InterNano Nanomanufacturing Repository
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NNI Sensor Fabrication, Integration, and Commercialization Workshop
No full textThe workshop report is a summary of the National Nanotechnology Initiative (NNI)-sponsored event held September 11-12, 2014, entitled “Sensor Fabrication, Integration, and Commercialization Workshop.” The goal of the workshop was to identify and discuss challenges that are faced by the sensor development community during the fabrication, integration, and commercialization of sensors, particularly those employing or addressing issues of nanoscale materials and technologies.
Workshop attendees, including sensor developers and representative from Federal agencies, identified ways to help facilitate the commercialization of nanosensors, which include:
- Enhancing communication among researchers, developers, manufacturers, customers, and the Federal Government agencies that support and regulate sensor development.
- Leveraging resources by building testbeds for sensor developers.
- Improving access of university and private researchers to federally supported facilities.
- Encouraging sensor developers to consider and prepare for market and regulatory requirements early in the development process
Nanoparticle-Stabilized Capsules for the Treatment of Bacterial Biofilms
No full textBacterial biofilms are widely associated with persistent infections. High resistance to conventional antibiotics and prevalent virulence makes eliminating these bacterial communities challenging therapeutic targets. We describe here the fabrication of a nanoparticle-stabilized capsule with a multicomponent core for the treatment of biofilms. The peppermint oil and cinnamaldehyde combination that comprises the core of the capsules act as potent antimicrobial agents. An in situ reaction at the oil/water interface between the nanoparticles and cinnamaldehyde structurally augments the capsules to efficiently deliver the essential oil payloads, effectively eradicating biofilms of clinically isolated pathogenic bacteria strains. In contrast to their antimicrobial action, the capsules selectively promoted fibroblast proliferation in a mixed bacteria/mammalian cell system making them promising for wound healing applications
Controlled integration of oligo- and polythiophenes at the molecular scale
No full textHigh molecular weight PBTTT-C-12 is blended with the pure trimer, BTTT-3, to enhance intergrain connectivity and charge transport. Analysis of the morphology and crystallinity of the blends shows that the polymer and oligomer are well-integrated, leading to high hole mobilities, greater than 0.1 cm(2) V-1 s(-1), in films that contain as much as 83% oligomer
Directed Self-Assembly of Poly(2-vinylpyridine)-b-polystyrene-b-poly(2-vinylpyridine) Triblock Copolymer with Sub-15 nm Spacing Line Patterns Using a Nanoimprinted Photoresist Template
No full textDetection of Escherichia coli in Drinking Water Using T7 Bacteriophage-Conjugated Magnetic Probe
No full textIn this study, we demonstrate a bacteriophage (phage)-based magnetic separation scheme for the rapid detection of Escherichia colt (E. coli) in drinking water. T7 phage is a lytic phage with a broad host range specificity for E. coli. Our scheme was as follows: (1) T7 bacteriophage-conjugated magnetic beads were used to capture and separate E. coli BL21 from drinking water; (2) subsequent phage-mediated lysis was used to release endemic beta-galactosidase (beta-gal) from the bound bacterial cells; (3) the release of beta-gal was detected using chlorophenol red-beta-D-galactopyranoside (CRPG), a colorimetric substrate which changes from yellow to red in the presence of beta-gal. Using this strategy, we were able to detect E. coli at a concentration of 1 x 10(4) CFU.mL(-1) within 2.5 h. The specificity of the proposed magnetic probes toward E. coli was demonstrated against a background of competing bacteria. By incorporating a pre-enrichment step in Luria-Bertani (LB) broth supplemented with isopropyl beta-D-thiogalactopyranoside (IPTG), we were able to detect 10 CFU.mL(-1) in drinking water after 6 h of pre-enrichment. The colorimetric change can be determined either by visual observation or with a reader, allowing for a simple, rapid quantification of E. coli in resource-limited settings
Cell surface-based sensing with metallic nanoparticles
No full textMetallic nanoparticles provide versatile scaffolds for biosensing applications. In this review, we focus on the use of metallic nanoparticles for cell surface sensings. Examples of the use of both specific recognition and array-based ``chemical nose'' approaches to cell surface sensing will be discussed
Centimeter-long electron transport in marine sediments via conductive minerals
No full textCentimeter-long electron conduction through marine sediments, in which electrons derived from sulfide in anoxic sediments are transported to oxygen in surficial sediments, may have an important influence on sediment geochemistry. Filamentous bacteria have been proposed to mediate the electron transport, but the filament conductivity could not be verified and other mechanisms are possible. Surprisingly, previous investigations have never actually measured the sediment conductivity or its basic physical properties. Here we report direct measurements that demonstrate centimeter-long electron flow through marine sediments, with conductivities sufficient to account for previously estimated electron fluxes. Conductivity was lost for oxidized sediments, which contrasts with the previously described increase in the conductivity of microbial biofilms upon oxidation. Adding pyrite to the sediments significantly enhanced the conductivity. These results suggest that the role of conductive minerals, which are more commonly found in sediments than centimeter-long microbial filaments, need to be considered when modeling marine sediment biogeochemistry
Visually tolerable tiling (VTT) for making a large-area flexible patterned surface
No full textThe fabrication of a large area mold is one of the most difficult challenges in the roll to roll nanoimprint field and eliminating the visible seams on a large areamold is evenmore difficult. We present a visually tolerable tiling (VTT) method to make large area micro/nano-patterns without visible seams and their applications. In this study, with small area micro/nano-pattern molds, the VTT method could produce a scaled up mold with the same features as the original mold without any visible seamlines. Also, a fabricated large sizemold was used in the roll to roll imprinting process as a flexible mold. By using the VTT method, large size metal wire grid polarizers and micro-prism sheets were fabricated and their potential was confirmed as feasible applications
Responsive single-chain polymer nanoparticles with host-guest features
No full textWe report a facile approach to form ultra-fine single-chain polymer nanoparticles (SCPNs) via disulfide-based intrachain crosslinking of single polymer chains of a random copolymer poly(HEMA-co-PDSEMA). The SCPNs, which were prepared under mild reaction conditions and at normal reaction concentrations (up to 10 mg mL(-1)), have been characterized by H-1 nuclear magnetic resonance (H-1 NMR) spectroscopy, atomic force microscopy (AFM), differential scanning calorimetry (DSC), gel permeation chromatography (GPC), and dynamic light scattering (DLS). The influences of the crosslinking density, the molecular weight and the initial concentration of the polymer upon the formation of SCPNs are also reported. In order to investigate the hydrophobic interior of SCPNs, we trace the emission spectrum of a pyrene probe. We highlight that these SCPNs exhibit host-guest properties to stably encapsulate hydrophobic guest molecules and release them in response to a redox stimulus