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Debates on slavery and abolition held by student debating societies at the University of Edinburgh, 1765-1870
No full textThis dataset compiles information relating to debates on slavery and abolition held by two student debating societies at the University of Edinburgh – the Dialectic Society (est. 1787) and the Speculative Society (est. 1764) – between the years 1765 and 1870. The dataset has been produced using published histories of the two student societies and the administrative records of the Dialectic Society (equivalent archival records for the Speculative Society have not been located): History of the Dialectic Society (1887); History of the Speculative Society of Edinburgh from its Institution in 1764 (1845); and Records of University of Edinburgh Dialectic Society, EUA GD9, Edinburgh University Library Archives. Data includes the debates' dates, titles, and outcomes (i.e. affirmative or negative, and the number of votes either way); and attendees’ names, positions taken during debates and additional information on their backgrounds and post-university careers. This dataset has been produced for the Decolonised Transformations project (2022-24), part of the University of Edinburgh’s Race Review, and forms the basis of a forthcoming historical study by the data depositor, Dr Simon Buck. Users should be aware that this dataset draws from historical sources meaning it contains both racist language and offensive ideas about people of African descent.University of Edinburgh Dialectic Society debates on slavery and abolition, 1792-1870.xlsx
This data tabulates information relating to University of Edinburgh Dialectic Society debates on slavery and abolition for the period 1792-1870, using History of the Dialectic Society (1887) and Records of the University of Edinburgh Dialectic Society (EUA GDP, Edinburgh University Archives).
University of Edinburgh Speculative Society debates on slavery and abolition, 1765-1838.xlsx
This data tabulates information relating to University of Edinburgh Speculative Society debates on slavery and abolition for the period 1765-1838, using History of the Speculative Society (1845)
The interplay between topography and contact line pinning mechanisms on flat and superhydrophobic surfaces
No full textDataset corresponding to arXiv pre-print of: "The interplay between topography and contact line pinning mechanisms on flat and superhydrophobic surfaces".
Wettability of a surface depends on both surface chemistry and topography. To move a three-phase contact line, a de-pinning force needs to be applied, which is of practical importance in various applications. However, a unified understanding and description of the de-pinning force on both flat and superhydrophobic surfaces is still lacking. This study aims to bridge the existing gap in our understanding of the three-phase contact line pinning on flat and microstructured superhydrophobic surfaces. The findings indicate that a general model, based on two different pinning mechanisms, can describe the pinning force on both flat and microstructured surfaces. We compare the general model against experimental data from literature, as well as our experiments on flat and microstructured surfaces coated with a liquid-like layer of grafted polymer chains. While this theoretical framework can be useful for designing micro-engineered surfaces on which the contact line behaviour is important, it also provides a potential experimental strategy to distinguish the contribution of defects from that of molecular re-orientation to contact line pinning on a given solid material
Supplemental material for 'Peace agreements in a changing climate: Three ways in which climate change and peace processes interact' journal article (Tim Epple)
No full textThis data is supplemental material for the journal article 'Peace agreements in a changing climate: Three ways in which climate change and peace processes interact' by Tim Epple, published in Environment and Security (https://doi.org/10.1177/27538796241310298). The data draws on the PA-X Peace Agreement Dataset Version 7. Abstract: Previous research has shown that climate change can exacerbate conflict drivers or, on the other hand, incentivise ‘environmental peacebuilding’. One might, therefore, expect to find references to climate issues in peace agreements. This study draws on the PA-X Peace Agreement Database to shed new light on climate–peace interactions. Only seven out of 2,003 peace agreements signed between 1990 and 2023 explicitly mention ‘climate change’. However, an analysis of provisions in 28 peace agreements reveals that climate–peace interactions are much more complex than the paucity of the term ‘climate change’ in agreements suggests. Based on PA-X data, I argue that there are three main ways in which climate change and peace processes interact: First, as existing literature shows, the consequences of climate change can affect conflict parties’ bargaining positions and lead to conflict (de-)escalation. Second, conflict parties agree on climate action – often implicitly and for political reasons. This article provides the first comparison of levels of climate action ambition in peace agreements, from incremental and transformational adaptation to mitigation. Third, the results of political bargaining in peace processes can have positive and negative unintended consequences for the climate. For example, although conflict de-escalation can produce a more conducive environment for climate action, its stabilising effect may also enable carbon-intensive economic activities.The supplemental material includes three files, ordered by when they are referred to in the article’s methodology section:
1 PA-X Search Results_PA-X Topic Categories Search.xlsx
2 PA-X Search Results_Keyword Search_IPCC Glossary.xlsx
3 PA-X Search Results_Free-Text Search_Sup Terms.xlsx
Each files contains a description of individual Excel sheets
The NE/AAT/CBG axis regulates adipose tissue glucocorticoid exposure
No full textThese are the source data underlying the figures presented in the manuscript accepted in Nature Communications. These are the source data underlying the figures presented in a manuscript entitled "The NE/AAT/CBG axis regulates adipose tissue glucocorticoid exposure", which has been provisionally accepted for publication in Nature Communications. Once published, the metadata for this dataset will be updated with the DOI of the published paper. Corticosteroid binding globulin (CBG; SERPINA6) binds >85% of circulating glucocorticoids but its influence on their metabolic actions is unproven. Targeted proteolytic cleavage of CBG by neutrophil elastase (NE; ELANE) significantly reduces CBG binding affinity, potentially increasing ‘free’ glucocorticoid levels at sites of inflammation. NE is inhibited by alpha-1-antitrypsin (AAT; SERPINA1). Using complementary approaches in mice and humans to manipulate NE or AAT, we show high-fat diet (HFD) increases the NE:AAT ratio specifically in murine visceral adipose tissue, an effect only observed in males. Notably, HFD-fed male mice lacking NE have reduced glucocorticoid levels and action specifically in visceral adipose tissue, with improved glucose tolerance and insulin sensitivity, independent of systemic changes in free glucocorticoids. The protective effect of NE deficiency is lost when the adrenals are removed. Moreover, human asymptomatic heterozygous carriers of deleterious mutations in SERPINA1 resulting in lower AAT levels have increased adipose tissue glucocorticoid levels and action. However, in contrast to mice, humans present with systemic increases in free circulating glucocorticoid levels, an effect independent of HPA axis activation. These findings show that NE and AAT regulate local tissue glucocorticoid bioavailability in vivo, providing crucial evidence of a mechanism linking inflammation and metabolism
Videos of eMouseAtlas Models: Theiler Stage 26 (18 dpc)
No full textA number of videos for each of the eMouseAtlas 3D mouse embryo models to show the overall form and in some cases selected anatomy. Each video is identified by the unique EMA ID with annotation if required. The videos labelled as "watermovies" are captured using the OPT system with the embryo spun on a longitudinal axis with no tissue clearing
Videos of eMouseAtlas Models: Theiler Stage 24 (16 dpc)
No full textA number of videos for each of the eMouseAtlas 3D mouse embryo models to show the overall form and in some cases selected anatomy. Each video is identified by the unique EMA ID with annotation if required. The videos labelled as "watermovies" are captured using the OPT system with the embryo spun on a longitudinal axis with no tissue clearing
Confirmation of p-tau Ser356’s association with Alzheimer’s disease pathology and lowering in response to WZ4003 treatment in brain slice cultures. Reply to: “Phospho-tau Ser356 is mostly confined to pre-NFT neurons in Alzheimer’s pathology”
No full textThis dataset relates to correspondence by Taylor et al. Here we repeat some key experiments from Taylor et al 2024 using the more more specific antibody ab92682. We find that the core findings from our original Taylor et al 2024 paper are robust and reproducible. Using the more specific ab92682 antibody we find that: 1. P-tau Ser356 increases in a Braak stage-dependent manner in human post-mortem temporal cortex (western blot); 2. P-tau Ser356 co-localises with methoxy positive tangles in AD post-mortem brain (both in paraffin sections and using array tomography); 3. P-tauSer356 co-localises with pre-synaptic terminals and astrocytic processes in AD post-mortem brain (array tomography); 4. P-tau Ser356 levels are lowered in response to treatment with the NUAK1/2 inhibitor WZ4003 in live brain slice cultures (mouse organotypic brain slice cultures)
Developing the interdisciplinary scope of golf strength and conditioning coaching: Learning from practitioners’ conceptualization and use of athletes’ errors
No full textInterdisciplinarity is increasingly recognised as a feature of expert sports coaching. Concurrently, the importance of coaches’ decision-making regarding the role and use of challenge during training has been emphasised. To address these developments and further understand their relatedness within the applied context, using semi-structured interviews, this study explored eight golf strength and conditioning (S&C) coaches’ perspectives on and experiences of athletes’ errors (as indicators of challenge) and interdisciplinary integration. Notably, findings indicate a clear need for development within the golf domain regarding interdisciplinary knowledge and practice as it pertains to support provision. Specifically, recommendations are made to support the bidirectional integration of S&C knowledge across golf coaching domains and stress the importance of developing golf S&C practitioners’ psychosocial competencies during accreditation and continuous professional development curricula.Refer to Data Description File.tx
Rational Engineering of a Thermostable α-Oxoamine Synthase Biocatalyst Expands the Substrate Scope and Synthetic Applicability
No full textThe dataset contains all raw data from the tables used in the manuscript, titled "Rational Engineering of a Thermostable α-Oxoamine Synthase Biocatalyst Expands the Substrate Scope and Synthetic Applicability".
Publication abstract: Carbon-carbon bond formation is one of the key pillars of organic synthesis. Green, selective and efficient biocatalytic methods for such are therefore highly desirable. The α-oxoamine synthases (AOSs) are a class of pyridoxal 5’-phosphate (PLP)-dependent, irreversible, carbon-carbon bond-forming enzymes, which have been limited previously by their narrow substrate specificity and requirement of acyl-CoA thioester substrates. We recently characterized a thermophilic enzyme from Thermus thermophilus (ThAOS) with a much broader substrate scope and described its use in a chemo-biocatalytic cascade process to generate pyrroles in good yields and timescales. Herein, we report the structure-guided engineering of ThAOS to arrive at variants able to use a greatly expanded range of amino acid and simplified N-acetylcysteamine (SNAc) acyl-thioester substrates. The crystal structure of the improved ThAOS V79A mutant with a bound PLP:l-penicillamine external aldimine ligand, provides insight into the properties of the engineered biocatalyst
Subscriptions towards the University of Edinburgh’s Old College (1789-1794) and Old Medical School (1873-1887)
No full textThis dataset includes lists of subscriptions (i.e. donations) for two historical capital campaigns at the University of Edinburgh to fundraise for the construction of two new campus buildings: the sites known today as Old College, on South Bridge, and the Old Medical School, on Teviot Place. The list of Old College subscriptions has been complied using digitised issues of the Caledonian Mercury newspaper and one surviving list of subscribers in the University’s archives, together covering the period 1789-1794. The list of Old Medical School subscribers has been complied using materials in the University of Edinburgh’s archives, namely two ‘contribution lists’ dated 1873-1881 and 1883-1887. Data includes subscribers’ names, places of residence, professions and other biographic information, as well as amounts of money subscribed or paid, the dates on which their subscriptions were published or recorded, and other subscription-related information (e.g. the name of intermediaries, or the original currency in which money was subscribed). This dataset was produced for the Decolonised Transformation project (2022-24), part of the University of Edinburgh’s Race Review. Analysis of subscribers (i.e. donors) identified as having links to slavery and colonialism – including those based in British colonies – can be found in an annexed report for that project, Slavery, Colonialism and Philanthropy at the University of Edinburgh (2024), by Dr Simon Buck, the data depositor.Subscribers to the University of Edinburgh's Old College (1789-1794).xlsx
This data compiles Old College subscriptions using digitised issues of the Caledonian Mercury newspaper for the period 1789-1794, and a printed list of subscribers in the University’s archives dated 5 March 1790: ‘Subscribers to the New College, Edinburgh’, 5 March 1790, EUA IN1/GOV/SEN/COR (former shelf mark Da.32.1), Correspondence, 18th-20th century, Senatus Academicus, 1733-2002, University of Edinburgh Library Archives.
Subscribers to the University of Edinburgh's Old Medical School (1873-1887).xlsx
This data compiles Old Medical School subscriptions from two alphabetical ‘contribution lists’ held within the University’s archives. Information relating to subscriptions has been transcribed from the original handwritten documents, meaning some information may a variant or incorrectly spelt. Text in square brackets explains parts of the record or indicates when there is a word/name that has not been deciphered, i.e. '[?]'. Entries recorded both single payments and those split over different dates, hence some dates in the data are recorded as periods of time (e.g. 1878-1882) rather than single years. In these cases only the total sum of their multiple payments has been included. However, some subscribers made additional subscriptions, meaning names occasionally feature more than once in the list. Some professions have been assumed using their titles (e.g. 'Dr' or 'Col.'). In general, where only a street address was recorded, it is assumed to be an Edinburgh residence. Information in the original texts that has not been transcribed include: day and month of subscription; date when subscriptions (or 'contributions') were intimated (i.e. promised); and the amount intimidated. Those who intimidated but did not pay have not been included in this list. In the final two years (1885-1887) there are some subscriptions that went towards the construction of what would become McEwan Hall rather than the Medical School building, which was opened in 1884: University Buildings Extension Contribution List, 1873-1881, and University Buildings Extension Contribution List, 1883-1887, EUA IN1/COM/B2/4/1-2, Records of the University Buildings Extension Scheme, University of Edinburgh Library Archives