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La Tecnologia REAC in medicina veterinaria: esperienze sperimentali e cliniche
Get PDFRadio Electric Asymmetric Conveyer (REAC) Technology is a platform technology for bio and neuro modulation, patented at international level (WO2001EP07800, EP1301241, US7333859 and other patents pending). The scientific background of REAC technology platform is based on a fundamental phenomenon for life: cells have an asymmetric structure, as several cellular components, including plasma membrane, cytoskeleton or organelles, asymmetrically organized. This cell structure implies that ion channels are asymmetrically distributed throughout cellular membrane and this generates ionic fluxes. These ionic fluxes in turn produce currents and these currents produce bioelectric fields. This phenomenon takes the name of "Cell polarity". Cell polarity is at the base of correct cell bioelectric activity and is implicated in important processes that influence normal cell functions such as cell differentiation, proliferation, morphogenesis, migration and neurotransmission in unicellular and multicellular organisms. Epigenetic factors, trauma, infections and other factors alter the mechanism of action of the cell polarity. This blocks the correct production of ion fluxes in cells and tissues, and consequently it alters electro-metabolic activity, functions and reparative processes in cells and tissues. The mechanism of action of REAC Technology is aimed to restore the correct cell polarity. This optimization of cell polarity allows the proper recovery of cellular electro-metabolic processes, moreover cell migration, proliferation and differentiation, by promoting reparative and regenerative process of tissues. REAC technology is so effective to induce remarkable biological effects at many scales, from gene modulations up to functional neuro biological optimization. The effects of REAC Technology are completely pervasive and have no limit in depth in the tissues to be treated. The results obtained in vitro and in vivo suggestarole of REAC in regenerative medicine that opens new scenarios in neurological, vascular, orthopaedic, trauma, and tissue repair. The key features of REAC technology are the absolute safety, ease of use, the presence of effective standardized protocols validated by years of use and the ability to be associated with other pharmacological and surgical treatments, supporting and enhancing them. All these features can open up new perspectives of REAC technology use in veterinary medicine
Autonomia d'impresa e garanzie personali
No full textPersonal guarantees represent an essential moment of entreprise baragaining power.
In the last years, italian legal system has known the importance of personal security bond and general guarantee. These contracts have caused a fundamental break with the rules of Civil Code about i) the traditional surety agreement, ii) consideration of contract; iii) object of contract.
The approach wich has been chosen in the study of these problems underlines the specific features of entreprise private autonomy that must bu distinguished from the classic and theoretical individual private autonomy.
The rules governing the theory of entreprise private autonomy could be found in Article 41 of the italian Constitution; in the Civil Code special provisions about the role of entreprise as contractor; in the lex mercatoria and global transaction rules.
The topic of new forms of personal securities needs to be tackled on a comparative analysis. In this field is essential looking at international regulatory solutions of Uncitral, Icc, and Dcfr. Furthermore, french legal standards can facilitate a more datailed study on the relationship between entreprise, personal securities and credit protection
Development of a post-lethality treatment to reduce the risk of <i>Listeria monocytogenes</i> contamination in Ricotta salata cheese
No full textListeria monocytogenes contamination in Ricotta salata cheese rind is a common finding. In the last year numerous cases of food alert and even of human listeriosis associated with the consume of Ricotta salata have been reported in different Member States of the European Union and other countries. The presence of L. monocytogenes in the cheese making plant environment represent an important risk factor in the contamination of ricotta salata (i.e. post-proces contamination). L. monocytogenes is mainly localized on the rind of the product. The reduction of the risk associated with environmental contamination can be obtained through the application of post-lethality treatment. The feasibility to inactivate L. monocytogenes using water bath heat-treatment under experimental conditions has already been demonstrated by Spanu et al., (2013). The aim of this work was to optimize a water bath heat treatment, which can be used at industrial level, allowing the control of L. monocytogenes post-process contamination in Ricotta salata wheels and wedges. For each type of product was tested the efficacy of 9 time-temperature combinations on samples artificially inoculated with L. monocytogenes. On the test units were conducted microbiological, physic-chemical and sensorial analysis. The best time-temperature combination would selected taking into account the inactivation level of L. monocytogenes (the target was set at 5-log reduction), the economic sustainability of the treatment and the influence on sensory properties of the product
Impiego del modello animale ovino per la messa a punto di innovativi protocolli terapeutici per il trattamento delle lesioni del nervo periferico
Get PDFBackground: The results of current treatments for multiple peripheral nerve injuries are not fully satisfactory. The lack of an adequate animal model is one of the main problems in brachial plexus research. A new concept of nerve-guide, called "NeuroBox" (NBX), double-halved, not-degradable and rigid, and does not require the use of any stitch to be sutured to the nerve stump have been recently proposed.
Our hypothesis is to treat brachial plexus lesions as they are occurring in a single big plexiform peripheral nerve and NBX could provide protection and guidance to nerves stump.
Aim: To verify the sheep as animal model in brachial plexus regeneration and test NBX for treating multiple nerve lesions.
Matherial and Methods: Pilot study: n°2 Sarda sheep. Operative technique, device dimensions, experimental lesions comparable in Humans were evaluated. Experimental study: n°8 Sarda sheep received the section of the thoracic nerve roots, NBX was positioned. Animals were randomly divided in two groups and were clinically evaluated for 10 and 32 weeks respectively. Histological and immune-histochemistry were performed.
Discussion and Results: N°4 animals completed the study. No scar tissue between the distal and proximal nerve stumps was observed in histological evaluation. Nerve regeneration was observed with tiny vessels dispersed into the regenerated. Ovine can be used as animal model. NBX can provide a suitable regeneration chamber in nerve lesions
Soil Greenhouse Gases emissions in Mediterranean forage systems
Get PDFMany studies on the impacts of soil management on Greenhouse Gases (GHG) emissions were carried
out in the last years. However, field studies on GHG emissions in forage systems under semi-arid
Mediterranean conditions are still limited. Modelling approaches are required for predicting the long
term performances of Mediterranean grasslands under different environmental and management
strategies, but so far very few attempts were made for these environments. The overall aim of the
PhD dissertation was to analyse the processes and the management options that influence the soil C
cycle and GHG emissions in two typologies of Mediterranean forage systems: extensively managed
pastures and irrigated maize-based systems. Field experiments were carried out for both forage
systems, while a modelling approach was undertaken only for the pastures.
The PaSim model was assessed for its ability to simulate C exchanges in Mediterranean grasslands.
A new model parameterization was derived for Mediterranean conditions from a set of ecophysiological parameters. The obtained results highlight the reliability of PaSim to simulate C cycle
components in Mediterranean grasslands although some improvements are required.
In the irrigated forage systems, soil GHG and the net Global Warming Potential were compared under
different fertilization strategies, which showed contrasting impacts on GHG emissions, providing
some insights on their different potential mitigation roles under Mediterranean conditions
A Modeling tool to assess local and regional impact of climate change on crop water requirement in Euro-Mediterranean Countries, and assessment of Mediterranean irrigated agriculture vulnerability
Get PDFIrrigation is a needed practice in arid and semi-arid Euro-Mediterranenan regions, where water scarcity is expected to be more severe under climate change, thus requiring optimal water management.
This work develops a tool able to estimate crop water consumption and irrigation demand at local and regional scale. The Simulation of Evapotranspiration of Applied Water model was implemented in R programming language (SIMETAW_R), and validated in ten European sites through the FLUXNET network. SIMETAW_R was improved using R-GIS libraries, to build a spatial platform (SIMETAW_GIS) that can interact with large geodatasets of environmental conditions and agronomic practices, to provide simulations of future water consumption and application. The study was conducted at Euro-Mediterranean scale on economically relevant crops (maize, wheat, and grape), for past (1976-2005) and future (2036-2065) climate, under Representative Concentration Pathways scenarios 4.5 and 8.5, with a resolution of 14 km. In addition, the vulnerability of irrigation agriculture to climate changes was assessed for five Mediterranean reservoirs and associated irrigation systems.
Results show an increasing future irrigation demand, which will worsen water use conflicts in Mediterranean. Although all investigated basins have a large capacity, the irrigated agriculture shows potential vulnerability to climate changes. Results may be useful to prioritize implementation of sustainable water use strategies
L'<i>Aviation safety</i> nel diritto internazionale ed europeo
Get PDFThe research provides an overview of the regulatory harmonization in the field of safety regulation, which has its own basis in ICAO International Civil Aviation Organization, the UN specialized Agency responsible for creating, at international level, rules and standard procedures (Cap. I).
After the liberalization and completation of the European internal market in air transport (Cap. II), the need for harmonization, in the field both of security and primarily of safety, has growth into the European Union. This carries forward birth and development of EASA European Aviation Safety Agency, the European Agency guarantor of the safety regulations in air transport for all Member States.
It emerges the need both to put the human factor at the center of every process – making him aware of its duties and responsibilities – and to consider security and safety as a whole, promoting the proactive and predictive approach, to detriment of the reactive one
La Facilitación de grupos en el movimiento agroecológico de Valencia y Sardegna: un ensayo de transformación social basado en la comprensión de las dinámicas grupales
No full textThe present document studies the Groups Facilitation, understood as a set of techniques and knowledge that serve to improve the functioning of any human group, and its possible effects on the Sardinian and Valencian agroecological movement. In Sardegna, the incipient agroecological movement has been characterized through 48 semi-structured interviews, to understand its situation and to find out how facilitation can be useful. In Valencia, a Facilitation process has been applied to 5 agroecological groups, analyzing the effects of its application with surveys and discussion groups in the beginning and in the end of the process. We found an embryonic state of the Sardinian agroecological movement but also good conditions of the territory and high level motivation to grow up. So the main conclusion is that Facilitation could be oriented to generate bonds of trust between the people already involved and to support the internal development of the groups linked to agroecology. In Valencia, Facilitation has had visible and obvious effects on the studied groups, especially improving communication within and outside the groups, the relationships between its members, and the behavior of their assemblies. It is, therefore, considered a useful tool to support the development of the agroecological movement
Queer e narrativa italiana: genealogie, impegno politico e linee letterarie
Get PDFThe objectives of our work are three: an analysis and comparison of the different Queer theories and theorists, drawing a picture of political movements queer “ante litteram” and the analysis of the work of Pier Vittorio Tondelli, from the queer perspective.
Our research traces an epistemological picture about the queer theory that contemplates the discussion of the sex and gender categories, the rejection of the strategies of claiming civil rights in favor of policies of transgression, and in literature the use of parody to deconstruct the dichotomous system of knowledge and cataloging of reality and people. Our research, through a genealogical and deconstructivist approach, dwells on Queer theory's critique of "scientia sexualis", especially the concept of natural sexuality, the sex/gender system, heteronormativity and the monolithic and essentialist identity.
Our study focuses on the gay movements and radical feminists who protest against the policies of emancipation or liberation to fight against the assimilation by the capitalist system of the emerging gay culture.
The research continues, in the following chapters with an analysis on the relations between gay identity and literature, constructed and reconstructed through the literary pages, especially in two novels by Pier Vittorio Tondelli, Altri libertini and Camere separate
Use of genetic, genomic and phenomic approaches to improve livestock performances
No full textTraditional methods to improve animal productions are derived from the quantitative genetics theory. The estimation of variance components, genetic parameters and genetic gains are essential steps of the selection process based on quantitative methods. The use of linear mixed models, algorithms for their solutions and computer to solve complex system of equations has made possible to estimate reliable genetic merits also from complex structures of relationships. More recently the high throughput technologies has provided a great increase of information both at genomic than phenomic level. This high informativeness has led two main consequences: improved accuracies and faster genetic gains from one hand, big data handling and unbalancing from the other hand. The present thesis will deal with these aspects. Two experimental contributions will focus on the estimation of genetic parameters for new criteria of selection on species of particular interest, with traditional and innovative phenotyping methods. A third contribution will deal with the research of new morphometric indicators that could have an economic impact if applied for the selection of the species of interest. Finally, a fourth contribution will address the issue of the data unbalancing derived from the current information gap generated by the speed of genotyping and the capacity of the phenotyping practices. All these contributions will have the same aim, the improvement of livestock performances