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7718 research outputs found
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FPR1&WT_Myeloid_NanoString_DataSet_24hpostAPAP
No full textWhole Liver from FPR1-/- and WT mice 24 hours post treatment with paracetamol 350mg/kg
Nanostring mouse myeloid panel gene set with additional 10 gene spike (see attached documents
Dataset for `Neutrophils have a temporal dichotomous role in acute liver injury and repair` - AT7519 neutrophil depletion
No full textWhole Liver from WT mice, 36 hours after 350mg/kg paracetamol i.p/ having received either 30mg/kg AT7159 or vehicle i.p. at 16 hours post.
36 hours is repair time point in this model, with 16 hours being peak inflammation.
Nanostring mouse myeloid panel gene set with additional 10 gene spike (see attached documents)
Liver Innate Immunity Response to Acute Injury with and with AT7519 mediated neutrophil depletio
High Resolution sections of eMouseAtlas Models: EMA24, Theiler Stage 13 TS13(8.5 dpc)
No full textHigh resolution images of each section used for the Mouse Atlas 3D models. Images are sub-sampled for the 3D models to provide approximately iso-tropic voxel dimensions, here the images are at the full resolution of the original digitisation
Nanoscale insights into vibration-induced heterogeneous ice nucleation
No full textAccelerating ice nucleation in confined liquids is desirable in applications like food freezing, cryopreservation, and ice casting, but current techniques have their limitations. The use of high-frequency acoustic waves (AW) is a promising alternative but remains poorly-understood. We employ molecular dynamics simulations to investigate the AW-induced ice nucleation within confined nanopores. By systematically varying vibrational amplitude and frequency, we identify five distinct nucleation regimes, forming a comprehensive regime map that links these parameters to nucleation outcomes. Our simulations reveal that ice nucleation is preceded by formation of ice-like clusters, and is strongly influenced by negative pressure induced by surface vibrations. A strain-based criterion is introduced to generalize the findings to larger lengthscales. This enables us to propose a universal framework for controlling ice formation via surface vibrations in industrial applications. The dataset is related to the publication by Pengxu Chen, Rohit Pillai, and Saikat Datta (2025), "Nanoscale insights into vibration-induced heterogeneous ice nucleation", Nanoscale, https://doi.org/10.1039/D5NR00326A
How Functional Groups Influence Asphaltene Aggregation: Molecular Simulations and Small-Angle Neutron Scattering
No full textThe dataset consists of a sample LAMMPS input file, sample LAMMPS data files for each asphaltene in 2:8 heptane:toluene mixtures, and the raw data plotted in Figures 3, 6, 7, 8, 9, 10, and 12. Asphaltenes are polycyclic aromatic molecules found in high-molecular-weight fractions of crude oil. They dissolve in aromatic solvents like toluene but not in aliphatic solvents like heptane. Low solubility leads to aggregate formation and many problems in transport applications. Natural asphaltene fractions contain complex mixtures of molecules that vary widely between sources of crude oil, and so the chemical and structural properties are difficult to characterize. Herein, three synthetic asphaltenes containing different oxidation states of sulfur in binary mixtures of toluene and heptane are studied. Aggregate formation is investigated using a combination of small-angle neutron scattering (SANS) and molecular dynamics (MD) simulations. The extent of aggregation is found to depend strongly on both the composition of the solvent and the functionality of the sulfur atom. A benzothiophene-functionalized asphaltene, without any oxygen, forms nanoaggregates in toluene that do not change significantly on addition of heptane. In contrast, asphaltenes containing the sulfoxide or sulfone analogs form nanoaggregates in toluene and much larger clusters above 40% by volume heptane content, with the initial nanoaggregates of the sulfone being slightly larger. Such behavior is apparent in both measured and simulated scattering profiles, and while these techniques probe different length scales, the results are consistent. The microscopic structures of the simulated aggregates are detailed. In systems with low heptane content, the asphaltenes form small clusters of 2-4 molecules, depending on the functionality. In systems with greater heptane content, the sulfoxide and sulfone form larger clusters. The variations in clustering behavior between functional groups and solvents are attributed mainly to the electrostatic interactions between the polar sulfur-containing functional groups, which stabilize "head-to-tail" configurations in the sulfoxide aggregates and more complex branched structures in the sulfone aggregates.See README.tx
High Resolution sections of eMouseAtlas Models: EMA48, Theiler Stage 16 TS16(10 dpc)
No full textHigh resolution images of each section used for the Mouse Atlas 3D models. Images are sub-sampled for the 3D models to provide approximately iso-tropic voxel dimensions, here the images are at the full resolution of the original digitisation
High Resolution sections of eMouseAtlas Models: EMA10, Theiler Stage 10 TS10(7 dpc)
No full textHigh resolution images of each section used for the Mouse Atlas 3D models. Images are sub-sampled for the 3D models to provide approximately iso-tropic voxel dimensions, here the images are at the full resolution of the original digitisation
High Resolution sections of eMouseAtlas Models: EMA9, Theiler Stage 9 TS9 (6.0 - 6.5 dpc)
No full textHigh resolution images of each section used for the Mouse Atlas 3D models. Images are sub-sampled for the 3D models to provide approximately iso-tropic voxel dimensions, here the images are at the full resolution of the original digitisation
High Resolution sections of eMouseAtlas Models: EMA38, Theiler Stage 16 TS16(10 dpc)
No full textHigh resolution images of each section used for the Mouse Atlas 3D models. Images are sub-sampled for the 3D models to provide approximately iso-tropic voxel dimensions, here the images are at the full resolution of the original digitisation
High Resolution sections of eMouseAtlas Models: EMA28, Theiler Stage 15 TS15(9.5 dpc)
No full textHigh resolution images of each section used for the Mouse Atlas 3D models. Images are sub-sampled for the 3D models to provide approximately iso-tropic voxel dimensions, here the images are at the full resolution of the original digitisation