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R script
No full textWe explored the quality of trypanocides sold on the Ugandan market by conducting a high performance liquid chromatography on all the samples from 45 drugshops. This was to investigate their quality against internationally established standards. The R script summaries the statistical approach used to explore this research question
Trypanocide usage within livestock breeds of Uganda
No full textThe script supports Chapter 4 Subsection 3 titled: “Trypanocide overdosing in livestock breeds” from my PhD thesis titled: Exploring trypanocide resistance: Lessons from Uganda (2024). This describes data (referenced as “Econ”) where the value for money is assessed in the community is presented. Responses are from 557 farmers who have been associated with heavy trypanocide consumption in southwestern Uganda. The loss expenditure frontier curve (LEF) models livestock losses and income per head among cattle and small ruminants in the study area. Weight estimates are applied on all livestock to quantify the effective dose (i.e., the amount of drug administered per animal) based on the number of sachets consumed per farmer. The net income adjusted herd size ratio (NIAHSR) measured money gained while the expenditure income adjusted herd size ratio (EIRAHS) was the proportion of money earned, that is spent on each livestock as a measure of money lost per animal.The script supports Chapter 4 Subsection 3 titled: “Trypanocide overdosing in livestock breeds” from my PhD thesis titled: Exploring trypanocide resistance: Lessons from Uganda (2024). This describes data (referenced as “Econ”) where the value for money is assessed in the community is presented. Responses are from 557 farmers who have been associated with heavy trypanocide consumption in southwestern Uganda. The loss expenditure frontier curve (LEF) models livestock losses and income per head among cattle and small ruminants in the study area. Weight estimates are applied on all livestock to quantify the effective dose (i.e., the amount of drug administered per animal) based on the number of sachets consumed per farmer. The net income adjusted herd size ratio (NIAHSR) measured money gained while the expenditure income adjusted herd size ratio (EIRAHS) was the proportion of money earned, that is spent on each livestock as a measure of money lost per animal
Exploring the Emergence of New Territorial Divides after Devolution: An Analysis of the Socio-Political Gap between Capital Cities and Peripheral Areas in Scotland and Wales
No full textThe dataset contains results from a survey conducted in Scotland and Wales, examining public opinion on devolved governance. It explores perspectives on the role of capital cities at both the state-wide and devolved levels, as well as the territorial distribution of the benefits of devolution
Adapting Global Coach Education Approaches within the Chinese Context: Coaches’ and Coach Developers’ Perceived Challenges, Cultural Influences and Pathways to Expertise
No full textBackground: Global coach education has shifted focus in recent decades, moving from prescriptive, competency-based training towards expertise-based approaches that prepares for complex coach–learner interactions. However, adopting one-size-fits-all coaching approaches across cultures is problematic, since there is potential to overlook important pedagogic and social norms. In China, coach education remains centrally administered and assessment-driven, with a structured certification hierarchy that contrasts starkly with Western approaches that centre on reflective practice. These contextual differences present a mismatch between China’s current competency-based system and the expertise-development approach emerging internationally.
Purpose: This study investigates the cultural and pedagogical complexities of introducing a Western expertise-based coach education approach in China. It explores Chinese coach developers’ and coaches’ perceptions of (1) the current versus their ideal coach education systems, (2) how cultural factors (e.g., power distance, learning habits) influence these systems, and (3) the challenges in transitioning from the existing competency-based to an expertise-based approach. The aim is to better understand how cultural context and educational beliefs shape coach development opportunities, and to inform future coach education practice reforms.
Methods: A mixed-methods (quantitative and qualitative) online survey required participants from China (N = 119; 87 coaches and 32 coach developers) to rate using a Likert-scale, items that addressed competency-based versus expertise-based coaching approaches in various scenarios, cultural factors (e.g., attitudes to authority, preference for structured learning) and potential transition challenges, plus open-ended questions for additional comments. Independent t-tests and MANOVA with post-hoc tests examined differences between coaches and coach developers, while thematic analysis was used to present qualitative feedback.
Results: While participants showed interest in a more expertise-based approach, their overall preference remained for familiar, competency-based structures. Coach developers were significantly more inclined to view the current system as lacking in expertise-focus and to desire a more expertise-based system. Correspondingly, coach developers differed from coaches on several cultural attitude measures: notably, they reported emphasis on youth development being positive to coach education systems, whereas the attitude and behaviours towards uncertainty and learning habits/styles are relatively negative to the systems. Both groups, however, identified similar challenges to adopting an expertise-based approach, particularly a ‘need for more knowledge’ and difficulties with assessment and certification processes. Qualitative comments (from a subset of respondents) echoed concerns about entrenched habits, institutional resistance to change, and the lack of role models to exemplify the new approach.
Discussion and Conclusion: Overall, this study highlights a clear mismatch between the current competency-based and an envisioned expertise-based approach. Data suggests that any transition in China towards an expertise-based coach education system will need to be gradual and culturally sensitive, blending new reflective practices into the existing structure to ensure buy-in and sustainability
Abradable DEM: A Novel Framework to Capture the Mechanistic Evolution of Particle Shape
No full textAlthough various methods exist for modelling non-spherical particles in DEM, particles’ shapes are usually treated as immutable. However, particles often change shape gradually, e.g., due to abrasion or accrued plastic deformation. This manner of shape evolution has largely been neglected in DEM even though it can significantly influence bulk-scale behaviour. The following introduces an extendable framework for modelling the gradual and permanent evolution of particle shapes in DEM, focusing on abrasion/wear as an exemplar. By extending the existing LAMMPS rigid-body implementation, a comprehensive novel wear model is employed to simulate the abrasion of arbitrarily shaped dynamic particles. These abradable particles are represented as hollow shells of discrete spheres collated into a series of triangular facets. Following an impact exceeding a material yield criterion, spheres are displaced inwards along their normals. The result is a reduction in volume and a permanent change in shape. Following this, each abraded particle’s moment of inertia is recomputed and used to resolve future rigid-body dynamics. Thus, particle-level changes in shape affect the bulk dynamics of the system, which in turn informs all subsequent abrasion. Results exhibit particle shape evolution in agreement with a variety of abrasion scenarios in literature and showcase the resulting effect on the bulk dynamics of such systems. This research provides a versatile methodology for linking microscale abrasion mechanisms to macroscale system behaviour, with widespread applications in both natural processes and industrial particle-handling systems. Furthermore, the outlined framework can be readily adapted to other sources of mechanistic particle shape evolution in DEM
Signalling cascade changes following apoE4 overexpression
No full textTo identify the molecular changes in signalling pathways triggered by altered apoE4 expression, we used lentiviral transduction to overexpress human apoE4 in 18-21 DIV primary hippocampal neurons. The molecular consequences of altered apoE4 expression in these neurons were the mapped by proteomic analysis. In silico investigations highlighted changes in proteins associated with mitochondrial dysfunction, sirtuin signalling and oxidative phosphorylation. Interestingly, by combining the data generated here with proteomic data from human patient AD APOE4 “spared” (BA17) and “affected” (BA41/42) synaptic isolates it is possible to identify physiological correlates in synaptic signalling pathways such as oxidative phosphorylation, sirtuin signalling, glutamate receptor signalling and calcium signalling. Thus, in combination with patient derived post mortem analyses, this viral apoE4 overexpression neuronal culture system could assist with delineation of apoE4 triggered molecular perturbations from chronic neurodegenerative processes present in end stage AD brain regions.
As explained above (using our standard workflows) the mass spec data output are provided in the files below –
BiolayoutclustersforApoE4.xlsx
ApoE4Comparisonmolecules.xlsx
The BiolayoutclustersforApoE4.xlsx files contains the Biolayout clusters identified by expression profile from the cell culture proteomic dataset.
The ApoE4Comparisonmolecules.xlsx file contains tabs of a number of signalling cascades containing proteins exhibiting log ratio fold changes between transduced cells and human tissue samples and include:
Sample details – including TMT tag information
LC-MS data filtered by number of unique peptides (2 or more only)As explained above (using our standard workflows) the mass spec data output are provided in the files below –
* "BiolayoutclustersforApoE4.xlsx"
* "ApoE4Comparisonmolecules.xlsx"
The "BiolayoutclustersforApoE4.xlsx" file contains the Biolayout clusters identified by expression profile from the cell culture proteomic dataset.
The "ApoE4Comparisonmolecules.xlsx" file contains tabs of a number of signalling cascades containing proteins exhibiting log ratio fold changes between transduced cells and human tissue samples and include:
* Sample details – including TMT tag information;
* LC-MS data filtered by number of unique peptides (2 or more only)
Smooth Operators: Promoting Skill Acquisition in Novice Tennis Players
No full textAccording to different skill acquisition theories, top-down/bottom-up processes will differentially impact on motor skill improvements and should inform the pedagogic approach adopted by the teacher/coach. Despite these predictions, there are few studies that compare different teaching/coaching approaches from these perspectives. Therefore, this study aimed to assess the effectiveness of different coaching approaches when acquiring the tennis forehand drive shot among secondary school children (N = 24, age 12–13 years) in Kuwait. Specifically, three methods were compared: demonstration only, verbal instructions with demonstration and a design informed by the constraints-led approach. Measures of performance outcome, expert coach rating, learner understanding and preference, as well as upper-limb kinematics were obtained following a practice block, at delayed retention test after 1 week and on a transfer task. ANOVA revealed no significant differences between conditions for performance outcome or expert coach ratings. However, there were significant differences in the upper-limb movement kinematics (p < .05), as measured by jerk, indicating that VID had lower levels of jerk compared to CLA in all phases. Additionally, when questioned after the study on their perceptions, 92% of the participants preferred being coached using verbal instructions with a demonstration. Overall, findings indicate that the more prescriptive coaching method in this case led to improved understanding and movement smoothness and was also preferred by most participants. Teachers and coaches are therefore encouraged to carefully consider what methods are employed against learner needs and expressed preferences.Data Description can be found in the file "Data Description.txt
Randomised Controlled Trial of -Mercaptopurine Versus Placebo to Prevent Recurrence of Crohn’s Disease Following Surgical Resection
No full textAnonymised TOPPIC trial datase
Data for `Abnormal vasculature reduces overlap between drugs and oxygen in a tumour computational model: implications for therapeutic efficacy`
No full textThis dataset contains the results of the drug and oxygen transport simulations in tumour and tumour decompressed microvascular networks published in the work "Abnormal vasculature reduces overlap between drugs and oxygen in a tumour computational model: implications for therapeutic efficacy"
A longitudinal study of living hens demonstrates tibia bone density increases at puberty and is maintained whilst keel bone damage only accumulates gradually during lay.
Full text linkCT Data for the validation study for estimating cortical and medullary bone density using 2D radiography.
A longitudinal study of bone density using the validated method over the laying period and prior to puberty