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August 3, 2020: Covid-19 Campus Update
Get PDFThe COVID-19 Response Team continues to work with Genesee County Public Health Department and with the Office of the President to adapt to the situation as it evolves and to provide our community with the most current information regarding the COVID-19 pandemic. The University is fully committed to the health and safety of its entire community, and will continue to closely monitor this situation and any others that impact our campu
November 11, 2020: Letter from the President- Covid-19 Town Hall Meeeting
Get PDFAll students, faculty and staff are invited to join members of the Kettering University’s COVID-19 Response Team for a virtual Town Hall to discuss COVID-19 and the safety measures put in place on campus
November 15, 2020: Covid-19 Campus Update
Get PDFWe are currently evaluating the full extent and impact on our campus community of the announcement by the Michigan Governor on Sunday evening. This announcement includes limitations to be imposed statewide effective this Wednesday.
Actions to be taken by the University to be in compliance with local and state directives will be determined and communicated promptly to the campus community
November 20, 2020: Covid-19 Campus Update
Get PDFAs we approach the Thanksgiving holiday, we want to encourage everyone to be very cautious so as to safely celebrate with loved ones. Stay safe and informed not just for the well-being of your friends and families, but also for our campus community upon your return. This means all of us continuing to practice social distancing, properly wearing a face mask and washing our hands often
Magnetic Hyperthermia in Y79 Retinoblastoma and ARPE19 Retinal Epithelial Cells: Tumor Selective Apoptotic Activity of Iron Oxide Nanoparticle
Get PDFPurpose: To evaluate selective apoptosis of Y79 retinoblastoma versus ARPE-19 retinal pigment epithelial cells by using different doses of dextran-coated iron oxide nanoparticles (DCIONs) in a magnetic hyperthermia paradigm. Methods: Y79 and ARPE-19 cells were exposed to different concentrations of DCIONs, namely, 0.25, 0.5, 0.75, and 1 mg/ml. After 2 hours of incubation, cells were exposed to a magnetic field with a frequency of 250 kHz and an amplitude of 4 kA/m for 30 minutes to raise the cellular temperature between 42 and 46°C. Y79 and ARPE-19 cells incubated with DCION without magnetic field exposure were used as controls. Cell viability and apoptosis were assessed at 4, 24, and 72 hours after hyperthermia treatment. Results: At 4 hours following magnetic hyperthermia, cell death for Y79 cells was 1%, 8%, 17%, and 17% for 0.25, 0.5, 0.75 and 1 mg/ml of DCION, respectively. Cell death increased to 47%, 59%, 70%, and 75% at 24 hours and 16%, 45%, 50%, and 56% at 72 hours for 0.25, 0.5, 0.75, and 1 mg/ml of DCIONs, respectively. Magnetic hyperthermia did not have any significant toxic effects on ARPE-19 cells at all DCION concentrations, and minimal baseline cytotoxicity of DCIONs on Y79 and ARPE-19 cells was observed without magnetic field activation. Gene expression profiling showed that genes involved in FAS and tumor necrosis factor alpha signaling pathways were activated in Y79 cells following hyperthermia. Caspase 3/7 activity in Y79 cells increased following treatment, consistent with the activation of caspase-mediated apoptosis and loss of cell viability by magnetic hyperthermia. Conclusion: Magnetic hyperthermia using DCIONs selectively kills Y79 cells at 0.5 mg/ml or higher concentrations via the activation of apoptotic pathways. Translational Relevance: Magnetic hyperthermia using DCIONs might play a role in targeted management of retinoblastoma
