University of Verona
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MedPop Corpus (1500-2025)
No full textThe corpus comprises English texts aimed at disseminating and popularizing knowledge related to health and well-being from the Early Modern period to the present day (1500-2025) and is organized into six subcorpora, one for each century. It was compiled to trace the development of medical popularization, from early printed books addressed to a non-specialist readership to articles in contemporary popular science magazines, and to investigate the pragma-linguistic and discursive strategies employed by experts when addressing the wider public
Disabilità: dare forma al Progetto di vita con il supporto dell’intelligenza artificiale
No full textQuanto previsto dal decreto legislativo 62/2024 costituisce una svolta non
solo giuridica ma anche culturale. Luciano Pasqualotto e Angelo Lascioli
dell’Università di Verona analizzano l’importanza del Progetto di Vita e
riflettono su come la AI possa supportare i servizi coinvolti nella sua
elaborazione, contribuendo a dare forma ai contenuti e a rafforzare la
coerenza e la qualità delle decision
New Hybrid Nanocomposite Films for Optical Diagnostics and Optical Temperature Sensing: Synergy Among α‐Synuclein, Gold and Upconverting Nanoparticles
No full textThe propensity of the unstructured protein alpha-synuclein to undergo a conformational transition to fibrillar aggregates was harnessed to prepare an upconverting organic-inorganic hybrid film composed of Au nanoparticles (NPs) and Yb3+, Er3+-activated CaF2 NPs, with alpha-synuclein serving as a structural linker. The 2D nanomaterial appears as a quasi-monolayer film, composed of distributed AuNPs and tightly packed CaF2:Yb,Er NPs. The film shows excellent upconversion emission arising from the Er3+ ions following excitation of the Yb3+ ions under 980 nm laser radiation. Optical thermometry investigations were conducted in various media (air, H2O, and D2O) to assess the performance of the film as an optical nanothermometer. The thermometric calibration curves obtained within the physiological temperature range (25-60 degrees C) support its potential application in 2D optical nanothermometry. By evaluating the energy gap between the two thermalized levels and calibrating the upconversion at one temperature, the nanocomposite film was found to perform reliably as a primary thermometer. Furthermore, image-based optical thermometry has demonstrated that upconversion emission can be successfully employed for local temperature estimation, thereby enabling image-based 2D optical thermometry with micrometer-scale spatial resolution
Newly defined clinical obesity versus body mass index-defined obesity: Differential risks of overall death and adverse events in a population-based cohort
No full textAims: To compare the prognostic implications of the newly proposed clinical obesity classification against traditional body mass index (BMI)-defined obesity in a population-based cohort. Materials and Methods: Using UK Biobank, we compared the impact of newly defined obesity, including clinical obesity (obesity status with obesity-related comorbidities) and pre-clinical obesity (obesity status with preserved organ function), with traditional BMI-defined obesity on death, cardiovascular disease (CVD), chronic kidney disease (CKD), and liver-related events (LREs). To further delineate heterogeneity within the clinical obesity group, we performed stratified analyses based on comorbidity burden (number of comorbidities), severity of adiposity, and presence of diabetes or hypertension. Results: A total of 502 129 participants were enrolled. About 375 585 (74.8%) had non-obesity, 126 544 (25.2%) had BMI-defined obesity (including 93 410 [73.8%] with clinical obesity and 13 875 [11.0%] with pre-clinical obesity). During a median follow-up of 15.8 years, clinical obesity was associated with significantly higher risks of death (HR = 1.097, 95% CI: 1.071-1.125, p < 0.001), LRE (HR = 1.103, 95% CI: 1.040-1.169, p < 0.001), CVD (HR = 1.118, 95% CI: 1.091-1.146, p < 0.001), and CKD (HR = 1.111, 95% CI: 1.081-1.141, p < 0.001) compared to BMI-based obesity. Conversely, pre-clinical obesity showed significantly lower risks across these outcomes. High-risk clinical obesity subgroups with multiple comorbidities or severe adiposity showed particularly increased risks. Conclusion: The clinical obesity classification helps to define a high-risk phenotype with substantially increased risks of mortality and major comorbidities, while pre-clinical obesity defines a distinct subgroup with more favourable outcomes
Editorial Compilation-Part XVIII
No full textWelcome to the latest issue of “Seminars in Thrombosis and Hemostasis (STH)” published under the “banner” of “Editorial Compilation,” this being the 18th such issue. Historically, “STH” is a theme-driven publication; however, ongoing opportunities emerge to disseminate wide-ranging contributions of current interest or controversy, which do not directly suit an ongoing themed issue. We also require a medium to enable publication of peer-reviewed “unsolicited” manuscripts if accepted, as well as contributions from our Eberhard F. Mammen Young Investigator Award winners for previous Editorials related to the Eberhard F. Mammen awards). As is now standard for this compilation series, this study contains a mixture of articles that comprise the above elements, as well as broadly fitting within the standard themes of “thrombosis” and “bleeding.
Clinical outcomes and economic impact of a digital telemedicine intervention in patients with functional motor disorders: a single-blind, randomised controlled trial
Full text linkBackground Functional motor disorders (FMD) cause long-term disability and economic burden. There is a need for multidisciplinary interventions to manage both motor and non-motor symptoms. We aim to evaluate the clinical and economic effects of integrating digital telemedicine into multidisciplinary FMD management.Methods This single-blind, randomised controlled trial involved patients with FMD. They were randomly assigned to receive 5-day multidisciplinary rehabilitation with either a digital telemedicine or a standard care programme. The digital telemedicine group received remote management and wearable sensors. A blinded evaluator assessed primary and secondary outcomes at baseline, post-treatment, 12-week and 24-week follow-ups. The primary outcomes were changes in motor symptoms. The secondary outcomes were changes in non-motor symptoms, quality of life (QoL) and mobility in unsupervised settings. The incremental cost-effectiveness ratio (ICER) and quality-adjusted life years (QALYs) were calculated at 24 weeks.Results Of the total of 62 patients, half made up the digital telemedicine group (n=31, 40.82% female, mean age 42.55 +/- 12.65 years) and half the standard care group (n=31, 59.18% female, mean age 43.77 +/- 14.44 years). The mental QoL score for the standard care group was lower (p=0.045) and declined compared with the digital telemedicine group (p=0.034), with lower scores at follow-up (p=0.03). At 24 weeks, the ICER (5503/QALY) showed that digital telemedicine, despite higher initial costs, yielded 0.037 additional QALYs and reduced healthcare use during follow-up.Conclusions Despite similar improvements in motor symptoms in both groups, digital telemedicine offers an effective adjunct to maintain mental health QoL and reduces healthcare costs in the long-term management of FMD.Trial registration number ClinicalTrials.gov ID: NCT05345340
Ignoring distractors takes its (memory) toll
Full text linkEffective attentional selection requires filtering task-irrelevant stimuli. We examined the cognitive cost of such filtering using an object-based attention paradigm across four experiments (N = 320). Participants discriminated the orientation of a Gabor patch presented either alone or overlapped with an irrelevant object or scrambled stimulus. The filtering cost was measured as an increase in response times on distractor-absent trials embedded in 'mixed' blocks (with interleaved distractor-present trials) compared to 'pure' distractor-absent blocks. The filtering cost was robust and scaled with distractor probability and with the presence of one, two or four possible distractors occurring within the session. The cost disappeared when eight distractors were interleaved randomly, but re-emerged when the same eight distractors were presented orderly, one in each sequential mini-block, indicating a strategy shift once working-memory capacity is exceeded. The cost correlated negatively with interference on distractor-present trials and was unaffected by distractor semantic content, consistent with the active maintenance in working memory of distractor templates
Histone deacetylases in Duchenne muscular dystrophy: a role in the mechanism of disease and a target for inhibition
Full text linkAberrant activity of histone deacetylases (HDACs) is a pathological phenomenon in several diseases, including Duchenne muscular dystrophy (DMD). In DMD, the upregulation of HDACs is driven by the disassembly of the dystrophin-associated protein complex (DAPC), which, under normal physiological conditions, provides mechanical stability to muscle fibres and acts as a signalling hub anchoring signalling proteins and molecules to their functional sites. In dystrophic muscle, DAPC disassembly causes delocalisation of signalling proteins and, therefore, disrupts signalling pathways. Displacement of epigenetic signalling molecules leads to the uncontrolled activity of HDACs and excessive removal of acetyl groups from histone proteins. Consequently, chromatin becomes tightly bound, preventing the expression of genes involved in muscle homeostasis. The pathological consequences of increased HDAC activity extend beyond muscle fibres, affecting several cell types, translating into a chronically activated immune system, promoting fibrotic and adipose tissue formation and impairing muscle regeneration. Here, we review the current evidence implicating HDACs as a key driver in DMD disease development and progression. We describe the mechanism of HDAC overactivity and the downstream consequences that contribute to the pathogenesis of the disease by disrupting muscle repair and regeneration. Finally, we highlight HDACs as targets for inhibition, offering a novel therapeutic strategy to counteract the multiple pathological events in DMD
Fostering Social Connection Responsibility in Value Creation: Lessons From the Assessment of a Local Participatory Guarantee System
No full textThis paper builds on the call for further research on stakeholder engagement as a relational and contextual process for value creation by examining a Participatory Guarantee System for organic agriculture in Lombardy (Italy). It emphasises that value creation is a collaborative effort within a stakeholder network, requiring the shared and ongoing responsibility of all actors beyond their specific interests. To explore how such shared responsibility unfolds, data collected through participant observation are analysed using Iris Marion Young's social connection responsibility approach. Specifically, the study investigates factors shaping stakeholder relationships, focusing on four parameters: power, privilege, interest and collective ability. Findings reveal that while the project aimed to foster a sustainable agricultural system, differing stakeholder positions complicate the engagement process, highlighting contradictions between collective goals and individual decisions. Power dynamics and privileges significantly shape stakeholder involvement, affecting motivations and commitment. Additionally, the analysis illustrates tensions between stakeholders' economic roles and their contributions to a shared purpose, revealing how functional or self-interested logics can overshadow relational goals. Theoretically, the study extends stakeholder theory by empirically applying Young's social connection model, demonstrating how power, privilege and interest operate both within and across stakeholder groups, shaping responsibility and collective value creation. Practically, it offers insights for designing and managing multi-stakeholder initiatives through inclusive, deliberative processes that balance power asymmetries, strengthen mutual understanding and sustain engagement across diverse contexts and settings. Indeed, the study underscores the importance of contexts and places in fostering effective engagement and responsibility
La "terra" e il "mare" del Delta del Po tra tutela dell'ambiente e sviluppo economico
No full textIl territorio del Delta del Po, a cavallo tra le regioni Veneto ed Emilia-Romagna, costituisce un unicum nel panorama italiano. In questa zona, da secoli terreno di scontro tra uomo e natura, si fronteggiano oggi con particolare forza l'istanza di protezione ambientale e quella di sfruttamento economico del territorio.
Nel contributo, si vuole offrire una panoramica di alcuni degli strumenti – normativi e amministrativi – che l’ordinamento usa per conciliare la tutela del territorio del Delta del Po e il suo utilizzo economico, attraverso il paradigma dello sviluppo sostenibile.
A tal fine, vengono presi in considerazione tre profili: quello della tutela delle zone umide di importanza internazionale ai sensi della Convenzione di Ramsar, quello della tutela della biodiversità relativo alle direttive “Uccelli” e “Habitat” e quello della valorizzazione del territorio deltizio attraverso il Programma MAB UNESC