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Subversive Content Design User Experience Survey Data
No full textThis study explores the use of subversive game content in critical game design to address sensitive social, political, and personal topics while avoiding the risk of undermining their significance. Critical game design is focused on conveying messages and addressing real-world issues, with the goal of fostering thoughtful engagement and critical thinking among players as they interact with the game. However, despite these serious intentions, critical games retain fundamental elements such as rules, mechanics, and in-game objectives. A seamless gaming experience may unintentionally shift players' focus towards entertainment rather than the intended message, due to typical expectations of the medium. This unintended diversion risks trivializing the serious messages embedded in the games. To address this challenge, several subversive game content design strategies are proposed, including leveraging familiarity, the early introduction of subversive elements, justifying subversion, and promoting player agency. Two video games, Border Politics and Get Good: Grinding Chronicles are developed to test the effectiveness of the proposed design strategies. These strategies are intended to challenge conventional gaming norms and intentionally induce player discomfort, which may be necessary to safeguard against the trivialization of sensitive topics. The user experience results (N = 54) show that the proposed design strategies are effective in maintaining player engagement with the intended messages, successfully balancing the need for critical reflection with the inherent entertainment aspects of gaming. The data demonstrates that these strategies work well in preventing the trivialization of sensitive topics, thereby validating their use in critical game design
The Impact of Colour Vision Deficiency on the Ability of Stroke Clinicians to Read Perfusion Brain Scans
Get PDFColour vision deficiency (CVD), more colloquially known as colour blindness, impairs the perception and differentiation of various colours. CVD affects 1-6% of the population including medical professionals. CVD has been negatively associated with how medical staff recognise abnormalities in various disciplines, including histopathology and microscopy.
Recent advances in treatment delivery have seen the increasing use of CT perfusion and colour maps in the management of acute stroke. The impact of CVD on interpretation of these colour perfusion maps has not been explored. It is possible that certain colour palettes may pose a problem for clinicians with CVD and if clinicians with CVD are less good at interpreting certain colour maps, this could directly impact on patient care. The colour palettes used in perfusion maps could be adjusted to accommodate professionals with CVD if a significant difference in interpretation is identified.
Dataset contents:
Study Protocol
Participant Information Sheet (PIS)
Questionnaire*
Anonymised participant responses to questionnaire*
Outputs from study*
*These items will be made available at the end of the study (expected mid 2025)
Genome-wide chromosome architecture prediction reveals biophysical principles underlying gene structure
No full textData associated with the paper:
Michael Chiang, Chris A Brackley, Catherine Naughton, Ryu-Suke Nozawa, Cleis Battaglia, Davide Marenduzzo, Nick Gilbert (in press). Genome-wide chromosome architecture prediction reveals biophysical principles underlying gene structure. Cell Genomics.
Classical observations suggest a connection between 3D gene structure and function, but testing this hypothesis has been challenging due to technical limitations. To explore this, we developed e-HiP-HoP, a model based on genome organisation principles to predict the 3D structure of human chromatin. We defined a new 3D structural unit, a “topos”, which represents the regulatory landscape around gene promoters. Using GM12878 cells, we predicted the 3D structure of over 10,000 active gene topoi and stored them in the 3DGene database. Data mining revealed folding motifs and their link to gene ontology features. We computed a structural diversity score and identified influential nodes—chromatin sites that frequently interact with gene promoters, acting as key regulators. These nodes drive structural diversity and are tied to gene function. e-HiP-HoP provides a framework for modelling high-resolution chromatin structure and a mechanistic basis for chromatin contact networks that link 3D gene structure with function. This dataset contains the simulation code and data underlying the figures of the associated paper
Plasticity in malaria parasite development: mosquito resources influence vector-to-host transmission potential
Get PDFParasites rely on exploiting resources from their hosts and vectors for survival and transmission. This includes nutritional resources, which vary in availability between different hosts and changes during infections. For malaria (Plasmodium) parasites, sexual reproduction (sporogony) and subsequent development of oocysts, which produce sporozoites infectious to the vertebrate host, occurs in the mosquito vector. Mosquitoes in the field exhibit diversity in the amount and type of food they acquire, directly impacting the nutrients available for the replication and development of parasites. While the rate of parasite transmission from vector to host is influenced by the nutritional state of mosquitoes, whether this is due to resource limitation mediating parasite development and productivity is poorly understood. We use the rodent model parasite P. chabaudi and the vector Anopheles stephensi to ask how variation in the amount of sugar and blood provided to malaria-infected mosquitoes affects parasite transmission potential. We show that parasites in well-resourced mosquitoes grow faster and have a 1.7-fold higher sporozoite burden those whose vectors only receive sugar. However, this increase in productivity is only partly explained by oocyst development, suggesting that resource availability also impacts the ability of sporozoites to reach the salivary glands. As well as challenging the assumption of a simple relationship between the number or size of oocysts and transmission, our findings suggest malaria parasites may actively adjust within-vector development to best exploit nutritional resources; while parasites in low-resourced mosquitoes exhibited a reduction in oocyst burden during sporogony, the remaining oocysts developed more rapidly, reaching a similar size to those in well-resourced mosquitoes. Understanding the impacts of resource availability for malaria transmission is urgent given that parasites encounter increasingly variable vectors as consequences of climate change and vector control tools
Tower Blocks UK: Knowsley Cantril Farm, Phase VII, n7-17.jpg
No full textMulti-storey block details: six 16-storey blocks containing 540 dwellings; Multi-storey block name(s): Whincraig; Turncliff; Mosscraig; Merecliff; Firscraig; Denecliff; Image detail: View of Southern 16-storey blocks on Little Moss Hey Original Commissioning Authority: Liverpool County Borough Council; Image taken: 1987;Context: Tower Block UK is a project supported by the Heritage Lottery Fund, bringing together public engagement and an openly-licensed image archive in an attempt to emphasise the social and architectural importance of tower blocks, and to frame multi-storey social housing as a coherent and accessible nationwide heritage. The Tower Block UK image archive is a searchable database of around 4,000 images of every multi-storey social housing development built in the UK. The photographs were largely taken in the 1980s by Miles Glendinning and are made available here for public use. As many of the blocks documented and photographed have since been demolished, the archive functions in part as a repository of information on an important aspect of UK heritage that is now vanishing. The archive itself catalogues multi-storey blocks as part of the developments within which they were initially commissioned and built. It gives details of notable dates, such as when local authorities approved the developments and when construction began or finished. Alongside this, the archive provides information on the local authorities, architects, and other agents involved in the processes of commissioning, designing, and constructing mass social housing. While the most historically 'accurate' identification labels in the database are the original overall development or project names, the archive also contains details of the individual blocks built
Tower Blocks UK: Southwark London Storks Road, l37-40.jpg
No full textMulti-storey block details: one 6-storey block containing 34 dwellings; Multi-storey block name(s): Bromfield Court; Image detail: View fo Bromfield Court Original Commissioning Authority: London County Council; Image taken: 1988;Context: Tower Block UK is a project supported by the Heritage Lottery Fund, bringing together public engagement and an openly-licensed image archive in an attempt to emphasise the social and architectural importance of tower blocks, and to frame multi-storey social housing as a coherent and accessible nationwide heritage. The Tower Block UK image archive is a searchable database of around 4,000 images of every multi-storey social housing development built in the UK. The photographs were largely taken in the 1980s by Miles Glendinning and are made available here for public use. As many of the blocks documented and photographed have since been demolished, the archive functions in part as a repository of information on an important aspect of UK heritage that is now vanishing. The archive itself catalogues multi-storey blocks as part of the developments within which they were initially commissioned and built. It gives details of notable dates, such as when local authorities approved the developments and when construction began or finished. Alongside this, the archive provides information on the local authorities, architects, and other agents involved in the processes of commissioning, designing, and constructing mass social housing. While the most historically 'accurate' identification labels in the database are the original overall development or project names, the archive also contains details of the individual blocks built
Tower Blocks UK: Thanet Millmead Road, Stage II, s7-22.jpg
No full textMulti-storey block details: one 15-storey block containing 89 dwellings; Multi-storey block name(s): Invicta House; Image detail: View of Millmead Road development with Invicta House in centre Original Commissioning Authority: Margate Municipal Borough Council; Image taken: 1988;Context: Tower Block UK is a project supported by the Heritage Lottery Fund, bringing together public engagement and an openly-licensed image archive in an attempt to emphasise the social and architectural importance of tower blocks, and to frame multi-storey social housing as a coherent and accessible nationwide heritage. The Tower Block UK image archive is a searchable database of around 4,000 images of every multi-storey social housing development built in the UK. The photographs were largely taken in the 1980s by Miles Glendinning and are made available here for public use. As many of the blocks documented and photographed have since been demolished, the archive functions in part as a repository of information on an important aspect of UK heritage that is now vanishing. The archive itself catalogues multi-storey blocks as part of the developments within which they were initially commissioned and built. It gives details of notable dates, such as when local authorities approved the developments and when construction began or finished. Alongside this, the archive provides information on the local authorities, architects, and other agents involved in the processes of commissioning, designing, and constructing mass social housing. While the most historically 'accurate' identification labels in the database are the original overall development or project names, the archive also contains details of the individual blocks built
Tower Blocks UK: Southwark London Elephant and Castle Comprehensive Development Area, Draper Street Area, l37-25.jpg
No full textMulti-storey block details: one 25-storey block containing 133 dwellings; one 8-storey block containing 33 dwellings; one 7-storey block containing 34 dwellings; Multi-storey block name(s): Wollaston Close; Sherston Court; Draper House; Image detail: View of Sherston Court Original Commissioning Authority: London County Council; Image taken: 1988;Context: Tower Block UK is a project supported by the Heritage Lottery Fund, bringing together public engagement and an openly-licensed image archive in an attempt to emphasise the social and architectural importance of tower blocks, and to frame multi-storey social housing as a coherent and accessible nationwide heritage. The Tower Block UK image archive is a searchable database of around 4,000 images of every multi-storey social housing development built in the UK. The photographs were largely taken in the 1980s by Miles Glendinning and are made available here for public use. As many of the blocks documented and photographed have since been demolished, the archive functions in part as a repository of information on an important aspect of UK heritage that is now vanishing. The archive itself catalogues multi-storey blocks as part of the developments within which they were initially commissioned and built. It gives details of notable dates, such as when local authorities approved the developments and when construction began or finished. Alongside this, the archive provides information on the local authorities, architects, and other agents involved in the processes of commissioning, designing, and constructing mass social housing. While the most historically 'accurate' identification labels in the database are the original overall development or project names, the archive also contains details of the individual blocks built
Tower Blocks UK: Hackney London Frampton Park Estate (West) Extension, l15-03.jpg
No full textMulti-storey block details: one 10-storey block containing 93 dwellings; Multi-storey block name(s): Pitcairn House; Image detail: View of Pitcairn House Original Commissioning Authority: London County Council; Image taken: 1988;Context: Tower Block UK is a project supported by the Heritage Lottery Fund, bringing together public engagement and an openly-licensed image archive in an attempt to emphasise the social and architectural importance of tower blocks, and to frame multi-storey social housing as a coherent and accessible nationwide heritage. The Tower Block UK image archive is a searchable database of around 4,000 images of every multi-storey social housing development built in the UK. The photographs were largely taken in the 1980s by Miles Glendinning and are made available here for public use. As many of the blocks documented and photographed have since been demolished, the archive functions in part as a repository of information on an important aspect of UK heritage that is now vanishing. The archive itself catalogues multi-storey blocks as part of the developments within which they were initially commissioned and built. It gives details of notable dates, such as when local authorities approved the developments and when construction began or finished. Alongside this, the archive provides information on the local authorities, architects, and other agents involved in the processes of commissioning, designing, and constructing mass social housing. While the most historically 'accurate' identification labels in the database are the original overall development or project names, the archive also contains details of the individual blocks built
Tower Blocks UK: Tower Hamlets London St Simon Zelotes (Extended) Site and Usk Street (No. 2) Site, l45-27.jpg
No full textMulti-storey block details: two 8-storey blocks containing 48 dwellings; Multi-storey block name(s): Trevelyan House; Sulkin House; Image detail: View of Trevelyan House looking North from Morpeth Street Original Commissioning Authority: Bethnal Green Metropolitan Borough Council; Image taken: 1981;Context: Tower Block UK is a project supported by the Heritage Lottery Fund, bringing together public engagement and an openly-licensed image archive in an attempt to emphasise the social and architectural importance of tower blocks, and to frame multi-storey social housing as a coherent and accessible nationwide heritage. The Tower Block UK image archive is a searchable database of around 4,000 images of every multi-storey social housing development built in the UK. The photographs were largely taken in the 1980s by Miles Glendinning and are made available here for public use. As many of the blocks documented and photographed have since been demolished, the archive functions in part as a repository of information on an important aspect of UK heritage that is now vanishing. The archive itself catalogues multi-storey blocks as part of the developments within which they were initially commissioned and built. It gives details of notable dates, such as when local authorities approved the developments and when construction began or finished. Alongside this, the archive provides information on the local authorities, architects, and other agents involved in the processes of commissioning, designing, and constructing mass social housing. While the most historically 'accurate' identification labels in the database are the original overall development or project names, the archive also contains details of the individual blocks built