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Post-concussion symptom burden and dynamics: insights from a digital health intervention and machine learning
No full textRaw HeadOn symptom burden data for 84 study participants. Participants were invited to rate a total of 8 post-concussion symptoms over the 35 day digital HeadOn program. Each symptom was rated on a Likert scale (0 = no symptoms; 4 = very severe symptom)
INSIDE-HIV: imaging neuroinflammation in severe and persistent depression in people with HIV
No full textThis dataset contains data generated for the INSIDE-HIV study, carried out at Brighton & Sussex Medical School (BSMS), University of Sussex, Brighton, UK. The objective of this pilot study was to assess whether neuroinflammation (as measured using neuroimaging techniques) is correlated with the severity of depressive symptoms in people living with HIV. A total of 20 people living with HIV with varying degrees of depressive symptom severity were recruited for a study involving neuroimaging and blood sampling to assess biomarkers of (neuro)inflammation
Symmetry perception for patterns defined by color and luminance
No full textThese are the Experiment 2a and 2b EEG datasets from the Martinovic et al. (2018) paper on symmetry perception, published in Journal of Vision, https://doi.org/10.1167/18.8.4
Perception of visual symmetry is fast and efficient and relies on both early low-level and late mid- and high-level neural mechanisms. To test for potential influences of early low-level mechanisms on symmetry perception, we used isoluminant, achromatic, and combined (color + luminance) patterns in a psychophysical and an event-related-potential (ERP) experiment. In the psychophysical experiment, pattern contrast was fixed at individual symmetry-discrimination threshold. Participants then judged whether a pattern was symmetric or random. Stimuli at isoluminance were associated with a large bias toward symmetry, achromatic stimuli introduced the opposite bias, and stimuli containing a balance of both color and luminance were perceived without bias. These findings are in line with distinct contrast sensitivity functions for color and luminance, with color providing low-frequency information useful for symmetry detection and luminance providing high-frequency information useful for detection of detail. The subsequent ERP experiment was run at high contrasts to assess processing of symmetry in suprathreshold conditions. Sustained posterior negativity, a symmetry-sensitive ERP component, was observed in all conditions and showed the expected dependence on symmetry. However, interactions between symmetry and contrast type were not observed. In conclusion, while our findings at threshold support models that propose an important contribution of low-level mechanisms to symmetry perception, at suprathreshold these low-level contributions do not persist. Therefore, under everyday viewing conditions, symmetry perception engages a relatively broad cortical network that is not constrained by low-level inputs.The Expt2a.zip and Expt2b.zip contain EEGlab-format files from Experiments 2a and 2b respectively. The readme.txt file contains the file descriptions and details of EEG event labels
Developing New Top-Down Mass Spectrometry Strategies for Studying Transient Protein-Protein Interactions
Full text linkDatasets related to the PhD Thesis of Maria Mateos Jimenez entitled 'Developing New Top-Down Mass Spectrometry Strategies for Studying Transient Protein-Protein Interactions'
Replication Materials for “Beyond ‘emergencies?’ Reporting on Humanitarian Issues Around the World”
No full textThis dataset contains all materials needed to replicate the analysis in the article “Beyond ‘emergencies?’ Reporting on Humanitarian Issues Around the World”, including R scripts used to construct and analyse the corpus, processed data files, and documentation. The ZIP archive includes:
• R scripts used for data collection and processing (0*_*.R) and analytical procedures (1*_*.R)
• Aggregated datasets derived from a multilingual corpus of over one million media texts (2010–2020)
• Summary output files and similarity scores
• A structured FILE_STRUCTURE.md file and a detailed README.md with usage notes
For copyright reasons, full-text source documents are not included in the archive. Additionally, some absolute file paths in the R scripts have been anonymised to preserve user privacy.
More information about the replication materials can be found in: https://github.com/danimadrid/humanitarian_new
A methylome-wide association study of major depression with out-of-sample case-control classification and trans-ancestry comparison
No full textThis dataset contains the summary statistics from a large-scale meta-analysis of methylome-wide association studies (MWAS) for Major Depression (MD), conducted by the Psychiatric Genomics Consortium Major Depressive Disorder Working Group and published in Nature Mental Health. The analysis included data from 18 studies comprising 24,754 European-ancestry participants (5,443 MD cases) and an East Asian sample (243 cases, 1846 controls). The study identified fifteen CpG sites significantly associated with lifetime MD, and provided evidence for the involvement of DNA methylation and immune system in MD
WITHDRAWN: What's Right with PE: Exploring Positive Narratives in Physical Education
No full textWITHDRAWN - This item has been withdrawn and replaced by https://doi.org/10.7488/ds/7924. Abstract:
For decades, physical education (PE) scholars have called for a change to how PE is conceptualised and enacted, highlighting that its current (and persistent) form and focus - organised around physical activities and sport - are not fit for purpose. Much of this change-oriented discourse highlights what is wrong with PE, leading to suggestions about how PE should change in and for the future, for example, by adopting critical approaches and connecting more to the lives of young people. While we do not disagree with these perspectives and ideas, it is important to note that, in general, they have had little impact on PE curricula or pedagogy. In this paper we suggest an alternative, strengths-based approach. Drawing from discussions with a range of professionals from the PE community (teachers, undergraduate and postgraduate pre-service teachers and teacher educators) across five national contexts - Canada, England, Ireland, Norway and Scotland - we generated narratives about ‘what’s right with PE’. The narratives highlighted that PE can be ‘fit for purpose’ when it connects to the wider school and community, when everyone has a shared understanding of its purpose, and when PE teachers enact a broad, holistic and inclusive curriculum. We present the narratives as a reflective tool, encouraging all professionals within the PE community to consider how they align with (or against) their current experiences. We hope that these reflections facilitate critical thinking and problem solving to ensure that the subject is (and remains) fit for purpose now and in the future
Data from paper: Evidence for trans-synaptic propagation of oligomeric tau in human Progressive Supranuclear Palsy
No full textIn the neurodegenerative disease Progressive Supranuclear Palsy (PSP), tau pathology progresses through the brain in a stereotypical spatiotemporal pattern, and where tau pathology appears, synapses are lost. We tested the hypothesis that pathological tau contributes to synapse loss and may spread through the brain by moving from pre- to post-synapses. Using post-mortem PSP brain samples and a living human brain slice culture model, we observe pathological tau in synaptic pairs and evidence that oligomeric tau can enter live human post-synapses. Proteomics revealed increased clusterin in synapses in PSP, and super-resolution imaging showed clusterin colocalised with tau in synapses in close enough proximity to be binding partners, which may mediate tau spread. Accumulation of tau in synapses correlated with synapse loss, and synaptic engulfment by astrocytes was observed, suggesting that astrocytes contribute to synapse loss. Together these data indicate that targeting synaptic tau is a promising approach to treat PSP
To promote network connectivity in colloidal-rod suspensions, end with a tip
No full textData and codes to support the manuscript "To promote network connectivity in colloidal-rod suspensions, end with a tip"
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Abstract - Colloidal gels formed from patchy rods provide a promising platform to design novel functional materials and formulations. Yet, the case for localised interactions at the rod tips remains relatively unexplored. Here we probe the structure and dynamics of such systems by means of coarse-grained computer simulations, and show that the emerging tipped gel networks are fundamentally different to uniform ones. Structurally, tipped networks are better connected, and, unlike in the uniform gels, the connectivity increases with the length of the constituent rods. The dynamics are also fundamentally different, with the gelation time in the tipped networks (contrary to the uniform gels) exhibiting an inverse relationship with rod-length
Hong Kong April 2024 - images of older estates
No full text### DOCOMOMO INTERNATIONAL MASS HOUSING ARCHIVE ### The provision of healthy modern housing for all was one of the foremost ideals of the Modern Movement, and inspired a vast wave of planning and building across the world during the 20th century. In the last quarter of the century, even as the foundational programmes of Europe and America lost their impetus, the baton was passed on to other countries, especially in eastern Asia, where the narrative of Modern mass housing was reinvigorated for the next century - a unique example of a key Modernist project that actually continues and thrives today, and which thus forms a principal focus of interest for DOCOMOMO – the leading international organisation promoting the documentation and conservation of buildings, sites and neighbourhoods of the Modern Movement. As heritage, the built legacies of this diverse and multi-generational adventure are almost always too controversial to qualify for conservation strategies. Instead, therefore, recording and inventorisation must dominate the heritage interest in this field. In the recognition of that fact, DOCOMOMO’s International Specialist Committee on Urbanism and Landscape, in partnership with the Scottish Centre for Conservation Studies at the University of Edinburgh, has launched the International Mass Housing Archive, whose aim is to provide an open-access library of images of significant housing projects in each working-group territory, free of copyright restrictions. These files may be copied, edited and shared on condition the appropriate citation is used, as per the terms of the attached Creative Commons Attribution licence. ### Structure ### The International Mass Housing Archive is subdivided under geographical headings corresponding to the constituent working groups of DOCOMOMO, and the individual housing projects are searchable under city and project name. Initially, the Image Archive will be managed and augmented centrally by DOCOMOMO and the SCCS, in partnership with University of Edinburgh Information Services, commencing with pilot city surveys sourced from our own photographic records in the first instance. The archive is related to several existing mass housing documentation initiatives. These include one concerning Britain, namely the online version of the 1994 book, Tower Block: http://towerblock.org/TowerBlock.pd