Ardabil University of Medical Sciences
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The Relationship between Telomerization Activity and Pathological Information with Breast Cancer Predisposing Factors in Ardabil in 2017
Get PDFBackground and Objective: Due to the high incidence and importance of breast concer in world and the increasing importance and concern about it, as well as the probable association between physical activity and predisposing nutritional and behavioral factors in the incidence and incidence of this study, The association of breast and pathologic information and telomerase activity with these predisposing factors for cancer has been addressed.
Methods: The study population included 20 people who had been diagnosed with breast cancer and underwent total mastectomy in Imam Khomeini Hospital and Fatemi Hospital in Ardebil. Patients filled out questionnaires containing demographic information such as age, gender, height, weight, place of residence, history of smoking, nutritional habits, educational level and history of family diseases, physical activity, radiation therapy, and so on. Patient samples were removed from the tumor tissue at least one g by the surgeon and transferred to sterile tubes and stored until use. Then, the samples were examined for telomerization activity and pathological tests. Finally, the relationship between telomerization activity and pathologic information with predisposing factors (individual characteristics) for breast cancer was analyzed by SPSS software.
Results: This study has 20 samples. patient was studied after chemotherapy and this is one of the deface factor that affect on results. Significant relation between breast cancer risk factor and thelomerase activity not found. But because the p-value of stage and grade and using beans near to p=0/05, we can continue our study with excelsior samples to find these relation.
Conclusion: At the end of our study, significant relation between breast cancer risk factor and thelomerase activity not found
The compatibility of the new undergraduate nursing curriculum with occupational needs from the viewpoint of the faculty members of some north and north-west Universities of Medical Sciences of Iran
Get PDFBackground: Nursing education is part of the higher education system that deals with human life and considering its quantitative and qualitative aspects is very important. Understanding educational needs is a prerequisite for successful education. This study is aims is to investigate the compatibility of nursing undergraduate curriculum with occupational needs from the viewpoints of faculty members of some north and north-west universities of medical sciences of Iran.
Methods: This is a cross-sectional descriptive study conducted with the participation of 61 nursing faculty members of Ardebil, Urmia, Zanjan, Tabriz, and Rasht Universities of Medical Sciences in the fall of 2017 using the census method. A checklist containing the curriculum of undergraduate nursing based on the approved headings of the Ministry of Health and Medical Education was used. Data were analyzed by SPSS software.
Results: The findings of this study showed that the highest compatibly with job requirements from the viewpoint of faculty members based on the checklist scores from 1 to 4 was related to biochemistry with a mean and standard deviation of 2.1 ± 1.03, among specific courses, epidemiology with mean and standard deviation of 1.90 ± 0.99, and among internship and field apprenticeship, adult and elderly internships with mean and standard deviation of 1.51 ± 0.03.
Conclusion: The findings of this study indicate that the curriculum developed for the undergraduate nursing degree is not suitable for nursing job requirements and needs modifications in some aspects. Therefore, presenting the results of this study can be used developing and modification of the undergraduate nursing curriculum based on occupational need
Survey The Effectiveness of Education on fall care behaviors of the elderly in Ardabil health centers, 2017-2018
Get PDFBackground and purpose: Falling is a serious problem in the elderly community, which is a result of the interaction of several risk factors such as biological, behavioral, environmental, socioeconomic factors and with many complications. The purpose of this study was to determine the effect of education on fall care behaviors among the elderly referred to health centers in Ardabil city.
Methods: This double-blind randomized clinical trial study was carried out among 110 elderly Referred to Health Centers of Ardabil City. Participants were selected by multi-stage random sampling according to Inclusion criteria and divided into intervention and control groups by random allocation. ¬¬¬The data collection tools consisted of demographic questionnaire, Abbreviated Mental Test Score (AMTS), Mini–Mental State Examination (MMSE), Fall Efficacy Scale International (FES-I) and Falls Behavioural (FaB) Scale. Data were analyzed using the descriptive and analytic statistics (Chi-Square, Independent-Samples T Test, One-way ANOVA and Repeated Measures) in SPSS v.22.
Results: The mean and standard deviation of fall care behaviors in the elderly of the intervention and control groups before intervention 64.01±11.06 and 65.12±9.30 respectively. The results of re-evaluation after 1 and 3 months of intervention in the elderly of the intervention group showed that the mean and standard deviation of the fall care behaviors increased (77.28±11.91 and 91.67±8.61 respectively), which was statistically significant (P = 0.001). Also the results of re-evaluation in the elderly of the intervention group showed that the mean and standard deviation of the fear of falling decreased, which was statistically significant (P = 0.001).
Conclusion: The results showed that education of fall care behaviors increases elderly's performance in preventing falling and also decreases the fear of falling, therefore, it is suggested that promotion of awareness and practice of elderly people in their self-care program should be considered
In vitro shear bond strength of luting agents to polyetheretherketone core materials
Get PDFBackground: PEEK has superior mechanical strength, heat resistance, chemical resistance and can be easily used. PEEK can also be used as an alternative rigid material in partial dentures and fixed dental prostheses. The adhesion between luting materials and materials used in crowns and fixed dental prostheses is an indispensable property of dental restorative materials. Currently, there is no established protocol for cemention of crowns and fixed dental prostheses using PEEK. To the best of our knowledge, the bond strengths between PEEK and the luting materials used in this study has not previously been evaluated.
Objectives: The purpose of this study was to evaluate the bond strength of polyetheretherketone (PEEK) to luting material.
Materials and Methods: Prepolymerized resin composite cylinders (3.5 mm internal diameter, n=45) were bonded to the pretreated surfaces of polyetheretherketone. The cementing agents tested were zinc-phosphate cement (Richer & Hoffmann,Berlin, Germany), resin cements (Panavia V, Panavia F). After bonding, all specimens were stored in distilled water at 37ċ for 24 hours and then thermal cycled 1000 times between 5ċ and 55ċ prior to testing. Bond strength was measured with a shear test, and failure modes were assessed by VMN machine )Easson,China(.
Statistical analysis was performed by SPSS software and one-way ANOVA.
Results: The highest bond strength was observed in panavia F2 (10.84 ± 6.05) and zinc phosphate (10.50 ± 2.88) the lowest bond strength was observed in panavia V5 (4.02 ± 2.87 ) and there was no statistically significant difference between shear bond strength of panavia F2 and zinc phosphate. (p=1) But There was a statistically significance difference between panavia F2 and panavia V5 ( p=0.001) and zinc phosphate and panavia V5( p<0.001). Among PEEK groups, all failure mode was adhesive failure between the material and the luting material.
Conclusion: According to the results of this study, Panavia F2 cement is recommended due to the highest shear bond strength for cementing PEEK surface
Searching for new cytotoxic agents based on chromen-4-one and chromane-2,4-dione scaffolds
Get PDFCancer is a major cause of death worldwide and novel anticancer agents for its better management are much needed. Benzopyrone-based compounds, such as chromones, possess several distinctive chemical and biological properties, of which the cytotoxicity against cancer cells seems to be prominent. In this study, two series of compounds based on chromen-4-one (3-10) and chromane-2,4-dione (11-18) scaffolds were synthesized in moderate/high yields and evaluated for cytotoxicity against HL-60, MOLT-4, and MCF-7 cancer cells using MTT assay. In general, the compounds exhibited moderate cytotoxic effects against the cancer cell lines, among which, a superior potency could be observed against MOLT-4 cells. Chroman-2,4-dione (11-18) derivatives had overall higher potencies compared to their chromen-4-one (3-10) counterparts. Compound 13 displayed the lowest IC50 values against HL-60 (IC50, 42.0 ± 2.7 µM) and MOLT-4 cell lines (IC50, 24.4 ± 2.6 µM), while derivative 11 showed the highest activity against MCF-7 cells (IC50, 68.4 ± 3.9 µM). In conclusion, this study provides important information on the cytotoxic effects of chromone derivatives. Benzochroman-2,4-dione has been identified as a promising scaffold, which its potency can be modulated by tailored synthesis with the aim of finding novel and dissimilar anticancer compounds
The effect of glutamine supplementation on serum levels of leptin, IL-6 and OX-LDL after exhaustive exercise in young males
Get PDFBackground and Objective: Glutamine is one of the nutritional supplement that has anti-inflammatory and antioxidant effects and is also the most abundant amino acid found in plasma and skeletal muscles. Consuming of glutamine supplement may be beneficial to athletes due to its anti-inflammatory and antioxidant effects. Therefore, the present study aimed to investigate the effect of glutamine supplementation on serum levels of Leptin, OX-LDL and IL-6 after exhaustive exercise in young male.
Methods: In this experimental study, 30 healthy male people were randomly selected into two groups, 15 in intervention group and 15 in control group. The intervention group received 0.3 g of glutamine per kg of body weight per day, with 25 g of sugar in 250 cc water and control group received 25 g of sugar per 250 cc water for 14 days. At the beginning and also at the end of the second week of the study the fasting blood sample was taken. On the 15th day, all participants performed an exhaustive exercise, and then once again immediately blood samples were taken for measuring the serum levels of total antioxidant capacity (TAC), leptin, IL-6 and OX-LDL after an exhaustive exercise. Paired and unpaired t-test were used for analyzing data.
Results: The mean of Leptin serum levels after consuming of glutamine in two weeks in intervention group was statistically less than control group (P<0.05). But reduction of the mean of IL-6, OX-LDL and enhancement of the serum levels of total antioxidant capacity was not significant in intervention group compared with control group. However, after exhaustive exercise, reduction of the mean of serum levels of leptin, IL-6 and OX-LDL, and enhancement of total antioxidant capacity in intervention group was statistically significant in comparison to control group (P<0.05).
Conclusion: The results of the study indicated that the glutamine supplementation for two weeks with an increase in serum total antioxidant capacity and reduction in serum levels of leptin, IL-6 and OX-LDL may be considered as an important indicator of anti-inflammatory and anti-oxidative effects of glutamine that may play an important role on the health of people. However, the glutamine supplementation may prevent harmful effects of exhaustive exercise by controlling inflammatory factors and oxidative damages in healthy male people
Design, synthesis and evaluation of cytotoxic, antimicrobial, and anti-HIV-1 activities of new 1,2,3,4-tetrahydropyrimidine derivatives
Get PDFA series of new 1,2,3,4-tetrahydropyrimidine (THPM) derivatives were designed and synthesized within a one-pot three component Biginelli reaction. The structures of compounds were characterized by FT-IR, 1H-NMR, mass spectroscopy, and elemental analysis. All synthesized derivatives were screened for their cytotoxic, antimicrobial, and anti-HIV activities. Due to significant cytotoxic and antimicrobial effects of 1,2,3,4-THPM scaffold, in this study, cytotoxic and antimicrobial activities of synthesized derivatives were evaluated on two cell lines and four bacterial strains. Compounds 4e and 4k showed highest cytotoxic activity against HeLa and MCF-7 cell lines. In addition, 4c and 4d were most active against MCF-7 and HeLa cell lines, respectively. Among the compounds, 4e revealed high antimicrobial activity against four strains. According to the results, 4e possessing m-bromophenyl group at C-4 position of THPM exhibited the highest cytotoxic and antimicrobial effects. Also, all the newly synthesized compounds were evaluated for their anti-HIV-1 assay. Compounds 4l and 4a indicated remarkable anti-HIV-1 activity. It is concluded from cytotoxic, antimicrobial, and anti-HIV-1 activities that the 1,2,3,4-tertahydropyrimidines may serve as hit compounds for development of new anticancer small-molecules
Dimensional Stability of Casts Derived from Three Types of Alginate at Different Times After Impression
Get PDFObjective:To evaluate the dimensional changes in three types of alginate following three different delay times after casting. Material and Methods:In this laboratory study, a maxillary arch-shaped stainless steel model was prepared and three pins with similar and determined diameters and heights were placed (one at mid-line and two on the underside of the model) as reference points to compare the dimensional stability of the three types of alginates. A special metal tray was made from the main model. The main moldel was imprisoned by the metal tray, and these were kept for a specific time in a humid environment. Gypsum Type 4 was poured over the impression to obtain 90 gypsum casts for three types of alginate. The dimensions of casts obtained from each alginate were compared in two lateral and anterior-posterior dimensions, they were compared with each other, and the alginates were also compared to the main model. Results:At a time interval of 15 minutes, the dimensional accuracy of the casts obtained from the three types of alginates, with the main model in both anterior-posterior and transverse dimensions was not significantly different (p<0.05); but there was a significant difference at 60 minutes and 24 hours in both dimensions (p<0.05). Although there was no significant difference between the alginates in both dimensions and all three studied time periods, the least difference with the main model was related to Zhermack and the highest difference was related to Golchai alginates. Pairwise comparisons showed that none of the samples had a significant difference in terms of dimensions. Conclusion:The dimensional stability of alginate was a time-dependent type of alginate and had no significant effect on the dimensional accuracy of casts
Investigating the Psychometric Properties of the Persian Version of Prodromal symptomsscreening scale (PS-SS
Get PDFBackground: Prodromal symptoms-screening scale (PS-SS) is used for screening people at risk of acute coronary syndrome (ACS) by examining the prodromal cardiac symptoms.
Purpose: This study was conducted to investigate the psychometric properties of PS-SS in patients with ACS in Iran. Method: In this psychometric evaluation, PS-SS was translated into Persian, and the final version was completed by 196 patients with ACS without any history of cardiac disease and 205 healthy people in terms of cardiac status (the healthy group) at Imam Khomeini Hospital in Ardabil, Iran. The reliability and validity of the scale determined by Cronbach’s alpha coefficient, content validity, construct validity, and criterion validity were investigated, and finally, its sensitivity and specificity were determined.
Findings: The PS-SS goodness of fit indices, including comparative fit index, goodness of fit index, and incremental fit index, higher than 0.9 and the internal consistency reliability (α =0.75) confirmed the PS-SS single-factor structure. Considering the higher scores in the patient group than in the healthy group (p <0.001), the criterion validity of the scale was confirmed, but the sensitivity and specificity of PS-SS were calculated at the best state with the cut-off point of 18.5 (65.3 and 52.7). Conclusion: This study showed that despite the confirmation of the psychometric properties of PS-SS, due to its low sensitivity and specificity, it has no diagnostic value for the screening of ACS in Iran