1997 research outputs found
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Move, Adapt, or Die: Lagopus Leucura Changes in Distribution, Habitat and Number at Glacier National Park, Montana
Get PDFABSTRACT.—Because of the “montane island” effect and relative rates of climate change, alpine species may be particularly affected by changing climate. White-tailed Ptarmigan (Lagopus leucura) are adapted to life in the alpine cold, but may be less well-adapted to hot summer temperatures. In 1996 and 1997, ptarmigan living in Glacier National Park (GNP) were closely associated with remnant snow and free water in the late summer, a resource that is rapidly changing in distribution and extent as climate changes. We examined White-tailed Ptarmigan distribution, habitat, and numbers in 2009-2010 for comparison with 1996-1997 data. Briefly, five areas within GNP were searched for ptarmigan during August. Habitat data including microclimate were collected at flock locations. Microclimate at ptarmigan flock locations differed from other areas nearby. Flocking ptarmigan appeared to be less numerous than described in 1996 and 1997, and mean flock locations on Logan Pass moved 335 m upslope between the 1990s and 2009 and 2010. Ptarmigan in 2009 and 2010 chose habitat that had the same coverage of vegetation and rock as 1996 and 1997, but contained less snow and water, was farther from snow and water, contained lower soil moisture content, was higher in elevation, and steeper in slope. Our study demonstrates that White-tailed Ptarmigan in GNP have changed distribution, altered habitat preferences, and perhaps on a local scale, experienced declining population numbers in late summer
The Role of BMP2 Signaling in the Skeleton.
No full textWhile new roles for the adult skeleton as an endocrine organ continue to emerge, our understanding of how bone homeostasis is maintained is also changing. Here we focus on BMP2, a molecule identified by its ability to induce bone formation at extraskeletal sites. We detail specific roles for BMP2 in the adult skeleton, where it acts to regulate the differentiation of periosteal skeletal progenitors during fracture healing and also mediates osteoblast formation in the bone marrow microenvironment. We highlight two areas of BMP2 biology that deserve further study: the specific signaling pathways used by BMP2 to affect bone formation, and the factors that regulate BMP2 production in the adult skeleton. These activities serve to distinguish BMP2 from other members of the TGF-b/BMP/Activin gene superfamily
BMPR-II is Dispensable for Formation of the Limb Skeleton.
Get PDFInitiation of BMP signaling is dependent upon activation of Type I BMP receptor by constitutively active Type II BMP receptor. Three Type II BMP receptors have been identified; Acvr2a and Acvr2b serve as receptors for BMPs and for activin-like ligands whereas BMPR-II functions only as a BMP receptor. As BMP signaling is required for endochondral ossification and loss of either Acvr2a or Acvr2b is not associated with deficits in limb development, we hypothesized that BMPR-II would be essential for BMP signaling during skeletogenesis. We removed BMPR-II from early limb mesoderm by crossing BMPR-II floxed mice with those carrying the Prx1-Cre transgene. Mice lacking limb expression of BMPR-II have normal skeletons that could not be distinguished from control littermates. From these data, we conclude that BMPR-II is not required for endochondral ossification in the limb where loss of BMPR-II may be compensated by BMP utilization of Acvr2a and Acvr2b
Effects of Different BMPR2 Mutations on Pulmonary Endothelial Cells from Patients with Hereditary Arterial Pulmonary Hypertension
No full textReal Challenges to Virtual Reality: Realizing Your Collection Through Digital Partnership
Get PDFThis article discusses the collaborative digitization effort between librarians at Marian College (now Marian University) and Indiana University Purdue University Indianapolis (IUPUI) to create a deliverable online collection of an oversized student newspaper (the Phoenix) using CONTENTdm software. The partnership provided mutual benefits for each institution. While Marian received an online collection, IUPUI used the digitization as an opportunity to house the collection as a digital sandbox for its School of Library and Information Science (SLIS) students. Other technological benefits came from the project, including experimentation with migration of collection from IUPUI servers to the PALNI (Private Academic Library Network of Indiana) consortium servers. Published in Computers in Libraries
ID Family Protein Expression and Regulation in Hypoxic Pulmonary Hypertension
No full textBone morphogenetic protein (BMP) signaling has been linked to the development of pulmonary hypertension (PH). Inhibitors of differentiation (ID) proteins (ID1-4) are a family of basic helix-loop-helix transcription factors that are downstream targets of the BMP signaling pathway, but the role that ID proteins play in the development of PH is unknown. To address this, we evaluated pulmonary expression of ID proteins in a mouse model of hypoxia-induced PH. There is selective induction of ID1 and ID3 expression in hypoxic pulmonary vascular smooth muscle cells (VSMCs) in vivo, and ID1 and ID3 expression are increased by hypoxia in cultured pulmonary VSMCs in a BMP-dependent fashion. ID4 protein is barely detectable in the mouse lung, and while ID2 is induced in hypoxic peripheral VSMCs in vivo, it is not increased by hypoxia or BMP signaling in cultured pulmonary VSMCs. In addition, the PH response to chronic hypoxia is indistinguishable between wild type and Id1 null mice. This is associated with a compensatory increase in ID3 but not ID2 expression in pulmonary VSMCs of Id1 null mice. These findings indicate that ID1 is dispensable for mounting a normal pulmonary vascular response to hypoxia, but suggest that ID3 may compensate for loss of ID1 expression in pulmonary VSMCs. Taken together, these findings indicate that ID1 and ID3 expression are regulated in a BMP-dependent fashion in hypoxic pulmonary VSMCs, and that ID1 and ID3 may play a cooperative role in regulating BMP-dependent VSMC responses to chronic hypoxia