Edinburgh DataShare
Not a member yet
7718 research outputs found
Sort by
Evaluation of impact of assessment changes on REDU11046
No full textThis dataset relates to a case study which evaluated the introduction of concept maps (CM) as a learning activity and assessment task on a 10 credit (ECTS 5 credits) social science research methods course at SCQF level 11 (taught postgraduate level). The course runs for five weeks in semester one and over the previous five years student enrolment has been between 575 and 971. Most (>90%) students have English as a second or other language (ESOL) and many are new to studying social sciences. The CM was introduced to allow students to focus on developing their conceptual understanding rather than their academic writing skills. The data set includes interview schedules used and the secondary data (course marks) analyse
Software package and dataset for “Large-Scale Data Processing Platform for Laser Absorption Tomography (Matlab)”
No full textThis software package provides a robust and scalable solution for processing large-scale data generated by Laser Absorption Tomography (LAT) experiments. Designed specifically for industrial applications, the platform accelerates LAT signal processing by leveraging parallel computing architecture, significantly reducing computation time. The platform includes advanced fault detection to identify and exclude noise-distorted measurements, ensuring accurate tomographic reconstructions.
Key features of this software include:
- Parallel Computing: Efficiently processes extensive LAT data by distributing tasks across multiple CPU cores, reducing the overall processing time by over 40% compared to traditional single-threaded methods.
- Fault Detection Scheme: Automatically identifies and removes noisy data, enhancing the accuracy of reconstructions.
- Flexible Configuration: Supports customization of tomographic settings, including the number of projection angles, laser beams per angle, and imaging rates, making it adaptable to various LAT applications.
This software is ideal for researchers and engineers working in high-resolution reactive flow-field imaging, providing a critical tool for analyzing and interpreting complex data sets in real time
Primary NMR data used during development of the FID post processing averaging methodology
No full text## This item has been replaced by the one which can be found at https://doi.org/10.7488/ds/7827 ## Primary NMR data used during development of the FID post processing averaging methodology. Abstract: In situ 1D NMR spectroscopic reaction monitoring allows detailed investigation of chemical kinetics and mechanism. Concentration versus time data are derived from a time-series of NMR spectra. Each spectrum in the series is obtained by Fourier transform of the corresponding FID. When the spectrometer outputs FIDs recorded from multiple scans, the spectra benefit from an increase in signal-to-noise (S/N). However, this reduces the number of FIDs and thus kinetic datapoints. We report a simple alternative in which the same number of scans are acquired by the spectrometer, but each scan is saved independently. Signal averaging is then conducted by post-acquisition processing. This leads to an increase in both the S/N and the number of kinetic datapoints and avoids "over-averaging" effects. The entire series of single scan FIDs spanning the reaction lifetime can be summed to yield a 'total reaction spectrum' in which intermediates can be identified. The method can be applied in coherence with phase-cycling to minimize spectral distortion during solvent signal suppression. Overall, the approach simplifies the pre-acquisition parameters to estimation of the reaction duration and T1 max, then selection of the pulse angle, q, and scan repetition time, τR, without the need to set the signal-averaging before the experiment
WAU - Maˈya (Wauyai dialect: ISO 369-3: lcc, Glottocode: lege1241) segmented files
No full textThis dataset contains segmented audio files from several (not all) of the raw recordings in the Maˈya (Wauyai dialect: ISO 369-3: wuy, Glottocode: wauy1247) collection. The full collection is available here: https://datashare.ed.ac.uk/handle/10283/8592. These segmented files are designed to facilitate searches for a particular word or construction in the Wauyai Maˈya collection. Full information on how to navigate these segmented files using the filenames is given in the Documentation file. The audio files in this dataset come from recordings that were made between 16 February and 1 March 2023, in Waimalata hamlet and Waisai town (Waigeo island, Raja Ampat regency, Southwest Papua province, Indonesia). This dataset relates to the British Academy Postdoctoral Fellowship 'Synchronic and diachronic investigations in Raja Ampat-South Halmahera, a little-known subbranch of Austronesian' (PF19\100004); additional fieldwork funds were provided by a British Academy Small Grant (SG1920\100342). Further deposits are available in the related DataShare sub-community (https://datashare.ed.ac.uk/handle/10283/8573)
[18F]LW223 has low non-displaceable binding in murine brain, enabling high sensitivity TSPO PET imaging
No full textNeuroinflammation is associated with a number of brain diseases, making it a common feature of cerebral pathology.
Among the best-known biomarkers for neuroinflammation in Positron Emission Tomography (PET) research is the
18 kDa translocator protein (TSPO). This study aims to investigate the binding kinetics of a novel TSPO PETradiotracer,
[18F]LW223, in mice and specifically assess its volume of non-displaceable binding (VND) in brain as well as investigate the
use of simplified analysis approaches for quantification of [18F]LW223 PET data. Adult male mice were injected with [18F]
LW223 and varying concentrations of LW223 (0.003–0.55 mg/kg) to estimate VND of [18F]LW223. Dynamic PET imaging
with arterial input function studies and radiometabolite studies were conducted. Simplified quantification methods,
standard uptake values (SUV) and apparent volume of distribution (VTapp), were investigated. [18F]LW223 had low
VND in the brain (<10% of total binding) and low radiometabolism ( 15–20%). The 2-tissue compartment model
provided the best fit for [18F]LW223 PET data, although its correlation with SUV90–120min or VTapp allowed for [18F]
LW223 brain PET data quantification in healthy animals while using simpler experimental and analytical approaches. [18F]
LW223 has the required properties to become a successful TSPO PET radiotracer.File descriptions are included in a Readme.txt fil
Primary NMR data used during development of the FID post processing averaging methodology
No full textPrimary NMR data used during development of the FID post processing averaging methodology. Abstract: In situ 1D NMR spectroscopic reaction monitoring allows detailed investigation of chemical kinetics and mechanism. Concentration versus time data are derived from a time-series of NMR spectra. Each spectrum in the series is obtained by Fourier transform of the corresponding FID. When the spectrometer outputs FIDs recorded from multiple scans, the spectra benefit from an increase in signal-to-noise (S/N). However, this reduces the number of FIDs and thus kinetic datapoints. We report a simple alternative in which the same number of scans are acquired by the spectrometer, but each scan is saved independently. Signal averaging is then conducted by post-acquisition processing. This leads to an increase in both the S/N and the number of kinetic datapoints and avoids "over-averaging" effects. The entire series of single scan FIDs spanning the reaction lifetime can be summed to yield a 'total reaction spectrum' in w
Audio-Visual 'buckets for feelings'
No full textThis dataset comprises 5 audio-visual pieces- 'buckets for feelings'. These are pieces which are designed for and with children who have severe and complex needs to recognize, hold and synthesize difficult emotions.Files are in mp4 forma
BIG - Biga (ISO 639-3: bhc, Glottocode: biga1238) segmented files
No full textThis dataset contains segmented audio files from several of the raw recordings in the Biga (ISO 639-3: bhc, Glottocode: biga1238) collection; the full collection is available here: https://datashare.ed.ac.uk/handle/10283/8686. These segmented files are designed to facilitate searches for a particular word or construction in the Biga collection. Full information on how to navigate these segmented files using the filenames is given in the Documentation file. The audio files in this dataset come from recordings that were made between 28 December 2019 and 2 January 2020, in Biga village (Misool island, Raja Ampat regency, Southwest Papua province, Indonesia). This dataset relates to the British Academy Postdoctoral Fellowship 'Synchronic and diachronic investigations in Raja Ampat-South Halmahera, a little-known subbranch of Austronesian' (PF19\100004); additional fieldwork funds were provided by a Moray Endowment Fund from the University of Edinburgh. Further deposits are available in the related DataShare sub-community (https://datashare.ed.ac.uk/handle/10283/8573)
What differences exist between the lead and trail wrist in extensor carpi ulnaris activity and golf swing joint kinematics in sub-elite golfers?
No full textThese data pertain to movement kinematics, muscle activity and clubhead performance during the golf swing with pitching wedge, 7-iron and driver clubs in sub-elite golfers:
1) Angular velocities of the lead and trail wrist;
2) lead and trail forearm and hand IMU data;
3) EMG activity of the lead and trail extensor carpi ulnaris muscles;
4) Clubhead kinematics of speed, swing path and angle of attack.
The dataset is related to the upcoming publication Robinson, P.G., Carson, H.J., Richards, J., Murray, A., Duckworth, A.D., Campbell, D. 'What differences exist between the lead and trail wrist in extensor carpi ulnaris activity and golf swing joint kinematics in sub-elite golfers?' (in submission)Microsoft Excel file containing EMG and Kinematic data for 15 participant
Dataset: Adiponectin influences the effects of caloric restriction on liver function, skeletal muscle, and systemic metabolic homeostasis _v2024_09_19
No full textThis dataset contains data for a manuscript that is being submitted for publication in September 2024. Once published, this dataset will be updated with the DOI for the manuscript. The Abstract for the current version of the manuscript is as follows:
Adiponectin is the most-abundant hormone in the circulation. Despite being secreted almost exclusively by adipocytes, circulating adiponectin decreases in obesity and insulin resistance but increases in lean states, including caloric restriction (CR) in animals and humans. Preclinical studies suggest that, in obesity and other adverse contexts, adiponectin deficiency promotes cardiometabolic dysfunction whereas increasing adiponectin improves cardiometabolic health. However, the fundamental roles of adiponectin in physiological, evolutionarily relevant contexts, including hyperadiponectinaemia during CR, have been largely overlooked. We hypothesised that increased adiponectin contributes to the metabolic benefits of CR, including greater glucose tolerance and fat oxidation. To test this, we investigated the effect of global adiponectin knockout (KO) in male and female mice fed ad libitum (AL) or 30% CR from 9-13 weeks of age. Adiponectin KO did not alter CR’s effects on body mass or composition but, unexpectedly, enhanced CR’s ability to improve glucose tolerance. This occurred without altering insulin sensitivity or secretion and instead was driven by fasting hypoglycaemia in KO mice during CR. Adiponectin KO also augmented CR-induced increases in plasma fatty acids but did not alter systemic lipid oxidation in either sex. Hepatic triglycerides and sphingolipids were also unaffected by adiponectin deficiency; however, RNAseq revealed that, during CR, KO compromised hepatic gluconeogenesis in males and promoted hepatic amino acid catabolism in both sexes. This occurred without sarcopenia or elevated protein catabolism in skeletal muscle. Instead, RNAseq indicated that adiponectin KO impaired mitochondrial metabolism and stimulated immunological activity in skeletal muscle of CR males, while CR females’ muscle was largely unaffected. Our study is the first to investigate the role of adiponectin in CR’s metabolic effects. Together, our findings suggest that, in both sexes, adiponectin evolved to help maintain blood glucose during prolonged fasting and that variation in adiponectin influences CR’s metabolic benefits. We contend that the widely reported functions of adiponectin in pathological contexts, such as obesity and insulin resistance, differ substantially to its roles during CR and other physiological conditions in which circulating adiponectin is increased.
For further details please see the file named "Readme metadata file"1. Adiponectin_KO_CR_Paper_Source_Data_all_figures_v2024_09_11.xlsx
This Excel file contains the source data for the figures presented in the manuscript submitted for publication in September 2024. It contains the following 83 worksheets, each of which consists of the data used to generate figures. It can be read as a csv file. Note that any abbreviations are defined in each worksheet:
1. The sheet named "Figures 1A" contains data from plasma adiponectin concentrations from male and female WT mice from 9-15 weeks of age
2. The sheet named "Figure 1B-C, S1A-B" contains data for body mass, fat mass and lean mass of wild-type (WT) and adiponectin knockout (KO) males and females fed ad libitum (AL) or 30% calorie restricted diet (CR) from 9-13 weeks of age
3. The sheet named "Figure 1D-E, S1C-D, S5A-B" and "Figure S12A-D" contains data for tissue masses of WT and adiponectin KO males and females fed AL or CR from 9-13 weeks of age. The masses were recorded at necropsy (13-week-old mice).
4. The sheets named "Figure 2A", "Figure 2B", "Figure 2C", "Figure 2D", "Figure 2E", "Figure 2E", "Figure S3A", and "Figure S3B" contain data from oral glucose tolerance test (OGTT) of WT and adiponectin KO males and females fed AL or CR for 3.5 weeks.
5. The sheets named "Figure S3C" and "Figure S3D" contain data from Insulin tolerance test (ITT) of WT and adiponectin KO males and females fed AL or CR for 3 weeks.
6. The sheet named "Figure 3A" contains data from plasma NEFA concentrations of WT and adiponectin KO males and females fed AL or CR for 4 weeks.
7. The sheets named "Figure 3B", "Figure 3C", "Figure 3D", "Figure 3E", and "Figure 3F" contain data from Oral lipid tolerance test (OLTT) of WT and adiponectin KO males and females fed AL or CR for 3.5 weeks.
8. The sheets named "Figure 4A", "Figure 4B", "Figure 4CDEF", "Figure S4A", " Figure S4B", "Figure S4CD", and "Figure S4EF"contain data from indirect calorimetry of WT and adiponectin KO males and females fed AL or CR for 2.5 weeks.
9. The sheets named "Figure 5A, S7C, S10A_M_AL_KO>WT ", " Figure 5A, S7C, S10A_M_AL_KOWT ", " Figure 5A, S7C, S10A, M_CR_KOWT", "Fig S7C, S8A, S10C F_AL_KOWT", "Fig S7C, S8A, S10C F_CR_KO<WT", "Figure S8B", "Figure S8C", "Figure S8D", "Figure S9A-E", "Figure S10B", "Figure S10D", and "Figure S11A-B" contain data from liver RNAseq of WT and adiponectin KO males and females fed AL or CR for 4 weeks.
10. The sheets named "Figure S5C-D" contains data for Liver TG concentrations of WT and adiponectin KO males and females fed AL or CR for 4 weeks.
11. The sheets named "Figure S6A-C" contains data for Ceramide, DHC and Ceramide:DHC ratio in the liver of WT and adiponectin KO males fed AL or CR for 4 weeks.
12. The sheets named " Figure 6A, S14C, S17A_M_AL_KO>WT ", " Figure 6A, S14C, S17A_M_AL_KOWT ", " Figure 6A, S14C, S17A_M_CR_KOWT ", "Fig S14C, S16A, S17C_F_AL_WT>KO", "Fig S14C, S16A, S17C_F_CR_KO>WT", "Fig S14C, S16A, S17C_F_CR_WT>KO", "Figure S15A", "Figure S15B", "Figure S16B", "Figure S16C", "Figure S17D", "Figure S18A", "Figure S18B", "Figure S18C", "Figure S19C", "Figure S20A",
Relationship between files, if important:
File 1 contains sheets of summary data, including raw data and calculations used to generate the final data
File 2 is this readme file