Ardabil University of Medical Sciences
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Value of Enhancer of Zeste Homolog 2 (EZH2) for Determining Prognosis in Colon Cancer
Get PDFIntroduction: It has been reported that Enhancer of Zeste Homolog 2 (EZH2) enhancer is expressed in Colorectal Cancer (CRC), but there are only limited findings of its overexpression with prognosis in CRC.Aim: To investigate the association between EZH2 expression and clinicopathologic variables and outcome in CRC.Materials and Methods: This retrospective study retrieved the archived histological samples for immunohistochemistry evaluation of EZH2 and PCR analysis of KRAS from patients with CRC who were followed-up between April 2009 and February 2019. Kaplan-Meier methods were used for Overall Survival (OS) and Disease-Free Survival (DFS). Cox proportional hazard model and time dependent Cox model were used to evaluating association of clinicopathologic factors with OS and DFS.Results: Hundred patients with CRC were included with mean age and range 57.39±13.52 years and 21-83 years. There wereno significant association between OS (log-rank p-value=0.50) and DFS (log-rank p-value=0.74) with EZH2 expression. Third quartile of OS was 30.7 days and for DFS was 107.83 days.According to the result of multivariate cox regression after adjusting for confounding variables, there was no significant association between EZH2 and OS (HR =1.53, 95% CI=0.63-3.72, p=0.35). Also, a borderline association was observed between EZH2 and DFS (HR=11.08, 95% CI=1.02-119.72, p=0.05). There were no significant associations between the DFS, OS and other clinicopathologic parameters except for the stage, respectively (HR=3.51, 95% CI=1.71-7.20, p=0.001) (HR=3.55, 95% CI=1.71-7.35, p=0.001).Conclusion: The expression of EZH2 in patients with CRC was not associated with clinical features, and does not appear to be associated with OS or DFS. EZH2 is an attractive target in cancer and much more research is clearly warrante
Frequency of Zygomatic Fractures Causes investigation in Patients Referring to Iran Northwest Trauma Hospitals in 2017-18.
Get PDFBackground & Objective: Facial trauma occurs mainly in adults in connection with motor vehicle accidents, although strife is also responsible for some injuries. Occasionally, falls and collisions can lead to these fractures, and there are other mechanisms that are rare. The aim of the present study was to determine the prevalence of bone fractures in patients referred to northwestern Iran traumatic hospitals during the period of 2017-18 years.
Methods: This descriptive and prospective study was performed on the records of four patients with read-only fracture who referred to Northwestern Iran trauma hospitals during 2017-18. The purpose of this study was to determine the prevalence and causes of trauma related to occupation, sex, age, and injury toxicity, type of treatment, and duration of trauma to surgery. Information includes information on the practitioner's history, time of fracture, age and gender, cause of fracture, side of fracture, place of residence and occupation of the individual.
Results: The mean age of the patients was 34.10±13.22 years with a mean age of 31 years, 85% were male and 15% were female. In terms of age group, the most frequent was in the age group of 21 to 30 years with frequency of 73 cases (36.5%). In the study of employment status of the studied patients, the highest frequency belonged to the worker and then to the farmer with the frequency of 24 (12%) and 23 (11.5%) respectively. Frequency of housework in women was equal to 23 cases (11.5%). In the study of frequency of living in the studied patients, the highest frequency was related to Tabriz city 39 cases (19.5%) and then Maragheh 18 cases (9%). In the studied patients, the most frequent cause of fracture of the species was related to motor vehicle accident with a frequency of 113 cases (56.5%). The most common type of treatment is open reduction & rigid fixation with a frequency of 178 (89%).
Conclusion: Frequency of species fracture was more prevalent in patients referred to trauma centers in northwest of Iran. By the age of 21-30 years, it is the most common age and the leading cause of motor vehicle accident is fracture. The most common site of fracture was the left cheek, which appears to be the result of accidents caused by deviations of the driving lane on the opposite lane as well as the presence of doors and glass on the left
Evaluation of Cytotoxic Potentials of Novel Cyclooxygenase-2 Inhibitor Against ALL Lymphocytes and Normal Lymphocytes and Its Anticancer Effect Through Mitochondrial Pathway
No full textIn the present study, we searched selective cytotoxicity and mitochondria mediated apoptosis of novel COX-2 inhibitor 2-(4-(Methylsulfonyl)phenyl)imidazo[1,2-a] pyridine-8-carboxylic acid on B-lymphocytes and their mitochondria isolated from normal subjects and ALL patients’ blood. Our results showed this compound can selectively induce cellular and mitochondrial toxicity on ALL B-lymphocytes and mitochondria without any toxic effects on normal B-lymphocytes and their mitochondria. Taken together, the results of this study suggest that cancerous mitochondria are a potential target for the ALL B-lymphocytes. Selective toxicity of COX-2 inhibitor in cancerous mitochondria could be an attractive therapeutic option for the effective clinical management of therapy-resistant ALL
Outcome of FOLFOX and Modified DCF Chemotherapy Regimen in Patients with Advanced Gastric Adenocarcinoma
Get PDFObjectives: Chemotherapy is used as an indispensable therapy for advanced gastric cancer. Different chemotherapy regimens have been used for this purpose. Toxicity due to the Chemotherapy drugs is one limiting factor. In this study we aim to compare the efficacy and toxicity of two regimens FOLFOX (leucoverin, 5-fluorouracil and oxaliplatin) and modified DCF (mDCF) (docetaxel, cisplatin, and 5-fluorouracil) in patients with advanced gastric adenocarcinoma. Methods: In this analytical cross-sectional study, 47 patients treated with FOLFOX regimen and 57 patients treated with mDCF regimen were recruited, Patients in both groups were compared for demographic findings, response rate, mortality rate, overall survival (OS) and progression free survival (PFS). Results: In FOLFOX and mDCF group, complete response (CR) occurred in 4.3% and 5.3%, partial response (PR) in 42.6% and 29.8%, stable disease in 34% and 52.6% and disease progression in 19.1% and 12.3%, respectively (p=0.25). Overall response rate was 48.9% and 56.1%, respectively. There was no significant difference between two regimens in OS and PFS (p=0.22). mDCF compared to FOLFOX had significantly higher hematologic, gastrointestinal complications, as well as creatinine rise, stomatitis and hair loss, but peripheral neuropathy was significantly lower. Conclusion: The results of current study showed that in patients with advanced gastric adenocarcinoma, FOLFOX regimen compared to mDCF regimen have similar ORR, OS and PFS. Toxicity rate are also lower in FOLFOX group, thus it seems a better regimen for chemotherapy
Relationship Between Medical Leaves Due to Musculoskeletal Disorders and Physical Activity Level in Workers at Cement Industry-Iran 2019
Get PDFIntroduction: Musculoskeletal disorders are the most common debilitating causes in workers and the main reason for medical leaves. Medial leave brings health, social, and economic consequences for individuals and society. The relationship between medical leaves due to pain and discomfort in different parts of the body and physical activity level at work, practice of sport, and leisure time in workers in cement industry in 2019 was examined. Methods: A descriptive-analytical study was conducted on 150 workers of a cement factory. The participants were selected randomly. Data gathering tools were demographics form, Nordic Musculoskeletal Questionnaire, and Baecke Physical Activity Questionnaire and the collected data was analyzed using SPSS (v.22). Results: The participants noted that the main painful areas over the past year were the waist, knee, ankle, and neck. There was a significant relationship between medical leave due to pain in the neck and overtime work. There was a significant relationship between the type of work activity and medical leave due to a pain in knee and ankle. Conclusion: The workers who used such medical leaves had a higher PAL at work. PAL at work increased the requests of medical leaves due to the pain in knee and waist. The PAL at sport practice decreased the rate of request for medical leave due to a pain in the Waist and Knee
Evaluation of Socioeconomic factors in patients with gastric cancer from march 2017 to march 2018
Get PDFBackground: Studies have found an inverse relationship between socioeconomic status and and stomach cancer. This association is stronger in cardia type cancers.
Aim: Evaluation of socioeconomic status of stomach cancer patients in Ardabil State.
Materials and methods: Our study population is all patients with gastric cancer living in Ardabil province And referring to the internal medicine and gastrointestinal clinics of Imam Khomeini Hospital It was also registered in the Digestive and Liver Research Center of Ardabil University of Medical Sciences in 2017. The instrument used was a checklist based on the objectives of the study Checklists included age, sex, education, marital status, smoking, occupation, household income, and housing ownership to collect information.
Results: The highest level of income mentioned (43.5%) among patients was one to two million tomans last month.75% of the patients were illiterate. Only 50% of sufferers had an income (employed or retired).Most patients were married (83.5%). The average smoking between them was 13.73 packs per year.The most common age of patients was 60-70 years, 70-80 years and more than 80 years, respectively.95.6% of the patients were homeowners
Conclusion: Low socioeconomic status is associated with a risk of stomach cancer
Identification of Health, Safety and Environment Aspects in Cement Factory using AHP and FMEA Techniques
Get PDFBackground and Purpose: Cement production processes are associated with different hazards, such as
health and safety hazards and environmental pollution. The current study was conducted to evaluate and
determine the safety, health, and environmental risks of using FMEA and AHP techniques in the cement
factories while providing certain suggestions for controlling them.
Materials and Methods: The study was conducted as a case in one cement factory in 2019. The checklists
for FMEA and AHP techniques were filled out by the evaluation team. The risks were identified and
prioritized. Controlled approaches were suggested for the identified risks.
Results: In this study, 101 risk cases were evaluated and categorized in various units of the factory, such
as manufacturing and service units. The results of FMEA technique showed that crushing, crushing
monitoring, milling, filtration, and pre-heater sections had the highest degree of health and safety risks. The
results of AHP technique also showed that the environmental pollution caused by the removal of electro
filter from the circuit, electro fan burning caused by over current, the failure of the equipment and process,
and the defect in the filtration system were all prioritized.
Conclusion: Through taking technical-engineering measures, adopting comprehensive HSE management
solutions, such as changes in the work process, making replacements in parts and used machinery, installing
recyclable systems, repairing and maintaining the system of air pollution protection, installing a warning
and responsive system, mechanizing activities, shielding, implementing instructions and regular curriculum
can greatly reduce the risk level
Evaluation of indications and results of CT-scan and comparison of the findings of CT-scan and CXR in imam khomeyni hospital of Ardebil in 1397
Get PDFBackground: Computed Tomography scan is an effective imaging method in the diagnosis of lung diseases, but due to its disadvantages, especially the high dose of radiation emitted, it should be performed according to the indication. Therefore, the aim of this study was to evaluate the indications and results of lung CT scan and compare it with chest radiographic findings of hospitalized patients with pulmonary symptoms.
Aim:Due to the harmful effecs of CT scan of the lung,it should be performed only in high-risk and symptomatic patients and taking into account clinical indications.
Materials and Methods: This study was performed on 351 patients with pulmonary symptoms. After recording demographic information, indication based on ACR was also recorded. Chi-square and Fisher tests were used to compare data.
Results: The findings of our study showed that the indication for CT scan in patients with pulmonary symptoms was necessary in 66.4%, but in 14.8% it was probably necessary and in 18.8% it was unnecessary. Also, the findings of our study showed that abnormal cases of radiography and CT scan of the lungs were significantly higher at older ages, but there was no significant difference in other variables including gender, place of residence, symptoms and hospitalization. Between CT and radiography is good. Regarding the observance of the indication, it was found that there is no relationship between the observance of the indication and the variables of age, gender, place of residence, symptoms and hospital ward.
Conclusion: Due to the high percentage of unnecessary cases of CT scan in patients with lung problems, training of medical personnel on the indications for CT scan of the lungs seems necessary to reduce the frequency of unnecessary CTs in patients to reduce its harm.
Evaluation of serum levels of sirtuin-1 in lung cancer
Get PDFBackground: Sirtuin-1 is a protein from the family of sirtuins that has been implicated in inflammaging and oxidative stress in cancer patients.
Aim: The aim of this study was to investigate the serum level of Sirtuin-1 and its relation with quality of life in lung cancer.
Methods & material: Sirtuin-1 levels were measured in 30 male with lung cancer and 50 healthy men. The two groups were matched for age. The difference between the serum levels of Sirtuin-1 between the two groups and its relationship with other clinical parameters were evaluated. Data were analyzed by independent T-test and Spearman correlation and P <0.05 was considered as significant.
Results: Sirtuin-1 levels were significantly lower in the patient group in comparison with healthy group (P <0.001). There was also a significant relationship between serum level of Sirtuin-1 and quality of life according to Karnofsky scale (P = 0.001 r = 0.558), arterial oxygen saturation (P = 0.009 r = 0.470) and smoking history (P=0.003 r = - 0.330). Also, the serum levels of Sirtuin-1 were significantly lower in adenocarcinoma than that in squamous cell carcinoma or small cell lung cancer (p = 0.001).
Conclusion: In this study, serum levels of sirtuin-1 were lower in patients with lung cancer. In addition, there was a correlation between serum levels of sirtuin-1 and patients' quality of life (according to Karnofsky scale), hypoxia and smoking history. Therefore, decreased serum sirtuin-1 levels in lung cancer reflect the cell aging process and correlate with poor quality of life