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Dynamic Scoring with Enhanced Semantics for Training-Free Human-Object Interaction Detection
Get PDFHuman-Object Interaction (HOI) detection aims to identify humans and objects within images and interpret their interactions. Existing HOI methods rely heavily on large datasets with manual annotations to learn interactions from visual cues. These annotations are labor-intensive to create, prone to inconsistency, and limit scalability to new domains and rare interactions. We argue that recent advances in Vision-Language Models (VLMs) offer untapped potential, particularly in enhancing interaction representation. While prior work has injected such potential and even proposed training-free methods, there remain key gaps. Consequently, we propose a novel training-free HOI detection framework for Dynamic Scoring with enhanced semantics (dysco) that effectively utilizes textual and visual interaction representations within a multimodal registry, enabling robust and nuanced interaction understanding. This registry incorporates a small set of visual cues and uses innovative interaction signatures to improve the semantic alignment of verbs, facilitating effective generalization to rare interactions. Additionally, we propose a unique multi-head attention mechanism that adaptively weights the contributions of the visual and textual features. Experimental results demonstrate that our dysco surpasses training-free state-of-the-art models and is competitive with training-based approaches, particularly excelling in rare interactions. Code is available at https://github.com/francescotonini/dysco
Fluids in paediatric diabetic ketoacidosis: the choice is not solely academic
No full textThe management of paediatric
diabetic ketoacidosis (DKA) requires
meticulous fluid and electrolyte
administration, where established
protocols guide gradual rehydration
and metabolic correction.1,2 While
the academic debate between saline
0·9% and balanced crystalloids like
Ringer’s solution continues, practical
considerations regarding additive
compatibility with Ringer’s solution,
particularly at DKA onset, deserve
specific attention. In paediatric DKA,
aggressive and precise electrolyte
repletion, especially of potassium
and often phosphate, is fundamental
Unveiling the Hidden: Early Manifestations of Extensive Macular Atrophy with Pseudodrusen-like appearance
No full textPurpose: To describe novel microperimetry and imaging findings in two patients affected by extensive macular atrophy with pseudodrusen-like appearance (EMAP) without signs of retinal pigment epithelium (RPE) atrophy. Methods: Case series. Both patients underwent mesopic and dark-adapted two-color scotopic microperimetry, followed by multimodal imaging assessment including ultra-widefield photography, fundus autofluorescence (AF), high-resolution optical coherence tomography (Hi-Res OCT), OCT angiography and high-magnification module (HMM). Results: Albeit normal visual acuity, both patients had a significant reduction of retinal sensitivity - especially under scotopic cyan conditions. One patient had macular pigment abnormalities, while the combination of blue and near-infrared AF modalities highlighted different patterns of pseudodrusen-like lesions.Of notice, Hi-Res OCT revealed a marked separation between the RPE and Bruch's membrane, containing a hyperreflective material with two different reflectivities. OCT angiography excluded the presence of macular neovascularization and documented several choriocapillaris flow voids. HMM images showed severe alteration of photoreceptors' mosaic in the perifovea. Conclusions: Our comprehensive assessment of two stage 1 EMAP patients revealed a predominant damage of perifoveal rods over areas of RPE-Bruch's membrane separation. These findings underscore the importance of basal laminar deposits in the initial stages of EMAP, contributing to a deeper understanding of its underlying mechanisms
Local Reasoning and Attribute-Based Memory Updates for Enforcing Global Invariants in Collective Adaptive Systems
Get PDFWe address the problem of enforcing global invariants, i.e., system-level properties, in Collective Adaptive Systems, such as distributed and decentralized Internet of Things (IoT) solutions. In particular, we propose a novel approach adopting Attribute-based memory Updates (AbU), a calculus modeling declarative, event-driven systems with attribute-based communication.
Our methodology leverages a combination of precise node-level scheduling and local reasoning, with local invariants derived from the system-level property to guarantee. This distributed and decentralized approach promotes efficient enforcing while ensuring desired system-wide behavior, without the need for a central controlling authority
The Routledge Companion to Literatures and Crisis
No full textThe Routledge Companion to Literatures and Crisis provides a deep insight into a complex and multi-layered phenomenon. The third decade of the twenty-first century is being marked by a polycrisis caused by various world crises, such as the COVID-19 pandemic, armed conflicts and climate change leading to economic, geopolitical, environmental, health and security crises.
Featuring 42 chapters, the collection examines crises through literary texts in relation to the environment, finance, migration and diaspora, war, human rights, values and identity, health, politics, terrorism and technology. It illuminates the many faces of the current permacrisis as well as the multifarious crises of the past and their representation in literatures across ages and cultures-from the Viking wars, Black Death in mediaeval Europe, technology in ancient China and the crisis of power in Elizabethan England to imperial biopower in nineteenth-century India, the genocides in the twentieth century, upsurge of domestic violence during the Covid lockdown in Spain and the development of Al.
The Companion connects diverse cultures, disciplines and academic traditions to show how and why literature, media and art can voice all types of crises across times
Update on Mpox Management: Epidemiology, Vaccines and Therapeutics, and Regulatory Changes
No full textMpox, caused by the monkeypox virus (MPXV), is categorized into two primary clades: Clade I and Clade II, with notable outbreaks linked to Clade IIb. Historically endemic in Africa, recent years have seen significant global spread. The World Health Organization (WHO) declared mpox a Public Health Emergency of International Concern in August 2024, highlighting the emergence of Clade Ib outside Africa and the broadening demographic impact of the outbreak. This review updates the current status of mpox vaccines and treatments, including their safety and effectiveness. There are two US Food and Drug Administration (FDA)-approved vaccines for the prevention of mpox disease, JynneosTM and ACAM2000®. The JynneosTM vaccine, recommended for high-risk individuals, has seen limited uptake despite its efficacy in preventing disease. Tecovirimat, while FDA-approved for smallpox and available in the European Union for mpox, has shown mixed results in recent trials, with new data suggesting limited effectiveness in Clade I infections and emergence of new mutations with resistance to this drug. Brincidofovir and Vaccinia Immune Globulin Intravenous offer additional treatment options, particularly for severe cases, although their use is constrained by regulatory and logistical challenges. Furthermore, the WHO recently approved the first commercial molecular assay, the Alinity m MPXV assay by Abbott Molecular Inc., for emergency use-an essential step in expanding testing capacity in regions experiencing mpox outbreaks. These updates underscore the critical need for continued research to enhance therapeutic outcomes and adapt public health strategies. Ensuring equitable access to vaccines, treatments, and diagnostics remains a significant challenge as the global community responds to the evolving mpox situation
Laboratory Testing for ADAMTS13 for Thrombotic Thrombocytopenia Purpura and Beyond
No full textADAMTS13 (a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13), also called von Willebrand factor (VWF) cleaving protease, acts as a moderator of VWF activity. ADAMTS13 cleaves VWF multimers, thereby reducing VWF activity in blood. When ADAMTS13 is absent (e.g., in patients with TTP [thrombotic thrombocytopenia purpura]), accumulation of VWF in plasma can occur, particularly as "ultra-large" VWF multimers, with this leading to adverse outcomes such as thrombosis. Relative ADAMTS13 deficiencies also occur in several other conditions, including secondary thrombotic microangiopathies (TMA), cancer, and with severe infections such as in COVID-19 (coronavirus disease 2019). These situations might therefore be accompanied with relative loss of ADAMTS13, thereby potentially also leading to pathological VWF accumulation, with this then generating a prothrombotic milieu, thus contributing to enhance the risk of thrombosis. Laboratory testing for ADAMTS13 can aid in the diagnosis of such disorders (i.e., TTP, TMA), and help guide their management, with testing now accomplished using various assays. As most presentations of TTP reflect an acquired condition due to anti-ADAMTS13 antibodies, there may also be a need to test for these, as this will also influence clinical management. We herein provide an overview of TTP, note other conditions in which low levels of ADAMTS13 may be present, and then detail laboratory testing for both ADAMTS13 and associated inhibitors
Benign Tumors and Tumor-Like Conditions of Ampulla and Small Intestine: The PathologyOutlines.com Review
No full text: Small intestine and ampulla can be involved in a heterogeneous group of benign tumors and tumor-like diseases, potentially mimicking malignant neoplasms. In-depth knowledge of them is critical for practicing pathologists since they represent potential pitfalls in routine diagnostic activity. Such conditions include the following: (1) Brunner gland lesions, including Brunner gland hyperplasia and hamartoma; (2) polyps, such as adenoma, hyperplastic, hamartomatous, and inflammatory; (3) mesenchymal proliferations encompassing inflammatory fibroid polyp, inflammatory myofibroblastic tumor, leiomyomas, lipomas, and lipomatosis of the ileocecal valve; (4) fibrosis-associated diseases, such as idiopathic retroperitoneal fibrosis, reactive nodular fibrous pseudotumor, and sclerosing peritonitis; (5) disorders of lymphatic vessels, including lymphangiectasia and lymphangiomas; and (6) other rare conditions/miscellanea, such as enteritis cystica profunda, intussusception, ischemia, and pneumatosis cystoides intestinalis. This review, inspired by the content of the PathologyOutlines website (https://www.pathologyoutlines.com), aims to provide a reference point in this complex scenario, summarizing the essential histopathological features of all these entities for better addressing routine practice and differential diagnoses
Enhancing value creation through stakeholder engagement in sustainable mega‐events: The case of Expo 2020 Dubai legacy
Get PDFValue creation by mega-events is still an underdeveloped issue. Through their legacy, mega-events can create long-term value for the local community hosting the event. In determining the importance of practices for increasing value creation, stakeholder en- gagement is growing in defining mega-events features and possible legacies. The study aims to understand how stakeholder engagement can enhance value creation through sustainable events legacy after mega-events. In doing so, the research analyses the practices and the processes of stakeholder engagement adopted by Expo 2020 Dubai. This unique case study presents an extensive range of stakeholder engagement prac- tices that enhanced the value co-creation of a mega-event legacy. Following the three phases of a mega-event development (pre–during–post), the stakeholder engagement tools were adapted to meet accountability needs and stakeholders’ claims
Premovement activity in the corticospinal tract is amplified by the placebo effect: an active inference account
Get PDFThe aim of this study is to investigate whether expectancy, induced through a placebo procedure, favors the activation of the corticospinal tract before movement initiation. By adopting the premovement facilitation paradigm, we applied transcranial magnetic stimulation over the left or right primary motor cortex at rest and 100 ms or 50 ms before movement onset while healthy volunteers performed a reaction time (RT) motor task consisting of abductions of the right or left thumb after a go signal. Participants in the placebo group received an inert electrical device applied on the right forearm along with information on its speed-enhancing properties. A control group received the same device with overt information about its inert nature, while another control group underwent no intervention. Along with RT, we measured the amplitude of the motor evoked potential (MEP) before and after the procedure. Compared to the control groups, the placebo group had faster RT and greater MEP amplitude before movement initiation. This study demonstrates that the placebo effect can boost the activity of the corticospinal tract before movement onset, and this modulation positively impacts motor performance. These results give experimental support to the active inference account