UK regions
Computational fluid dynamics analysis of draft tube flow characteristics in a Kaplan turbine
Get PDFThis study presents a numerical investigation of the internal flow characteristics within the draft tube of a Kaplan turbine using computational fluid dynamics (CFD). The distribution and evolution of vortical structures, particularly the formation and development of vortex ropes under various operating conditions, are systematically analyzed. The study aims to explore the effects of blade angle and guide vane opening on the internal flow characteristics of the unit, thereby providing guidance for flow control strategies. The influence of guide vane opening and turbine head on vortex dynamics and flow stability is examined, with a focus on the pressure pulsations induced by vortex ropes through frequency-domain analysis. The results indicate that increased guide vane openings and higher heads lead to the expansion and downstream extension of the vortex rope into the elbow section, causing significant low-frequency pressure pulsations and enhancing flow instability. These findings contribute to a deeper understanding of unsteady flow behavior in Kaplan turbine draft tubes and provide a theoretical foundation for improving hydraulic stability and optimizing operational performance
Revisioning Practice in Education
No full textWe are living through the effects of a series of serious crises. Covid-19 had an impact that was world-wide, and we are still experiencing the longer term economic and social after-effects of this pandemic. Warfare and conflict rage in different parts of the world and threaten the safety and security of many people. This results in hardship, deprivation and displacement – often affecting the most vulnerable in society in a disproportionate way. Economies around the world are struggling on account of the disruption caused by the pandemic and warfare and conflict. It is within this context that hard and challenging questions are being posed about the aims, purpose and outcomes of education throughout the world and whether education needs to be re-Visioned.
Responsible Research and Innovation is the vision that drives the LSME research agenda. Social justice is at the heart of this vision and arguably should be at the heart of education. This keynote will argue that a re-Visioning of education does not necessarily require a completely new vision of education but should begin with a critical recovery of the principles and practice of social justice and the ways in which these relate to education. In practical terms, this means returning to the foundational principles of social justice: human rights, access, participation/inclusion and equity
The individual and situational factors predicting unethical behaviour in the workplace: a direct and conceptual replication of Jones & Kavanagh (1996)
Get PDFIntentions to act unethically in the workplace are purported to be driven by a number of situational and individual factors. Across two seminal vignette experiments, Jones and Kavanagh reported inconsistent effect sizes for manager and peer influence and locus of control, consistent significant effects for work quality and Machiavellianism, and consistent non-significant effects for gender. Using an innovative multi-site collaboration, the current Registered Report represents a direct replication of these experiments (N = 2218), and adds a longitudinal conceptual replication capturing self-reported unethical work behaviour (N = 1747). Both replications found a consistent small effect of having a more external locus of control and male identity, and a consistent moderate effect of machiavellianism, for increasing unethical intentions and behaviour. The situational factors, whilst consistent in direction with that of the original study, varied more substantively in effect size. Our results highlight the value of multi-site collaborations and different replication types in developing conceptual, methodological, measurement and theoretical clarity to ensure future works can progress more rapidly to minimize the negative impacts of unethical workplace behaviour and improve individual’s working lives. All materials, code and data for this project can be found here: osf.io/d3arx
The X-ray class of the Carrington flare
Get PDFThe geomagnetic “solar flare effect” (SFE) results from excess ionization produced by solar X-ray and EUV radiation in the Earth’s upper atmosphere. The simultaneous detection of an SFE at the time of the Carrington flare in 1859 allows us to calibrate this event on the (revised) modern GOES X-ray scale. For this purpose we make a basic correlation analysis of SFEs recorded at 1-min averaging at a single geomagnetic observatory, the Hartland station, as the site closest to London and the two original observing stations (Kew and Greenwich). We find the equivalent GOES magnitude of the Carrington event to have been X105+41, −24 based on a sample of 39 X-class flare events observable as SFEs, with the estimate limited by systematic errors in the interpretation of the modern data. This estimate agrees with estimates based on the visual observations of the flare. This suggests that the Carrington flare was not a “superflare” in the sense that it required physics beyond that needed for ordinary flares
On the universal pairing for 2‐complexes
Get PDFThe universal pairing for manifolds was defined and shown to lack positivity in dimension 4 in [Freedman, Kitaev, Nayak, Slingerland, Walker, and Wang, J. Geom. Topol. 9 (2005), 2303–2317]. We prove an analogous result for 2‐complexes, and show that the universal pairing does not detect the difference between simple homotopy equivalence and 3‐deformations. The question of whether these two equivalence relations are different for 2‐complexes is the subject of the Andrews–Curtis conjecture. We also discuss the universal pairing for higher dimensional complexes and show that it is not positive
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