1997 research outputs found
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Driving LibGuide Usage via iPads: OMS-1
No full textMarian University\u27s COM opened in 2013. Medical library resources are 95% online only -- however there was no specific online access point outside of the undergraduate library\u27s website. I made the decision to utilize the LibGuide platform from Springshare as the defacto website for our medical library
The Impact of Medically-Related Experiences on Spatial Ability: Instrument Creation
No full textIn medical school, students frequently depend on spatial ability to be successful in medical school courses. For example, it is vital for medical students to be able to visualize vasculature relative to organs to be successful during anatomy. Spatial ability can be broken down into several distinct pieces including the ability to differentiate left from right, the ability to give/follow directions, and the ability to mentally manipulate objects. The aim of this study was the development of an electronic survey and a battery of spatial tests to be pilot tested on a voluntary sample of medical students at MUCOM. This descriptive study focuses on the modifications and adaptations made to both survey questions and original paper-and-pencil versions of the spatial ability tests in order to administer them in an electronic format. The survey, developed specifically for this project, is designed to collect information on past education, occupations, medical experience, and extracurricular activities. And the spatial tests assess different, sometimes overlapping, areas of spatial ability. These paper-and-pencil tests typically have low quality images and are very difficult to administer to a large population. Converting them into electronic format will provide an opportunity to enhance the image quality and reach a large sample of participants. The survey and battery of spatial tests will be administered to participant through Qualtrics survey software. The images in the spatial ability tests were modified using PDF mate PDF converter, Adobe Photoshop CS2 version 9.0, and Microsoft paint. A variety of techniques were necessary depending upon the extent of editing needed. The final instrument produced is of high quality and is currently in the pilot testing, phase. Pilot testing is scheduled to end on October 7, 2015
Loss of BMPR2 Expression in Skeletal Progenitor Cells Reduces Age-Related Bone Loss
Get PDFOsteoporosis is a disease of low bone mineral density (BMD) that affects 10 million Americans with an additional 34 million at risk for developing the disease. Current FDA-approved therapies for osteoporosis involve anti-resorptive agents but many patients would benefit from augmenting bone formation as well as inhibiting bone loss. We recently reported that targeted deletion of the type 2 BMP receptor BMPR2 using Prx1-Cre in skeletal progenitor cells in mice leads to dramatically increased bone mass and bone formation rate by ten weeks of age in the absence of changes in osteoclast function (Lowery et al 2015). In the present study, we examined the age-related impact of Bmpr2 deletion and found that, consistent with our previous results, both male and female Bmpr2-cKO mice exhibit high bone mass when compared to control mice at 55 weeks of age. We also found that the age-related decline in bone mass from 15 weeks to 55 weeks of age in Bmpr2-cKO mice is reduced approximately three-fold compared to control mice, with male and female Bmpr2-cKO mice losing on average only 18% and 27%, respectively, while male and female control mice lost 55% and 77%, respectively, over the same time span. High bone mass in aged Bmpr2-cKO mice is associated with elevated serum levels of the bone formation marker Procollagen Type I N-terminal Propeptide (P1NP). In contrast, serum levels of the bone resorption marker Collagen Type I C-telopeptide (CTx) are unchanged in Bmpr2-cKO mice. Collectively, these findings indicate that loss of Bmpr2 in skeletal progenitor cells causes a sustained imbalance in bone formation vs. bone resorption and results in high bone mass in the aging skeleton. Our findings suggest that strategies aimed at controlling signaling through BMPR2 have the potential to impact bone mass in the aging adult skeleton
Hamlet, Art, and Apoptosis: The Shakespearean Artwork of Julie Newdoll
Get PDFContemporary artist Julie Newdoll\u27s painted series “Shakespeare: The Mirror up to Science” explores the connection between Shakespeare\u27s Hamlet, suicide, and science. Using the thesis supported by the work of Burton R. Pollin that Hamlet\u27s revenge is fueled by his desire to commit suicide, Newdoll shows how the biological process of apoptosis—that is, programmed cell death—can be used as a metaphor for Hamlet\u27s suicide narrative through her paintings
Sr. Delouise Menges
Get PDFIn this interview, Sister Delouise Menges discusses her decision to become a Sister of Saint Frances after witnessing her father’s strong Catholic faith. She reflects on her admiration for the sisters who taught her throughout her years in school. As a postulant, Sister Menges was sent on mission to St. Mary’s in Middletown, Ohio and Saint Christopher’s in Indianapolis to experience community life. Both occasions helped Sister Menges transition to community living in a time of change. She discusses such issues as the interpretation of dress code and changes in the habit. Sister Menges also recalls her time teaching religion classes through Marian University, her experience working at the Indiana Boys’ and Girls’ Schools, and her 45 years as a classroom teacher—experiences that continue to shape her prayer life and outlook on the world. Sister Menges speaks candidly about her many years as a seventh grade English and religion teacher, and how she realized her primary call as a Sister of Saint Francis was to help students “see the light in others”—a true Franciscan value.https://mushare.marian.edu/wrp/1029/thumbnail.jp
Muscle Regulatory Factors Regulate T1R3 Taste Receptor Expression
No full textT1R3 is a T1R class of G protein-coupled receptors, composing subunit of the umami taste receptor when complexed with T1R1. T1R3 was originally discovered in gustatory tissue but is now known to be expressed in a wide variety of tissues and cell types such the intestine, pancreatic β-cells, skeletal muscle, and heart. In addition to taste recognition, the T1R1/T1R3 complex functions as an amino acid sensor and has been proposed to be a control mechanism for the secretion of hormones, such as cholecystokinin, insulin, and duodenal HCO3(-) and activates the mammalian rapamycin complex 1 (MTORC1) to inhibit autophagy. T1R3 knockout mice have increased rate of autophagy in the heart, skeletal muscle and liver. Thus, T1R3 has multiple physiological functions and is widely expressed in vivo. However, the exact mechanisms regulating T1R3 expression are largely unknown. Here, we used comparative genomics and functional analyses to characterize the genomic region upstream of the annotated transcriptional start of human T1R3. This revealed that the T1R3 promoter in human and mouse resides in an evolutionary conserved region (ECR). We also identified a repressive element located upstream of the human T1R3 promoter that has relatively high degree of conservation with rhesus macaque. Additionally, the muscle regulatory factors MyoD and Myogenin regulate T1R3 expression and T1R3 expression increases with skeletal muscle differentiation of murine myoblast C2C12 cells. Taken together, our study raises the possibility that MyoD and Myogenin might control skeletal muscle metabolism and homeostasis through the regulation of T1R3 promoter activity
