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Epigenetic alterations in multiple myeloma and potential therapy approaches
No full textMultiple myeloma remains an incurable hematological disease originating from the bone marrow. Many drugs and drug combinations are used to treat multiple myeloma. Although most chemotherapeutics are used to correct the course of the disease and control its progression, drug resistance occurs. For this reason, eliminating the genetic factors that cause the disease may be an option. Apart from a large number of mutations, epigenetic mechanisms may be effective in the formation and maturation of multiple myeloma. The importance of epigenetic regulation in various human diseases is gradually growing in interest, and its contribution to multiple myeloma has recently been investigated. In this chapter, we explain epigenetic changes in multiple myeloma in comparison to prior research. The role of epigenetic mechanisms and chemotherapeutics for the treatment of multiple myeloma were reviewed, and potential epigenetic drug targets and their contribution to therapy were emphasized. The effect and benefaction of the bone marrow microenvironment on epigenetic alterations in multiple myeloma are discussed. There are few studies targeting epigenetic changes in multiple myeloma, but the studies in this chapter provide an important contribution to the literature to inspire future research
4D-printed continuous fiber-reinforced PLA/TPU auxetic composites: mechanical performance, energy absorption, shape recovery, and reusability evaluation
No full textThis study explores the mechanical performance, energy absorption, shape recovery, and reusability of 4D-printed continuous carbon fiber-reinforced auxetic composite structures based on PLA/TPU blends, designed for load-bearing applications. PLA–TPU mixtures with different TPU content were developed to optimize the balance between flexibility and strength, with carbon fibers incorporated to enhance the mechanical properties of the resulting composites. Thermo-mechanical characterization of the blends was conducted, followed by a detailed evaluation of the structures’ mechanical behavior and energy absorption capacity under room temperature conditions, simulating practical industrial scenarios. The shape recovery performance of these composite structures was also investigated. To assess reusability, the programming–recovery cycle was repeated five times, analyzing the retention of mechanical properties and shape recovery over multiple cycles to determine durability. Results revealed that TPU integration provided sufficient flexibility for cold programming, while carbon fiber reinforcement significantly enhanced stiffness and strength. The 4D-printed composites exhibited consistent shape recovery and maintained mechanical integrity after five cycles, confirming their reusability. These findings demonstrate the potential of 4D-printed PLA/TPU-based carbon fiber-reinforced composites as smart, durable materials for load-bearing applications in industries such as biomedical engineering, automotive, and aerospace
Self-beliefs, transactive memory systems, and collective identification in teams: articulating the socio-cognitive underpinnings of COHUMAIN
No full textSocio-cognitive theory conceptualizes individual contributors as both enactors of cognitive processes and targets of a social context's determinative influences. The present research investigates how contributors’ metacognition or self-beliefs, combine with others’ views of themselves to inform collective team states related to learning about other agents (i.e., transactive memory systems) and forming social attachments with other agents (i.e., collective team identification), both important teamwork states that have implications for team collective intelligence. We test the predictions in a longitudinal study with 78 teams. Additionally, we provide interview data from industry experts in human–artificial intelligence teams. Our findings contribute to an emerging socio-cognitive architecture for COllective HUman-MAchine INtelligence (i.e., COHUMAIN) by articulating its underpinnings in individual and collective cognition and metacognition. Our resulting model has implications for the critical inputs necessary to design and enable a higher level of integration of human and machine teammates
Nonlinear complexity from the Hermitian and the Suzuki function fields
No full textThe notion of k- th order nonlinear complexity has been studied from various aspects. Geil, Özbudak and Ruano (Semigroup Forum 98:543–555, 2019) gave a construction of a sequence of length (q- 1) (q2- 1) with high nonlinear complexity by using the Weierstrass semigroup of two distinct rational points on a Hermitian function field over Fq2 , and they improved the bounds on the k- th order nonlinear complexity Nk(s) and Lk(s) obtained by Niederreiter and Xing (IEEE Trans Inf Theory 60(10):6696–6701, 2014), where Fq2 is the finite field with q2 elements, and q is a prime power. In this work, we exhibit the lower bounds on Nk(s) and Lk(s) on a Hermitian function field using Hermitian triangles over Fq2. We study the effect of a Hermitian triangle by its type. The possible cases on the k-th order nonlinear complexity are explained, for each type, and we improve the lower bounds obtained by Geil et al. We construct two different sequences with the help of the Weierstrass semigroup of l distinct collinear rational points, and we compare our results of the lower bounds on Nk(s) and Lk(s). Also, we study the lower bounds on Nk(s) and Lk(s) using the Weierstrass semigroup of two distinct rational points on a Suzuki function field over Fq, where q=2q02,q0=2t,t≥1
Prolonged grief symptoms predict social and emotional loneliness and depression symptoms
No full textA minority of bereaved individuals develops severe, persistent, and disabling grief, termed “prolonged grief.” The International Classification of Diseases, eleventh edition (ICD-11) and the Diagnostic and Statistical Manual of Mental Disorders, fifth edition, text revision (DSM-5-TR) include such grief reactions as prolonged grief disorder (PGD). Loneliness is often experienced by bereaved persons and can have severe health consequences. Preliminary research suggests that loneliness may perpetuate grief, but prolonged grief may also aggravate loneliness. Since existing empirical research provides limited information on temporal relationships between both constructs, we aimed to fill this gap in knowledge. Bereaved adults (88% female, mean age 54 years) filled in questionnaires assessing general, social, and emotional loneliness and prolonged grief and depression symptoms across two time points, 6 months apart. Cross-lagged panel model analyses showed that prolonged grief symptoms predicted more severe general, social, and emotional loneliness, as well as more depression symptoms. Loneliness did not predict prolonged grief symptoms and depression symptoms. Depression symptoms did not predict prolonged grief symptoms and loneliness. Additionally, latent change score analyses demonstrated that within person changes in prolonged grief symptoms and loneliness were related. Findings are inconsistent with the notion that loneliness causes prolonged grief and depression. Possibly, severe grief could lead to stigmatization, reduced social support, and feeling socially disconnected, perpetuating loneliness and depression symptoms
Tri-chamber polysulfide/iodide-based redox flow batteries with improved coulombic efficiency
No full textThe polysulfide/iodide flow battery is a promising candidate for large-scale energy storage systems, but the technology suffers from a notably low Coulombic efficiency. This phenomenon arises because the crossover of hydroxide ions triggers the disproportionation reaction of I3–ions in the posolyte. To mitigate these issues, a middle chamber filled with Na2SO4solution is created between two cation-exchange membranes to separate the posolyte and negolyte chambers of the PSIFB, thereby constructing a trichamber reactor. This middle chamber can serve as a reservoir for the cross-transportation OH–ions during charge-discharge processes, thereby minimizing their adverse effects on the posolyte. Experimental results reveal that the introduction of the middle chamber leads to a 97.3% reduction in the concentration of OH–ions within the posolyte. Furthermore, finite element analysis demonstrates that the trichamber configuration significantly reduces the flux of OH–ions entering the posolyte, achieving levels even lower than half of those in the dual-chamber structure. This innovative architecture markedly enhances the Coulombic efficiency from approximately 78% in the dual-chamber structure to around 91% in the trichamber structure with a high-concentration electrolyte (4 M NaI and 3 M Na2S2), while concurrently sustaining a highly competitive energy density of 20.05 W h Lposolyte+negolyte–1at 75% state-of-charge. These findings demonstrate an effective strategy for improving the performance of the polysulfide/iodide flow battery through OH–management, showing potential for developing more efficient flow battery systems for renewable energy storage application
Reducing Food Waste Through Experimental Interventions: Consumer Choice And Retail Strategy For Near-Expiry Products
Get PDFThis dissertation presents an experimental investigation into how retailers can encourage consumers to choose near-expiry food products—an important step toward reducing food waste and promoting sustainable retail operations. Near-expiry products, while still safe and consumable, are often avoided by consumers due to concerns over freshness and perceived quality. Through three controlled experiments, this study examines how various interventions—including nudges, brand-related signals, and bundling strategies—influence consumer decision-making in near-expiry contexts. Study 1 finds that social norm messages significantly increase the selection of near-expiry items, outperforming both financial discounts and other nudges such as self-image or quality appeals. Study 2 tests the roles of premium branding and customer loyalty but finds that neither increases selection, suggesting that expectations tied to brand image may backfire when product freshness is perceived as compromised. Study 3 evaluates bundling as an operational strategy and shows that immediate delivery options are preferred over flexible ones, especially under low discount conditions—contrary to what temporal and control-based theories would suggest. Collectively, these findings demonstrate that carefully designed, low-cost behavioral interventions can outperform traditional pricing approaches in promoting near-expiry product selection. They also reveal that some widely accepted consumer behavior theories may not fully hold in the perishable goods setting, where concerns about simplicity, immediacy, and perceived freshness are dominant. Future research should explore the role of personalized nudging, substitution behavior between product types, and real-world testing in dynamic retail environments to further assess scalability and long-term effectiveness
The Making Of Queer Parenting: New Kinship Formations Beyond Borders And Norms
Get PDFAfter the introduction of assisted reproductive technologies in late 20th centuryprimarily in the United States and gradually throughout the globe, the methodssuch as IVF and surrogacy have enabled new kinship arrangements for single intendedparents and same-sex couples, as well as heterosexuals. In some countrieslike Turkey, these technologies became a subject of political debate and legal limitationsagainst egg/sperm donation and surrogacy were taken. I examined twodifferent contexts in this debate, the United States where these reproductive technologiesare legalized and Turkey where they are prohibited. I looked at how parentingwith biological kin for queer people is possible through navigating potentialresources and mobility options for reproductive purposes. Having conducted 24in-depth interviews and participant observations in those countries, I encountereddifferent opportunities and challenges for queer people. In the United States, queerpeople are channeled into the commercial reproductive system and the costly natureof it stratifies the intended parents; in Turkey, transgender and bisexual parentsmanage state-recognition through heterosexual marriages and the access to reproductivetechnologies in nearby Northern Cyprus meanwhile the same sex intendedparents either look for ways to move abroad or keep it there in secrecy. Readingthese reproductive landscapes together with a gender lens, I aim to provide a crossculturalanalysis of how the making of queer parenting works concurrently as anapproximation to the normative dynamics and a deconstruction
Visualizing And Identifying The Othered MonstersWithin The Self
Get PDFThis thesis argues that the emergence of monstrosity is the blurred boundary betweenself and other and animation is uniquely capable of expressing it. Drawing ontheories of the uncanny, abjection, the shadow self, and projection, it explores howanimated transformations visualize both internal psychological conflict and externalthreats. This thesis explores the emergence and function of monsters through theconceptual lens of the self and the other, emphasizing the role of projection from theself onto the other, with the objective of informing and enhancing monster designin visual media. Furthermore, it highlights how animation’s unique capabilities canserve as a medium for integrating these internal aspects rather than merely rejectingthem. By integrating insights from psychology, philosophy, and evolutionary theory,the study emphasizes that effective monster design requires acknowledging the otherwithin the self. The history of visual representations of monstrosity within paintingsand film is also analyzed to gain insights into the portrayal and perception ofotherness. These insights are then applied to an original animated motion graphicsfilm, Phantasmagoria (2025), where the established theoretical principles inform thedesign of monstrous characters
At The Threshold Of Gender And Culture: An Analyis Of Magıcal Realism In Animation
Get PDFThis thesis examines how the intersection of magical realism, queer theory, and animationcan reimagine and reconstruct memory and identity. Using personal andfound family archives, it explores animation’s formal flexibility and magical realism’snarrative strategies to challenge dominant narratives of family, identity, and memory.Central to this study is the author’s animated short Threshold, which combinesarchival footage, occult symbolism, and experimental techniques to interrogate exclusionaryfamily rituals. Through a tripartite structure, the film transitions fromoppressive domestic realism to a liberatory magical realist utopia, embodying magicalrealism’s capacity to merge the ordinary and the extraordinary. The thesisalso engages with my heart knows, the author’s fabric sculpture that materializesqueer kinship and memory through tactile, durational labor, further expanding thediscussion on alternative archives. Theoretical frameworks emphasize how magicalrealism and animation challenge fixed epistemologies. By reclaiming suppressed historiessuch as Anatolian folk magic and queer counter-memory, this work positionsartistic practice as a site of utopian intervention. Ultimately, the thesis argues thatmagical realism in animation offers a transformative space for reconfiguring identity,memory, family, and temporality, opening pathways to queer utopian futuresbeyond cis-heteropatriarchal constraints